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Peer Reviewed
See detailDesign of concrete columns based on EC2 tabulated date - A critical review
Franssen, Jean-Marc ULg

in Proceedings of the 1st International Structures in Fire workshop (2000)

Detailed reference viewed: 84 (2 ULg)
See detailDesign of connections in steel and composite structures
Jaspart, Jean-Pierre ULg

in ECCS Eurocode Design Manuals (2010)

Detailed reference viewed: 157 (10 ULg)
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See detailDesign of cross-linked semicrystalline poly(ε-caprolactone)-based networks with one-way and two-way shape-memory properties through Diels–Alder
Raquez, Jean-Marie; Vanderstappen, Sophie; Meyer, Franck et al

in Chemistry : A European Journal (2011), 17(36), 10135-10143

Cross-linked poly(ε-caprolactone) (PCL)-based polyesterurethane (PUR) systems have been synthesized through Diels–Alder reactions by reactive extrusion. The Diels–Alder and retro-Diels–Alder reactions ... [more ▼]

Cross-linked poly(ε-caprolactone) (PCL)-based polyesterurethane (PUR) systems have been synthesized through Diels–Alder reactions by reactive extrusion. The Diels–Alder and retro-Diels–Alder reactions proved to be useful for enhancing the molecular motion of PCL-based systems, and therefore their crystallization ability, in the design of cross-linked semicrystalline polymers with one-way and two-way shape-memory properties. Successive reactions between alpha,omega-diol PCL (PCL2), furfuryl alcohol, and methylene diphenyl 4,4′-diisocyanate straightforwardly afforded the alpha,omega-furfuryl PCL-based PUR systems, and subsequent Diels–Alder reactions with N,N-phenylenedimaleimide afforded the thermoreversible cycloadducts. The cross-linking density could be modulated by partially replacing PCL-diol with PCL-tetraol. Interestingly, the resulting PUR systems proved to be semicrystalline cross-linked polymers, the melting temperature of which (close to 45 °C) represented the switching temperature for their shape-memory properties. Qualitative and quantitative measurements demonstrated that these PUR systems exhibited one-way and two-way shape-memory properties depending on their cross-linking density. [less ▲]

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See detailThe Design of Cylindrical Orthotropic Plates and Shells
Rigo, Philippe ULg

in IASS Congress, Numerical Methods, Vol. 5 (1989, September)

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See detailDesign of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.
Munde, Manoj; Ismail, Mohamed A; Arafa, Reem et al

in Journal of the American Chemical Society (2007), 129(44), 13732-43

The classical model of DNA minor groove binding compounds is that they should have a crescent shape that closely fits the helical twist of the groove. Several compounds with relatively linear shape and ... [more ▼]

The classical model of DNA minor groove binding compounds is that they should have a crescent shape that closely fits the helical twist of the groove. Several compounds with relatively linear shape and large dihedral twist, however, have been found recently to bind strongly to the minor groove. These observations raise the question of how far the curvature requirement could be relaxed. As an initial step in experimental analysis of this question, a linear triphenyl diamidine, DB1111, and a series of nitrogen tricyclic analogues were prepared. The goal with the heterocycles is to design GC binding selectivity into heterocyclic compounds that can get into cells and exert biological effects. The compounds have a zero radius of curvature from amidine carbon to amidine carbon but a significant dihedral twist across the tricyclic and amidine-ring junctions. They would not be expected to bind well to the DNA minor groove by shape-matching criteria. Detailed DNase I footprinting studies of the sequence specificity of this set of diamidines indicated that a pyrimidine heterocyclic derivative, DB1242, binds specifically to a GC-rich sequence, -GCTCG-. It binds to the GC sequence more strongly than to the usual AT recognition sequences for curved minor groove agents. Other similar derivatives did not exhibit the GC specificity. Biosensor-surface plasmon resonance and isothermal titration calorimetry experiments indicate that DB1242 binds to the GC sequence as a highly cooperative stacked dimer. Circular dichroism results indicate that the compound binds in the minor groove. Molecular modeling studies support a minor groove complex and provide an inter-compound and compound-DNA hydrogen-bonding rational for the unusual GC binding specificity and the requirement for a pyrimidine heterocycle. This compound represents a new direction in the development of DNA sequence-specific agents, and it is the first non-polyamide, synthetic compound to specifically recognize a DNA sequence with a majority of GC base pairs. [less ▲]

