Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailCurrent concepts in the pathology and epigenetics of endometrial carcinoma.
Arafa, Mohammad; Somja, Joan ULg; Dehan, Pierre ULg et al

in Pathology (2010), 42(7), 613-7

In the Western world, endometrial carcinoma is the most common malignant tumour of the female genital tract and is the fourth most common cancer in women. Two different clinicopathological subtypes are ... [more ▼]

In the Western world, endometrial carcinoma is the most common malignant tumour of the female genital tract and is the fourth most common cancer in women. Two different clinicopathological subtypes are recognised: the oestrogen-related (type I, endometrioid) and the non-oestrogen related (type II, non-endometrioid). This article reviews the epidemiology, risk factors, genetic alterations during endometrial carcinogenesis, features of tumours and precursors and early detection of the disease. Insights into the epigenetic alterations, with emphasis on DNA methylation during endometrial carcinogenesis, and their diagnostic value are also provided. [less ▲]

Detailed reference viewed: 55 (9 ULg)
See detailCurrent Concepts in the Prolactinomas therapy
Beckers, Albert ULg

Scientific conference (1988, October)

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailCurrent Concepts in the Therapeutic Management of Osteoarthritis with Glucosamine
Reginster, Jean-Yves ULg; Bruyère, Olivier ULg; Fraikin, Genevieve et al

in Bulletin / Hospital for joint diseases (2005), 63(1-2), 31-36

Over the last 10 years, several studies have investigated the ability of glucosamine sulfate to improve the symptoms (pain and function) and to delay the structural progression of osteoarthritis. There is ... [more ▼]

Over the last 10 years, several studies have investigated the ability of glucosamine sulfate to improve the symptoms (pain and function) and to delay the structural progression of osteoarthritis. There is now a large, convergent body of evidence that glucosamine sulfate, given at a daily oral dose of 1,500 mg, is able to significantly reduce the symptoms of osteoarthritis in the lower limbs and spine. This effect is usually seen with a minimal time for the onset of significant action - around 2 weeks. A similar dose of glucosamine sulfate has also been shown, in two independent studies, to prevent the joint space narrowing observed at the femorotibial compartment in patients with mild to moderate knee osteoarthritis. This effect, which is not affected by the radiographic technique used for the assessment of joint space width, also translated into a 50% reduction in the incidence of osteoarthritis-related surgery of the lower limbs during a 5-year period following the withdrawal of the treatment. There is a high degree of consistency in the literature showing that when glucosamine sulfate is used for the treatment of osteoarthritis, an efficacious response with minimum side effects can be expected. Since some discrepancies have been described between the results of studies performed with a patent-protected formulation of glucosamine sulfate distributed as a drug and those having used glucosamine preparations purchased from global suppliers, packaged, and sold over-the-counter as nutritional supplements (not regulated as drugs and with some potential issues concerning the reliability of their content), caution should be used when extrapolating conclusive results obtained with prescription drugs to over-the-counter or food supplements. [less ▲]

Detailed reference viewed: 24 (7 ULg)
Full Text
See detailCurrent controversies around tight glucose control in critically ill patients
Devos, P.; Preiser, Jean-Charles ULg

in Current Opinion in Clinical Nutrition & Metabolic Care (2007), 10(2), 206-209

Purpose of review This review updates our knowledge on the benefits and risks of tight glucose control by intensive insulin therapy critically ill patients, as well as discussing unanswered questions ... [more ▼]

Purpose of review This review updates our knowledge on the benefits and risks of tight glucose control by intensive insulin therapy critically ill patients, as well as discussing unanswered questions related to the subject. Recent findings At the cellular level, the toxic effects of elevated and highly variable glucose concentration are related to an increase in oxidative stress and to several toxic intracellular derivates generated as by-products of the glycolytic pathway. Clinically, several recent studies have suggested that the optimal target for blood glucose may be higher than the 'normal' values of 4.4-6.1 mmol/l for various categories of patients. Also, the variability in glucose level, appears to be an important determinant of glucose toxicity. Conflicting data on the hazards of,hypoglycaemia are emerging. Summary Practical recommendations for the implementation of tight glucose control using intensive insulin therapy cannot be disseminated until questions relating to optimal blood glucose level and the corresponding categories of patients have been resolved. The issues of glucose, variability and the most efficient method of preventing hypoglycaemia will probably represent important parameters for comparing the safety and quality of protocols used for tight glucose control. [less ▲]

