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See detailConclusions: Réceptions plurielles sur le long terme
Henneau, Marie-Elisabeth ULg

in Henneau, Marie-Elisabeth; DELVILLE, Jean-Pierre; Famerée, Joseph (Eds.) Marie figures et réceptions. Enjeux historiques et théologiques (2012)

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See detailConcomitant adsorption of poly(ethylene oxide)-b-poly(epsilon-caprolactone) copolymers and sodium dodecyl sulfate at the silica-water interface
Vangeyte, Patrick; Leyh, Bernard ULg; De Clercq, C. et al

in Langmuir (2005), 21(17), 7710-7716

Upon addition of silica to aqueous solutions of poly(ethylene oxide)-b-poly(epsilon-caprolactone) copolymers (PEO-b-PCL) and sodium dodecyl sulfate (SDS), adsorption of the solutes occurs at the silica ... [more ▼]

Upon addition of silica to aqueous solutions of poly(ethylene oxide)-b-poly(epsilon-caprolactone) copolymers (PEO-b-PCL) and sodium dodecyl sulfate (SDS), adsorption of the solutes occurs at the silica-water interface. The amount of the adsorbed constituents has been measured by the total concentration depletion method. Small-angle neutron scattering experiments (SANS) have been carried out to investigate the structure of the adsorbed layer. Although SDS is not spontaneously adsorbed onto hydrophilic silica, adsorption is observed in the presence of PEO-b-PCL diblocks, in relation to the relative concentration of the two compounds. Conversely, SDS has a depressive effect on the adsorption of the copolymer, whose structure at the interface is modified. Copolymer desorption is however never complete at high SDS content. These observations have been rationalized by the associative behavior of PEO-b-PCL and SDS in water. [less ▲]

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See detailConcomitant coronary and carotid artery surgery: operative outcome and long-term results
Kolh, Philippe ULg; Tchana-Sato, Vincent ULg; Honoré, Charles ULg et al

in European Heart Journal (2004), 25(Suppl. S), 360-361

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See detailConcomitant inhibition of class I HDAC and COX-2 exerts a antitumor effect in a human pancreatic cancer model
Gonzalez, Arnaud ULg; Peixoto, Paul ULg; Turtoi, Andrei ULg et al

Poster (2013, July 11)

- Introduction : Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in developed countries. Early-stage pancreatic cancer is usually clinically silent, and disease only ... [more ▼]

- Introduction : Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in developed countries. Early-stage pancreatic cancer is usually clinically silent, and disease only becomes apparent after the tumor invades surrounding tissues or metastatises to distant organs. Moreover, the current chemotherapeutic treatments have no or few effects on this type of cancer, increasing only slightly the median survival of the patients. The survival rate at 5-years is only 3%. There is a need to develop new effective therapies for PDAC patients together with a robust and fast in vivo model allowing drug screening. In this study, We tested whether the combined inhibition of cyclooxygenase-2 (COX-2) and class I histone deacetylase (HDAC) may result in a better control of PDAC. We improved the formation of pancreatic tumor on Chorioallantoic membrane (CAM), an alternative to murine model. - Methods : The impact of the concomitant HDAC and COX-2 inhibition on cell growth, apoptosis and cell cycle was assessed in vitro on human pancreas BxPC-3 cells treated with chemical inhibitors (SAHA, MS-275 and celecoxib) or HDAC1/3/7 siRNA. To test the potential antitumoral activity of this combination in vivo, we improved, characterized and used model of pancreas tumors growing on chick chorioallantoic membrane. - Results : The inhibition of HDAC1/3 by SiRNA or MS-275 treatment reduced significantly the growth of BxPC-3 cells in vitro. Furthermore, we showed by QPCR and immunoblotting that both HDAC1 and HDAC3 inhibition induced the expression of COX-2 at least via the NF-kB pathway. Based on this observation, we decided to test the effect of MS-275 combined with celecoxib a COX-2 inhibitor. This combination was more effective then either drug used alone to reduce the growth of BxPC-3 cells. By FACS analysis we showed that MS-275/celecoxib combination decreased significantly the proportion of cells in S phase and increased significantly and drastically the proportion in G0/G1 at 24, 48 and 72h. By immunobloting this GO/G1 arrest was confirmed by accumulation of cell cycle repressors (P21, P27) and disappearance of hyper phosphorylated form of RB protein. Following a procedure development, we produced on CAM 60 mm3 functionally vascularized tumors mimicking human pancreatic tumors on CAM model. The clinical relevance of this model is supported by the CK7+/CK19+/CK20-/CEA+/Ki67+/CD56- immunolabeling. Recently we have discovered several novel biomarkers of human PDAC: MYOF, TGFBI, LTBP2. These antigens were expressed in tumors grown on CAM, reaffirming its clinical relevance. The concept of the co-treatment by MS-275 and celecoxib was validated using this model. We showed that celecoxib alone did not significantly reduce tumor growth. MS-275 alone decreased tumor growth by 50% and combination of celecoxib and MS-275 stalled entirely the tumor growth. - Conclusions : Our data demonstrate a significant synergic anti-tumoral action of HDAC and COX-2 inhibitors, which set a basis for the development of potentially effective new combinatory therapies for PDAC patients. [less ▲]

