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See detailCrystallographic data for the beta-lactamase from Enterobacter cloacae P99.
Charlier, Paulette ULg; Dideberg, O.; Frère, Jean-Marie ULg et al

in Journal of Molecular Biology (1983), 171(2), 237-8

The beta-lactamase from Enterobacter cloacae P99 has been crystallized from polyethylene glycol solution at pH 7. X-ray examination of the orthorhombic crystals shows the space group is P2(1)2(1)2 with ... [more ▼]

The beta-lactamase from Enterobacter cloacae P99 has been crystallized from polyethylene glycol solution at pH 7. X-ray examination of the orthorhombic crystals shows the space group is P2(1)2(1)2 with unit cell dimensions a = 77.4 A, b = 69.4 A, and c = 63.6 A. There is one molecule of molecular weight 39,000 in the asymmetric unit. [less ▲]

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See detailCrystallographic data for the DD-carboxypeptidase-endopeptidase of low penicillin sensitivity excreted by Streptomyces albus g
Dideberg, Otto; Frère, Jean-Marie ULg; Ghuysen, Jean-Marie ULg

in Journal of Molecular Biology (1979), 129(4), 677-679

The DD-carboxypeptidase-endopeptidase of low penicillin sensitivity that is excreted by Streptomyces albus G has been crystallized from a polyethylene glycol (Mr 6000 to 7500) solution at pH 8.0. X-ray ... [more ▼]

The DD-carboxypeptidase-endopeptidase of low penicillin sensitivity that is excreted by Streptomyces albus G has been crystallized from a polyethylene glycol (Mr 6000 to 7500) solution at pH 8.0. X-ray examination of the prismatic crystals shows that the space group is P21 with unit cell dimensions a = 51.1 Å, B = 49.7 Å, C = 38.7 Å, β = 100.6 ° and one molecule in the asymmetric unit. A crystal suspension made in 50 mM -Tris • HCl buffer (pH 8.0) supplemented with 5 mM-MgCl2 and 16% (w/v) polyethylene glycol exhibits enzyme activity on the substrate Ac2-L-Lys-D-Ala-D-Ala. [less ▲]

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See detailCrystallographic mapping of β-lactams bound to a D-alanyl-D-alanine peptidase target enzyme
Kelly, Judith A.; Knox, James R.; Zhao, Haiching C. et al

in Journal of Molecular Biology (1989), 209(2), 281-295

X-ray crystallography has been used to examine the binding of three members of the beta-lactam family of antibiotics to the D-alanyl-D-alanine peptidase from Streptomyces R61, a target of penicillins ... [more ▼]

X-ray crystallography has been used to examine the binding of three members of the beta-lactam family of antibiotics to the D-alanyl-D-alanine peptidase from Streptomyces R61, a target of penicillins. Cephalosporin C, the monobactam analog of penicillin G and (2,3)-alpha-methylene benzylpenicillin have been mapped at 2.3 A resolution in the form of acyl-enzyme complexes bound to serine 62. On the basis of the positions of these inhibitors, the binding of a tripeptide substrate for the enzyme, L-lysyl-D-alanyl-D-alanine, has been modeled in the active site. The binding of both inhibitors and substrate is facilitated by hydrogen-bonding interactions with a conserved beta-strand (297-303), which is antiparallel to the beta-lactam's acylamide linkage or the substrate's peptide bond. The active site is similar to that in beta-lactamases. [less ▲]

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See detailCrystallographic studies of low penicillin-sensitive enzyme excreted by Streptomyces albus G [proceedings]
Dideberg, O.; Charlier, Paulette ULg

in Archives Internationales de Physiologie et de Biochimie (1979), 87(5), 1045

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See detailThe CSDP Olympiad from a Scientific Point of View
Paile, Sylvain ULg

in Zambas, Symeon (Ed.) The 1st Common Security and Defence Policy Olympiad (2013)

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See detailCSL TV chambers Updating
Grodent, Christophe ULg; franco

Conference (2006)

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See detailCSR Performance Measurements: Motivations, Tools and Survey Results
Crutzen, Nathalie ULg

Scientific conference (2010, December 02)

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See detailCT FEATURES OF A LACRIMAL GLAND TUMOR IN A DOG
Etienne, Anne-Laure ULg; Grauwels, Magda ULg; Storms, Goedele ULg et al

Poster (2014, August)

Background: In the dog, neoplasms of the lacrimal gland are rare. Lacrimal cysts were also reported. Computed tomography (CT) scan findings of these lacrimal gland abnormalities have not been described in ... [more ▼]

