2D DIGE, label free quantification, principal component and mass spectrometry analysis for biomarkers discovery in MCF-7/BOS cells exposed to 17β-estradiol and endocrine disruptors.

in Organohalogen Compounds (2011)

Endocrine system disruption has become a subject of great interest over the last few decades, since it has become evident that natural and also synthetic substances can mimic or reduce the activity of ... [more ▼]

Endocrine system disruption has become a subject of great interest over the last few decades, since it has become evident that natural and also synthetic substances can mimic or reduce the activity of endogenous hormones. Compounds with estrogenic activity are an important family of potential endocrine disruptors that have to be monitored either in the food chain or in the environment. Estrogens are known to induce or promote hormonal dependent cancers, to reduce sperm counts and fertility in men and generate the feminization of exposed wildlife populations. The rapid screening of unwanted chemicals in the food chain is beset by difficulties. The number of toxic compounds is very large and no universal method can cope with their diversity. In this work, emergent differential proteomic techniques are used to discover a set of biomarkers for the development of a multiple estrogen contaminants screening test. [less ▲]

2D Elemental imaging tool with a mobile EDXRF system

Conference (2010)

2D Harmonic Balance FE Modelling of Electromagnetic Devices coupled to Nonlinear Circuits

in COMPEL (2004), 23(3), 800--812

2D numerical flow modeling in a macro-rough channel

in International Journal for Numerical Methods in Fluids (2009), 61(11), 1227-1246

A 2D numerical flow model, developed at the Research unit of Hydrology, Applied Hydrodynamics and Hydraulic Constructions at ULg, has been applied to flows in a macro-rough channel. The model solves the ... [more ▼]

A 2D numerical flow model, developed at the Research unit of Hydrology, Applied Hydrodynamics and Hydraulic Constructions at ULg, has been applied to flows in a macro-rough channel. The model solves the shallow water equations (SWE) with a two length scale, depth-integrated k-type approach for turbulence modeling. Data for the comparison have been provided by experiments conducted at the Laboratory of Hydraulic Constructions at EPFL. In the experiments with different non-prismatic channel configurations, namely large-scale cavities at the side walls, three different 2D flow characteristics could be observed in cavities. With the used numerical model features, especially regarding turbulence and friction modeling, a single set of bottom and side wall roughness could be found for a large range of discharges investigated in a prismatic channel. For the macro rough configurations, the numerical model gives an excellent agreement between experimental and numerical results regarding backwater curves and flow patterns if the side wall cavities have low aspect ratios. For configurations with high aspect ratios, the head loss generated by the preservation of important recirculation gyres in the cavities is slightly underestimated. The results of the computations reveal clearly that the separation of turbulence sources in the mathematical model is of great importance. Indeed, the turbulence related to 2D transverse shear effects and the 3D turbulence, generated by bed friction, can have very different amplitude. When separating these two effects in the numerical models, most of the flow features observed experimentally can be reproduced accurately. [less ▲]

A 2D vertical model for incompressibleflows, using a level set free surface tracking

Poster (2010, May)

2D1/2 Thermal-Mechanical Model of Continuous Casting of Steel Using Finite Element Method

Doctoral thesis (2002)

The thesis deals with a numerical model based on the finite element method applied to the continuous casting of steel. The model is developed using the LAGAMINE finite element code and two industrial ... [more ▼]

The thesis deals with a numerical model based on the finite element method applied to the continuous casting of steel. The model is developed using the LAGAMINE finite element code and two industrial applications of steel casting are presented to illustrate the capabilities of the model. The first chapter introduces the continuous casting process, defining the essential terminology and the industrial challenges. Then, the objectives of the model are detailed: the model is applied to the upper part of the caster (in the mould region) as well as to the bending and straightening zones. Chapters two, three and four are dedicated to the theoretical developments of thermal aspects (phase transformations, thermal contraction, heat flow and thermal boundary conditions), mechanical aspects (generalized plain strain state, material constitutive law, ferrostatic pressure and mechanical contact) and the staggered analysis used for thermal / mechanical coupling. In the two next chapters, some numerical results are presented. The model has been first applied to a 125mm square billet in the mould region. The industrial goal is to evaluate the effect of the mould taper on the cooling of the billet (temperature evolution, solid shell growing, stress and strain development). The second application focuses on the risk of transverse cracking during straightening of steel slabs and the effect of some local defects (reduction of secondary cooling, locking or misalignment of rolls). The thesis ends with some concluding remarks and perspectives for the model. [less ▲]

2e campagne de fouille à Chagar Bazar (Syrie)

in Orient-Express 2000/4 (2000)

2ème Cours de Mécanique Analytique II (2011-12), Bac3 math & phys fichier pdf+vidéos (mov, m4v)

Learning material (2011)

The 2nd Workshop on Active Internet Measurements (AIMS-2) Report

in Computer Communication Review (2010), 40(5), 53-58

On February 8-10, 2010, CAIDA hosted the second Work- shop on Active Internet Measurements (AIMS-2) as part of our series of Internet Statistics and Metrics Analysis (ISMA) workshops. The goals of this ... [more ▼]

On February 8-10, 2010, CAIDA hosted the second Work- shop on Active Internet Measurements (AIMS-2) as part of our series of Internet Statistics and Metrics Analysis (ISMA) workshops. The goals of this workshop were to further our understanding of the potential and limitations of active mea- surement research and infrastructure in the wide-area Inter- net, and to promote cooperative solutions and coordinated strategies to addressing future data needs of the network and security research communities. The three-day workshop included presentations, group discussion and analysis, and focused interaction between participating researchers, oper- ators, and policymakers from all over the world. This report describes the motivation and findings of the workshop, and reviews progress on recommendations developed at the 1st Active Internet Measurements Workshop in 2009 [18]. Slides from the workshop presentations are available at [9]. [less ▲]

3 cases of Non Hodgkin Lymphoma among welders exposed more than 10 years to a spray containing methylene chloride (dichloromethane)

Conference (2011, April)