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See detailCytotoxic interactions of 5-fluorouracil and nucleoside analogues in vitro
Li, Y-X; COUCKE, Philippe ULg; Paschoud, N et al

in Anticancer Research (1997), 17(1A), 21-27

The cytotoxic interaction of combined 5-fluorouracil (5-FU) with different nucleoside analogues was investigated in vitro on a colon (WiDr) and a breast (MCF-7) cancer cell line. Azidothymidine (AZT), 3 ... [more ▼]

The cytotoxic interaction of combined 5-fluorouracil (5-FU) with different nucleoside analogues was investigated in vitro on a colon (WiDr) and a breast (MCF-7) cancer cell line. Azidothymidine (AZT), 3'-deoxy-2', 3'-didehydrothymidine (D4T), 5-iododeoxyuridine (IdUrd) and 2',3'-dideoxycytidine (DDC) were tested at different concentrations (5-600 microM) as modulators of 5-FU. The experimental endpoints were cellular viability and cell cycle distribution. The combination of 5-FU and AZT or D4T yielded supra-additive cytotoxic effects in both cell lines at all concentrations. On WiDr, IdUrd at high concentrations of 50 and 100 microM showed a supra-additive effect whereas at low concentrations (5, 10 and 20 microM) the effect was antagonistic. 5-FU combined with IdUrd produced a synergistic effect on MCF-7 cells at all concentrations. DDC antagonised the toxic effect of 5-FU on the WiDr cell line. In WiDr cells, a significant increase in the overall S-phase was observed 48 and 72 hours after exposure to D4T, AZT and DDC at the low concentration of 10 microM. On the contrary, this accumulation in S-phase was not present in MCF-7 cells. The combined effect of 5-FU and nucleoside analogues in vitro is dependent on the type and concentration of nucleosides and the cell-line tested. AZT, D4T and IdUrd are more likely to be subjected to more intensive in vitro and in vivo research as far as modulation of 5-FU toxicity is concerned. [less ▲]

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See detailCytotoxic triterpenoid saponins from the roots of Cephalaria gigantea
Tabatadze, Nino; Elias, Riad; Faure, Robert et al

in Chemical & Pharmaceutical Bulletin (2007), 55(1), 102-105

Three new oleanane-type saponins, giganteosides L (1)(I), M (2) and N (3) along with eight known ones were isolated from the roots of Cephalaria gigantea. Their structures were established as 3-O-[-D ... [more ▼]

Three new oleanane-type saponins, giganteosides L (1)(I), M (2) and N (3) along with eight known ones were isolated from the roots of Cephalaria gigantea. Their structures were established as 3-O-[-D-galactopyranosyl-(12)--D-glucuronopyranosyl]-28-O-[-D-glucopyranosyl-(16)--D-glucopyranosyl]-oleanolic acid, 3-O-[-D-galactopyranosyl-(12)--D-glucuronopyranosyl]-28-O-[-D-glucopyranosyl-(16)--D-glucopyranosyl]-hederagenin, 3-O-[-L-rhamnopyranosyl-(12)--D-glucuronopyranosyl]-28-O-[-D-glucopyranosyl-(16)--D-glucopyranosyl]-hederagenin, resp., by means of spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Cytotoxic activity of monodesmosides was investigated in vitro using three cancer cell lines, namely, human non pigmented melanoma MEL-5 and human leukemia HL-60. Giganteosides D (4) and E (5) showed antiproliferative effect on human cell lines with IC50 values in the range 3.15-7.5 M. [less ▲]

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See detailCytotoxicity towards human endothelial cells, induced by neutrophil myeloperoxidase: protection by ceftazidime.
Mathy, Marianne ULg; Deby, Ginette ULg; Deby, C. et al

in Mediators of Inflammation (1995), 4(6), 437-43

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H(2)O(2)/Cl(-)). In this system ... [more ▼]

