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See detailDevelopment of adenocarcinoma in chronic fistula in Crohn's disease
Laurent, Stanislas; Barbeaux, A.; Detroz, Bernard ULg et al

in Acta Gastro-Enterologica Belgica (2005), 68(1, Jan-Mar), 98-100

The authors report the case of a 55 yr-old woman suffering from Crohn's disease since 31 years with stricture and fistulas developed in the ileocolic junction and anorectal portion. Long-standing ... [more ▼]

The authors report the case of a 55 yr-old woman suffering from Crohn's disease since 31 years with stricture and fistulas developed in the ileocolic junction and anorectal portion. Long-standing anorectal fistulas and stricture led to adenocarcinoma and finally fistulisation in the vagina. Diagnosis was made by perineal examination with biopsies under general anaesthesia. Treatment was first posterior pelvectomy with resection of the anterior wall of vagina. Secondarily, radiochemotherapy was administrated. The authors discuss the incidence and risk factors of carcinoma in Crohn's disease with chronic fistulas. [less ▲]

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See detailDevelopment of Advanced Driver Assistance Systems by means of the traffic flow simulation tool PELOPS with HiL-functionalities
Christen, Fréderic ULg; Benmimoun, A.; Breuer, K. et al

in Berechnung und Simulation im Fahrzeugbau (2004, September 29)

During the last years a rapid increase of traffic volume in association with limited road space could be observed. This led to a raising load of the driver while achieving his driving tasks. Therefore so ... [more ▼]

During the last years a rapid increase of traffic volume in association with limited road space could be observed. This led to a raising load of the driver while achieving his driving tasks. Therefore so called Advanced Driver Assistance Systems (ADAS) are under development in recent years with an upward tendency. Such systems will relieve the driver and improve safety on the road in the future. A rising number of computed-aided-simulation becomes important for the development and evaluation of such systems. Developing ADAS makes a specific demand on the simulation environment. ADAS interact strongly with their traffic environment. Therefore the simulation has to cover both, a detailed model of the ego vehicle and an adequate representation of the traffic environment. The traffic flow simulation program PELOPS meets these requirements. The newly implemented extension of PELOPS with techniques of Software- and Hardware-in-the-Loop-simulation (SiL- and HiL-simulation) allows system developers a fast functional check and an assessment of new ADAS. External software can be linked to PELOPS via Ethernet-based network communication, which has already been realised for the widely used development tool MATLAB/Simulink. Besides the Ethernet interface PELOPS-HiL (PHIL) gives the developer two other possibilities for providing a HIL-environment: a serial interface which can be used for a connection to a dSpace development platform and a CAN data bus interface. The following article describes by means of chosen examples how flexible the PHIL-simulation can be adapted to a development task and which results can be obtained. [less ▲]

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See detailDevelopment of advanced models for transition to turbulence in hypersonic flows and prediction of transition under uncertainties
Serino, Gennaro ULg; Terrapon, Vincent ULg; Magin, Thierry et al

in Serino, Gennaro (Ed.) Review of the VKI Doctoral Research 2012-2013 (2013, March)

Detailed reference viewed: 114 (9 ULg)
Peer Reviewed
See detailDevelopment of alumina xerogel catalysts for biogas cleaning
Claude, Vincent ULg; Heinrichs, Benoît ULg; Toye, Dominique ULg et al

Poster (2014)

This poster resume the synthesis and characterizations of Ni/y-Al2O3 catalysts for the reforming of tars during the bio-syngas purification. The effect of an additionnal organosilane (EDAS) and a ... [more ▼]

This poster resume the synthesis and characterizations of Ni/y-Al2O3 catalysts for the reforming of tars during the bio-syngas purification. The effect of an additionnal organosilane (EDAS) and a surfactant (stearic acid) on the size,the dispersion and the sinterability of the nickel nanoparticles have been investigated. [less ▲]

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See detailDevelopment of an absolute quantification method targeting growth hormone biomarkers using liquid chromatography coupled to isotope dilution mass spectrometry.
Kirsch, Stéphanie ULg; Widart, Joëlle ULg; Louette, Joel et al

in Journal of Chromatography. A (2007), 1153(1-2), 300-6

A method to perform absolute quantification of two biomarkers (IGF-1 and IGFBP-3) of growth hormone abuse has been developed. Isotope dilution is used with synthetically labelled peptides as internal ... [more ▼]