Background: In the dog, neoplasms of the lacrimal gland are rare. Lacrimal cysts were also reported. Computed tomography (CT) scan findings of these lacrimal gland abnormalities have not been described in dogs. Purpose: The present report describes clinical and CT features of a lacrimal gland tumor in a dog. Methods: A 3,5 year old female intact Leonberger with a good general health status was presented with a progressive swelling at the level of the supero-temporal area of the left upper eyelid and of the bulbar conjunctiva since 3 weeks. Ocular examination revealed a slight enophthalmia and a ventronasal strabismus, the presence of a firm mass in the upper eyelid which was anteriorly well circumscribed and extending posteriorly between the globe and the orbital ligament. Findings: A CT scan pre- and post- contrast studies of the head were performed. A 3 cm hypoattenuating (+/- 10 HU) ovoid mass was observed dorsolateral to the indented left globe. This mass was well circumscribed by an unevenly thick irregular soft tissue- attenuating wall (50HU), which was strongly contrast-enhanced (150HU) and measured about 2 to 10mm in thickness. The left globe was displaced caudoventromedially. No adjacent bone lesion, or foreign body was observed. No normal left lacrimal gland was observed. These findings were suggestive of an abscess or an orbital tumor with a necrotic/cystic center; a lacrimal cyst was considered less likely because of the unevenness and the thickness of the wall. Complete surgical ablation was done by a modified lateral orbitotomy. Histopathology revealed a mixed benign tumor of the lacrimal gland and a lymphocytic necrotic adenitis. Six months postoperatively no recurrence is noted and the tear production is 15mm/min. Conclusion: The lacrimal gland is located dorsolateral to the globe and produces tears. In human medicine, a wide range of lacrimal gland pathologies were described and assessed by computed imaging techniques. Pleomorphic adenomas (mixed benign tumor) could reveal irregular bone erosion and could undergo malignant transformation. In dogs, lacrimal cysts were described as thin walled structures.4 Only few articles reported lacrimal gland tumor. To the authors knowledge, CT findings of a lacrimal gland tumor have not been described previously. In conclusion, lacrimal gland tumor should be included in the differential diagnosis of a firm ovoid cystic/necrotic mass dorsolateral to the orbit. [less ▲]

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See detailCT findings of an intra-abdominal metastatic sertoli cell tumor in a dog
Taylor, Olivia; Hamaide, Annick ULg; Mercier, Elise ULg et al

Poster (2013, December 01)

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See detailCT SCAN FEATURES OF PRESUMPTIVE HAEMORRHAGIC STROKE IN A DOG WITH CUSHING’S DISEASE
Liotta, Annalisa Pia ULg; Cavrenne, Romain; Peeters, Dominique ULg et al

in Case reports in Veterinary Medicine (in press)

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See detailCTD measurements, with emphasis on Elephant Island surroundings
Dauby, Patrick ULg

in Berichte zur Polar- und Meeresforschung (2003), 470

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See detailCTIP2 is a negative regulator of P-TEFb.
Cherrier, Thomas ULg; Le Douce, Valentin; Eilebrecht, Sebastian et al

in Proceedings of the National Academy of Sciences of the United States of America (2013), 110(31), 12655-60

The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac hypertrophy. The balance between its active ... [more ▼]

The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac hypertrophy. The balance between its active and inactive form is tightly controlled to ensure cellular integrity. We report that the transcriptional repressor CTIP2 is a major modulator of P-TEFb activity. CTIP2 copurifies and interacts with an inactive P-TEFb complex containing the 7SK snRNA and HEXIM1. CTIP2 associates directly with HEXIM1 and, via the loop 2 of the 7SK snRNA, with P-TEFb. In this nucleoprotein complex, CTIP2 significantly represses the Cdk9 kinase activity of P-TEFb. Accordingly, we show that CTIP2 inhibits large sets of P-TEFb- and 7SK snRNA-sensitive genes. In hearts of hypertrophic cardiomyopathic mice, CTIP2 controls P-TEFb-sensitive pathways involved in the establishment of this pathology. Overexpression of the beta-myosin heavy chain protein contributes to the pathological cardiac wall thickening. The inactive P-TEFb complex associates with CTIP2 at the MYH7 gene promoter to repress its activity. Taken together, our results strongly suggest that CTIP2 controls P-TEFb function in physiological and pathological conditions. [less ▲]

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See detailCu doping as a tool for understanding CMR
Vertruyen, Bénédicte ULg; Cloots, Rudi ULg; Rulmont, André ULg et al

in Key Engineering Materials [=KEM] (2002), 206-2

Doping at the Mn-site in CMR manganate-based perovskites has been shown to affect strongly the physical properties of those compounds. We study here the effect of copper substitution in the low doping ... [more ▼]

Doping at the Mn-site in CMR manganate-based perovskites has been shown to affect strongly the physical properties of those compounds. We study here the effect of copper substitution in the low doping range on the electrical transport properties of La0.7Ca0.3MnO3. It turns out that the transition temperature decrease observed in doped samples can be drastically reduced by addition of silicon dioxide SiO2. It is shown that copper is trapped in a secondary phase composed of La,Ca,Si,Cu and O. The resultant Mn-site vacancies appear to be less detrimental to the electronic conduction than the likely antiferromagnetic clusters induced by the copper ions in the Mn-O network. [less ▲]

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See detailCu/carbon xerogel catalysts for the selective catalytic reduction of NO by NH3 : effect of the pore texture
Cabiac, A.; Job, Nathalie ULg; Pirard, Jean-Paul ULg et al

in Journal of Chemistry for Sustainable Development (2006), 6

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