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See detailDeterminants of blood pressure control in hypertensive patients seen in third referral centers
Persu, Alexandre; Ngueta, G.; Krzesinski, Jean-Marie ULg et al

in Acta Clinica Belgica (2010, January 02), 65(1), 68

This work was designed to look for the main characteristics of hypertensive patients seen in Academic Centers from Belgium, with special emphasis on factors influencing blood pressure (BP) control.

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See detailThe determinants of CDS prices: an industry-based investigation
Sougné, Danielle ULg; Heuchenne, Cédric ULg; Hübner, Georges ULg

in Wagner, Niklas (Ed.) Credit Risk: Models, Derivatives and Management. Empirical Studies and Analysis. Financial Mathematics Series. (2008)

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See detailThe determinants of charitable giving in Belgium
Mernier, Amélie ULg; Dufays, Frédéric ULg; Dal Fior, Catherine

Conference (2013, July)

Charitable giving is a research topic that has largely been addressed in the U.S.-context. However, there exist only very few studies on Belgian donating behavior. This paper aims to fill this gap using a ... [more ▼]

Charitable giving is a research topic that has largely been addressed in the U.S.-context. However, there exist only very few studies on Belgian donating behavior. This paper aims to fill this gap using a combination of fiscal, demographic and political data. OLS regressions and Fixed effects regressions are performed and show a positive effect of age and income on the probability to donate. In addition, age and income increase the average donation amount, whereas gender and declaring jointly tend to decrease it. Further, the region and the political party to which belongs the mayor of the municipality in which one lives also affect the likelihood of charitable giving and the donated amount. This paper has implications both for researchers and charity practitioners. The latter are likely to pay attention to the factors that increase the probability to donate and the average donated amount, especially in times of economic crises as charities may rely less and less on the state to cover their financial resource needs. [less ▲]

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See detailDeterminants of exercise-induced changes in e/ea in patients with chronic systolic left ventricular dysfunction
Lancellotti, Patrizio ULg; Cosyns, B.; Van Camp, G. et al

in European Heart Journal (2006, August), 27(Suppl. 1), 711

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See detailDeterminants of exercise-induced changes in mitral regurgitation in patients with coronary artery disease and left ventricular dysfunction
LANCELLOTTI, Patrizio ULg; Lebrun, F.; PIERARD, Luc ULg

in Journal of the American College of Cardiology (2003), 42(11), 1921-1928

OBJECTIVES: We sought to examine the determinants of exercise-induced changes in ischemic mitral regurgitation (MR) in patients with left ventricular (LV) dysfunction. BACKGROUND: In the post-myocardial ... [more ▼]

OBJECTIVES: We sought to examine the determinants of exercise-induced changes in ischemic mitral regurgitation (MR) in patients with left ventricular (LV) dysfunction. BACKGROUND: In the post-myocardial infarction (MI) phase, ischemic MR contributes to worsening of symptoms and of LV dysfunction. METHODS: In this study, 70 patients in the chronic, post-MI phase, with LV ejection fraction <45% and at least mild MR, underwent semi-supine exercise Doppler echocardiography. The effective regurgitant orifice (ERO) of MR was quantified at rest and during exercise. Exercise-induced changes in ERO were compared with changes in mitral deformation and in local and global LV remodeling. RESULTS: The wide range of exercise-induced ERO changes that were observed was unrelated to the degree of MR at rest (r = 0.20). Effective regurgitant orifice changes correlated best with changes in mitral deformation (i.e., differences in systolic mitral tenting area, systolic annular area, and coaptation height) (p < 0.0001). Posterior displacement of the papillary muscles was associated with larger changes in the ERO in both infarct groups. In patients with inferior MI, a decrease in the ERO was related to improvement in wall motion (r = 0.68). The independent predictors of ERO changes during exercise were changes in systolic annular area for all infarct categories, in tenting area and wall motion score in the global population and those with inferior infarction, and in apical displacement of mitral leaflets for patients with anterior MI. CONCLUSIONS: The degree of MR at rest is unrelated to exercise-induced changes in EROs, which are related to those in local LV remodeling and in mitral deformation but not those in global LV function. [less ▲]

