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See detailCyclosporine a Inhibits Partially Spermine-Induced Differentiation but Not Cell Loss of Suckling Rat Small Intestine
Peulen, Olivier ULg; Dandrifosse, Guy ULg

in Digestive Diseases & Sciences (2000), 45(4), 750-4

The polyamines are of great importance in several biological processes, such as cell proliferation, and differentiation. The ingestion of spermine by suckling rats induces the precocious maturation of ... [more ▼]

The polyamines are of great importance in several biological processes, such as cell proliferation, and differentiation. The ingestion of spermine by suckling rats induces the precocious maturation of their small intestine. This phenomenon is preceded by a cell elimination at the villus tip. We hypothesize that these two phenomena could be mediated by the immune system and thus inhibited by an immunosuppressive agent such as cyclosporine A. Cyclosporine A inhibits, at least partially, the spermine-induced increase of the maltase- and sucrase-specific activities in the small intestine but failed to inhibit lactase-specific activity decrease and cell loss. Spermine does not act by the same mechanism in differentiation and in cell loss. Moreover, spermine acts in a different way on lactase-specific activity compared to maltase- or sucrase-specific activity. We hypothesize that spermine acts on differentiation by a T-cell/IL-2-dependent mechanism. [less ▲]

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See detailCyclosporine, a P-glycoprotein modulator, increases [18F]MPPF uptake in rat brain and peripheral tissues: microPET and ex vivo studies.
Lacan, Goran; Plenevaux, Alain ULg; Rubins, Daniel J. et al

in European Journal of Nuclear Medicine and Molecular Imaging (2008), 35(12), 2256-66

PURPOSE: Pretreatment with cyclosporine, a P-glycoprotein (P-gp) modulator increases brain uptake of 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl)-p-[(18)F]fluorobenzamido]ethylpiperaz ine ([(18)F]MPPF) for ... [more ▼]

PURPOSE: Pretreatment with cyclosporine, a P-glycoprotein (P-gp) modulator increases brain uptake of 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl)-p-[(18)F]fluorobenzamido]ethylpiperaz ine ([(18)F]MPPF) for binding to hydroxytryptamine(1A) (5-HT(1A)) receptors. Those increases were quantified in rat brain with in vivo microPET and ex vivo tissue studies. MATERIALS AND METHODS: Each Sprague-Dawley rat (n = 4) received a baseline [(18)F]MPPF microPET scan followed by second scan 2-3 weeks later that included cyclosporine pretreatment (50 mg/kg, i.p.). Maximum a posteriori reconstructed images and volumetric ROIs were used to generate dynamic radioactivity concentration measurements for hippocampus, striatum, and cerebellum, with simplified reference tissue method (SRTM) analysis. Western blots were used to semiquantify P-gp regional distribution in brain. RESULTS: MicroPET studies showed that hippocampus uptake of [(18)F]MPPF was increased after cyclosporine; ex vivo studies showed similar increases in hippocampus and frontal cortex at 30 min, and for heart and kidney at 2.5 and 5 min, without concomitant increases in [(18)F]MPPF plasma concentration. P-gp content in cerebellum was twofold higher than in hippocampus or frontal cortex. CONCLUSIONS: These studies confirm and extend prior ex vivo results (J. Passchier, et al., Eur J Pharmacol, 2000) that showed [(18)F]MPPF as a substrate for P-gp. Our microPET results showed that P-gp modulation of [(18)F]MPPF binding to 5-HT(1A) receptors can be imaged in rat hippocampus. The heterogeneous brain distribution of P-gp appeared to invalidate the use of cerebellum as a nonspecific reference region for SRTM modeling. Regional quantitation of P-gp may be necessary for accurate PET assessment of 5-HT(1A) receptor density when based on tracer uptake sensitive to P-gp modulation. [less ▲]