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See detailConcomitant manipulation of NMDA- and AMPA-receptors to produce pro-cognitive drug effects
Vignisse, Julie ULg; Steinbusch, Harry W.M.; Grigoriev, Vladimir et al

in European Neuropsychopharmacology (2014), 24

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA ... [more ▼]

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA receptors or the potentiation of AMPA receptors is well documented to result in memory enhancement. Here, we compared the efficacy of the low-affinity NMDA receptor blocker memantine or the positive modulator of AMPA receptor QXX (in C57BL/6J at 1 or 5 mg/kg, ip) with new derivatives of isothiourea (0.5-1 mg/kg, ip) that have bifunctional efficacy. Low-affinity NMDA blockade by these derivatives was achieved by introducing greater flexibility into the molecule, and AMPA receptor stimulation was produced by a sulfamide-containing derivative of isothiourea. Contextual learning was examined in a step-down avoidance task and extinction of contextual memory was studied in a fear-conditioning paradigm. Memantine enhanced contextual learning while QXX facilitated memory extinction; both drugs were effective at 5 mg/kg. The new derivative IPAC-5 elevated memory scores in both tasks at the dose 0.5 mg/Kg and exhibited the lowest IC50 values of NMDA receptor blockade and highest potency of AMPA receptor stimulation. Thus, among the new drugs tested, IPAC-5 plicated the properties of memantine and QXX in one administration with increased potency. Our data suggest that a concomitant manipulation of NMDA- and AMPA-receptors results in pro-cognitive effects and supports the concept bifunctional drug therapy as a promising strategy to replace monofunctional therapies with greater efficacy and improved compliance. [less ▲]

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See detailConcomitant nodal involvement by Langerhans Cell Histiocytosis and Hodgkin Lymphoma
Geurten, Claire ULg; THIRY, Albert ULg; Jamblin, Paul et al

Poster (2015, March 12)

Introduction : Langerhans cell histiocytosis is defined as a clonal neoplastic proliferation of myeloid dendritic cells that upon activation migrate from the mucosal to lymph nodes. Definitive diagnosis ... [more ▼]

Introduction : Langerhans cell histiocytosis is defined as a clonal neoplastic proliferation of myeloid dendritic cells that upon activation migrate from the mucosal to lymph nodes. Definitive diagnosis is made by anatomo-pathological and immunohistochemical analysis. Langerhans cell histiocytosis is rarely, yet not exceptionally, found coexisting with other malignant neoplasms, suggesting it might arise in reaction to the cytokinic secretion of malignant cells. Case : We report the case of a 10-year-old female presenting with an isolated laterocervical lymphadenopathy and a mild general condition alteration tracing back to two months earlier. Nodal biopsy was performed and revealed concomitant involvement by Langerhans cell histiocytosis and Hodgkin lymphoma. Treatment of lymphoma led to the disappearance of the whole symptomatology. Discussion : Literature beholds reports of 30 cases of the simultaneous occurence of Hodgkin lymphoma with Langerhans cell histiocytosis, which is more than fortuitous regarding the low incidence of both diseases. A common etiology could explain such an association, but it might also be possible that background inflammatory cells of Hodgkin lymphoma stimulate the proliferation of Langerhans cells, making it a reactive process when occurring simultaneously with other neoplasms. Clinicians should thus be aware of the possibility of this association and carefully exclude any other life-threatening malignant proliferation when confronted to apparently isolated Langerhans cell histiocytosis. [less ▲]