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H(2)O(2)/Cl(-)). In this system, myeloperoxidase catalyses the conversion of H(2)O(2) and CI(-) to the cytotoxic agent HOCl. Stimulated neutrophils can release MPO into the extracellular environment and then may cause tissue injury through direct endothelial cells lysis. We showed that human umbilical vein endothelial cells (HUVEC) were capable of taking up active MPO. In presence of H(2)O(2) (10(-4) M), this uptake was accompanied by cell lysis. The cytolysis was estimated by the release of (51)Cr from HUVEC and expressed as an index of cytotoxicity (IC). Dose dependent protection was obtained for CAZ concentrations ranging from 10(-5) to 10(-3) M;this can be attributed to inactivation of HOCl by the drug. This protection is comparable to that obtained with methionine and histidine, both of which are known to neutralize HOCl. This protection by CAZ could also be attributed to inactivation of H(2)O(2), but when cytolysis was achieved with H(2)O(2) or O(2) (-) generating enzymatic systems, no protection by CAZ was observed. Moreover, the peroxidation activity of MPO (action on H(2)O(2)) was not affected by CAZ, while CAZ prevented the chlorination activity of MPO (chlorination of monochlorodimedon). So, we concluded that CAZ acts via HOCl inactivation. These antioxidant properties of CAZ may be clinically useful in pathological situations where excessive activation of neutrophils occurs, such as in sepsis. [less ▲]

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See detailCZC-GC miniaturized analysis of POPs in 20 µL blood
L'Homme, Benjamin ULg; Focant, Jean-François ULg

Conference (2013, May)

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See detailCZE separation of basic and acidic drug by use of cyclodextrin additives
Bechet, I.; Fillet, Marianne ULg; Fotsing, Lucas ULg et al

Poster (1995)

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See detailCzochralski crystal growth, thermal conductivity, and magnetic properties of Pr(x)La(1- x)AlO3, where x = 1, 0.75, 0.55, 0.40, 0
Turczynski, S.; Orlinski, K.; Pawlak, D. A. et al

in Crystal Growth & Design (2011), 11(4), 1091-1097

Crystals of Pr(x)La(1-x)AlO3 solid solution have been grown by the Czochralski method for the first time, to the best of our knowledge. Crystals with high praseodymium concentration tend to grow spirally ... [more ▼]

Crystals of Pr(x)La(1-x)AlO3 solid solution have been grown by the Czochralski method for the first time, to the best of our knowledge. Crystals with high praseodymium concentration tend to grow spirally. The color of the crystals changes with chemical composition. X-ray diffraction shows an increase of the lattice constants with an increase in lanthanum ion concentration. The thermal conductivity has been investigated in the temperature range from 5 to 300 K. Completely different behavior of thermal conductivity is observed at low temperatures for the investigated crystals, whereas it remains roughly constant at high temperatures. The values of magnetic susceptibility lie within the expected range that could be expected for a paramagnetic material. (Figure Presented) © 2011 American Chemical Society. [less ▲]

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See detail'D’abord sa manière étoit gottique'. L'œuvre peint de Bernard van Orley jusqu'au début des années 1520
Galand, Alexandre ULg

Doctoral thesis (2011)

Les années 1510 et 1520 apparaissent comme un moment crucial pour l’introduction de la Renaissance dans les anciens Pays-Bas. Or, cette période coïncide avec la première période d’activité de Bernard van ... [more ▼]

Les années 1510 et 1520 apparaissent comme un moment crucial pour l’introduction de la Renaissance dans les anciens Pays-Bas. Or, cette période coïncide avec la première période d’activité de Bernard van Orley, un témoin majeur de cette époque de transition. Jusqu’à présent, la recherche a surtout envisagé l’artiste par le prisme de ses magnifiques tapisseries. De la fin de la première décennie du 16e siècle à 1521 où il signe le monumental Polyptyque de Job et de Lazare (Bruxelles, MRBAB/KMSKB, Inv. 1822), l’artiste a pourtant élaboré un œuvre peint de plus en plus perméable aux formes en provenance de la péninsule italienne. Ce changement de perspective a-t-il entraîné des différences importantes en termes de pratiques d’atelier ? Comment peuvent être caractérisées de manière précise les œuvres constituant le noyau dur d’un catalogue aux frontières mouvantes ? En quoi les documents d’archives peuvent-ils donner un nouvel éclairage sur l’activité de l’artiste ? Ces questions sont au centre d’un travail qui se donne pour ambition de renouveler la vision de la peinture de Bernard van Orley, domaine jusqu’à aujourd’hui négligé. [less ▲]

