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See detailDevelopment of the Crohn's disease digestive damage score, the Lemann score.
Pariente, Benjamin; Cosnes, Jacques; Danese, Silvio et al

in Inflammatory Bowel Diseases (2011), 17(6), 1415-22

Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural ... [more ▼]

Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural damage to the bowel, which may predict long-term disability, is needed. The aim of this article is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lemann score), should take into account damage location, severity, extent, progression, and reversibility, as measured by diagnostic imaging modalities and the history of surgical resection. It should not be "diagnostic modality driven": for each lesion and location, a modality appropriate for the anatomic site (for example: computed tomography or magnetic resonance imaging enterography, and colonoscopy) will be used. A total of 24 centers from 15 countries will be involved in a cross-sectional study, which will include up to 240 patients with stratification according to disease location and duration. At least 120 additional patients will be included in the study to validate the score. The Lemann score is expected to be able to portray a patient's disease course on a double-axis graph, with time as the x-axis, bowel damage severity as the y-axis, and the slope of the line connecting data points as a measure of disease progression. This instrument could be used to assess the effect of various medical therapies on the progression of bowel damage. [less ▲]

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See detailDevelopment of the Geer basin Hydrological model for climatic scenarios and first results about impacts evaluation
Goderniaux, Pascal ULg; Brouyère, Serge ULg; Orban, Philippe ULg et al

Report (2008)

A surface – subsurface flow numerical model of the Geer basin (465 km²) has been implemented to assess the possible impacts of climate change on the groundwater resources. This model is physically-based ... [more ▼]

A surface – subsurface flow numerical model of the Geer basin (465 km²) has been implemented to assess the possible impacts of climate change on the groundwater resources. This model is physically-based, spatially-distributed and it integrates totally the groundwater and surface water. Simulations were performed using 6 climate change scenarios generated by the University of Newcastle-Upon-Tyne. These scenarios simulate changes in the amplitude, but also in the frequency and persistence of some meteorological events. First results show that, according the implemented flow model and the used climatic scenarios, significant decreases are expected in the groundwater levels (up to 12 meters) and in the surface water flow rates (reduction between 16% and 32%) [less ▲]

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See detailDevelopment of the National Forest Inventory in Luxembourg
Rondeux, Jacques ULg; Wagner, Marc

in Tomppo, Erkki; Gschwantner, Thomas; Lawrence, Mark (Eds.) et al National Forest Inventories - Pathways for common reporting (2010)

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See detailDevelopment of the Osteoporosis Risk Assessment by Composite Linear Essay (ORACLE)
Richy, Florent; Uhoda, Emmanuelle ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2002, November), 13(Suppl.3), 11

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See detailDevelopment of the paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.
Peyrin-Biroulet, Laurent; Billioud, Vincent; D'Haens, Geert et al

in American Journal of Gastroenterology (2012), 107(12), 1770-6

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen ... [more ▼]

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD. [less ▲]

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See detailDevelopment of the Regional Forest Inventory (RFI) in Wallonia
Rondeux, Jacques ULg; Sanchez, Christine; Latte, Nicolas ULg

in Tomppo, Erkki; Gschwantner, Thomas; Lawrence, Mark (Eds.) et al National Forest Inventories. Pathways for Common Reporting (2010)

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See detailDevelopment of the surface structure of TRIP steels prior to hot-dip galvanizing
Bellhouse, Erika M.; Mertens, Anne ULg; McDermid, Joe R.

Conference (2006, March)

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See detailDevelopment of the surface structure of TRIP steels prior to hot-dip galvanizing
Bellhouse, Erika M.; Mertens, Anne ULg; McDermid, Joe R.

in Materials Science & Engineering : A (2007), 463

Focusing on improving the reactive wetting of transformation-induced plasticity (TRIP) steels during hot-dip galvanizing, the effect of the alloying elements manganese, silicon and aluminum on the surface ... [more ▼]

Focusing on improving the reactive wetting of transformation-induced plasticity (TRIP) steels during hot-dip galvanizing, the effect of the alloying elements manganese, silicon and aluminum on the surface structure prior to galvanizing was studied. A C-Mn steel and two TRIP steels with aluminum either completely or partially replacing silicon were investigated. [less ▲]

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See detailDevelopment of the ultrastructure of sonic muscles: a kind of neoteny?
Millot, Sandie; Parmentier, Eric ULg

in BMC Evolutionary Biology (2014), 14

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See detailDevelopment of thermal comfort models for various climatic zones of North-East India
Singh, Manoj Kumar; Mahapatra, Sadhan; Teller, Jacques ULg

in Sustainable Cities and Society (2015), 14

Thermal comfort study provides crucial information about thermal performance of naturally ventilated buildings. Humphreys and Auliciems comfort model uses indoor and outdoor temperatures to predict ... [more ▼]