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See detailDeterminants of exercise-induced pulmonary arterial hypertension in systemic sclerosis.
Voilliot, Damien; Magne, Julien ULg; Dulgheru, Raluca et al

in International journal of cardiology (2014)

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the ... [more ▼]

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the incidence and the determinants of EIPH in SSc. METHODS AND RESULTS: We prospectively enrolled 63 patients with SSc (age 54+/-3years, 76% female) followed in CHU Sart-Tilman in Liege. All patients underwent graded semi-supine exercise echocardiography. Systolic pulmonary arterial pressure (sPAP) was derived from the peak velocity of the tricuspid regurgitation jet and adding the estimation of right atrial pressure, both at rest and during exercise. Resting pulmonary arterial hypertension (PH) was defined as sPAP >35mmHg and EIPH as sPAP >50mmHg during exercise. The following formulas were used: mean PAP (mPAP)=0.61xsPAP+2, left atrial pressure (LAP)=1.9+1.24xleft ventricular (LV) E/e' and pulmonary vascular resistance (PVR)=(mPAP-LAP)/LV cardiac output (CO) and slope of mPAP-LVCO relationship=changes in mPAP/changes in LVCO. Resting PH was present in 3 patients (7%) and 21 patients developed EIPH (47%). Patients with EIPH had higher resting LAP (10.3+/-2.2 versus 8.8+/-2.3mmHg; p=0.03), resting PVR (2.6+/-0.8 vs. 1.4+/-1.1Woods units; p=0.004), exercise LAP (13.3+/-2.3 vs. 9+/-1.7mmHg; p<0.0001), exercise PVR (3.6+/-0.7 vs. 2.1+/-0.9 Woods units; p=0.02) and slope of mPAP-LVCO (5.8+/-2.4 vs. 2.9+/-2.1mmHg/L/min; p<0.0001). After adjustment for age and gender, exercise LAP (beta=3.1+/-0.8; p=0.001) and exercise PVR (beta=7.9+/-1.7; p=0.0001) were independent determinants of exercise sPAP. CONCLUSION: EIPH is frequent in SSc patients and is mainly related to both increased exercise LV filling pressure and exercise PVR. [less ▲]

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See detailDeterminants of fat mass percentage and absolute fat-free mass in preterm infants at the time of hospital discharge
Simon, Laure; Frondas-Chauty, Anne; SENTERRE, Thibault ULg et al

Conference (2014)

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See detailDeterminants of gastro-protective drugs co-prescription during treatment with nonselective NSAIDs: a prospective survey of 2197 patients recruited in primary care
Rabenda, Véronique ULg; Burlet, N.; Belaiche, Jacques ULg et al

in Osteoarthritis and Cartilage (2006), 14(7), 625-630

Objective: Our goal was to identify the magnitude of gastro-protective drugs (GPDs) co-prescription and the profile of patients who received GPD co-prescription, during nonsteroidal anti-inflammatory ... [more ▼]

Objective: Our goal was to identify the magnitude of gastro-protective drugs (GPDs) co-prescription and the profile of patients who received GPD co-prescription, during nonsteroidal anti-inflammatory drugs (NSAIDs) treatment in a "real life setting" of primary care practice. Methods: A pragmatic prospective 6-month survey of 2197 new takers of nonselective NSAIDs, selected and followed by general practitioners (GPs) on the bias of their usual standards of care. Results: Forty-seven percent of our survey population used at least one GPD during the 6-month follow-up. No difference was identified between piroxicam, diclofenac, ibuprofen, meloxicam and nimesulid for the GPD co-prescription. Besides the presence of gastro-intestinal (GI) symptoms, previous use of GPD, previous occurrence of GI disorders and increase in age are the most prominent predictive factors of GPD use during NSAID treatment. When adjusted for other risk factors, co-prescription of GPD was significantly increased in patients aged 55 years and above (odds ratio (OR): 1.29, 95% confidence interval (Cl): 1.01-1.64) with no further increase in the co-prescription in older subjects. Conclusion: Patients above 55 years with previous history of GI symptoms or GPD use are more likely to benefit from cytoprotective medications. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved. [less ▲]