A method to perform absolute quantification of two biomarkers (IGF-1 and IGFBP-3) of growth hormone abuse has been developed. Isotope dilution is used with synthetically labelled peptides as internal standards. Peptide selection and multiple reaction monitoring design are discussed. A simple sample preparation based on the reduction and alkylation of cysteine residues followed by tryptic digestion provides a sufficient digestion of proteins. Serum samples fortified with increasing amounts of target proteins are analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) on a triple quadrupole mass spectrometer. Specificity is ensured by the selection of sequences with no homology in BLAST, as well as retention time deviation check, and ion ratio monitoring. Linearity is studied in terms of calibration curves. These curves for IGFBP-3 and IGF-1 are generated with mean slopes of 0.055 and 0.065, intercepts of 0.107 and -0.011, and with coefficients of correlation of 0.95 and 0.98, respectively. These curves result from the addition of proteins to the serum. Risks of variations related to potential matrix effects are therefore reduced, as well as probable variations related to the digestion steps. The working concentration ranges are 4-10 ng/microl for IGFBP-3 and 2-8 ng/microl for IGF-1. Preliminary data regarding repeatability show that relative standard deviations (RSDs) range between 13 and 32% for IGFBP-3 and between 7 and 29% for IGF-1. [less ▲]

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See detailDevelopment of an active H maser: first results
Mandache, Cipriana ULg; Léonard, D.; Bastin, Thierry ULg

Conference (2009)

Detailed reference viewed: 36 (6 ULg)
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See detailDevelopment of an algorithm for using PINP to monitor treatment of patients with teriparatide
Eastell, R.; Krege, J. H.; Chen, P. Q. et al

in Current Medical Research & Opinion (2006), 22(1), 61-66

Introduction: Teriparatide effects are mediated via the preferential stimulation of osteoblastic activity over osteoclastic activity. Amino-terminal propeptide of type I procollagen (PINP) is an indicator ... [more ▼]

Introduction: Teriparatide effects are mediated via the preferential stimulation of osteoblastic activity over osteoclastic activity. Amino-terminal propeptide of type I procollagen (PINP) is an indicator of osteoblastic activity. Objective: Develop an algorithm using PINP as an aid in the management of patients with postmenopausal osteoporosis treated with teriparatide. Research design and methods: For inclusion in this post-hoc analysis, trials had to be investigations of teriparatide 20 mu g/day in postmenopausal women with osteoporosis having measurements of PINP at 3 months and bone mineral density (BMD) at 12 months. Signal-to-noise ratio was calculated for a series of markers of bone turnover in the Fracture Prevention Trial. An algorithm was developed to monitor patients treated with teriparatide using PINP. Results:Three trials met inclusion criteria and included the Fracture Prevention, Forteo-Alendronate Comparator and Anabolic After Antiresorptive trials. PINP had the highest signal-to-noise ratio of all bone-turnover markers. Positive PINP responses defined as increases > 10 mu g/L were observed in 77-97% of teriparatide- and in 6% of placebo-treated patients after 3 months of study drug. Mean lumbar spine BMD increases after 12 months of teriparatide in patients having PINP changes > 10 mu g/L ranged from 8.3% to 9.5% and in patients with PINP changes <= 10 mu g/L ranged from 5.9% to 7.6%. In the algorithm, PINP is measured at baseline and after 1-3 months of therapy. Patients with PINP increases > 10 mu g/L are given a positive message. Patients with PINP increases <= 10 mu g/L are assessed for adherence, teriparatide administration and storage techniques, and for the presence of medical conditions that might limit their therapeutic response, and these issues are addressed as appropriate. Patients without these issues and with PINP increases <= 10 mu g/L should be given a neutral message because BMD may significantly increase with continued therapy. Conclusions: The PINP algorithm provides information regarding the anabolic response to teriparatide therapy and has the potential to identify patients requiring help with issues of adherence, injection technique, teriparatide storage, and medical problems limiting therapeutic responsiveness to teriparatide treatment, Data assessing the relationship of changes in PINP to fracture risk reduction are not available. We recommend physicians audit the use of the algorithm in practice so that improvements can be made. [less ▲]

