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Peer Reviewed
See detailDesign, synthesis, and pharmacological evaluation of cromakalim analogues as pancreatic β-cell-selective KATP channel openers
Florence, X.; De Tullio, Pascal ULg; Lebrun, Ph. et al

Conference (2007, October)

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See detailDesign, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors
Francotte, Pierre ULg; De Tullio, Pascal ULg; Goffin, Eric ULg et al

in Journal of Medicinal Chemistry (2007), 50(13), 3153-3157

A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as potentiators of AMPA receptors. Attention was paid to the impact of the substituent introduced at the ... [more ▼]

A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as potentiators of AMPA receptors. Attention was paid to the impact of the substituent introduced at the 7-position of the heterocycle. The biological evaluation was achieved by measuring the AMPA current in rat cortex mRNA-injected Xenopus oocytes. The most potent compound, 4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (12a) was found to be active in an object recognition test in rats demonstrating cognition enhancing effects in vivo after oral administration. [less ▲]

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See detailLes désignations de plats étrangères dans le Cuisnier gascon (1740)
Colson, Maryse ULg

Conference (2011, May 13)

Œuvre originale de la première moitié du XVIIIe siècle, Le Cuisinier gascon est certainement l’un des ouvrages culinaires les plus énigmatiques de son époque. Publié de façon anonyme, le livre est ... [more ▼]

Œuvre originale de la première moitié du XVIIIe siècle, Le Cuisinier gascon est certainement l’un des ouvrages culinaires les plus énigmatiques de son époque. Publié de façon anonyme, le livre est aujourd’hui attribué au Prince de Dombes, frère du comte d’Eu et grand veneur de Louis XV avec lequel il partage le goût de la chasse et des bons repas. L’ouvrage présente deux cent dix-sept recettes disparates dont l’écriture ne déroge à aucune règle fondamentale : concision et efficacité du style, sobriété de la syntaxe, homogénéité des moyens d’expression de l’injonction. En effet, la recette de cuisine, par sa nature prescriptive, laisse peu de place aux figures stylistiques et à la créativité de son auteur. En réalité, le seul espace qui permet de laisser quelque latitude à l’imagination est concentré dans l’intitulé du plat décrit. Or, Le Cuisinier gascon présente de nombreuses désignations de plats fantaisistes et, en particulier, un nombre impressionnant de dénominations « étrangères » telles que les Cuisses de poularde à la Suisse ou les Poulpettes à l’Italienne. Il est donc évident que l’ouvrage se veut cosmopolite, résolument tourné vers l’ailleurs – qu’il soit géographique ou imaginaire. De manière générale, nous nous demanderons dans quelle mesure les emprunts lexicaux tels que Woatre fiche, oille et niocs peuvent être considérés comme des transferts culturels, à la fois matériel (la spécialité culinaire) et linguistique (sa dénomination). Peut-on voir dans cet exotisme culinaire le signe d’influences culturelles entre des pays dont les frontières politiques ne cessent de se redessiner durant un siècle éclairé par les Lumières ? En particulier, deux types de désignations problématiques retiendront notre attention ; le premier type portant sur « l’ailleurs spatial » et le second sur « l’ailleurs imaginaire ». Premièrement, on note de nombreux adjectifs invariables construits sur le modèle « à la + adj. fém. sg. » : les uns réfèrent à des régions (à la Provençale) et les autres à des entités culturelles plus vastes (à l’Espagnole). Si le lien entre la désignation et la référence est parfois évident (par exemple, on trouve presque invariablement du parmesan dans la composition des plats à l’Italienne), il peut s’avérer abscons dans d’autres cas ; ainsi, nous rencontrons des Choux à la Turque et des Foyes gras à l’Indienne qui n’ont rien d’oriental. Ces qualifications sont-elles purement fantaisistes ou ont-elles une explication rationnelle ? Ces adjectifs font-il véritablement référence à une nation ou plutôt à une tradition, à un événement historique ou à une personnalité ? Deuxièmement, on observe des désignations inédites, propres au Cuisinier gascon : les Yeux de veau farcis au gratin, le Hachis d’œufs sans malice et le Veau en crotte d’âne roulé à la Nenteau en sont les meilleurs exemples. Ici, ce ne sont plus les frontières géographiques qui sont franchies, mais celles du réel. Comment comprendre l’étrangeté de ces appellations qui mêlent la représentation imagée des aliments et une poésie pleine d’humour ? Ne pourrait-on lire dans cette liberté nominative la volonté de l’auteur-cuisinier de s’émanciper en s’appropriant la matière culinaire grâce à l’usage qu’il fait de la langue ? Par l’étude de quelques désignations, nous verrons à quel point les transferts culturels imprègnent la gastronomie de l’époque et lui permettent d’évoluer. De plus, nous envisagerons la possibilité que le cuisinier, en introduisant l’étrange ou l’étranger dans son texte, devienne lui-même autre (un véritable auteur) et qu’il emmène le genre culinaire vers un ailleurs: la gasconnade. [less ▲]