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See detailDeterminants of high, median and low rates of caesarean deliveries in Belgium
Absil, Gaëtan ULg; Van Parys, A. S.; Bednarek, Stéphanie et al

Report (2011)

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See detailThe determinants of homogenous, vertically differentiated and horizontally differentiated European trade flows
Henry de Frahan, Bruno; Tharakan, Joseph ULg

in Loader, R. J.; Henson, S. J.; Traill, W. B. (Eds.) Globalisation of the Food Industry : Policy Implications (1997)

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See detailDeterminants of left ventricular preload-adjusted maximal power
Segers, Patrick; Tchano-Sato, Vincent; Leather, H. Alex et al

in American Journal of Physiology - Heart and Circulatory Physiology (2003), 284(6), 2295-2301

Maximal left ventricular (LV) hydraulic power output (PWRmax), corrected for preload as PWRmax/(V-ed)(beta) (where V-ed is the end-diastolic volume and beta is a constant coefficient), is an index of LV ... [more ▼]

Maximal left ventricular (LV) hydraulic power output (PWRmax), corrected for preload as PWRmax/(V-ed)(beta) (where V-ed is the end-diastolic volume and beta is a constant coefficient), is an index of LV contractility. Whereas preload-adjusted maximal power (PAMP) is usually calculated with beta = 2, there is uncertainty about the optimal value of beta (beta = 1 for the normal LV and 2 for the dilated LV). The aim of this work is to study the determining factors of beta. The data set consisted of 245 recordings (steady state and vena cava occlusion) in 10 animals in an ischemic heart pig model. The occlusion data yielded the slope (E-es; 2.01 +/- 0.77 mmHg/ml, range 0.71-4.16 mmHg/ml) and intercept (V-0; -11.9 +/- 22.6 ml; range -76 to 39 ml) of the end-systolic pressure-volume relation, and the optimal beta-factor (assessed by fitting an exponential curve through the V-ed-PWRmax relation) was 1.94 +/- 0.88 (range 0.29-4.73). The relation of beta with V-ed was weak [beta = 0.60 + 0.02(V-ed); r(2) = 0.20]. In contrast, we found an excellent exponential relation between V-0 and beta [beta = 2.16e(0.0189(V0)), r(2) = 0.70]. PAMP, calculated from the steady-state data, was 0.64 +/- 0.40 mW/ml(2) (range 0.14-2.83 mW/ml(2)) with a poor correlation with E-es (r = 0.30, P < 0.001). An alternative formulation of PAMP as PWRmax/(V-ed - V-0)(2), incorporating V-0, yielded 0.47 +/- 0.26 mW/ml(2) (range 0.09-1.42 mW/ml(2)) and was highly correlated with E-es (r = 0.89, P < 0.001). In conclusion, correct preload adjustment of maximal LV power requires incorporation of V-0 and thus of data measured under altered loading conditions. [less ▲]

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See detailDeterminants of long duration sickness absence after an occupational back injury in the Belgian working population
Mairiaux, Philippe ULg; Mazina, D. ULg

Poster (2007, August)

Aims Occupational low-back injuries are a major cause not only of lost time but also of job loss and early retirement for health reasons. To promote the employability of an aging workforce, a better ... [more ▼]

