Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailDesign of reversibly core cross-linked micelles sensitive to reductive environment
Cajot, Sébastien ULg; Lautram, N.; Passirani, Catherine et al

in Journal of Controlled Release (2011), 152(1), 30-36

Azido-functional amphiphilic macromolecules based on a biodegradable aliphatic polyester (poly-epsilon-caprolactone, PCL) and a bioeliminable hydrophilic poly(ethylene oxide) (PEO) block have been used in ... [more ▼]

Azido-functional amphiphilic macromolecules based on a biodegradable aliphatic polyester (poly-epsilon-caprolactone, PCL) and a bioeliminable hydrophilic poly(ethylene oxide) (PEO) block have been used in order to build micellar drug delivery systems. Such azido groups being able to react by alkyne-azide 1,3 Huisgens cycloaddition (a click reaction) have been used further in order to cross-link the micelles via redox-sensitive disulfide bridges. This reversible cross-linking allows to prevent micelles dissociation at high dilution upon injection and to trigger their dissociation in more reductive environment, such as the cytosol. Copolymers having three different architectures, i.e. able to crosslink either the core or the shell of core-shell-corona system have been used to investigate their micellization, cross-linking and cross-linking reversibility. The stealthiness of these micelles crosslinked in the hydrophobic segment has also been studied in vitro. [less ▲]

Detailed reference viewed: 79 (28 ULg)
See detailDesign of reversibly disulfide core cross-linked polymer micelles
Cajot, Sébastien ULg; Schol, Daureen ULg; Danhier, F. et al

Poster (2011, November 21)

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block ... [more ▼]

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block copolymers are supramolecular core-shell type assemblies of tens of nanometers in diameter. An accumulation of polymer nanocarriers to solid tumours is possible due to the EPR effect. Even if micelles get a high stability in aqueous media, the dissociation of micelles is not always preserved when they are injected in the blood compartment. This work aims at reporting on the design of reversibly cross-linked micelles based on PEO-b-PCL copolymers by introducing disulfide bridges in the micelle core to provide higher stability. Different kinds of macromolecular architectures are employed to study their impact on the micelles and their biological behavior. These new functional copolymers were all successfully micellized, reversibly cross-linked and are stealthy, which show the efficiency of the developed cross-linking process and offer a set of nanocarriers to be tested further, as shown on the first biological tests. [less ▲]

Detailed reference viewed: 46 (5 ULg)
See detailDesign of reversibly disulfide core cross-linked polymer micelles
Cajot, Sébastien ULg; Schol, Daureen ULg; Danhier, F. et al

Poster (2011, December 07)

Detailed reference viewed: 32 (10 ULg)
Full Text
Peer Reviewed
See detailDesign of River Navigation weirs and Flood Protection Barriers
Rigo, Philippe ULg; Sarghiuta, Radu; Herbillon, Vincent ULg et al

in 78th ICOLD Annual Meeting - Hanoi 2010 (2010, May 23)

The aim of the WG (Working Group) was to conduct a comprehensive review (state-of-the-art) of the modern technologies, design tools and recent research used to design and build structures controlling ... [more ▼]

The aim of the WG (Working Group) was to conduct a comprehensive review (state-of-the-art) of the modern technologies, design tools and recent research used to design and build structures controlling water level and flow in rivers, waterways and ports (for navigation & flood protection). The WG considered regulatory structures such as: - Gates controlling water level and flow in rivers (even non navigable) and waterways (lifting gate, tilting gate, radial gate, sector, etc.; designed in one piece or with an upper flap). These are referred to as WEIRS. - Gates controlling water level and flow in estuaries with regards to high tides and storms (lifting gate, articulated, tilting, rolling, floating, sliding, etc.). These structures are referred to as BARRIERS. [less ▲]

Detailed reference viewed: 167 (9 ULg)
See detailDesign of smart polymer micelles for pH triggered drug delivery systems
Jérôme, Christine ULg

Conference (2009, April 02)

Detailed reference viewed: 19 (6 ULg)
See detailDesign of smart SPM probes by electrografting
Gabriel, Sabine ULg; Jérôme, Christine ULg; Duwez, Anne-Sophie ULg

Conference (2007, May 11)