Thermal comfort study provides crucial information about thermal performance of naturally ventilated buildings. Humphreys and Auliciems comfort model uses indoor and outdoor temperatures to predict comfort temperatures. It is found that the comfort temperatures obtained by using these methods do not take into account the occupant behavioral adaptability to a particular climatic zone. This demands development of new set of comfort models based on local environmental parameters, socio-cultural setup and behavioral action. Analysis shows that four major variables like indoor and outdoor temperature, relative humidity and clothing pattern plays an important role in defining comfort and greatly influence the occupant’s perception and acceptance on thermal comfort. In this study, comfort models are developed based on these variables. The computed neutral temperatures based on the models are compared with the comfort temperatures obtained through comfort survey. The models are developed using the measured data of January and July months and validated with the measured data of April and October months. This study also concludes that it is not possible to obtain a generalized thermal comfort model for all climatic zone because adaptation process, expectation and perception of people are region specific and governed by local socio-cultural requirement. [less ▲]

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See detailDevelopment of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors
Francotte, Pierre ULg; Goffin, Eric ULg; Fraikin, Pierre et al

in Journal of Medicinal Chemistry (2013), 56(20), 7838-7850

On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the ... [more ▼]

On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the design of original isosteric 3,4-dihydro-2H-thieno-1,2,4-thiadiazine 1,1-dioxides. Owing to the sulfur position, three series of compounds were developed and their activity as AMPA potentiators was characterized. In each of the developed series, potent compounds were discovered. After screening the selected active compounds on a safety in vivo test, 6-chloro-4-ethyl-3,4-dihydro-2H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide (24) appeared as the most promising compound and was further evaluated. Its effects on long-term potentiation in vivo and on AMPA-mediated noradrenaline release were measured to predict its potential cognitive enhancing properties. Finally, an object recognition test performed in mice revealed that 24 was able to significantly enhance cognition, after oral administration, at doses as low as 0.3 mg/kg. This study validates the interest of the isosteric replacement of the benzene or pyridine nuclei by the thiophene nucleus in the ring-fused thiadiazine dioxides class of AMPA potentiators. [less ▲]

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See detailDevelopment of thromboxane A2 modulators as promising anti-metastatic and anti-angiogenic compounds
De Leval, X.; Dassesse, T.; Benoit, V. et al

Conference (2004, May)

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See detailDevelopment of thymus autografts under the kidney capsule in the pig: a new 'organ' for xenotransplantation
Lambrigts, Denis; Franssen, Colette ULg; Martens, Henri ULg et al

in Xenotransplantation (1996), 3

Detailed reference viewed: 28 (0 ULg)
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See detailDevelopment of upland cotton plants highly resistant to the reniform nematode from the G. Hirsutum x G. Thurberi x G. Longicalyx hybrid
Mergeai, Guy ULg; Konan, N.O; Baudoin, Jean-Pierre ULg

in Proceedings of the beltwide cotton improvement conference (2010)

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See detailDevelopment of urine-based DNA methylation assay for prostate cancer screening
Vener, T. I.; Derecho, C.; Varde, S. et al

Poster (2007)

Introduction: The best outcome for patients with prostate cancer (PCa) is seen for those treated at an early stage of the disease. A digital rectal examination (DRE) and the measurement of serum prostate ... [more ▼]

Introduction: The best outcome for patients with prostate cancer (PCa) is seen for those treated at an early stage of the disease. A digital rectal examination (DRE) and the measurement of serum prostate specific antigen (PSA) levels are the current standards for PCa early detection. However, serum PSA testing lacks both sensitivity and specificity, and core biopsies frequently fail to identify small foci of PCa. The availability of non-invasive diagnostic molecular tests that could allow for a more precise identification of malignant prostate cells in asymptomatic men would be of great clinical value to improve PCa diagnosis. Study design: 114 men scheduled to undergo a prostate biopsy were enrolled in the study. The biopsies were triggered either by an abnormally high PSA value or by suspicious findings on DRE. Patients with other known or suspected urinary malignancy were excluded from the study. Morning, post-prostate massage and post-biopsy urine samples were collected from all individuals. The main goals of this study were a) to determine if prostate massage can improve the prostate DNA quantity compared to urine collected in the morning or after biopsy, and b) to evaluate the methylation status of a gene panel in urine samples from subjects with cancer found in prostate biopsy tissue cores versus subjects without cancer. Methods: Gene promoter methylation is associated with prostate cancer and has been successfully used for the molecular detection of neoplasia in urine. We have developed real-time methylation specific PCR assays to define the methylation status of several genes. Results: Median age of the patients was 65 years (range 48-85). PCa was found in 51% of the patients. Histological diagnosis of the biopsies was compared to methylation results in urine from 102 samples (89% success rate due low DNA yields for 12 samples). The comparison between different urine sampling techniques showed that prostate massage is needed. The best results were obtained in post massage urine samples with a combination of GSTP1, p14, p16, RARβ2 and RASSF1A resulting in a sensitivity of 74% and a specificity of 75%. Future: A multiplex assay using the Cepheid SmartCycler™ II platform is under development. Further studies are in progress to validate the assay across multiple centers. [less ▲]

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See detailThe development of visual memory span : The role of expertise
Thibaut, Jean-Pierre; Comblain, Annick ULg

Poster (1999, May 20)

Detailed reference viewed: 7 (0 ULg)