Aims Occupational low-back injuries are a major cause not only of lost time but also of job loss and early retirement for health reasons. To promote the employability of an aging workforce, a better understanding of the prognostic factors for a long duration sick leave after such injuries is needed. The Belgian national database of work accidents was used to investigate these factors. Methods The data were retrieved from the Belgian Fund for Work Accidents (FAT) database over a three-year period (2001-2003). The population source involved all the workers under a job contract in the private sector recorded during that period as compensated cases for an accident that occurred at the workplace (n=558.276); 6,6% of those cases had the back as “location of injury”. Taking into account the calendar year system for counting time on benefits, the analysis was restricted to the 18936 workers who had reported a back injury during the first 6 months of each year. Eight factors (gender, age, region, professional category, size of enterprise, seniority, sector of activity and accident circumstances) were analyzed in relation with the duration of sick leave as attributed by the insurance company. For each factor, the relative prevalence of cases with more than 92 days of work absence (outcome variable) was compared using the Pearson’s 2 in the bivariate analysis. In the multivariate analysis, a Stepwise Logistic Regression was performed to obtain the final model. Results The proportion of back injured workers with more than 92 lost days was 6.8 % (CI 95%: 6.4-7.1). In the bivariate analysis, all the 8 factors under study, gender and seniority excepted, were correlated with sick leave duration. After adjustment for confounding factors, the final model involved 5 factors statistically associated to a long duration sick leave: age (older than 40 years : OR=1.45(1.25-1.68)); geographical location of company (Wallonia: OR=1.70(1.47-1.98); Brussels: OR=1.61(1.29-2.02)); professional category (blue collar: OR=1.71 (1.32-2.20)); circumstance of accident (falls : OR=1.26 (1.03-1.52); overexertion: OR=0.75(0.64-0.89)); and sector of activity (building industry: OR=1.47(1.22-1.78)). Discussion and conclusions This study showed that in the Belgian working population, 6.8 % of the compensated back injuries can be considered as chronic back pain cases. This figure is however likely to underestimate the actual incidence of the problem as the FAT statistics showed that 21.7% of the back injury claims were rejected by the insurers. The proportion of back injured workers with a long sick leave (chronic low back pain) is clearly related to the worker age, blue-collar status, accident precipitating cause, and some high-risk activities; these observations are in line with the literature. The observed regional differences in incidence could not be explained by a differential distribution of high risk sectors in the country; they are probably to be ascribed to cultural and social factors but these could not be studied on the basis of the variables recorded in the FAT database. In conclusion, this study shows that considerable prevention efforts have to be focused on some categories of workers with back injury, who are at risk for a long sickness absence leading to chronic low back pain. References 1. Nielens H., Van Zundert J., Mairiaux P., Gailly J., Van Den Hecke N., Mazina D., Camberlin C., Bartholomeeussen S., De Gauquier K., Paulus D., Ramaekers D. Chronic Low Back Pain. Good Clinical Practice (GCP). Bruxelles: Centre fédéral d'expertise des soins de santé (KCE); 2006. KCE reports 48B (D/2006/10.273/64). 2. Crook J, Milner R, Schultz IZ et al. Determinants of occupational disability following a low back injury: a critical review of the literature. [Review] [68 refs]. Journal of Occupational Rehabilitation.12:277-95, 2002. [less ▲]

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See detailDeterminants of Market Success for Commercial Movies
Choffray, Jean-Marie ULg; Pras, Bernard

in Der Markt (1987), 73

This paper shows how a systematic analysis of the way commercial movies are perceived by potential viewers allows a better understanding of the factors leading to their success. It proposes a model-based ... [more ▼]

This paper shows how a systematic analysis of the way commercial movies are perceived by potential viewers allows a better understanding of the factors leading to their success. It proposes a model-based methodology that could be used to improve the development process and the market introduction of new movies. [less ▲]

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See detailDeterminants of persistent negative T waves and early versus late T wave normalisation after acute myocardial infarction
PIERARD, Luc ULg; LANCELLOTTI, Patrizio ULg

in Heart (2005), 91(8), 1008-1012

OBJECTIVE: To determine whether persistent versus early or delayed T wave normalisation of negative T waves after acute myocardial infarction is determined by the myocardial state, the treatment strategy ... [more ▼]