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailDesign of statistical measures for the assessment of image segmentation schemes
Van Droogenbroeck, Marc ULg; Barnich, Olivier ULg

in International Conference on Computer Analysis of Images and Patterns (CAIP 2005) (2005)

Image segmentation is discussed for years in numerous papers, but assessing its quality is mainly dealt with in recent works. Quality assessment is a primary concern for anyone working towards better ... [more ▼]

Image segmentation is discussed for years in numerous papers, but assessing its quality is mainly dealt with in recent works. Quality assessment is a primary concern for anyone working towards better segmentation tools. It both helps to objectively improve segmentation techniques and to compare performances with respect to other similar algorithms. In this paper we use a statistical framework to propose statistical measures capable to describe the performances of a segmentation scheme. All the measures rely on a ground-truth segmentation map that is supposed to be known and that serves as a reference when qualifying the results of any segmentation tool. We derive the analytical expression of several transition probabilities and show how to calculate them. An important conclusion from our study, often overlooked, is that performances can be content dependent, which means that one should adapt a measure to the content of an image. [less ▲]

Detailed reference viewed: 236 (14 ULg)
See detailDesign of stealth nanoparticles for drug delivery based on new amphiphilic copolymers
Rieger, Jutta ULg; Passirani, Catherine; Dubois, Philippe et al

Conference (2006, May 18)

Detailed reference viewed: 36 (1 ULg)
Peer Reviewed
See detailDesign of Steel Connections according ENV 1993-1
Jaspart, Jean-Pierre ULg

in Proceedings of the IABSE Congress on Structural Engineering in Consideration of Economy, Environment, Energy, Workshop on Structural Connections and Assembly Techniques (1996)

Detailed reference viewed: 40 (0 ULg)
Full Text
Peer Reviewed
See detailDesign of steel I-girders in bending and shear stiffened by one or two trapezoidal longitudinal stiffeners
Thomas, G.; Degée, Hervé ULg; Maquoi, René ULg et al

in Proceedings of the 5th Conference on Advances in Steel Structures (2007)

Present paper focuses on the design of stiffened plates under bending and shear that are used in steel or composite bridges. Special attention is paid to situations involving one or two stiffeners, where ... [more ▼]

Present paper focuses on the design of stiffened plates under bending and shear that are used in steel or composite bridges. Special attention is paid to situations involving one or two stiffeners, where Eurocode 3 Part 1.5 provides specific rules. First, the paper describes briefly the FEM numerical models used in parametric studies. Then, comparisons between results obtained respectively from numerical simulations and from application of the code clauses are presented. Also, some proposals for improved rules are made. [less ▲]

Detailed reference viewed: 35 (1 ULg)
Full Text
See detailDesign of Steel Structures subjected to Fire. Background and Design Guide to Eurocode 3.
Franssen, Jean-Marc ULg; Zaharia, Raul

Book published by Les Éditions de l'Université de Liège (2005)

The information that is necessary to perform the fire design of a structure made of a particular material, say a steel structure, is: a) The bases of design, stated in EN 1990. b) The mechanical actions ... [more ▼]

The information that is necessary to perform the fire design of a structure made of a particular material, say a steel structure, is: a) The bases of design, stated in EN 1990. b) The mechanical actions, i.e. the forces, acting on the structure in the fire situation. Some information is found in EN 1991-1-2, but explicit reference is also made to EN 1991-1-1 that is therefore also necessary. c) The thermal actions, i.e. the fire and the heat flux induced in the elements by the fire. The information is in EN 1991-1-2. d) The rules for determining the temperatures in the structure during the course of the fire. They are given in the fire part of the relevant material eurocode, e.g. EN 1993-1-2 for a steel structure. e) The rules for determining the structural stability. They are given in the fire part of the relevant material Eurocode, e.g. EN 1993-1-2 for a steel structure, but reference is often made to the cold part of the same material Eurocode, EN 1993-1-1 for a steel structure. This layout is valid in general but some exceptions do exist: the structural stability of timber elements, for example, does not necessarily require the determination of the temperatures in the element and step d) may be omitted; the same holds if the fire resistance is determined from tabulated data, for concrete elements for example. The rest of this book is organised according to this layout, see Fig. 1-2: Chapter 2 deals with bases of design and mechanical loads. Chapter 3 deals with thermal attack from the fire. Chapter 4 deals with thermal analysis by simple calculation model. Chapter 5 deals with mechanical analysis by simple calculation model. Chapter 6 deals with the design of joints. Chapter 7 deals with thermal and mechanical analysis by the advanced calculation model. Chapter 8 gives four design examples showing how a complete and sometimes complex structure can be designed using the concept of element or substructure analysis. [less ▲]

