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See detailCortical excitability dynamics of during sleep deprivation set PVT performance
Borsu, Chloé; Gaggioni, Giulia ULg; Ly, Julien et al

Conference (2014)

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See detailCortical excitability dynamics of during sleep deprivation set PVT performance
Borsu, Chloé; Gaggioni, Giulia ULg; Ly, Julien ULg et al

Poster (2014, September)

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See detailCortical interneurons tangential migration : p27(Kip1) as a novel master regulator.
Godin, Juliette ULg; Thomas, Noémie; Laguesse, Sophie ULg et al

Poster (2012)

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See detailCortical processing of noxious somatosensory stimuli in the persistent vegetative state
Laureys, Steven ULg; Faymonville, Marie-Elisabeth ULg; Peigneux, Philippe ULg et al

in NeuroImage (2002), 17(2), 732-741

The persistent vegetative state (PVS) is a devastating medical condition characterized by preserved wakefulness contrasting with absent voluntary interaction with the environment. We used positron ... [more ▼]

The persistent vegetative state (PVS) is a devastating medical condition characterized by preserved wakefulness contrasting with absent voluntary interaction with the environment. We used positron emission tomography to assess the central processing of noxious somatosensory stimuli in the PVS. Changes in regional cerebral blood flow were measured during high-intensity electrical stimulation of the median nerve compared with rest in 15 nonsedated patients and in 15 healthy controls. Evoked potentials were recorded simultaneously. The stimuli were experienced as highly unpleasant to painful in controls. Brain glucose metabolism was also studied with [F-18]fluorodeoxyglucose in resting conditions. In PVS patients, overall cerebral metabolism was 40% of normal values. Nevertheless, noxious somatosensory stimulation-activated midbrain, contralateral thalamus, and primary somatosensory cortex in each and every PVS patient, even in the absence of detectable cortical evoked potentials. Secondary somatosensory, bilateral insular, posterior parietal, and anterior cingulate cortices did not show activation in any patient. Moreover, in PVS patients, the activated primary somatosensory cortex was functionally disconnected from secondary somatosensory, bilateral posterior parietal, premotor, polysensory superior temporal, and prefrontal cortices. In conclusion, somatosensory stimulation of PVS patients, at intensities that elicited pain in controls, resulted in increased neuronal activity in primary somatosensory cortex, even if resting brain metabolism was severely impaired. However, this activation of primary cortex seems to be isolated and dissociated from higher-order associative cortices. (C) 2002 Elsevier Science (USA). [less ▲]

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See detailCorticatus
Pfister, Max; Valenti, Gianluca ULg

in Lessico Etimologico Italiano (in press)

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See detail*Corticea
Pfister, Max; Valenti, Gianluca ULg

in Lessico Etimologico Italiano (in press)

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See detailCorticomotoneuronal synaptic connections in normal man. An electrophysiological study.
Maertens de Noordhout, Alain ULg

in Brain : A Journal of Neurology (1999), 122

In order to determine the mono- or oligosynaptic character of connections between pyramidal axons and individual spinal motor neurons, we constructed peri-stimulus time histograms (PSTHs) of the firing ... [more ▼]

