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See detailDeterminants of gastro-protective drugs co-prescription during treatment with nonselective NSAIDs: a prospective survey of 2197 patients recruited in primary care
Rabenda, Véronique ULg; Burlet, N.; Belaiche, Jacques ULg et al

in Osteoarthritis and Cartilage (2006), 14(7), 625-630

Objective: Our goal was to identify the magnitude of gastro-protective drugs (GPDs) co-prescription and the profile of patients who received GPD co-prescription, during nonsteroidal anti-inflammatory ... [more ▼]

Objective: Our goal was to identify the magnitude of gastro-protective drugs (GPDs) co-prescription and the profile of patients who received GPD co-prescription, during nonsteroidal anti-inflammatory drugs (NSAIDs) treatment in a "real life setting" of primary care practice. Methods: A pragmatic prospective 6-month survey of 2197 new takers of nonselective NSAIDs, selected and followed by general practitioners (GPs) on the bias of their usual standards of care. Results: Forty-seven percent of our survey population used at least one GPD during the 6-month follow-up. No difference was identified between piroxicam, diclofenac, ibuprofen, meloxicam and nimesulid for the GPD co-prescription. Besides the presence of gastro-intestinal (GI) symptoms, previous use of GPD, previous occurrence of GI disorders and increase in age are the most prominent predictive factors of GPD use during NSAID treatment. When adjusted for other risk factors, co-prescription of GPD was significantly increased in patients aged 55 years and above (odds ratio (OR): 1.29, 95% confidence interval (Cl): 1.01-1.64) with no further increase in the co-prescription in older subjects. Conclusion: Patients above 55 years with previous history of GI symptoms or GPD use are more likely to benefit from cytoprotective medications. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved. [less ▲]

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See detailDeterminants of high, median and low rates of caesarean deliveries in Belgium
Absil, Gaëtan ULg; Van Parys, A. S.; Bednarek, Stéphanie et al

Report (2011)

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See detailThe determinants of homogenous, vertically differentiated and horizontally differentiated European trade flows
Henry de Frahan, Bruno; Tharakan, Joseph ULg

in Loader, R. J.; Henson, S. J.; Traill, W. B. (Eds.) Globalisation of the Food Industry : Policy Implications (1997)

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See detailDeterminants of left ventricular preload-adjusted maximal power
Segers, Patrick; Tchano-Sato, Vincent; Leather, H. Alex et al

in American Journal of Physiology - Heart and Circulatory Physiology (2003), 284(6), 2295-2301

Maximal left ventricular (LV) hydraulic power output (PWRmax), corrected for preload as PWRmax/(V-ed)(beta) (where V-ed is the end-diastolic volume and beta is a constant coefficient), is an index of LV ... [more ▼]

Maximal left ventricular (LV) hydraulic power output (PWRmax), corrected for preload as PWRmax/(V-ed)(beta) (where V-ed is the end-diastolic volume and beta is a constant coefficient), is an index of LV contractility. Whereas preload-adjusted maximal power (PAMP) is usually calculated with beta = 2, there is uncertainty about the optimal value of beta (beta = 1 for the normal LV and 2 for the dilated LV). The aim of this work is to study the determining factors of beta. The data set consisted of 245 recordings (steady state and vena cava occlusion) in 10 animals in an ischemic heart pig model. The occlusion data yielded the slope (E-es; 2.01 +/- 0.77 mmHg/ml, range 0.71-4.16 mmHg/ml) and intercept (V-0; -11.9 +/- 22.6 ml; range -76 to 39 ml) of the end-systolic pressure-volume relation, and the optimal beta-factor (assessed by fitting an exponential curve through the V-ed-PWRmax relation) was 1.94 +/- 0.88 (range 0.29-4.73). The relation of beta with V-ed was weak [beta = 0.60 + 0.02(V-ed); r(2) = 0.20]. In contrast, we found an excellent exponential relation between V-0 and beta [beta = 2.16e(0.0189(V0)), r(2) = 0.70]. PAMP, calculated from the steady-state data, was 0.64 +/- 0.40 mW/ml(2) (range 0.14-2.83 mW/ml(2)) with a poor correlation with E-es (r = 0.30, P < 0.001). An alternative formulation of PAMP as PWRmax/(V-ed - V-0)(2), incorporating V-0, yielded 0.47 +/- 0.26 mW/ml(2) (range 0.09-1.42 mW/ml(2)) and was highly correlated with E-es (r = 0.89, P < 0.001). In conclusion, correct preload adjustment of maximal LV power requires incorporation of V-0 and thus of data measured under altered loading conditions. [less ▲]

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See detailDeterminants of long duration sickness absence after an occupational back injury in the Belgian working population
Mairiaux, Philippe ULg; Mazina, D. ULg