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See detailCyclostratigraphic implications of Devonian-climate astronomical forcing.
De Vleeschouwer, David; Da Silva, Anne-Christine ULg; Boulvain, Frédéric ULg et al

in Geological Society of America Abstracts with Programs (2010), 42(5), 540

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See detailCylinder Seal Inscriptions of Samsi-Adad and his officials from Acemhöyük
Tunca, Önhan ULg

in Anatolia and the Ancient Near East (1989)

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See detailCYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells.
Sergent, Thérèse; Dupont, Isabelle; Van Der Heiden, Edwige ULg et al

in Toxicology Letters (2009), 191

Flavonoids have been proposed to exert beneficial effects in a multitude of disease states. However, evidence of potential toxic actions has also emerged. Since large doses of flavonoids can be ... [more ▼]

Flavonoids have been proposed to exert beneficial effects in a multitude of disease states. However, evidence of potential toxic actions has also emerged. Since large doses of flavonoids can be encountered in the intestine simultaneously with ingested drugs and pollutants, this study aimed at investigating nine individual flavonoid compounds and their interactions with the major intestinal isoforms of cytochrome P450, i.e. CYPs 1A1 and 3A4, using human intestinal Caco-2 cells cultivated in a serum-free medium. Genistein, quercetin and chrysin provoked a dose-dependent inducing effect on the CYP1A1 activity, measured with the EROD assay. However, they did not affect the CYP1A1 mRNA expression, suggesting they are not aryl hydrocarbon receptor-ligands in intestinal cells and act at a post-transcriptional level. Chrysin, at 50muM, was detected as a potent inhibitor of the TCDD-induced CYP1A1 activity, leading the activity to ca. 10% of the TCDD-control value (n=3), this effect involving, at least partly, direct interactions at the enzyme level. Quercetin was also shown to significantly inhibit the constitutive CYP3A4 activity, measured by the 6beta-(OH)-testosterone assay, and to impair its induction by 1,25-vitamin D(3). Chrysin, quercetin and genistein, were detected as significant inhibitors of the 1,25-vitamin D(3)-induced CYP3A4 activity. In vivo, these effects could result in reduced activation of procarcinogens and/or in drug bioavailability limitation. They underline the importance of intestinal studies to assess food safety and health risks linked to the ingestion of flavonoid-enriched supplements or functional foods. [less ▲]

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See detailCYP1A1 induction and CYP3A4 inhibition by the fungicide imazalil in the human intestinal Caco-2 cells-Comparison with other conazole pesticides
Sergent, Thérèse; Dupont, Isabelle; Jassogne, Coralie et al

in Toxicology Letters (2009), 184(3), 159-168

Imazalil (IMA) is a widely used imidazole-antifungal pesticide and. therefore. a food contaminant. This compound is also used as a drug (enilconazole). As intestine is the first site of exposure to ... [more ▼]

Imazalil (IMA) is a widely used imidazole-antifungal pesticide and. therefore. a food contaminant. This compound is also used as a drug (enilconazole). As intestine is the first site of exposure to ingested drugs and pollutants, we have investigated the effects of IMA, at realistic intestinal concentrations, on xenobiotic-metabolizing enzymes and efflux pumps by using Caco-2 cells, as a validated in vitro model of the human intestinal absorptive epithelium. For comparison, other conazole fungicides, i.e. ketoconazole, propiconazole and tebuconazole. were also studied. IMA induced cytochrome P450 (CYP) 1A1 activity to the same extent as benzo(a)pyrene (B(a)P) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), in a dose-and time-dependent manner. Cell-free aryl hydrocarbon receptor (AhR) binding assay and reporter gene assay suggested that IMA is not an AhR-ligand, implying that IMA-mediated induction should involve an AhR-independent pathway. Moreover, IMA strongly inhibited the CYP3A4 activity in 1,25-vitamin D-3-induced Caco-2 cells. The other fungicides had weak or nil effects on CYP activities. Study of the apical efflux pump activities revealed that ketoconazole inhibited both P-glycoprotein (Pgp) and multidrug resistance-associated protein 2 (MRP-2) or breast cancer resistance protein (BCRP), whereas IMA and other fungicides did not. Our results imply that coingestion of IMA-contaminated food and CYP3A4- or CYP1A1-metabolizable drugs or chemicals could lead to drug bioavailability modulation or toxicological interactions, with possible adverse effects for human health. (C) 2008 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailCyprinid herpesvirus 3
Michel, Benjamin; Fournier, Guillaume; Lieffrig, François et al