In order to determine the mono- or oligosynaptic character of connections between pyramidal axons and individual spinal motor neurons, we constructed peri-stimulus time histograms (PSTHs) of the firing probability of voluntarily activated single motor units (SMUs) of various upper and lower limb muscles upon slightly suprathreshold transcranial anodal electrical stimulations of the motor cortex in normal subjects. Weak anodal cortical stimuli are known to activate preferentially fast-conducting pyramidal axons directly, bypassing cell bodies and cortical interneurons. A narrow bin width (0.1 ms) was chosen to measure precisely the duration of the PSTH excitatory peak, which corresponds to the rise time of the underlying compound excitatory post-synaptic potentials (EPSP). A short duration PSTH peak indicates sharp-rising EPSPs, most commonly encountered in the case of monosynaptic connections. In flexor carpi radialis and soleus SMUs, the PSTHs of built-in responses to anodal cortical stimuli were compared with those produced by 1A afferent stimulation able to elicit a Hoffmann reflex, which is known to be largely monosynaptic. In all upper and lower limb muscles, excitable SMUs responded to anodal cortical stimuli with a highly synchronized peak of increased firing probability. In flexor carpi radialis and soleus SMUs, the mean duration of this peak was significantly narrower than that evoked by 1A afferent stimulation, indicating that monosynaptic corticomotor neuronal transmission dominates low-threshold motor units, even in proximal arm and leg muscles. In the various muscles studied, and particularly in forearm SMUs, we did not observe broad PSTH peaks against the activation of non-monosynaptic corticomotor neuronal pathways, even with near-threshold stimuli. In some triceps and forearm flexor SMUs, subthreshold anodal pulses caused significant inhibition of their voluntary firing, with a latency consistent with activation of 1A inhibitory interneurons by the descending volleys. Measurements of the maximal number of counts in the excitatory PSTH peak upon anodal cortical stimuli provide comparisons of the strength of monosynaptic inputs to various muscles which seems to be maximal for hand and finger extensor muscles, and also for deltoid. [less ▲]

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See detailCorticosensitivity in whole blood cell cultures in Crohn's disease and healthy subjects
Franchimont, Denis; Louis, Edouard ULg; Geenen, Vincent ULg et al

in Digestive Diseases & Sciences (1999), 44

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See detailCorticospinal excitability in patients with anoxic, traumatic, and non-traumatic diffuse brain injury.
Lapitskaya, Natallia; Moerk, Sofie Kirial; Gosseries, Olivia ULg et al

in Brain Stimulation (2013), 6(2),

BACKGROUND: Transcranial magnetic stimulation (TMS) have been frequently used to explore changes in motor cortex excitability in stroke and traumatic brain injury, while the extent of motor cortex ... [more ▼]

BACKGROUND: Transcranial magnetic stimulation (TMS) have been frequently used to explore changes in motor cortex excitability in stroke and traumatic brain injury, while the extent of motor cortex reorganization in patients with diffuse non-traumatic brain injury remains largely unknown. OBJECTIVE/HYPOTHESIS: It was hypothesized that the motor cortex excitability would be decreased and would correlate to the severity of brain injury and level of functioning in patients with anoxic, traumatic, and non-traumatic diffuse brain injury. METHODS: TMS was applied to primary motor cortices of 19 patients with brain injury (5 traumatic and 14 non-traumatic causes; on average four months after insult), and 9 healthy controls. The test parameters included resting motor threshold (RMT), short intracortical inhibition (SICI), intracortical facilitation (ICF), and short latency afferent inhibition (SAI). Excitability parameters were correlated to the severity of brain injury measured with Glasgow Coma Scale and the level of functioning assessed using the Ranchos Los Amigos Levels of Cognitive Functioning Assessment Scale and Functional Independence Measure. RESULTS: The patient group revealed a significantly decreased SICI and SAI compared to healthy controls with the amount of SICI correlated significantly to the severity of brain injury. Other electrophysiological parameters did not differ between the groups and did not exhibit any significant relationship with clinical functional scores. CONCLUSIONS: The present study demonstrated the impairment of the cortical inhibitory circuits in patients with brain injury of traumatic and non-traumatic aetiology. Moreover, the significant correlation was found between the amount of SICI and the severity of brain injury. [less ▲]

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See detailCorticosteroid Treatment in Active Crohn's Disease
Belaiche, Jacques ULg; Louis, Edouard ULg

in Acta Gastro-Enterologica Belgica (1998), 61(2, Apr-Jun), 153-7

Despite recent improvements in the management of Crohn's disease, steroids are still the most efficacious treatment in flare ups of the disease. However they have significant side effects and are only ... [more ▼]

Despite recent improvements in the management of Crohn's disease, steroids are still the most efficacious treatment in flare ups of the disease. However they have significant side effects and are only effective in the short term. There is no consensus regarding initial dose or duration of corticotherapy. With 1 mg/Kg a day of oral prednisolone given for 3 to 7 weeks, 92% of the patients achieve clinical remission. Topical acting oral corticosteroids such as budesonide seem to represent an important therapeutic advance due to their better tolerance. The promising results of budesonide in mild and moderate flare ups need to be confirmed and its indication in severe disease beside high dose prednisolone has to be clarified. [less ▲]