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See detailDesign of electrical conductive composites : key role of the morphology on the electrical properties of carbon black filled polymer blends
Gubbels, Frédéric; Blacher, Silvia ULg; Vanlathem, E. et al

in Macromolecules (1995), 28(5), 1559-1566

Effect of carbon black (CB) on the morphology of filled polyethylene (PE)/polystyrene (PS) blends has been investigated by image analysis of optical micrographs (2-D analysis) and by the selective ... [more ▼]

Effect of carbon black (CB) on the morphology of filled polyethylene (PE)/polystyrene (PS) blends has been investigated by image analysis of optical micrographs (2-D analysis) and by the selective extraction of one phase of the binary blends (3-D analysis). The macroscopic electrical resistivity of the filled polyblends strongly depends on the selective localization of CB in one phase or at the interface and above all on the double percolation, i.e. percolation of the polymer phases and percolation of the CB particles. The selective localization of CB in the PE phase has remarkable effects on the polyblend phase morphology. The phase cocontinuity is indeed extended over a much larger composition range, and the phase morphology is stabilized toward post-thermal treatment at 200 degrees C. In the case of double percolation and selective localization of CB at the polyblend interface, electrical conductivity is observed at a CB content as low as 0.4 wt %. [less ▲]

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See detailDesign of FIR Filters by Genetic Algorithms through Bit-Level Manipulation of their Coefficients
Gary, Renaud; Andries, A.; Verly, Jacques ULg

Conference (2002, March)

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See detailDesign of growth-dependent biosensors based on destabilized GFP for the detection of physiological behavior of Escherichia coli in heterogeneous bioreactors
Han, Shanshan; Delvigne, Frank ULg; Brognaux, Alison ULg et al

in Biotechnology Progress (2013), 29(2), 553-563

In this work we present the design and characterization of GFP-based reporter systems designed in order to describe cellular activity in ‘complex’, heterogeneous bioreactors. The reporter systems consist ... [more ▼]

In this work we present the design and characterization of GFP-based reporter systems designed in order to describe cellular activity in ‘complex’, heterogeneous bioreactors. The reporter systems consist of Escherichia coli strains carrying growth dependent promoters fused to genes expressing stable and unstable variants of GFP, respectively. The response of Escherichia coli cells to transient exposure to glucose was studied in a two-compartment scale down bioreactor (SDR) consisting of a stirred tank reactor (STR) connected to plug-flow reactor (PFR). Such a SDR system is employed to mimic the situation that often encountered in large-scale, fed-batch bioreactors. The response of E. coli coli to oxygen-poor and glucose-rich regions was simulated by continuously pumping E. coli cells from STR to the PFR. A concentrated glucose pulse (400 g/L) was consecutively added at the entrance of the PFR and samples were taken from PFR. The GFP expressions were significantly marked after 10 hours of culture in STR (control reactor) and SDR, whereas, growth rates were rather similar. Additional experiments in chemostat (D=0.14 h-1) with programmed glucose perturbation (30 g/L, frequency: 100/900 s) suggested that the activities of the promoter are linked with the substrate limitation signal. Taken together with immunoblot analysis, we suppose protein leakage is responsible for the overexpression of fis and the related promoters, such as rrnB in this case study, but additional works are required in order to confirm this relationship. Our finding are of great interest for industrial application since the GFP signal can be detected very early during the culture and is related to relevant physiological changes. This investigation is useful for a better understanding of the fast dynamic phenomena occurring in heterogeneous large-scale bioreactors. [less ▲]