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See detailLes désignations romanes de l'ECUREUIL
Boutier, Marie-Guy ULg; Baiwir, Esther ULg

in Contini, Michel; Veny, Joan (Eds.) Atlas linguistique roman (ALiR) (in press)

L'ALiR a pour objectif de fournir une description globale du lexique roman par champ sémantique, à travers l'étude onomasiologique des désignations romanes de concepts. Les analyses lexicale, phonétique ... [more ▼]

L'ALiR a pour objectif de fournir une description globale du lexique roman par champ sémantique, à travers l'étude onomasiologique des désignations romanes de concepts. Les analyses lexicale, phonétique, morphosyntaxiques sont mises en valeur par la production de cartes interprétatives. [less ▲]

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See detailDesigned combination of chiral selectors for adjustment of enantioseparation selectivity in capillary electrophoresis.
Fillet, Marianne ULg; Chankvetadze, Bezhan; Crommen, Jacques ULg et al

in Electrophoresis (1999), 20(13), 2691-7

In this study an attempt has been made to explain the reasons for changing the enantioseparation selectivity in some dual cyclodextrin (CD) systems compared to the use of single chiral selectors in ... [more ▼]

In this study an attempt has been made to explain the reasons for changing the enantioseparation selectivity in some dual cyclodextrin (CD) systems compared to the use of single chiral selectors in capillary electrophoresis (CE). An explanation for selectivity changes is proposed based on the effect of the chiral selector on the mobility of the analyte. In order to support the proposed mechanism, several dual systems were designed on the basis of the known recognition pattern of enantiomers for individual CDs. In most cases the separation selectivity could be adjusted in a designed way. There was no experimental evidence for simultaneous binding of a given chiral analyte with both chiral selectors or of chiral recognition of an analyte complex with one CD by another CD. [less ▲]

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See detailDesigners Guide to EN 1998-1 and 1998-5. Eurocode 8: Design Provisions for Earthquake Resistant Structures
Carvalho; Elnashai; Fardis et al

in Designers Guide to EN 1998-1 and 1998-5. Eurocode 8: Design Provisions for Earthquake Resistant Structures (2005)

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See detailDesigning a linear pension scheme with forced savings and wage heterogeneity
Cremer, Helmuth; De Donder, Philippe; Maldonado, Dario et al

in International Tax and Public Finance (2007)

This paper studies the optimal linear pension scheme when society consists of rational and myopic individuals. Myopic individuals have, ex ante, a strong preference for the present even though, ex post ... [more ▼]

This paper studies the optimal linear pension scheme when society consists of rational and myopic individuals. Myopic individuals have, ex ante, a strong preference for the present even though, ex post, they would regret not to have saved enough. While rational and myopic persons share the same ex post intertemporal preferences, only the rational agents make their savings and labor supply decisions according to these preferences. Individuals are also distinguished by their productivity. The social objective is “paternalistic”: the utilitarian welfare function depends on ex post utilities. We examine how the presence of myopic individuals affects both the size of the pension system and the degree of redistribution it operates, with and without liquidity constraints. The relationship between proportion of myopic individuals and characteristics of the pension system turns out to be much more complex than one would have conjectured. Neither the impact on the level of pensions nor the effect on their redistributive degree is unambiguous. Nevertheless, we show that under some plausible assumptions adding myopic individuals increases the level of pension benefits and leads to a shift from a flat or even targeted scheme to a partially contributory one. However, we also provide an example where the degree of redistribution is not a monotonic function of the proportion of myopic individuals. [less ▲]

