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See detailDabigatran Etexilate and Risk of Myocardial Infarction, Other Cardiovascular Events, Major Bleeding, and All-Cause Mortality: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Douxfils, Jonathan; Buckinx, Fanny ULg; Mullier, Francois et al

in Journal of the American Heart Association (in press)

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of ... [more ▼]

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of the published literature and a clinical trials registry maintained by the drug manufacturer. Criteria for inclusion in our meta-analysis included all RCTs and the availability of outcome data for MI, other cardiovascular events, major bleeding, and all-cause mortality. Among the 501 unique references identified, 14 RCTs fulfilled the inclusion criteria. Stratification analyses by comparators and doses of dabigatran etexilate were conducted. Peto odds ratio (ORPETO) values using the fixed-effect model (FEM) for MI, other cardiovascular events, major bleeding, and all-cause mortality were 1.34 (95% CI 1.08 to 1.65, P=0.007), 0.93 (95%CI 0.83 to 1.06, P=0.270), 0.88 (95% CI 0.79 to 0.99, P=0.029), and 0.89 (95% CI 0.80 to 1.00, P=0.041). When compared with warfarin, ORPETO values using FEM were 1.41 (95% CI 1.11 to 1.80, P=0.005), 0.94 (95%CI 0.83 to 1.06, P=0.293), 0.85 (95% CI 0.76 to 0.96, P=0.007), and 0.90 (95% CI 0.81 to 1.01, P=0.061), respectively. In RCTs using the 150-mg BID dosage, the ORPETO values using FEM were 1.45 (95% CI 1.11 to 1.91, P=0.007), 0.95 (95% CI 0.82 to 1.09, P=0.423), 0.92 (95% CI 0.81 to 1.05, P=0.228), and 0.88 (95% CI 0.78 to 1.00, P=0.045), respectively. The results of the 110-mg BID dosage were mainly driven by the RE-LY trial. CONCLUSIONS: This meta-analysis provides evidence that dabigatran etexilate is associated with a significantly increased risk of MI. This increased risk should be considered taking into account the overall benefit in terms of major bleeding and all-cause mortality. [less ▲]

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See detailDaclizumab versus antithymocyte globulin in high-immunological-risk renal transplant recipients.
Noel, Christian; Abramowicz, Daniel; Durand, Dominique et al

in Journal of the American Society of Nephrology [=JASN] (2009), 20(6), 1385-92

Nondepleting anti-CD25 monoclonal antibodies (daclizumab) and depleting polyclonal antithymocyte globulin (Thymoglobulin) both prevent acute rejection, but these therapies have not been directly compared ... [more ▼]

Nondepleting anti-CD25 monoclonal antibodies (daclizumab) and depleting polyclonal antithymocyte globulin (Thymoglobulin) both prevent acute rejection, but these therapies have not been directly compared in a high-risk, HLA-sensitized renal transplant population. We randomly assigned 227 patients, who were about to receive a kidney graft from a deceased donor, to either Thymoglobulin or daclizumab if they met one of the following risk factors: current panel reactive antibodies (PRA) >30%; peak PRA >50%; loss of a first kidney graft from rejection within 2 yr of transplantation; or two or three previous grafts. Maintenance immunosuppression comprised tacrolimus, mycophenolate mofetil, and steroids. Compared with the daclizumab group, patients treated with Thymoglobulin had a lower incidence of both biopsy-proven acute rejection (15.0% versus 27.2%; P = 0.016) and steroid-resistant rejection (2.7% versus 14.9%; P = 0.002) at one year. One-year graft and patient survival rates were similar between the two groups. In a comparison of rejectors and nonrejectors, overall graft survival was significantly higher in the rejection-free group (87.2% versus 75.0%; P = 0.037). In conclusion, among high-immunological-risk renal transplant recipients, Thymoglobulin is superior to daclizumab for the prevention of biopsy-proven acute rejection, but there is no significant benefit to one-year graft or patient survival. [less ▲]

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See detailDag van de Nieuwste Geschiedenis 2010 – Journée de l’Histoire contemporaine 2010. Compte rendu de la session « Belgique et relations internationales : état des lieux, tendances historiographiques »
Lanneau, Catherine ULg

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2010), XXXII(3), 5-6

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See detail‘Dagongzhe’ Write to the magazines: suffering, borders stretching and longings. Dialectics of identification and legitimation
Florence, Eric ULg

Conference (2009, June 23)

‘Dagongzhe’ Write to the magazines: suffering, borders stretching and longings. Dialectics of identification and legitimation. Eric Florence, PhD in Political and Social Sciences, Researcher at the Centre ... [more ▼]