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See detailCorticosteroid-binding capacity, but not total corticosterone, is decreased during lactation in rat dams
Pawluski, Jodi L; Charlier, Thierry ULg; Hammond, Geoffrey L et al

Poster (2006)

The role of corticosterone on the hippocampal structure and function is well documented in male rats. More recently research has shown that chronically stressed female rats with elevated corticosterone ... [more ▼]

The role of corticosterone on the hippocampal structure and function is well documented in male rats. More recently research has shown that chronically stressed female rats with elevated corticosterone levels, exhibit significant dendritic alterations in the hippocampus and, paradoxically, enhanced learning and memory performance. Similar changes have been shown with first reproductive experience (primiparity) compared to further reproductive experience (multiparity). We have shown that at the time of weaning, primiparous rats exhibit altered hippocampal morphology (Pawluski and Galea, 2006), decreased hippocampal cell survival (Pawluski and Galea 2006), and improved reference memory performance (Pawluski et al, 2006) compared to multiparous and virgin female rats. Therefore, given the similarities to what has been shown in the chronically stressed virgin female rat, it seems plausible that corticosterone may play an active role in mediating the alterations seen in primiparous rats. The present study aimed to investigate whether there are differences in the level of free circulating corticosterone during late pregnancy and the postpartum period with reproductive experience. Total corticosterone and corticosteroid-binding capacity were assayed from serum in five groups of rats; multiparous, primiparous, pregnant-only, pup-exposed virgins, and nulliparous rats on 6 days (2 days during gestation: days 14 and 19, and 4 days during lactation; days 1, 5, 14, and 21, where applicable). Results show that total corticosterone level on postpartum day 1 was significantly elevated compared to all other days. In addition, primiparous and multiparous rats have significantly lower corticosteroid-binding capacity throughout lactation. This suggests that primiparous and multiparous rats have more free-circulating corticosterone during lactation. Further research is needed to determine the mechanism underlying the changes in hippocampal structure and function with primiparity. [less ▲]

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See detailCorticostéroides et tissu osseux
Reginster, Jean-Yves ULg; Lecart, MP; Fontaine, MA et al

in Revue Médicale de Liège (1989), 10

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See detailCorticosteroids: still at the frontline in asthma treatment?
LOUIS, Renaud ULg; SCHLEICH, FLorence ULg; Barnes, Peter J.

in Clinics in Chest Medicine (2012), 33(3), 531-41

Inhaled corticosteroids (ICS) have led to improved asthma control and reduced asthma mortality in the Western world. ICS are effective in combating T-helper type 2-driven inflammation featuring mast cell ... [more ▼]

Inhaled corticosteroids (ICS) have led to improved asthma control and reduced asthma mortality in the Western world. ICS are effective in combating T-helper type 2-driven inflammation featuring mast cell and eosinophilic airway infiltration. Their effect on innate immunity-driven neutrophilic inflammation is poor and their ability to prevent airway remodeling and accelerated lung decline is controversial. Although ICS remain pivotal drugs in asthma management, research is needed to find drugs complementary to the combination ICS/long-acting beta2-agonist in refractory asthma and perhaps a new class of drugs as a first-line treatment in mild to moderate noneosinophilic asthma. [less ▲]

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See detailCortisol awakening response (CAR)’s flexibility leads to larger and more consistent associations with psychological factors than CAR magnitude
Mikolajczak, M.; Quoidbach, Jordi ULg; Vanootighem, Valentine ULg et al

in Psychoneuroendocrinology (2010)

The cortisol awakening response (CAR) is increasingly recognized as a potential biological marker of psychological and physical health status. Yet, the CAR literature is replete with contradictory results ... [more ▼]