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See detailDevelopment of an all-solid-state pulsed Nd:YAG laser for pumping picosecond OPO systems
Mani, A. A.; Dreesen, Laurent ULg; Hollander, Ph. et al

in Proceedings (1999)

High performance mode-locking of a pulsed Nd:YAG laser was achieved at 1.064 µm by using a frequency doubling nonlinear mirror (FDNLM) based on a BBO crystal for second harmonic generation and on a ... [more ▼]

High performance mode-locking of a pulsed Nd:YAG laser was achieved at 1.064 µm by using a frequency doubling nonlinear mirror (FDNLM) based on a BBO crystal for second harmonic generation and on a dichroïc mirror. A GaAs platelet was inserted into the laser cavity for providing a passive negative feedback. Pulses shorter than 15 ps were generated. The FDNLM has the following merits: photochemical stability, short response time, simplicity and applicability to a wide spectral range. The optical oscillator is the first element of a two-color laser system including two synchronously pumped optical parametric oscillators (OPO) built around a BBO and a LiNbO3 crystal, and tunable from 410 to 2600 nm and from 2.5 to 3.6 µm, respectively. [less ▲]

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See detailDevelopment of an all-solid-state pulsed picosecond laser system for nonlinear spectroscopy
Mani, A. A.; Jazmati, A. K.; Zidan, M. D. et al

in Physical Chemical News (2007), 36

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See detailDevelopment of an analytical method to detect metabolites of nitrofurans. Application to the study of furazolidone elimination in Vietnamese black tiger shrimp (Penaeus monodon)
Douny, Caroline ULg; Widart, Joëlle ULg; De Pauw, Edwin ULg et al

in Aquaculture (2013), 376-379

Nitrofurans, banned antibiotics in European Union (EU), have often been found in imported aquaculture products in the past and are still found nowadays according to the Rapid Alert System for Feed and ... [more ▼]

Nitrofurans, banned antibiotics in European Union (EU), have often been found in imported aquaculture products in the past and are still found nowadays according to the Rapid Alert System for Feed and Food (RASFF) of the European Commission. A quantitative method based on liquid chromatography coupled to isotopic dilution tandem mass spectrometry (LC–IDMS/MS) was developed for the determination of the residues of four nitrofuran antibiotic residues in shrimps. The experimental protocol consisted of an acid-catalysed release of protein-bound metabolites, followed by derivatisation with 2-nitrobenzaldehyde (NBA). Then, a double liquid–liquid extraction with ethyl acetate was performed before LC–IDMS/MS analysis by positive electrospray ionisation (ES+) with multiple reaction monitoring (MRM) of two transitions per compound. An “in-house” validation of the method for shrimp analysis was conducted according to the EU criteria for the analysis of veterinary drug residues in foods. The decision limits (CCalpha) were 0.08–0.36 µg kg -1 and the detection capabilities (CCbeta) were 0.12–0.61 µg kg-1, which are both below the minimum required performance limit (MRPL) set at 1 µg kg -1 by the EU. The developed method was applied to evaluate the elimination of furazolidone residues in shrimp muscles after a contamination experiment. After 28 days of decontamination, a concentration of 115 µg kg-1 of furazolidone metabolite 3-amino-2-oxazolidinone (AOZ) was still measured in shrimp muscle. [less ▲]

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See detailDevelopment of an analytical method to detect simultaneously bisphenols using a multiplexed surface-enhanced Raman scattering quantitative approach
De Bleye, Charlotte ULg; Dumont, Elodie ULg; Sacre, Pierre-Yves ULg et al

Poster (2014, May 15)

Over the last decade, bisphenol A (BPA) attracted a lot of attention. This molecule, commonly used as a precursor to produce epoxy-resin and plastics, is an endocrine disruptor presenting an estrogenic ... [more ▼]