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See detailConcomitant nodal involvement by Langerhans cell histiocytosis and Hodgkin's lymphoma
Geurten, Claire ULg; THIRY, Albert ULg; Jamblin, Paul et al

in Pediatrics International : Official Journal of the Japan Pediatric Society (2015), 56(6), 1214-1217

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See detailConcordance between HIV-1 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA.
Verhofstede, C.; Brudney, D.; Reynaerts, J. et al

in HIV Medicine (2011), 12(9), 544-52

OBJECTIVE: The aim of the study was to evaluate the use of proviral DNA as a source of viral genetic material for genotypic coreceptor tropism testing (GTT). METHODS: GTT consisted of bulk V3 sequencing ... [more ▼]

OBJECTIVE: The aim of the study was to evaluate the use of proviral DNA as a source of viral genetic material for genotypic coreceptor tropism testing (GTT). METHODS: GTT consisted of bulk V3 sequencing followed by geno2pheno interpretation with the interpretative cut-off [false positive rate (FPR)] set at 5 and 10%. GTT was performed for 165 patients with a viral load of >500 HIV-1 RNA copies/mL on simultaneously collected plasma RNA and proviral DNA, and for 126 patients with a viral load of <500 copies/mL on current proviral DNA and pretreatment plasma RNA. Phenotypic tropism testing (PTT) results were available for 142 samples. RESULTS: In the simultaneous RNA/DNA comparison, concordance in prediction was 95.2% (at FPR 10%) and 96.4% (at FPR 5%). Six RNA-R5/DNA-X4 and two RNA-X4/DNA-R5 discordances were observed at an FPR of 10%, and six RNA-R5/DNA-X4 discordances were observed at an FPR of 5%. In the longitudinal RNA/DNA comparison, concordance was 88.1% (at FPR 10%) and 90.5% (at FPR 5%). Eight RNA-X4/DNA-R5 and seven RNA-R5/DNA-X4 discordances were seen at an FPR of 10%, and 10 RNA-R5/DNA-X4 and two RNA-X4/DNA-R5 discordances at an FPR of 5%. The overall concordance of RNA GTT with PTT was 82% (at FPR 10%) and 83% (at FPR 5%). The overall concordance of DNA GTT with PTT was 85% (at both 10 and 5% FPRs). CONCLUSIONS: GTT produced highly concordant tropism predictions for proviral DNA and plasma RNA. GTT on proviral DNA offers a promising approach for tropism prediction in clinical practice, particularly for the assessment of treated patients with low or suppressed viraemia. [less ▲]

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See detailConcordance between iohexol and iothalamate plasma clearance
DELANAYE, Pierre ULg; JOURET, François ULg; LE GOFF, Caroline ULg et al

in American Journal of Kidney Diseases (2016)

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See detailConcordance between muscle mass assessed by bioelectrical impedance analysis and by dual energy X-ray absorptionmetry among elderly people: a cross-sectional study
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Dardenne, Nadia ULg et al

in BMC Musculoskeletal Disorders (2015), 16(1), 60-67

BACKGROUND: Besides magnetic resonance imaging, dual energy X-ray absorptiometry (DXA) seems the most reliable tool to evaluate body composition and is often considered as the gold standard in clinical ... [more ▼]