Poster (2007, August)

Aims Occupational low-back injuries are a major cause not only of lost time but also of job loss and early retirement for health reasons. To promote the employability of an aging workforce, a better ... [more ▼]

Aims Occupational low-back injuries are a major cause not only of lost time but also of job loss and early retirement for health reasons. To promote the employability of an aging workforce, a better understanding of the prognostic factors for a long duration sick leave after such injuries is needed. The Belgian national database of work accidents was used to investigate these factors. Methods The data were retrieved from the Belgian Fund for Work Accidents (FAT) database over a three-year period (2001-2003). The population source involved all the workers under a job contract in the private sector recorded during that period as compensated cases for an accident that occurred at the workplace (n=558.276); 6,6% of those cases had the back as “location of injury”. Taking into account the calendar year system for counting time on benefits, the analysis was restricted to the 18936 workers who had reported a back injury during the first 6 months of each year. Eight factors (gender, age, region, professional category, size of enterprise, seniority, sector of activity and accident circumstances) were analyzed in relation with the duration of sick leave as attributed by the insurance company. For each factor, the relative prevalence of cases with more than 92 days of work absence (outcome variable) was compared using the Pearson’s 2 in the bivariate analysis. In the multivariate analysis, a Stepwise Logistic Regression was performed to obtain the final model. Results The proportion of back injured workers with more than 92 lost days was 6.8 % (CI 95%: 6.4-7.1). In the bivariate analysis, all the 8 factors under study, gender and seniority excepted, were correlated with sick leave duration. After adjustment for confounding factors, the final model involved 5 factors statistically associated to a long duration sick leave: age (older than 40 years : OR=1.45(1.25-1.68)); geographical location of company (Wallonia: OR=1.70(1.47-1.98); Brussels: OR=1.61(1.29-2.02)); professional category (blue collar: OR=1.71 (1.32-2.20)); circumstance of accident (falls : OR=1.26 (1.03-1.52); overexertion: OR=0.75(0.64-0.89)); and sector of activity (building industry: OR=1.47(1.22-1.78)). Discussion and conclusions This study showed that in the Belgian working population, 6.8 % of the compensated back injuries can be considered as chronic back pain cases. This figure is however likely to underestimate the actual incidence of the problem as the FAT statistics showed that 21.7% of the back injury claims were rejected by the insurers. The proportion of back injured workers with a long sick leave (chronic low back pain) is clearly related to the worker age, blue-collar status, accident precipitating cause, and some high-risk activities; these observations are in line with the literature. The observed regional differences in incidence could not be explained by a differential distribution of high risk sectors in the country; they are probably to be ascribed to cultural and social factors but these could not be studied on the basis of the variables recorded in the FAT database. In conclusion, this study shows that considerable prevention efforts have to be focused on some categories of workers with back injury, who are at risk for a long sickness absence leading to chronic low back pain. References 1. Nielens H., Van Zundert J., Mairiaux P., Gailly J., Van Den Hecke N., Mazina D., Camberlin C., Bartholomeeussen S., De Gauquier K., Paulus D., Ramaekers D. Chronic Low Back Pain. Good Clinical Practice (GCP). Bruxelles: Centre fédéral d'expertise des soins de santé (KCE); 2006. KCE reports 48B (D/2006/10.273/64). 2. Crook J, Milner R, Schultz IZ et al. Determinants of occupational disability following a low back injury: a critical review of the literature. [Review] [68 refs]. Journal of Occupational Rehabilitation.12:277-95, 2002. [less ▲]

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See detailDeterminants of Market Success for Commercial Movies
Choffray, Jean-Marie ULg; Pras, Bernard

in Der Markt (1987), 73

This paper shows how a systematic analysis of the way commercial movies are perceived by potential viewers allows a better understanding of the factors leading to their success. It proposes a model-based ... [more ▼]

This paper shows how a systematic analysis of the way commercial movies are perceived by potential viewers allows a better understanding of the factors leading to their success. It proposes a model-based methodology that could be used to improve the development process and the market introduction of new movies. [less ▲]

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See detailDeterminants of persistent negative T waves and early versus late T wave normalisation after acute myocardial infarction
PIERARD, Luc ULg; LANCELLOTTI, Patrizio ULg

in Heart (2005), 91(8), 1008-1012

OBJECTIVE: To determine whether persistent versus early or delayed T wave normalisation of negative T waves after acute myocardial infarction is determined by the myocardial state, the treatment strategy ... [more ▼]