The cortisol awakening response (CAR) is increasingly recognized as a potential biological marker of psychological and physical health status. Yet, the CAR literature is replete with contradictory results: both supposedly protective and vulnerability psychosocial factors have been associated with both increased and decreased CAR. In this study, we tested the hypothesis that the CAR flexibility would be a better indicator of psychological status than CAR magnitude. Forty-two men measures of happiness, perceived stress and neuroticism, and took saliva samples immediately on awakening, then at 15, 30, 45 and 60 min post-awakening on three study days (i.e., Sunday, Monday and Tuesday). When considering the CAR magnitude, our effects perfectly reflect the inconsistencies previously observed in the literature (i.e., the main effects of the psychological predictors are not consistent with each other, and the effect of one predictor on a given day contradicts the effect of the same predictor on another day). However, considering the CAR flexibility leads to a fully consistent pattern: protective factors (i.e., high happiness, low stress, low neurotiscim) are associated with a flexible CAR (i.e., lower CAR during weekends compared to workdays) whereas vulnerability factors (i.e., low happiness, high stress, high neurotiscim) are associated with a stiff CAR (i.e., same magnitude during weekends and workdays). We conclude that considering the CAR flexibility (e.g., between weekends and workdays) rather than the traditional CAR magnitude might be a way to understand the apparent conflicts in the CAR literature. [less ▲]

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See detailCortisol is responsible for positive and negative effects in the ovarian maturation induced by the exposure to acute stressors in Nile tilapia, Oreochromis niloticus
Gennotte, Vincent ULg; Sawadogo, Philippe; Milla, Sylvain et al

in Fish Physiology and Biochemistry (2012), 38

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See detailLe cortisol salivaire comme indicateur du bien-être chez la truie gestante lors de regroupement.
Wavreille, José; Planchon, V.; Remience, Virginie et al

in 41èmes Journées de la Recherche porcine (2009)

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See detailCorynebacterium-associated skin infections.
Blaise, Géraldine; Nikkels, Arjen ULg; Hermanns-Lê, Trinh ULg et al

in International Journal of Dermatology (2008), 47(9), 884-90

BACKGROUND: Corynebacterium spp. are diphtheroid bacteria responsible for pitted keratolysis, a common plantar infection confined to the thick stratum corneum. AIM: To study a series of demographic ... [more ▼]

BACKGROUND: Corynebacterium spp. are diphtheroid bacteria responsible for pitted keratolysis, a common plantar infection confined to the thick stratum corneum. AIM: To study a series of demographic features of patients suffering from pitted keratolysis, and to present a review of the Corynebacterium-associated infections, including pitted keratolysis, erythrasma, and trichobacteriosis. MATERIALS AND METHODS: A 2-year, two-center, prospective survey assessed the demographics of pitted keratolysis, including age, gender, site of infection, symptoms, patients' complaints, the use of protective and/or occlusive shoes, seasonality of diagnosis, drug intake, associated skin signs (including dyshidrosis, erythrasma, and trichobacteriosis), recurrences, and previous diagnoses and treatments. RESULTS: The mean age of the 53 patients with pitted keratolysis was 24.9 years (range, 10-57 years). The male to female ratio was 7.8:1. The soles of both feet were commonly involved (92.4%). Pressure-bearing areas were the usual sites of infection, ranging from restricted involvement of the toes (12/53, 22.6%) to spreading to the entire plantar surface (15/53, 28.3%). A total of 36 (68%) of the 53 patients complained of hyperhidrosis. An unpleasant smell and pain were noted by 35 (66%) and 25 (47%) of the 53 patients, respectively. Occlusive and protective shoes were worn in 51 (96.2%) and 31 (58.4%) of the 53 cases, respectively. CONCLUSION: Pitted keratolysis commonly affects young male patients wearing protective shoes for professional reasons, inducing a moist and warm environment. Hyperhidrosis, an unpleasant smell, and pain are the main clinical complaints. [less ▲]

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See detailLe coryza chez le chat : implication de l'herpèsvirus et du calicivirus félin
Zicola, A.; Thiry, Etienne ULg

in Point Vétérinaire (2010), 41

Detailed reference viewed: 20 (3 ULg)