BACKGROUND: Besides magnetic resonance imaging, dual energy X-ray absorptiometry (DXA) seems the most reliable tool to evaluate body composition and is often considered as the gold standard in clinical practice. Bioelectrical impedance analysis (BIA) could provide a simpler, portative, and less expensive alternative. Because the body composition assessment by BIA is device-dependent, the aim of this study was to appraise the concordance between the specific bioelectrical impedance device InBody S10 and DXA for the body composition evaluation. METHODS: Body composition, included appendicular lean mass divided by height squared (ALM/ht2) was measured by DXA (Hologic QDR Discovery device) and by BIA (InBody S10 Biospace device). Agreement between tools was assessed by means of the Bland Altman method and reliability was determined using the IntraClass Coefficient (ICC). ICC was also computed to assess the reliability of the test-retest performed by the same operator or by two different ones. RESULTS: A total of 219 subjects were enrolled in this study (mean age: 43.7 +/- 19.1 years old, 51.6% of women). For the ALM/ht2, reliability of the test-retest of the BIA was high with an ICC of 0.89 (95%CI: 0.86-0.92) when performed by the same operator and an ICC of 0.77 (95%CI: 0.72-0.82) when performed by two different operators. Agreement between ALM/ht2 assessed by DXA and BIA was low (ICC = 0.37 (95%CI: 0.25-0.48)). Mean ALM/ht2 was 9.19 +/- 1.39 kg/m2 with BIA and 7.34 +/- 1.34 kg/m2 with DXA, (p < 0001). A formula developed using a multiple regression analysis, and taking into account muscle mass assessed by BIA, as well as sex and body mass index, explains 89% of the ALM/ht2 assessed by DXA. CONCLUSIONS: Although our results show that the measure of ALM/ht2 by BIA is reliable, the agreement between DXA and BIA is low. Indeed, BIA seems to overestimate ALM/ht2 compared to DXA and, consequently, it is important to use an adapted formula to obtain measurement of the appendicular lean mass by BIA close to that measured by DXA. [less ▲]

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See detailConcordance of attachment representations in mother- and father-child dyads and between siblings.
Stievenart, Marie ULg; Roskam, Isabelle

in Psychologica Belgica (2013), 53(3),

This study focuses on the concordance of attachment representations in twoparent, two-child families as an original contribution to the current attachment literature. It uses both categorical attachment ... [more ▼]

This study focuses on the concordance of attachment representations in twoparent, two-child families as an original contribution to the current attachment literature. It uses both categorical attachment patterns and continuous scores. Data was collected on 92 native French-speaking Belgian families. In order to disentangle conceptual and methodological interpretations, each hypothesis was tested in two complementary ways: first in a sample where the parent completed the Cartes pour les Modèles Internes de Relation (CaMir) and their young children (four- to seven-year-olds) the French version of the Attachment Story Completion Task (Fr-ASCT) and second, in a sample where both parents and their teenage to young-adult children (15- to 34-year-olds) completed the CaMir. Our results indicated very little if any concordance of attachment representations, either when using categorical scores or when using continuous scores. The implications of these results for both theoretical and research purposes are discussed. [less ▲]

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See detailConcordantia in Appianum
Famerie, Etienne ULg

Book published by Georg Olms Verlag (1993)

Lemmatized concordance to Appian's Roman History (ed. by Mendelssohn-Viereck-Roos-Gabba, 2 vol., Leipzig, 1905-1962). The concordance is completed by three indexes of lemmata (alphabetical, reverse ... [more ▼]

Lemmatized concordance to Appian's Roman History (ed. by Mendelssohn-Viereck-Roos-Gabba, 2 vol., Leipzig, 1905-1962). The concordance is completed by three indexes of lemmata (alphabetical, reverse, frequency list) and a new latin Index nominum. [less ▲]

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See detailConcordantia in Nicolaum Damascenum
Famerie, Etienne ULg

Book published by Georg Olms Verlag (2007)

First lemmatized concordance of all fragmentary works by Nicolas of Damascus (éd. Jacoby).The work is completed by three indices of lemmata (alphabetical, reverce, frequency list) and an analytical index ... [more ▼]

First lemmatized concordance of all fragmentary works by Nicolas of Damascus (éd. Jacoby).The work is completed by three indices of lemmata (alphabetical, reverce, frequency list) and an analytical index nominum [less ▲]

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See detailConcordantiae Senecanae. Quid ?
Delatte, Louis; Govaerts, Suzanne; Denooz, Joseph ULg

in Revue de l'Organisation Internationale pour l'Etude des Langues Anciennes par Ordinateur (1979), (1), 25-32

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See detailConcordanze del «Canto novo» di Gabriele d’Annunzio.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailLe concordat est-il une hypothèse de concours? Eléments théoriques et pratiques
Georges, Frédéric ULg

in Les point sur le droit des sûretés (2000)

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See detailLes concours d'infractions en droit pénal social
Kefer, Fabienne ULg

in Le droit pénal social et les contrats de travail spéciaux (1997)

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See detailLe concours d'infractions
Monville, Pierre ULg

Part of book (2004)

Detailed reference viewed: 149 (10 ULg)