OBJECTIVE: To determine whether persistent versus early or delayed T wave normalisation of negative T waves after acute myocardial infarction is determined by the myocardial state, the treatment strategy, or both. DESIGN: 127 consecutive patients with a first acute myocardial infarction and > or = 2 negative T waves on the 24-36 hour ECG were studied. They underwent dobutamine stress echocardiography and coronary angiography during the first week. ECG was recorded at hospital discharge and at a mean (SD) of 4 (1) months. SETTING: University hospital. RESULTS: T wave normalisation was observed in 88 patients (early at discharge in 19 and delayed at four months in 69). Early T wave normalisation was associated with sustained contractile reserve during dobutamine stress (13 of 19 (68%)), whereas delayed T wave normalisation was observed mainly in patients with an ischaemic response (49 of 69 (71%)). The persistence of negative T waves was associated with an ischaemic response (21 of 39 (54%)) or persistent akinesis (17 of 39 (44%)). Among patients with an ischaemic response to dobutamine, in-hospital elective angioplasty was an independent determinant of delayed T wave normalisation (39 of 49 v 4 of 21 patients with persistent negative T waves at four months, p < 0.0001). CONCLUSIONS: Early T wave normalisation is associated with dobutamine induced, sustained improvement indicating myocardial stunning. Delayed normalisation is observed mainly in patients with ischaemic myocardium who have undergone revascularisation. Persistent negative T waves correspond to either extensive necrosis or non-revascularised, jeopardised myocardium. [less ▲]

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See detailDeterminants of pulmonary artery hypertension at rest and during exercise in patients with heart failure
Tumminello, G.; LANCELLOTTI, Patrizio ULg; Lempereur, Mathieu ULg et al

in European Heart Journal (2007), 28(5), 569-574

Aims Pulmonary hypertension, a marker of poor prognosis in heart failure, may develop or increase during exercise. We sought to examine the determinants of pulmonary hypertension at rest and during ... [more ▼]

Aims Pulmonary hypertension, a marker of poor prognosis in heart failure, may develop or increase during exercise. We sought to examine the determinants of pulmonary hypertension at rest and during exercise in heart failure patients. Methods and results Forty-six patients with left ventricular (W) dysfunction (ejection fraction: 30 +/- 6%) underwent a semi-recumbent, incremental bicycle exercise Doppler echocardiography. LV systolic and diastolic function, pulmonary artery systolic pressure (PASP), functional mitral regurgitation (MR), and left atrial volume were quantified at rest and during exercise. Wide changes in PASP at exercise were unrelated to PASP at rest (r = 0.12). Independent predictors of PASP at rest were left atrial. volume (P = 0.006), E-wave velocity (P = 0.02), mitral tenting area (P = 0.005), and mitral effective regurgitant orifice (ERO) (P=0.02). The incidence of dyspnoea was similar in patients with and without moderately severe pulmonary hypertension at baseline. At peak exercise, LV ejection fraction (P = 0.03) and mitral ERO (P = 0.008) were independently associated with PASR Patients with a larger exercise increase in PASP (> 60 mmHg) interrupted frequently exercise for dyspnoea (70 vs. 27%; P = 0.04). A larger rise in mitral regurgitant volume during exercise emerged as the single determinant of exercise-induced increases in PASP. Conclusion In patients with HF, left atrial. volume, mitral deformation, and mitral regurgitant orifice correlated with pulmonary pressure at rest, whereas dynamic MR and limited contractile reserve correlated with pulmonary pressure at exercise. The magnitude of pulmonary pressure during exercise in these patients mainly depends on dynamic MR. [less ▲]

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See detailDeterminants of serum concentrations of 1,1 dichloro 2,2 bis (p-chlorophenyl)ethylene and polychlorinated biphenyls among French women in the CECILE study
Bachelet, D.; Truong, T.; Verner, M.-A. et al

in Environmental Research (2011), 111

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See detailDeterminants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
Thijs, Lutgarde; Staessen, Jan; Amery, Antoon et al

in Environmental Health Perspectives (1992), 98

This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 197 participants (959 men and 1018 women), 20-80 years ... [more ▼]

This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 197 participants (959 men and 1018 women), 20-80 years old, constituted a stratified random sample of the population of four Belgian districts, representing two areas with low and two with high environmental exposure to cadmium. For each exposure level, a rural and an urban area were selected. The serum concentration of zinc, frequently used as an index for zinc status in human subjects, was higher in men (13.1 µmole/L, range 6.5-23.0 µmole/L) than in women (12.6 µmoleL, range 6.3-23.2 µmole/L). In men, 20% of the variance of serum zinc was explained by age (linear and squared term, R=0.29), diurnal variation (r=0.29), and total cholesterol (r=0.16). After adjustment for these covariates, a negative relationship was observed between serum zinc and both blood (r= -0.10) and urinary cadmium (r= -0.14). In women, 11% of the variace could be explained by age (linear and squared term, R = 0.15), diurnal variation in serum zinc (r=0.27), creatinine clearance (r= -0.11), log y-glutamyltranspeptidase (r= 0.08), cholesterol (r= 0.07), contraceptive pill intake (r= -0.07), and log serum ferritin (r=0.06). Before and after adjustment for significant covariates, serum zinc was, on average, lowest in the two districts where the body burden of cadmium, as assessed by urinary cadmium excretion, was highest. These results were not altered when subjects exposed to heavy metals at work were excluded from analysis. [less ▲]