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See detailDesigning a new scaffold for Anterior Cruciate Ligament tissue engineering
Laurent, Cédric ULg

in Computer Methods in Biomechanics & Biomedical Engineering (2010)

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See detailDesigning a Platform for Flexible and Performant Virtual Routers on Commodity Hardware
Egi, Norbert; Greenhalgh, Adam; Handley, Mark et al

in Electronic Communications of the EASST (2009)

Multi-core CPUs, along with recent advances in memory and buses, render commodity hardware a strong candidate for software router virtualization. In this context, we present the design of a new platform ... [more ▼]

Multi-core CPUs, along with recent advances in memory and buses, render commodity hardware a strong candidate for software router virtualization. In this context, we present the design of a new platform for virtual routers on x86 hardware. We also elaborate on our design choices in order to achieve both high performance and flexibility for packet processing. [less ▲]

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See detailDesigning and implementing a GIS in an international context
Pantazis, Dimos N; Cornélis, Bernard ULg

in Transactions in GIS (1997), 1(4), 301-320

International collaborations between private companies, national research laboratories, and universities in the field of GIS have opened up new ways of exchanging knowledge and experiences between ... [more ▼]

International collaborations between private companies, national research laboratories, and universities in the field of GIS have opened up new ways of exchanging knowledge and experiences between different countries. However, when a collaboration involves the actual design and implementation of an operational GIS, rather than simply theoretical or applied research, or the development of specific applications, many problems can arise, sometimes leading either to the partial success or the complete failure of the project. Some of these problems are frequently encountered in all kinds of international collaborations: problems arising from different cultural mentalities, difficulties establishing a single common leadership, difficulties with communication and information exchange, and so on. Problems relating to the specific nature of the GIS are also present, for example the absence of digital geographic data format standards, the absence of metadata standards, the omission to use GIS or IS design methods, etc. This paper focuses on a joint Sino-Belgian project for the design and implementation of an urban geographical information system (UGIS) integrating remote sensing techniques in Hangzhou city, China and examines the general, specific, and international aspects of the problems encountered in an international collaboration. [less ▲]

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See detailDesigning and testing an air-PCM heat exchanger for building ventilation application coupled to energy storage
Dechesne, Bertrand ULg; Gendebien, Samuel ULg; Martens, Jonathan et al

in 2014 Purdue Conferences Proceedings (2014)

This paper studies a PCM heat exchanger coupled to a building ventilation system. This PCM module can either store heat during the day (e.g. by cooling solar PV panels) and restore it to the building ... [more ▼]

This paper studies a PCM heat exchanger coupled to a building ventilation system. This PCM module can either store heat during the day (e.g. by cooling solar PV panels) and restore it to the building during the night for space heating purposes or store coolness during the night and give it back during the day and thus act as a free cooling system. This project aims to develop a performing air-PCM heat exchanger providing latent energy storage of 0.5 kWh, this energy is delivered between 15 and 30°C. This heat exchanger is based on corrugated cells that can be easily filled, lined up and then locked in a box, letting the air pass between the cells. The PCM used for the prototype is c omposed of fatty acids. In order to develop an efficient PCM ventilation module, two different ways of investigation were followed and used in parallel. The first one used CFD simulations and the second one, a semi-empirical model based on correlations. The CFD simulations were able to predict the convection coefficient on the air side and also show the flow repartition between the different channels whereas the semi-empirical model allowed a parametrical study in order to identify the best geometry possible. Once the heat exchanger geometry was optimized, a test bench was built and a prototype of air-PCM heat exchanger was manufactured in order to measure its thermal and hydraulic performances. The tests consist in either a complete solidification or liquefaction of the PCM starting from respectively liquid PCM at 30°C or solid PCM at 15°C. The airflow rate was set to 45m³/h, which corresponds barely to the ventilation rate of a traditional room in a residential building. A comparison between the models and the measurements was carried out in order to calibrate the semi-empirical model. It will be shown that a simple semi-empirical model satisfactorily predicts the evolution of heat transfer rate for different operating conditions. [less ▲]