‘Dagongzhe’ Write to the magazines: suffering, borders stretching and longings. Dialectics of identification and legitimation. Eric Florence, PhD in Political and Social Sciences, Researcher at the Centre for Ethnic and Migration Studies, the University of Liege. In this paper, I will look at the different kinds of values that are fostered within articles (diaries, letters, etc.) published in magazines for rural migrant workers. After having detailed the criterion used by editors of these magazines in the process of selecting or rejecting writings sent to them by migrant authors, I will detail three types of narrative modes found in magazines aimed at migrant workers. The first one signals suffering, disillusionment and sometimes irony. The second narrative mode entails claim making by migrant workers which are often backed by editors. I argue that this belongs to what O’Brien calls “contentious politics”. Eventually, the third mode examined in this paper will be thought of as strategic narrative framing on the part of migrant authors. In such framing the pedagogic role of guidance by editors is central I shall stress. But I shall argue at the same time that despite such framing, much of these writings are permeated by a powerful politics of desire and that such politics is particularly hard to analyse. In addition to a qualitative analysis of both published and unpublished writings by migrant workers and editors, I will also confront such writings and the values they convey to the fruit of my ethnographic fieldwork carried out in the Pearl River Delta between 2001 and 200 [less ▲]

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See detailDaily activity rhythms of the African catfish Heterobranchus longifilis (Clariidae) in an experimental enclosure
Anselme, Patrick ULg; Bernaerts, Pascale; Poncin, Pascal ULg

in Aquatic Living Resources (2008), 21(4), 419-422

The swimming, air-gaping, and agonistic behaviours of Heterobranchus longifilis (318 +/- 67 mm) were examined while fish were in a fasted state under 12L: 12D and variable group size ( 2, 5, 10 and 15 ... [more ▼]

The swimming, air-gaping, and agonistic behaviours of Heterobranchus longifilis (318 +/- 67 mm) were examined while fish were in a fasted state under 12L: 12D and variable group size ( 2, 5, 10 and 15 fish) in a 1000-L aquarium. Fish exhibited a predominantly nocturnal activity pattern independent of group size. A diurnal peak of activity occurred, however, at the usual feeding time. A reduction in frequency of agonistic interactions was observed in larger groups. Five fish were then observed under 72L: 0D and 0L: 72D. The nocturnal activity pattern remained, contrary to the diurnal peak, and was independent of the duration of illumination or darkness. These results suggest the absence of biological clock in H. longifilis, although fish may somehow be influenced by past feeding experience. Behavioural plasticity in this species may provide potential for aquaculture in northern latitudes. [less ▲]

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See detailDaily and seasonal movements of radio-tagged trout (Salmo trutta) in the Belgian Ardennes: mobility versus residency
Ovidio, Michaël ULg

Conference (1996, August)

This study describes the mobility patterns of two trout (Salmo trutta L.) of different morphotypes (one typical brown trout and one intermediate between the sea and brown trout) telemetred during 172 ... [more ▼]

This study describes the mobility patterns of two trout (Salmo trutta L.) of different morphotypes (one typical brown trout and one intermediate between the sea and brown trout) telemetred during 172 consecutive days in the River Meuse Basin (Belgian Ardennes). The two trout behaved quite differently. The typical brown trout showed little mobility (home range < 1.1 km and longest net daily journey of 850 m) and a constant fidelity to a main area. The other trout was highly mobile (home range extending over 46 km, with net daily journeys as long as 14 km) with no apparent attachment to any particular residence. These results further question the colloquial belief that all freshwater trout are resident fish and support the idea that different ecotypes (i.e. stream and large river trout) would coexist in the same hydroecosystem. Due to small sample size, it is not permitted to affirm that these ecotypes would be associated to different morphotypes. [less ▲]

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See detailDaily and seasonal variations of the partial pressure of CO2 in surface seawater along the Belgian and southern Dutch coastal areas
Borges, Alberto ULg; Frankignoulle, Michel

in Journal of Marine Systems (1999), 19

The variations of the partial pressure of CO2 pCO2.and related parameters were determined in surface seawater along the Belgian coast, from January 1995 to June 1996, at both daily and seasonal time ... [more ▼]

The variations of the partial pressure of CO2 pCO2.and related parameters were determined in surface seawater along the Belgian coast, from January 1995 to June 1996, at both daily and seasonal time scales. The distribution of pCO2 in this area is regulated by river input from the Scheldt, biological activity and hydrodynamics. The contribution of each of these processes varies as a function of the considered time scale: i. the daily variation of pCO2 depends on the tide although modulated by the biological diel cycle; ii. the seasonal variation of pCO2 depends on the input from the Scheldt and the seasonal variations of phytoplanktonic biomass. During winter, the plume of the river Scheldt is oversaturated in pCO2 with respect to the atmosphere. During spring and summer, phytoplankton blooms occur both in the lower Scheldt estuary and in the river plume and may lead to undersaturation of pCO2 in the easternmost area of the river plume. However, the degradation of phytoplankton induces oversaturation of pCO2, in the westernmost area of the plume. Furthermore, the inter-annual variation of pCO2 depends partly on the fluctuations of the discharge of the Scheldt. Our preliminary results strongly suggest that, on an annual basis, the Scheldt plume behaves as a net source of CO2 to the atmosphere [less ▲]