OBJECTIVE: To determine whether persistent versus early or delayed T wave normalisation of negative T waves after acute myocardial infarction is determined by the myocardial state, the treatment strategy, or both. DESIGN: 127 consecutive patients with a first acute myocardial infarction and > or = 2 negative T waves on the 24-36 hour ECG were studied. They underwent dobutamine stress echocardiography and coronary angiography during the first week. ECG was recorded at hospital discharge and at a mean (SD) of 4 (1) months. SETTING: University hospital. RESULTS: T wave normalisation was observed in 88 patients (early at discharge in 19 and delayed at four months in 69). Early T wave normalisation was associated with sustained contractile reserve during dobutamine stress (13 of 19 (68%)), whereas delayed T wave normalisation was observed mainly in patients with an ischaemic response (49 of 69 (71%)). The persistence of negative T waves was associated with an ischaemic response (21 of 39 (54%)) or persistent akinesis (17 of 39 (44%)). Among patients with an ischaemic response to dobutamine, in-hospital elective angioplasty was an independent determinant of delayed T wave normalisation (39 of 49 v 4 of 21 patients with persistent negative T waves at four months, p < 0.0001). CONCLUSIONS: Early T wave normalisation is associated with dobutamine induced, sustained improvement indicating myocardial stunning. Delayed normalisation is observed mainly in patients with ischaemic myocardium who have undergone revascularisation. Persistent negative T waves correspond to either extensive necrosis or non-revascularised, jeopardised myocardium. [less ▲]

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See detailDeterminants of pulmonary artery hypertension at rest and during exercise in patients with heart failure
Tumminello, G.; LANCELLOTTI, Patrizio ULg; Lempereur, Mathieu ULg et al

in European Heart Journal (2007), 28(5), 569-574

Aims Pulmonary hypertension, a marker of poor prognosis in heart failure, may develop or increase during exercise. We sought to examine the determinants of pulmonary hypertension at rest and during ... [more ▼]

Aims Pulmonary hypertension, a marker of poor prognosis in heart failure, may develop or increase during exercise. We sought to examine the determinants of pulmonary hypertension at rest and during exercise in heart failure patients. Methods and results Forty-six patients with left ventricular (W) dysfunction (ejection fraction: 30 +/- 6%) underwent a semi-recumbent, incremental bicycle exercise Doppler echocardiography. LV systolic and diastolic function, pulmonary artery systolic pressure (PASP), functional mitral regurgitation (MR), and left atrial volume were quantified at rest and during exercise. Wide changes in PASP at exercise were unrelated to PASP at rest (r = 0.12). Independent predictors of PASP at rest were left atrial. volume (P = 0.006), E-wave velocity (P = 0.02), mitral tenting area (P = 0.005), and mitral effective regurgitant orifice (ERO) (P=0.02). The incidence of dyspnoea was similar in patients with and without moderately severe pulmonary hypertension at baseline. At peak exercise, LV ejection fraction (P = 0.03) and mitral ERO (P = 0.008) were independently associated with PASR Patients with a larger exercise increase in PASP (> 60 mmHg) interrupted frequently exercise for dyspnoea (70 vs. 27%; P = 0.04). A larger rise in mitral regurgitant volume during exercise emerged as the single determinant of exercise-induced increases in PASP. Conclusion In patients with HF, left atrial. volume, mitral deformation, and mitral regurgitant orifice correlated with pulmonary pressure at rest, whereas dynamic MR and limited contractile reserve correlated with pulmonary pressure at exercise. The magnitude of pulmonary pressure during exercise in these patients mainly depends on dynamic MR. [less ▲]

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See detailDeterminants of serum concentrations of 1,1 dichloro 2,2 bis (p-chlorophenyl)ethylene and polychlorinated biphenyls among French women in the CECILE study
Bachelet, D.; Truong, T.; Verner, M.-A. et al

in Environmental Research (2011), 111

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