Over the last decade, bisphenol A (BPA) attracted a lot of attention. This molecule, commonly used as a precursor to produce epoxy-resin and plastics, is an endocrine disruptor presenting an estrogenic activity [1]. Despite its health toxicity, BPA is present in a broad variety of consumer goods released from plastic bottles and packaging for example. Since the discovery of its adverse health effect of BPA, the manufacturers tend to use structural analogues of BPA such as BPS, BPF and BPB to produce plastic materials [2]. However, the health safety of these molecules is still not demonstrated. Currently, bisphenols are actively researched and quantified using solid phase extraction and chromatography techniques which are time and solvents consuming. Therefore, it could be very interesting to quantify simultaneously bisphenols using a fast and “green” technique. Surface-enhanced Raman scattering (SERS) exalts dramatically the Raman scattering of molecules adsorbed or very closed to metallic surface enabling to detect very low amounts of analytes while keeping the structural information obtained from the spectrum which is very interesting to consider multiplexed analyses [3-4]. Moreover, SERS, which is a solvent free and fast acquisition technique, is an attractive tool in “Green Chemistry” [5]. In this context, the development of a multiplexed quantitative approach to detect bisphenol was considered. Silver nanoparticles (AgNps) were selected as SERS substrate and their functionalization was investigated taking into account the weak affinity of phenolic molecules for gold and silver surface [6]. Pyridine was selected as surface modifier and allowed to attract bisphenols around metallic surface thanks to hydrophobic interaction and hydrogen bonds [7]. Afterwards, the SERS samples preparation was optimized playing on the concentrations of pyridine and aggregating agent used to get the nanoparticles closer to each other which promotes the SERS effect. Tap water samples were spiked with different concentration of BPA from 5 ppb to 1000 ppb and analyzed using the optimized SERS sample preparation. A good linearity of the response was observed and a calibration curve with coefficient of determination (R2) of 0.9922 was obtained by plotting the intensity of a principal band of BPA versus the concentration. This last step was repeated using BPB as analyte and a calibration curve with a R2 of 0.9991 was obtained for the same range of concentration using a specific band intensity of BPB. Finally, tap water samples were spiked with different concentrations of BPA and BPB simultaneously and analyzed using SERS and it was possible to detect selectively the two molecules thanks to specific bands and a good linearity of the response was observed for both. To conclude, promising results were obtained which pave the way to “green” multiplexed quantitative analyses of very low concentrated analytes using SERS. References: [1] J.-H. Kang et al., Toxicology 226 (2006) 79-89 [2] C. Liao et al., J. Agric. Food Chem. 61 (2013) 4655-4662 [3] K. Kneipp et al., Chem. Rev. 99 (1999) 2957-2975. [4] R.F. Aroca et al., Adv.Colloid Interface Sci. 116 (2005) 45-61. [5] C. De Bleye et al., Talanta 116 (2013) 899-905. [6] X.X. Han et al., Anal. Chem., 83 (2011) 8582-8588. [7] B. San Vicente et al., Anal. Bioanal. Chem. 380 (2004) 115-122. [less ▲]

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See detailDevelopment of an analytical method to determine the composition of cryolitic baths used in the Hall-Heroult process, by Raman spectroscopy, at 1000°C
Malherbe, Cédric ULg

Doctoral thesis (2013)

Worldwide metallic aluminium production involves the Hall-Héroult process where the metal is electro-deposited from aluminium oxide solubilised in a molten NaF-AlF3-CaF2 mixture at around 950°C. The ... [more ▼]