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See detailDesigning large-scale CO2 capture units with assessment of solvent degradation
Léonard, Grégoire ULg; Crosset, Cyril; Dumont, Marie-Noëlle ULg et al

in Energy Procedia (2014), 63

Solvent degradation is one of the main operational drawbacks of post-combustion CO2 capture with amine solvents. Although the different degradation mechanisms have been largely studied in recent years, it ... [more ▼]

Solvent degradation is one of the main operational drawbacks of post-combustion CO2 capture with amine solvents. Although the different degradation mechanisms have been largely studied in recent years, it is still impossible to predict the solvent losses and the emissions of degradation products that may occur in a CO2 capture plant depending on its size and on its operating conditions. In the present work, we experimentally study the degradation of MEA monoethanolamine) under accelerated conditions implying high temperature, continuous gas feed and vigorous agitation. A special focus is set on the oxidative degradation of MEA, which is studied in the absence of CO2. Based on the experimental results, we propose a kinetic model to describe both MEA oxidative and thermal degradation pathways. The degradation kinetics is then included into a global model of the CO2 capture process, enabling solvent losses and emissions of degradation products to be predicted as a function of the process operating conditions. The predicted MEA loss is in the same order of magnitude as reported in degradation measurements from pilot plants, although lower by a factor 3. This kind of model assessing solvent degradation could and should be used for the design of large-scale CO2 capture plants in order to simultaneously consider the energy consumption of the process and its environmental impact related to the emissions of degradation products and amine solvent. Further developments shall consider the effect of SOx, NOx and dissolved metals on MEA degradation. [less ▲]

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See detailDesigning large-scale CO2 capture units with assessment of solvent degradation
Léonard, Grégoire ULg; Crosset, Cyril; Dumont, Marie-Noëlle ULg et al

Poster (2014, October)

Solvent degradation is a major drawback for the large-scale implementation of post-combustion CO2 capture due to amine consumption and emission of degradation products. In the present work, we refine a ... [more ▼]

Solvent degradation is a major drawback for the large-scale implementation of post-combustion CO2 capture due to amine consumption and emission of degradation products. In the present work, we refine a previous kinetic model for describing solvent oxidative and thermal degradation based on experimental results. The CO2 capture process is then modeled in Aspen Plus with assessment of solvent degradation. As a result, this work provides a useful tool for the identification of optimal operating conditions that minimize both the energy and environmental impacts of the process. [less ▲]

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See detailDesigning new materials for environmental catalysis
Heinrichs, Benoît ULg

Learning material (2009)

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See detailDesigning optimal calcium phosphate scaffold-cell combinations using an integrative model-based approach.
Carlier, Aurélie ULg; Chai, Y.C.; Moesen, M. et al

in Acta Biomaterialia (2011), 7(10), 3573-85

Bone formation is a very complex physiological process, involving the participation of many different cell types and regulated by countless biochemical, physical and mechanical factors, including ... [more ▼]

Bone formation is a very complex physiological process, involving the participation of many different cell types and regulated by countless biochemical, physical and mechanical factors, including naturally occurring or synthetic biomaterials. For the latter, calcium phosphate (CaP)-based scaffolds have proven to stimulate bone formation, but at present still result in a wide range of in vivo outcomes, which is partly related to the suboptimal use and combination with osteogenic cells. To optimize CaP scaffold selection and make their use in combination with cells more clinically relevant, this study uses an integrative approach in which mathematical modeling is combined with experimental research. This paper describes the development and implementation of an experimentally informed bioregulatory model of the effect of calcium ions released from CaP-based biomaterials on the activity of osteogenic cells and mesenchymal stem cell driven ectopic bone formation. The amount of bone formation predicted by the mathematical model corresponds to the amount measured experimentally under similar conditions. Moreover, the model is also able to qualitatively predict the experimentally observed impaired bone formation under conditions such as insufficient cell seeding and scaffold decalcification. A strategy was designed in silico to overcome the negative influence of a low initial cell density on the bone formation process. Finally, the model was applied to design optimal combinations of calcium-based biomaterials and cell culture conditions with the aim of maximizing the amount of bone formation. This work illustrates the potential of mathematical models as research tools to design more efficient and cell-customized CaP scaffolds for bone tissue engineering applications. [less ▲]