Detailed reference viewed: 237 (3 ULg)
See detailDesign of Steel Structures according to the General Model of Eurocode 3
Franssen, Jean-Marc ULg

Scientific conference (2003, April 25)

Detailed reference viewed: 17 (0 ULg)
See detailDesign of Steel Structures subjected to Fire. Background and Design Guide to Eurocode 3. 2nd édition
Franssen, Jean-Marc ULg; Zaharia, Raul

Book published by Les édtions de l'Université de Liège (2006)

The information that is necessary to perform the fire design of a structure made of a particular material, say a steel structure, is: a) The bases of design, stated in EN 1990. b) The mechanical actions ... [more ▼]

The information that is necessary to perform the fire design of a structure made of a particular material, say a steel structure, is: a) The bases of design, stated in EN 1990. b) The mechanical actions, i.e. the forces, acting on the structure in the fire situation. Some information is found in EN 1991-1-2, but explicit reference is also made to EN 1991-1-1 that is therefore also necessary. c) The thermal actions, i.e. the fire and the heat flux induced in the elements by the fire. The information is in EN 1991-1-2. d) The rules for determining the temperatures in the structure during the course of the fire. They are given in the fire part of the relevant material eurocode, e.g. EN 1993-1-2 for a steel structure. e) The rules for determining the structural stability. They are given in the fire part of the relevant material Eurocode, e.g. EN 1993-1-2 for a steel structure, but reference is often made to the cold part of the same material Eurocode, EN 1993-1-1 for a steel structure. This layout is valid in general but some exceptions do exist: the structural stability of timber elements, for example, does not necessarily require the determination of the temperatures in the element and step d) may be omitted; the same holds if the fire resistance is determined from tabulated data, for concrete elements for example. The rest of this book is organised according to this layout, see Fig. 1-2: Chapter 2 deals with bases of design and mechanical loads. Chapter 3 deals with thermal attack from the fire. Chapter 4 deals with thermal analysis by simple calculation model. Chapter 5 deals with mechanical analysis by simple calculation model. Chapter 6 deals with the design of joints. Chapter 7 deals with thermal and mechanical analysis by the advanced calculation model. Chapter 8 gives four design examples showing how a complete and sometimes complex structure can be designed using the concept of element or substructure analysis. [less ▲]

Detailed reference viewed: 264 (4 ULg)
Peer Reviewed
See detailDesign of Structural Fire Protection and Fire Protection Systems
Franssen, Jean-Marc ULg

in Hosser, Dietmar (Ed.) Proceedings of the International Fire protection Symposium (2005)

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailDesign of structural joints in building frames
Jaspart, Jean-Pierre ULg

in Progress in Structural Engineering and Materials (2002), 4(1), 18-34

A single and unified concept for the design of structural joints in building frames made of any material has been developed in recent years, and is now widely implemented in European design codes. In the ... [more ▼]

A single and unified concept for the design of structural joints in building frames made of any material has been developed in recent years, and is now widely implemented in European design codes. In the present paper, this concept is presented, its merits as far as the economy of a project are demonstrated, and practical design tools for its application in daily practice are briefly described. The paper also contains references to user's manuals and design handbooks. [less ▲]

Detailed reference viewed: 43 (1 ULg)
See detailDesign of sugar-based surface active agents for emulsion polymerization in supercritical carbon dioxide
Boyère, Cédric ULg; Favrelle, Audrey; Broze, Guy ULg et al

Conference (2012, May 10)

The use of aqueous dispersed media, such as emulsions, has many advantages over solution processes for chemical transformations and polymerization reactions, i.e. limited environmental impact, ease of ... [more ▼]