Worldwide metallic aluminium production involves the Hall-Héroult process where the metal is electro-deposited from aluminium oxide solubilised in a molten NaF-AlF3-CaF2 mixture at around 950°C. The cryolitic melt is conveniently characterised by both the molar NaF/AlF3 ratio and the Al2O3 content. Nowadays the Hall-Héroult process remains the more economically efficient process even if it still suffers from a high consumption of energy. In particular the overvoltage required by the electrolysis is strongly dependent on the melt composition, especially regarding the Al2O3 content. Controlling the industrial baths composition during the process is therefore critical to reduce the energy loss. Unfortunately there is, up to now, no in situ direct analytical method to do so. Considering our experience in the study of such highly corrosive media by Raman spectroscopy, that technique has been applied to directly determine the melt composition. Three sets of reference spectra are considered in this study, each of them recorded with a different setup. The employed setups were developed to reach progressively, at the laboratory scale, a design that is suitable for a plant application. Eventually, a high quality spectrum can be recorded by the top of the melt, in less than 20 seconds. The employed apparatus is found to influence significantly the shape and quality of the spectra, and consequently their involvement in the quantification. A complex digital treatment of the spectral data acquired is necessary because all Raman bands of interest strongly overlap and some are situated close to the Rayleigh decay. Two main quantitative procedures for the melt composition determination are studied. The first one, the AutoAnalysis procedure, developed in the past and adapted here to the new data, gives reliable predictive results for both the NaF/AlF3 molar ratio and the alumina content. They can be determined with an absolute deviation of 0.06 molar ratio unit and 0.5 wt% respectively. However, the intensity normalisation, required for comparing the intensities of different spectra, relies on the Rayleigh decay that is likely to change with the experimental conditions in the plants. In our second quantitative procedure, the NormaAnalysis procedure, the intensity normalisation is based on the equilibria taking place in the melt. Since those equilibria do no differ with the experimental setup, the NormaAnalysis procedure can be imported to the industrial field. The predicted composition is also evaluated with a good precision: the NaF/AlF3 molar ratio and the alumina content can be determined with an absolute deviation of 0.08 cryolitic ratio unit and 0.3 wt% respectively. It is concluded that the composition of the melt can now be determined with our NormaAnalysis procedure, from a single Raman spectrum, recorded with a Raman apparatus exportable for an in situ measurement on the industrial cells. [less ▲]

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See detailDevelopment of an analytical method to determine the cryolitic bath composition by Raman spectroscopy
Malherbe, Cédric ULg; Gilbert, Bernard ULg

Poster (2010, April 23)

Since the end of the nineteenth century, metallic aluminium is produced by electro-deposition from a solution of aluminium oxide in cryolitic melts around 1000°C (Hall-Héroult process). The industrial ... [more ▼]

Since the end of the nineteenth century, metallic aluminium is produced by electro-deposition from a solution of aluminium oxide in cryolitic melts around 1000°C (Hall-Héroult process). The industrial melt is composed mostly of cryolite (Na3AlF6) and AlF3 and is characterized by the molar NaF/AlF3 ratio, named cryolitic ratio (CR). It turns out that the bath composition is critical: for instance, it has been shown that a small change in the Al2O3 content leads to a great change in the overvoltage required for the electrolysis. Therefore controlling the melt composition is very important in order to reduce the energy lost. Unfortunately no in situ analytical method allows studying the composition of the melt yet. Considering our experience in the study of such highly corrosive media by Raman spectroscopy and since the bath spectrum is function of both the CR and the Al2O3 content, we have proposed in the past to apply that technique to the direct determination of the melt composition. Despite the CR could be well evaluated in the lab, experimental problems however made the practical application difficult. The purpose of this presentation will be to show the new results obtained on an updated instrument: - Spectra are recorded in 20 s or less with a higher quality than before. - The previously developed home-made software was adapted to the updated instrument and various spectra analysis procedures are under study. - A procedure to prepare reference samples was also developed taking into account the homogeneity problems that have been met. - The slopes of the alumina calibration curves are depending on the bath CR, in confirmation of our previous results. - The new results are compared with the previous ones. It will be concluded that Raman spectroscopy is indeed becoming a suitable technique for developing an analytical method to determine the composition of industrial cryolitic melts. [less ▲]

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Peer Reviewed
See detailDevelopment of an analytical strategy to measure major selenium-containing species in juvenile turtles (Trachemys scripta scripta) by SAX-HPLC-ICP MS
Far, Johann ULg; Dyc, Christelle; Das, Krishna ULg et al

Poster (2013, July)

Sea turtles are exposed to many environmental elements such as selenium (Se). Sea turtles are listed under the Red List of threatened species by the International Union for Conservation of Nature. It is ... [more ▼]

