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See detailDEVELOPMENT OF AN INTRAPERITONEAL IMPLANT FOR THE ENDOMETRIOSIS TREATMENT
Krier, Fabrice ULg; Nizet, Dominique; Riva, Raphaël ULg et al

Poster (2008)

Detailed reference viewed: 37 (11 ULg)
See detailDEVELOPMENT OF AN INTRAPERITONEAL IMPLANT FOR THE ENDOMETRIOSIS TREATMENT
Krier, Fabrice ULg; Nizet, Dominique; Riva, Raphaël ULg et al

Conference (2007)

Detailed reference viewed: 24 (6 ULg)
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Peer Reviewed
See detailDevelopment of an inverse method for identification of materials parameters in the single point incremental sheet forming process
Bouffioux, Chantal ULg; Henrard, Christophe ULg; Gu, Jun et al

in Tisza, M. (Ed.) Proceedings of the IDDRG 2007 International Conference (2007)

The purpose of this article is to develop an inverse method for adjusting the material parameters during single point incremental forming. The main idea consists in simulating tests performed on the same ... [more ▼]

The purpose of this article is to develop an inverse method for adjusting the material parameters during single point incremental forming. The main idea consists in simulating tests performed on the same machine as the one used for the process itself. This reduces the costs of the equipment since no specific and costly standard test equipment is needed. Moreover, it has the advantage that the material parameters are fitted for a heterogeneous stress and strain state occurring during the real process. Before using the inverse method, the numerical results must be compared with the experimental ones. Several boundary conditions will be tested. [less ▲]

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See detailDevelopment of an Open Source GIS Based Decision Support System for locating Wind Farms in Wallonia (Sourthern Belgium)
Lejeune, Philippe ULg; Gheysen, Thibaut ULg; Ducenne, Quentin et al

in Delvin, Ger (Ed.) Decision Support Systems , Advances in (2010)

The Walloon Region - Southern Belgium – aims at significantly increasing its wind-power electricity production capacity by the end of 2020. Such a development requires a comprehensive body of reliable ... [more ▼]

The Walloon Region - Southern Belgium – aims at significantly increasing its wind-power electricity production capacity by the end of 2020. Such a development requires a comprehensive body of reliable procedures pertaining to land use and landscape issues and subsequent controversy arising from wind farms located in densely populated areas. These procedures should enable experts and decision-makers to perform robust impact assessment analyses. To this end, an analytical framework based on GIS functionalities has been developed to evaluate and contrast various constraints against suitability criteria regarding building wind farms. This system can perform exhaustive spatial analyses over the whole region, i.e. 17,000 km², using a 10-m resolution in a raster mode. The approach is two-fold. Firstly, the framework allows an aggregation of 40 criteria related to both environmental and landscape constraints. The aggregation process is derived from Boolean algebra. It results into a 3-level constraint scale, i.e. exclusion, highly sensitive and sensitive. Secondly, the framework involves a weighted linear combination aggregation method where criteria are standardized on a [0,1] scale prior to aggregation. Different weights are required to translate criteria into a preference scale. In this process, the constraint map can be used as a mask for further suitability analysis. The geo-database and analysis functionalities were developed in an open source GIS GRASS environment. These functionalities are used to either import or export data from other GIS platforms, to update constraint and suitability maps, to perform an analysis of sensitivity with regard to criteria-defining parameters, and to perform exhaustive appraisals of wind farm projects. Grass GIS-tools seem to offer a good alternative to commercial GIS software for the development of such a Decision Support System as they ensure an easier access to stakeholders involved in the development of wind energy in Wallonia. [less ▲]

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See detailDevelopment of an optimized activatable MMP-14 targeted SPECT imaging probe
Watkins, G. A.; Jones, E. F.; Scott Shell, M. et al

in Bioorganic & Medicinal Chemistry (2009), 15(17), 653-9

Matrix metalloproteinase-14 (MT1-MMP or MMP-14) is a membrane-associated protease implicated in a variety of tissue remodeling processes and a molecular hallmark of select metastatic cancers. The ability ... [more ▼]

Matrix metalloproteinase-14 (MT1-MMP or MMP-14) is a membrane-associated protease implicated in a variety of tissue remodeling processes and a molecular hallmark of select metastatic cancers. The ability to detect MMP-14 in vivo would be useful in studying its role in pathologic processes and may potentially serve as a guide for the development of targeted molecular therapies. Four MMP-14 specific probes containing a positively charged cell penetrating peptide (CPP) d-arginine octamer (r8) linked with a MMP-14 peptide substrate and attenuating sequences with glutamate (8e, 4e) or glutamate-glycine (4eg and 4egg) repeating units were modeled using an AMBER force field method. The probe with 4egg attenuating sequence exhibited the highest CPP/attenuator interaction, predicting minimized cellular uptake until cleaved. The in vitro MMP-14-mediated cleavage studies using the human recombinant MMP-14 catalytic domain revealed an enhanced cleavage rate that directly correlated with the linearity of the embedded peptide substrate sequence. Successful cleavage and uptake of a technetium-99m labeled version of the optimal probe was demonstrated in MMP-14 transfected human breast cancer cells. Two-fold reduction of cellular uptake was found in the presence of a broad spectrum MMP inhibitor. The combination of computational chemistry, parallel synthesis and biochemical screening, therefore, shows promise as a set of tools for developing new radiolabeled probes that are sensitive to protease activity. [less ▲]

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See detailDevelopment of an original approach to evaluate effects of surfactants, biomass and pollutants on the scaling-up of a two-phase partitioning bioreactor
Aldric, Jean-Marc ULg