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See detailDesigning Photobioreactors based on living cells immobilized in silica gel for carbon dioxide mitigation
Rooke, Joanna; Léonard, Alexandre ULg; Meunier, Christophe et al

in ChemSusChem (2011), 4

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See detailDesigning scroll expanders for use in heat recovery Rankine cycles
Lemort, Vincent ULg; Quoilin, Sylvain ULg

(2009)

This paper first investigates experimentally the performance of a prototype of oilfree open-drive scroll expander working with water and with HCFC-123. Using experimental data, two different simulation ... [more ▼]

This paper first investigates experimentally the performance of a prototype of oilfree open-drive scroll expander working with water and with HCFC-123. Using experimental data, two different simulation models of the expander are then proposed and validated. These models are finally used to analyze the measured performance with regard to the expander design characteristics. [less ▲]

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See detailDesigning Steel Structures for Fire Safety
Franssen, Jean-Marc ULg; Kodur, Venkatesh; Zaharia, Raul

Book published by Taylor & Françis Ed. (2009)

In this book the information relevant to fire design of steel structures is presented in a systematic way in seven chapters. Each Chapter begins with an introduction of various concepts to be covered and ... [more ▼]

In this book the information relevant to fire design of steel structures is presented in a systematic way in seven chapters. Each Chapter begins with an introduction of various concepts to be covered and follows with detailed explanation of the concepts. The calculation methods as relevant to code provisions (in Europe, North America or other continents) are discussed in detail. Worked examples relevant to calculation methodologies on simple structural elements are presented. For the case of complete structures guidance on how analysis can be carried out is presented. Chapter 1 of the book is devoted to providing relevant background information to codes and standards and principles of fire resistance design. The chapter discusses the fire safety design philosophies, prescriptive and performance-based design fire safety design issues. Chapter 2 deals with basis of design and mechanical loads. The load combinations to be considered for fire design of structures, as per European and North American codes and standards, are discussed. Chapter 3 discusses the detailed steps involved in establishing the fire scenarios for various cases. Both Eurocode and North American temperature-time relationships are discussed. Procedures in this section allow the designer to establish the time-temperature relationships or heat flux evolutions under a specified design fire. Chapter 4 deals with steps associated in establishing the temperature history in the steel structure, resulting from fire temperature. The various approaches for undertaking thermal analysis by simple calculation models are discussed. Chapter 5 presents the steps associated for establishing the mechanical response of a structure exposed to fire. The possibilities for analysis at different levels: member level, sub-structure level and global level are discussed. Full details related to simple calculation methods for undertaking strength analysis at member level are presented. Chapter 6 is devoted to fire resistance issues associated with design of joints. The steps associated with the fire resistance of a bolted or a welded joint through simplified and detailed procedure are discussed. Chapter 7 deals with thermal and mechanical analysis through advanced calculation models. The procedures involved in the sub-structure analysis or global structural analysis under fire exposure is fully discussed. Case studies are presented to illustrate the detailed fire resistance analysis of various structures. Chapter 8 presents four design examples showing how a complex structure can be designed using the concept of element or sub-structure analysis. The book concludes with two Annexes which present some of the design information related to material properties and temperature profiles. Annex 1 focuses on thermal properties of structural steel and commonly used insulation materials and resulting temperature profiles in steel. Annex 2 focuses on mechanical properties of structural steel. [less ▲]

Detailed reference viewed: 191 (6 ULg)