Sea turtles are exposed to many environmental elements such as selenium (Se). Sea turtles are listed under the Red List of threatened species by the International Union for Conservation of Nature. It is thus mandatory to use low-invasive tissue collection (skin, carapace, blood ) for estimating Se exposure in these highly protected turtles. For this purpose, a biological modal Trachemys scripta scripta (or slider turtle) was selected. For two months, juvenile turtles were dietary exposed to Se by spiking the food with Selenomethionine (SeMet) or Methionine as control groups. Individuals were sacrificed after different time of exposure and tissues (skin, liver, muscle, carapace and blood) collected to perform Se speciation and determine some biological endpoints. An analytical strategy was developed to cope with the very low amount of available sample. It is briefly consisting by reduction, alkylation and proteolysis of the entire freeze-dried tissues followed by sample clean-up using ultra-filtration membrane. Then anion exchange HPLC using salt and pH gradient was developed to prevent the introduction of organic solvents, which cause severe fooling of ICP MS and avoid ultra-trace analyses of sea water in routine analysis. This method successfully achieved the detection and quantification at ppm level of expected species (i.e SeMet, selenocysteine, inorganic Se) and also unknown species but their relative amounts were time and tissues dependent. [less ▲]

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See detailDevelopment of an animal experimental model to study the effects of levonorgestrel on the human endometrium.
Alvarez Gonzalez, Maria-Luz ULg; Galant, C.; Frankenne, F. et al

in Human Reproduction (2009), 24(3), 697-704

BACKGROUND: This study was designed to develop an animal model to test the response of endometrium to local progestin delivery. METHODS: Proliferative human endometrium was subcutaneously grafted in two ... [more ▼]

BACKGROUND: This study was designed to develop an animal model to test the response of endometrium to local progestin delivery. METHODS: Proliferative human endometrium was subcutaneously grafted in two groups of SCID mice that received, 2 days before, a subcutaneous estradiol (E2) pellet and, for half of them, an additional implant of levonorgestrel (LNG). Mice were sacrificed 1, 2, 3 or 4 weeks after endometrial implantation and grafts were histologically analysed. Proliferation, steroid hormone receptors, blood vessels and stromal decidualization in both groups (E2 and LNG) were immunohistologically evaluated and compared with proliferative endometrium and endometrium from women with an LNG intrauterine device. RESULTS: Grafts presented normal morphological endometrial characteristics. The expression of progesterone receptors was significantly decreased in glands and stroma of the LNG group as compared with the E2 group at all times. A significant decrease was also observed in the stromal expression of estrogen receptor- in the LNG group. At 4 weeks, the mean cross-sectional area of vessels was significantly higher after LNG treatment. CONCLUSIONS: These morphological and immunohistochemical characteristics are similar to those observed in women treated with local LNG. This mouse model might facilitate further investigations needed to understand the mechanisms responsible for the breakthrough bleeding frequently observed in progestin users. [less ▲]

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See detailDevelopment of an antidepressant compliance questionnaire
Demyttenaere, K.; Bruffaerts, R.; Albert, Adelin ULg et al

in Acta Psychiatrica Scandinavica (2004), 110(3), 201-207

Objective: The development of the Antidepressant Compliance Questionnaire (ADCQ), assessing patients' attitudes and beliefs on depression and antidepressants. Method: A 51-item questionnaire was applied ... [more ▼]

Objective: The development of the Antidepressant Compliance Questionnaire (ADCQ), assessing patients' attitudes and beliefs on depression and antidepressants. Method: A 51-item questionnaire was applied to 85 psychiatric out-patients with a DSM-IV diagnosis of major depressive disorder (MDD). This data set was used to assess psychometric properties of the ADCQ. The questionnaire was also applied to 272 primary care out-patients with MDD. Results: A principal component analysis revealed four dimensions with good internal consistency and acceptable test-retest reliability: 'perceived doctor-patient relationship', 'preserved autonomy', 'positive beliefs on antidepressants' and 'partner agreement', resulting in a final questionnaire comprising 33-items. Responses were independent from depression severity and patient age. The response patterns of both psychiatric and primary care patients are provided and illustrate the many erroneous beliefs on antidepressants. Conclusion: The ADCQ has good psychometric properties; further investigation should investigate whether this questionnaire is predictive of patient compliance. [less ▲]

Detailed reference viewed: 18 (0 ULg)