in Emerging Infectious Diseases (2010), 16

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See detailCyprinid herpesvirus 3 : an intersting virus for applied and fundamental research
Rakus; Ouyang, Ping; Boutier, Maxime ULg et al

in Veterinary Research (2013), 44

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See detailCyprinid herpesvirus 3: An interesting virus for applied and fundamental research
Fournier, G; Vanderplasschen, Alain ULg

in Bulletin de l'Académie Vétérinaire de France (2011), 164(4), 353-358

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See detailCyproterone and a comparison with its acetate ester
de Ruyck, J.; de Hassonville, S. H.; Liégeois, Jean-François ULg et al

in Acta Crystallographica Section E-Structure Reports Online (2005), 61(Part 11), 3576-3578

The crystal structure of cyproterone (systematic name: 6-chloro-1,2-dihydro-17-hydroxy-30H-cyclopropa[a]pregna-1,4,6- triene-3,20-dione), C22H27ClO3, is compared with cyproterone acetate, a potent anti ... [more ▼]

The crystal structure of cyproterone (systematic name: 6-chloro-1,2-dihydro-17-hydroxy-30H-cyclopropa[a]pregna-1,4,6- triene-3,20-dione), C22H27ClO3, is compared with cyproterone acetate, a potent anti-androgen steroid. The two compounds adopt a similar conformation, except for the cyclopropyl ring attached to the cyclohexenone ring (ring A). Cyproterone further adopts a crystal packing distinct from that of the acetate form. These differences result from hydrogen bonding between the free hydroxy group and the carbonyl group of ring A. [less ▲]

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See detailCyrano de Bergerac et l'utopie
Torero-Ibad, Alexandra ULg

in Utopia and Utopianism (2007), 2

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See detailCyrano de Bergerac et la matérialité de l'âme
Torero-Ibad, Alexandra ULg

in Bargy, Hervé; Mothu, Alain (Eds.) Cyrano de Bergerac, Cyrano de Sannois (2008)

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See detailCyrano et l’éthique d’Épicure
Torero-Ibad, Alexandra ULg

in Libertinage et philosophie au XVIIe siècle (2009), 11

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See detailCyrtodactylus sanook (Squamata: Gekkonidae), a new cave-dwelling gecko from Chumphon Province, southern Thailand
Pauwels, Olivier S.G.; Sumontha, Montri; Latinne, Alice ULg et al

in Zootaxa (2013), 3635(3), 275-285

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See detailCyrtospiriferid brachiopods from the mid-Late Devonian of southern Belgium (Namur-Dinant Basin)
Mottequin, Bernard ULg

in The Palaeontological Association. 54th Annual Meeting. Programme and Abstracts (2010, December 18)

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See detailCyrus Console, Brief Under Water
Delville, Michel ULg

in Sentence: A Journal of Prose Poetics (2009), 7

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See detailCystatin C as a GFR Marker in Renal Transplantation: Promises and Challenges.
Masson, Ingrid; Mariat, Christophe; DELANAYE, Pierre ULg

in Cohen, J. B.; Ryseck, L. P. (Eds.) Cystatins: Protease Inhibitors, Biomarkers and Immunomodulators (2011)

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See detailCystatin C blood level as a risk factor for death after heart surgery
Ledoux, Didier ULg; Monchi, M.; Chapelle, Jean-Paul ULg et al

in European Heart Journal (2007), 28(15), 1848-53

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See detailCystatin C in HIV Patients: More than just a GFR marker ?
Gagneux-Brunon, Amandine; Mariat, Christophe; DELANAYE, Pierre ULg

in Cohen, J. B.; Ryseck, L. P. (Eds.) Cystatins: Protease Inhibitors, Biomarkers and Immunomodulators (2011)

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