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See detailDaily changes in the expression of the steroid receptor coactivator SRC-1
Charlier, T. D.; Ball, G. F.; Balthazart, Jacques ULg

in Hormones & Behavior (2005, June), 48(1), 93

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See detailDaily changes in the expression of the steroid receptor coactivator SRC-1.
Charlier, Thierry ULg; Ball, Gregory F.; Balthazart, Jacques ULg

in Hormones & Behavior (2005), 48

Steroid receptor coactivators such as SRC-1 significantly modulate the expression of steroid-dependent physiological and behavioral characteristics in birds and mammals. Changes in coactivator protein ... [more ▼]

Steroid receptor coactivators such as SRC-1 significantly modulate the expression of steroid-dependent physiological and behavioral characteristics in birds and mammals. Changes in coactivator protein expression are therefore likely to affect receptor-mediated transcriptional activity. We previously reported a tissue-dependent regulation of SRC-1 mRNA and protein levels by sex, stress and testosterone in the quail brain. In addition, SRC-1 expression has been shown to vary in mammals during development or in adulthood as a function of seasonal variation in photoperiod. We describe here tissue-specific changes of SRC-1 expression over the course of the day in quail. SRC-1 protein quantified by Western blots in the hindbrain gradually increased in the morning, reached a peak around midday and declined significantly in the afternoon. In contrast, SRC-1 protein levels in the optic lobes progressively decreased in the morning to reach their lowest values around midday before rising in the afternoon. The coactivator concentration in the hippocampus exhibited a progressive increase throughout the day. No change in the SRC-1 protein was detected during the day in the preoptic area and in the cerebellum. The functional significance and the mechanisms of regulation underlying such changes remain to be understood. An important unresolved question is whether this diurnal variation in SRC-1 expression is circadian in nature and if so if SRC-1 is an active player linked to clock genes in the generation of circadian rhythms or if the observed changes in SRC-1 expression are a consequence of the rhythms generated by these genes. [less ▲]

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See detailDaily induction combination treatment with alpha 2b interferon and ribavirin or standard combination treatment in naive chronic hepatitis C patients. A multicentre randomized controlled trial
Van Vlierberghe, H.; Leroux-Roels, G.; Adler, M. et al

in Journal of Viral Hepatitis (2003), 10(6), 460-466

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the ... [more ▼]

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the hepatitis C virus (HCV) load and a better response rate. Naive chronically infected HCV patients (n = 454) were randomized into two arms to receive either induction treatment with interferon alpha 2b 5 million units (MU) subcutaneously (s.c.) daily during a period of 8 weeks (arm A); or treatment with interferon alpha 2b 5 MU s.c. three times a week (TIW) for a period of 8 weeks (arm B). After week 8, interferon treatment in both arms was 3 MU s.c. TIW for a total period of 12 months. In both arms, ribavirin (1000-1200 mg orally per day) was added at week 4. Induction treatment resulted in a higher virological response at week 8 of treatment (66%vs 47%; P < 0.01). However, response at the end of treatment and at 6 months follow-up was not different (53%vs 50%, 41%vs 33%). The occurrence of adverse events and the drop-out rate were similar in both arms. Although an early virological response is observed more frequently in the induction treatment, end of treatment response and sustained responses did not differ. [less ▲]

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See detailThe daily life of four-year-olds in ten countries
Hindryckx, Geneviève ULg

Conference (1992, November 12)

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See detailDaily management of the transition to the future.
Goffinet, Nathalie ULg; Delvenne, Catherine ULg; Chalon, Patrice ULg et al

in Proceedings of the 8th European Conference of medical and Health Libraries, Köln, Septembre 16-21, 2002. (2002)

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See detailDaily monitoring of the gravitational lens QSO 2237+0305 at the Nordic Optical Telescope
Puga, E.; Alcalde, D.; Barrena, R. et al

in Gorgas, Javier; Zamorano, Jaime; Gallego, Jesus (Eds.) Highlights of Spanish astrophysics II (2001)

Not Available

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See detailDaily quality control of activimeters: an absolute usefulness.
Seret, Alain ULg; Greffe, J.-L.

Poster (2007, May)

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See detailDaily Seasonalities on the Brussels Spot Equity Market
Corhay, Albert ULg

in Cahiers Economiques de Bruxelles (1991), (132), 415-430

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See detailDaily somatic cellular counts variations in milk of healthy cows
Pluvinage, Pascal; Hanzen, Christian ULg

in Mastitis in dairy production (2005, November)

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See detailDaily-life difficulties in person recognition reported by young and elderly subjects
Schweich, M.; Van der Linden, Martial ULg; Brédart, Serge ULg et al

in Applied Cognitive Psychology (1992), 6

Detailed reference viewed: 16 (2 ULg)