(2009)

BACKGROUND: Two-phase partitioning bioreactors (TPPBs) are considered as a new technology for xenobiotic degradation in gaseous effluents. However, there is still a need for more knowledge on how to ... [more ▼]

BACKGROUND: Two-phase partitioning bioreactors (TPPBs) are considered as a new technology for xenobiotic degradation in gaseous effluents. However, there is still a need for more knowledge on how to design and scale-up TPPBs. The partitioning of the two phases remains a misunderstood way of research. In particular, the impact of pollutant (isopropylbenzene), biomass and surfactant extract needs to be better evaluated. RESULTS:. An adaptated scale-down apparatus has been developed in order to quantify the speed of phase partitioning (SPP) into a plug flow section. Firstly, it was shown that isopropylbenzene (IPB) doesn’t destabilize more significantly the system. Secondly, respectively 0.5 g.L-1 and 0.05 g.L-1 of biomass and surfactant extract, separately or in mixture, were sufficient to ensure the stability of the two-phase system. Finally, a 100 m3 limit of scaling-up was suggested on the basis of the circulation time comparison. CONCLUSION: The scaling-up of an aqueous/silicone-oil TPPB was found to be definitely conceivable when the presence of biotic compounds were considered. However, further considerations are needed to verify our assumptions, in particular by taking into account the velocity field pattern in full-scale bioreactors and reproduce it in lab-scale apparatus. [less ▲]

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See detailDevelopment of an original approach to evaluate effects of surfactants, biomass and pollutants on the scaling-up of a two-phase partitioning bioreactor
Aldric, Jean-Marc ULg; Gillet, Sébastien ULg; Delvigne, Frank ULg et al

in Journal of Chemical Technology & Biotechnology (2010), 84

BACKGROUND: Two-phase partitioning bioreactors (TPPBs) are considered as a new technology for xenobiotic degradation in gaseous effluents. However, there is still a need for more knowledge on how to ... [more ▼]

BACKGROUND: Two-phase partitioning bioreactors (TPPBs) are considered as a new technology for xenobiotic degradation in gaseous effluents. However, there is still a need for more knowledge on how to design and scale-up TPPBs. The partitioning of the two phases remains a misunderstood way of research. In particular, the impact of pollutant (isopropylbenzene), biomass and surfactant extract needs to be better evaluated. RESULTS:. An adaptated scale-down apparatus has been developed in order to quantify the speed of phase partitioning (SPP) into a plug flow section. Firstly, it was shown that isopropylbenzene (IPB) doesn’t destabilize more significantly the system. Secondly, respectively 0.5 g.L-1 and 0.05 g.L-1 of biomass and surfactant extract, separately or in mixture, were sufficient to ensure the stability of the two-phase system. Finally, a 100 m3 limit of scaling-up was suggested on the basis of the circulation time comparison. CONCLUSION: The scaling-up of an aqueous/silicone-oil TPPB was found to be definitely conceivable when the presence of biotic compounds were considered. However, further considerations are needed to verify our assumptions, in particular by taking into account the velocity field pattern in full-scale bioreactors and reproduce it in lab-scale apparatus. [less ▲]

Detailed reference viewed: 75 (22 ULg)
Peer Reviewed
See detailDevelopment of an original intra-uterine implant allowed specific release kinetics of several drugs
Nizet, Dominique; Zalfen, Alina; Collard, Laurence ULg et al

Poster (2007)

Detailed reference viewed: 23 (1 ULg)
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See detailDevelopment of an RMS model based on colored object-oriented Petri nets with changeable structures
Zhang, Linda; Ittoo, Ashwin ULg

in IEEE Proceedings of the 16th International Conference on Industrial Engineering and Engineering Management (2009)

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See detailDevelopment of an urban typology to assess residential environmental performance at the city scale
Wallemacq, Véronique; Marique, Anne-Françoise ULg; Reiter, Sigrid ULg

in Evrard Arnaud, Bodard Magali (Ed.) Proceedings of International Conference PLEA 2011 : Architecture & Sustainable Development (2011, July)

In this research, a typology of urban blocks is drawn up for the urban area of Liege. This typology of urban blocks is organized into a set of themes according to various environmental parameters. This ... [more ▼]

In this research, a typology of urban blocks is drawn up for the urban area of Liege. This typology of urban blocks is organized into a set of themes according to various environmental parameters. This paper presents the energy part of this typology on the residential building stock of Liege, which includes four topics: residential buildings energy consumption; transport energy consumption of residents; development potentialities of public transport and development potentialities of energy networks. The proposed typology was elaborated through the use of GIS tools combined with a statistical treatment of several specific criteria at the urban block scale. For each class of this typology, a representative block is selected for further energy simulations in order to model residential energy use related to buildings, transport and energy networks at the city scale. The methodology developed in this paper is adapted to urban, suburban and rural zones. It can thus be adapted and/or reproduced on many other territories in Belgium but also in Europe or even further. [less ▲]

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See detailDevelopment of anti-HPV lipoplexes for the treatment of cervical cancer
Lechanteur, Anna ULg; Furst, Tania ULg; Evrard, Brigitte ULg et al

Conference (2013, December 03)

Detailed reference viewed: 13 (5 ULg)
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See detailDevelopment of anti-HPV lipoplexes for the treatment of cervical cancer
Lechanteur, Anna ULg; Furst, Tania ULg; Evrard, Brigitte ULg et al

Conference (2013, October 17)

Detailed reference viewed: 17 (5 ULg)