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See detailD'Alexandrie à Constantinople : l'acquisition et la transmission du savoir en anatomie et en chirurgie, de la période hellénistique à la période byzantine
Marganne, Marie-Hélène ULg

in Perdicoyanni-Paleologou, Helen (Ed.) History of anatomy and surgery from Antiquity to the Renaissance (2014)

This paper proposes to reconstruct the means of acquisition and transmission of anatomical and surgical knowledge in the period from the death of Alexander the Great (323 BC) to the reign of Constantine ... [more ▼]

This paper proposes to reconstruct the means of acquisition and transmission of anatomical and surgical knowledge in the period from the death of Alexander the Great (323 BC) to the reign of Constantine VII Porphyrogenitus (913-959), through the study of archaeological, epigraphic, papyrological and manuscript sources. These testimonies bring to view strategies such as observation, experimentation, analogy and imitation, as well as oral and written teaching, redaction and copy of books (illustrated or not), elaboration of commentaries, abridgments, questionnaires and word-lists. A distinction will be drawn between texts which were addressed to physicians and medical students, on the one hand, those which were destined to philiatroi and to an educated readership, and finally those which might interest copyists and eventually tachygraphists. [less ▲]

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See detailD'Alexandrie à Damas et retour. La poste privée à l'époque mamlouke à la lumière d'une commission accomplie pour le compte d'un Vénitien (821 A.H./1418 È.C.)
Bauden, Frédéric ULg

in Vermeulen, Urbain; D'hulster, Kristof (Eds.) Egypt and Syria in the Fatimid, Ayyubid and Mamluk Eras VI. Proceedings of the 14th and 15th International Colloquium Organized at the Katholieke Universiteit Leuven in May 2005 and May 2006 (2010)

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See detailD'Amour et de Neutralité : Ce(ux) qui résiste(ent)
Erpicum, Martin ULg

Master's dissertation (2005)

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See detailD'Anatole France à Jean Paulhan : Terreur et Littérature
Denis, Benoît ULg

in Etudes Sartriennes (2006), (11), 81-97

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See detailD'Annunzio come personaggio nell'immaginario italiano ed europeo (1938-2008) : Una mappa
Curreri, Luciano ULg

Book published by Peter Lang (2008)

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See detailD’Edgar Allan Poe à Marlene Streeruwitz : lecture « palimpsestueuse » du roman Partygirl
Pontzen, Alexandra ULg; Letawe, Céline ULg

in D'Amelio, Nadia (Ed.) Les Traductions extraordinaires d’Edgar Allan Poe. (2010)

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See detaild'Hane-Steenhuyse (Charles-François)
Vandersmissen, Jan ULg

E-print/Working paper (2012)

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See detailD’Hérodote à Alexandre. L’appropriation gréco-macédonienne d’Ammon de Siwa, entre pratique oraculaire et légitimation du pouvoir
Caneva, Stefano ULg

in Mythos. Rivista di Storia delle Religioni - Supplemento (2012), 2(2012), 205-234

Abstract The gods of the others are not simply other gods. In compliance with this belief, Herodotus puts the Libyan oracular divinity Ammon of Siwah in relation with the royal gods Amun of Thebes and ... [more ▼]

Abstract The gods of the others are not simply other gods. In compliance with this belief, Herodotus puts the Libyan oracular divinity Ammon of Siwah in relation with the royal gods Amun of Thebes and Zeus of Dodona. This paper starts from Herodotus’ text to study, on one hand, the spread of religious and political success of Zeus Ammon in the V and IV centuries’ Greek and Macedonian tradition, before to compare them, on a second hand, with the new significance that the god acquired at the time of Alexander and his successors in Egypt, the Ptolemies. [less ▲]

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