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See detailDesign of hybrid nanovehicles for remotely triggered drug release: an overview
Liu, Ji; Detrembleur, Christophe ULg; Mornet, Stéphane et al

in Journal of Materials Chemistry B (in press)

n the past few decades, various nanovehicles have been developed as drug delivery systems, in which inorganic and organic components are integrated within a nano-object. Upon the application of remote ... [more ▼]

n the past few decades, various nanovehicles have been developed as drug delivery systems, in which inorganic and organic components are integrated within a nano-object. Upon the application of remote stimuli, e.g. alternating magnetic field, near infrared or ultrasound radiations, the release of guest molecules can be triggered in a quite controlled manner. Herein, we review different hybrid nanostructures which have already been reported for the remotely triggered release, such as those based on (1) host–guest conjugates, (2) core–corona nanoparticles, (3) polymer nanogels, (4) polymer micelles, (5) liposomes, (6) mesoporous silica particles and (7) hollow nanoparticles. Moreover, we also summarize six underlying mechanisms that govern such a kind of remotely triggered release behaviours: (1) enhanced diffusion and/or permeation, (2) thermo- or photo-labile bond cleavage, (3) fusion of phase-changed materials, (4) photo-induced isomerisation, (5) thermo-induced swelling/de-swelling of thermo-responsive polymers, and (6) destruction of the nanostructures. The ways in which different components are incorporated into an integrated hybrid nanostructure and how they contribute to the remotely triggered release behaviours are detailed. [less ▲]

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See detailDesign of IMEPS (Ipriflavone Multicentric European Fracture Study)
Reginster, Jean-Yves ULg; Roux, Ch; Riis, BJ

in Osteoporosis International (1996), 6(S1), 318

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See detailDesign of Innovative Ship Concepts Using an Integrated Decision Support System for Ship Production and Operation
Rigo, Philippe ULg; Žanić, Vedran; Ehlers, Sören et al

in Brodogradnja : Journal of Naval Architecture and Shipbuilding Industry (2010), 61(4), 367-381

Design of Innovative Ship Concepts Using an Integrated Decision Support System for Ship Production and Operation

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See detailDesign of interactive visualization of models and students data
Mazza, R; Mazzola, L; Glahn, C et al

Report (2009)

This document reports the design of the interactive visualizations of open student models that will be performed in GRAPPLE. The visualizations will be based on data stored in the domain model and student ... [more ▼]

This document reports the design of the interactive visualizations of open student models that will be performed in GRAPPLE. The visualizations will be based on data stored in the domain model and student model, and aim at supporting learners to be more engaged in the learning process, and instructors in assisting the learners. [less ▲]

Detailed reference viewed: 32 (1 ULg)
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See detailDesign of joints in industrial portal frames made of slender built-up members
Braham, M.; Jaspart, Jean-Pierre ULg

in Proceedings of the International Conference on Experimental Model, research and testing of thin-Walled Structures (1997)

Detailed reference viewed: 23 (1 ULg)
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See detailDesign of Load Shedding Schemes against Voltage Instability
Moors, Cedric; Lefebvre, Daniel; Van Cutsem, Thierry ULg

(2000, January 27)

This paper proposes a methodology for the design of automatic load shedding against long-term voltage instability. In a first step, a set of training scenarios is set up, corresponding to various ... [more ▼]

This paper proposes a methodology for the design of automatic load shedding against long-term voltage instability. In a first step, a set of training scenarios is set up, corresponding to various operating conditions and disturbances. Each scenario is analyzed to determine the minimal load shedding which stabilizes the system, with due consideration for the shedding location and delay. In a second step, the parameters of a closed-loop undervoltage load shedding scheme are determined so as to: (i) approach as closely as possible the optimal sheddings computed in the first step, over the whole set of scenarios; (ii) stabilize the system in all the unstable scenarios and (iii) shed no load in the stable ones. The corresponding optimization problem is solved using a (micro-)Genetic Algorithm. A detailed example is given on the Hydro-Quebec system in which load shedding is presently planned. [less ▲]

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See detailDesign of Load Shedding Schemes against Voltage Instability using Combinatorial Optimization
Van Cutsem, Thierry ULg; Moors, Cedric; Lefebvre, Daniel

(2002, January 31)

This paper proposes a methodology for the design of automatic load shedding against voltage instability. In a first step, we describe a method allowing to find the minimal shedding required in a given ... [more ▼]

This paper proposes a methodology for the design of automatic load shedding against voltage instability. In a first step, we describe a method allowing to find the minimal shedding required in a given unstable scenario. In a second step, we describe the structure of various controllers and identify the parameters to be optimized. Next, we present an optimization approach to find the controller parameters which optimize an overall performance objective. Results are presented on the Hydro-Québec system, in which load shedding is presently planned. [less ▲]

Detailed reference viewed: 66 (4 ULg)