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See detailDeterminants of sickness absence duration after an occupational back injury in the Belgian population
Mazina, Déogratias; Donneau, Anne-Françoise ULg; Mairiaux, Philippe ULg

in American Journal of Industrial Medicine (2012), 55(3), 270-280

Background This study aimed at assessing factors associated to the duration of sickness absence after a back injury in the Belgian working population, with a special emphasis on cultural factors. Methods ... [more ▼]

Background This study aimed at assessing factors associated to the duration of sickness absence after a back injury in the Belgian working population, with a special emphasis on cultural factors. Methods The data were retrieved from the Belgian Fund for Work Accidents database over a three-year period (2001-2003). The population source involved all Belgian workers under a job contract in the private sector registered as compensated cases for an accident that occurred at the workplace (n=558276). From that database, all back injury cases involving a complete data set and registered during the first 6 months of each year (n= 11262) were selected and eight factors (gender, age, seniority in the current job, job category, accident regional location, enterprise size, sector of activity and accident circumstances) were analyzed in relation to the outcome variable, sick leave duration recorded as ordered time intervals between 0 day and 183-366 days. Results Sick leave duration was strongly associated in a multivariate model to age (>= 40 years: OR=2.18), blue collar job (1.55), work in building industry (1.32) and enterprise size (>100 : 0.85), and to a less extent to seniority (>10y: 0.88), and circumstance of accident (falls: 1.26). Injuries occurring in the French-speaking part of the country were associated to a longer sick leave (1.07; p=0.034). Conclusions This study shows that besides well-known risk factors, subtle cultural language-linked factors and/or regional differences in economic climate may significantly influence the length of disability period after a back injury. [less ▲]

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See detailDeterminants of terrestrial ecosystem carbon balance inferred from European eddy covariance flux sites
Reichstein, Markus; Papale, Dario; Valentini, Riccardo et al

in Geophysical Research Letters (2007), 34(1),

Pioneering work in the last century has resulted in a widely accepted paradigm that primary production is strongly positively related to temperature and water availability such that the northern ... [more ▼]

Pioneering work in the last century has resulted in a widely accepted paradigm that primary production is strongly positively related to temperature and water availability such that the northern hemispheric forest carbon sink may increase under conditions of global warming. However, the terrestrial carbon sink at the ecosystem level (i.e. net ecosystem productivity, NEP) depends on the net balance between gross primary productivity (GPP) and ecosystem respiration ( TER). Through an analysis of European eddy covariance flux data sets, we find that the common climate relationships for primary production do not hold for NEP. This is explained by the fact that decreases in GPP are largely compensated by parallel decreases in TER when climatic factors become more limiting. Moreover, we found overall that water availability was a significant modulator of NEP, while the multivariate effect of mean annual temperature is small and not significant. These results indicate that climate- and particularly temperature-based projections of net carbon balance may be misleading. Future research should focus on interactions between the water and carbon cycles and the effects of disturbances on the carbon balance of terrestrial ecosystems. [less ▲]

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See detailThe determinants of the Ricardian equivalence in the OECD nations
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Verbon, H.; Van Winden, F. (Eds.) The Political Economy of Pubic Debt (1993)

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See detailLes déterminants perceptuels du résultat commercial des films
Choffray, Jean-Marie ULg; Pras, Bernard

in CERESSEC Working Paper, Groupe ESSEC PARIS (1979)

L'objet de ce document de recherche est de montrer comment une analyse rigoureuse de la manière dont les films sont perçus permet de mieux comprendre les déterminants de leur succès commercial. La méthode ... [more ▼]

L'objet de ce document de recherche est de montrer comment une analyse rigoureuse de la manière dont les films sont perçus permet de mieux comprendre les déterminants de leur succès commercial. La méthode proposée constitue une première étape dans le développement de systèmes d'aide à la conception et au développement des nouveaux films. [less ▲]

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See detailDétermination automatique de l'ammoniaque dans le liquide du rumen par la méthode de Berthelot adaptée à l'auto-analyzer
Van Eenaeme, Christian ULg; Bienfait, Jean-Marie ULg; Lambot, Olivier et al

in Annales de Médecine Vétérinaire (1969), 113

Detailed reference viewed: 12 (1 ULg)