The use of aqueous dispersed media, such as emulsions, has many advantages over solution processes for chemical transformations and polymerization reactions, i.e. limited environmental impact, ease of products recovery and increased reaction rate. Emulsions are usually implemented from a water/organic solvent mixture in the presence of a surfactant. However, supercritical carbon dioxide (scCO2) (Pc =74 bars; Tc = 31°C) constitutes an interesting alternative to the traditional organic solvents in these heterogeneous systems because it is inexpensive, non-toxic, non-inflammable and environmentally friendlier. In this context, we developed a novel class of surfactants for the stabilization of H2O/scCO2 emulsions, i.e. fluorinated modified carbohydrates. The hydrophilic head of the surfactant consists in a sugar moiety whereas a fluorinated tail is specifically located in the scCO2 phase. The strategies for the synthesis of these carbohydrates esters rely on selective lipase-catalyzed modifications of sugars and on the versatile thiol-Michael addition reaction. The ability of these molecules to decrease the H2O/scCO2 interfacial tension and to stabilize such emulsions will be presented. Finally, high internal phase scCO2-in-water emulsion (HIPE) were prepared with these new surfactants and used as template for the acrylamide polymerization. The monomer is polymerized in the continuous aqueous phase before removing the CO2 droplets (at least 70 % of the total volume). The resulting permeable porous polymers, called polyHIPEs, exhibit highly interconnected voids (cfr SEM picture) and should be valuable in many applications including support for catalyst, filtration process, immobilization of proteins, etc. [less ▲]

Detailed reference viewed: 46 (17 ULg)
See detailDesign of sugar-based surface active agents for emulsion polymerization in supercritical carbon dioxide
Boyère, Cédric ULg

Doctoral thesis (2013)

The use of supercritical CO2 (scCO2) as alternative to traditional organic solvents and the valorization of biomass are interesting approaches to reduce the ecological footprint of chemical processes. On ... [more ▼]

The use of supercritical CO2 (scCO2) as alternative to traditional organic solvents and the valorization of biomass are interesting approaches to reduce the ecological footprint of chemical processes. On the other hand, emulsions offers many advantages over bulk and solution processes for polymerization reactions including limited environmental impact, ease of products recovery and increased reaction rate. In this context, this thesis aims to design novel fluorinated sugar-based surfactants able to stabilize water/CO2 (W/C) emulsion systems and explore their potential as template for polymerization reactions. Such surface active agents were prepared either by lipase-catalyzed esterification of mannose with fluorinated acid derivatives or following chemoenzymatic approaches involving very efficient and versatile "click" chemistries like the thiol-Michael addition or the thiol-ene/-yne reactions. The W/C interfacial activity of these novel glycosurfactants was confirmed by tensiometry as well as their ability to form stable W/C microemulsions. Then, we tested a range of these neutral fluorinated carbohydrate esters as stabilizers for the CO2-in-water (C/W) emulsion polymerization. In particular, the radical polymerization of acrylamide was performed in the continuous aqueous phase of a C/W high internal phase emulsion (HIPE) leading to highly interconnected macroporous polymer matrices, also called polyHIPEs. In this case, we emphasized a clear dependence of morphology of the porous structure with the concentration and the structure of the glycosurfactant. Thanks to the electrical neutrality of these fluorinated glycosurfactants which confers them a lower sensitivity to the ionic forces compared to their ionic counterparts, we could extend this system to the polymerization of ionic liquid monomers. Porous poly(ionic liquid)s were thus formed by emulsion polymerization for the first time and exhibit spherical cells interconnected by pores with size (~ 1 μm) among the lowest reported for polyHIPEs produced from C/W emulsions. The emulsion C/W templating methodology based on the designed fluorinated glycosurfactants thus appears as a technique of choice for the preparation of valuable macroporous polymer matrices. [less ▲]

Detailed reference viewed: 75 (16 ULg)
Full Text
See detailDesign of the cryo-optical test of the PLANCK reflectors
Roose, Stéphane ULg; Cucchiaro, Antonio ULg; De Chambure, Daniel

Conference (2003, March 18)

PLANCK is the third Medium size mission of the ESA long-term scientific plan Horizon 2000. This paper present the current design status of the design of the cryo-optical test for the Planck primary ... [more ▼]

PLANCK is the third Medium size mission of the ESA long-term scientific plan Horizon 2000. This paper present the current design status of the design of the cryo-optical test for the Planck primary reflector and Planck secondary reflector [less ▲]

Detailed reference viewed: 15 (1 ULg)