Detailed reference viewed: 8 (1 ULg)
See detailCurrent crowding effects in nanostructured superconductors
Silhanek, Alejandro ULg

Conference (2013, September)

When current stream lines are forced to depart from their rectilinear trajectory due to the presence of an obstacle, they conglomerate at the sharp bends encountered on their path. The consequent current ... [more ▼]

When current stream lines are forced to depart from their rectilinear trajectory due to the presence of an obstacle, they conglomerate at the sharp bends encountered on their path. The consequent current crowding is present in normal metals as well as in superconductors and has been recently recognized as an important factor limiting the performance of superconducting single-photon detectors, leading to vortex motion rectification, and being a source of unwanted ratchet signal. In this talk we will show that in nanostructured superconductors at low temperatures, current crowding can also trigger abrupt flux avalanches developing well defined geometrical patterns. [less ▲]

Detailed reference viewed: 15 (5 ULg)
Full Text
See detailCURRENT CROWDING EFFECTS IN NANOSTRUCTURED SUPERCONDUCTORS
Silhanek, Alejandro ULg

Conference (2013, December)

Detailed reference viewed: 13 (5 ULg)
Full Text
Peer Reviewed
See detailCurrent crowding effects in superconducting corner-shaped Al microstrips
Adami, Obaïd-Allah ULg; Cerbu, Dorin; Cabosart, Damien et al

in Applied Physics Letters (2013)

The superconducting critical current of corner-shaped Al superconducting microstrips has been investigated. We demonstrate that the sharp turns lead to asymmetric vortex dynamics, allowing for easier ... [more ▼]

The superconducting critical current of corner-shaped Al superconducting microstrips has been investigated. We demonstrate that the sharp turns lead to asymmetric vortex dynamics, allowing for easier penetration from the inner concave angle than from the outer convex angle. This effect is evidenced by a rectification of the voltage signal otherwise absent in straight superconducting strips. At low magnetic fields, an enhancement of the critical current with increasing magnetic field is observed for a particular combination of field and current polarity, confirming a theoretically predicted competing interplay of superconducting screening currents and applied currents at the inner side of the turn. [less ▲]

Detailed reference viewed: 106 (70 ULg)
Full Text
See detailCurrent developments in the improvement of PE teachers’ action with overweight students
Cloes, Marc ULg

Conference (2013, August 30)

Globally, researchers regularly note the growing prevalence of weight excess and obesity among all population groups (Sassi, 2010). This trend is now considered a real epidemic. Weight gain and obesity ... [more ▼]

Globally, researchers regularly note the growing prevalence of weight excess and obesity among all population groups (Sassi, 2010). This trend is now considered a real epidemic. Weight gain and obesity are associated with several endogenous and exogenous factors among which inappropriate nutrition and sedentary lifestyle are clearly emphasized (Gahagan, 2004). Beyond the harmful consequences on individual health, the increasing proportion of overweight/obese individuals is already contributing to an increase in health care costs that will reach unmanageable proportions in few decades. Therefore, an increasing number of national and international bodies underline the need to implement effective programs designed to improve the citizen’s lifestyle. Over the last decade, the literature is replete with studies that demonstrate the positive effects of local and/or broader programs designed to address the issue of weight control and obesity prevention/treatment. Despite the encouraging data, it seems that the real impact on the society lacks consistency. It appears that multi-sectoral approaches are required. In such models, the School is identified as a determining component that should be implemented but cannot be considered as the magic remedy of a complex challenge like obesity (Fridlund Dunton et al., 2011; Lee et al., 2006). In fact, at school, each child is expected to acquire competences and knowledge that she/he will be able to use lifelong. Nevertheless, without the support of the other pillars of the society, any action undertaken at school would be a sword strike into water. Moreover, within the school, the fight against obesity needs the combined action of several partners in a multidimensional intervention. As a result of its links to the promotion of physical activity and health, physical education (PE) is logically presented as a key element in the strategies to be implemented (Tappe & Burgeson, 2004). However, for PE teachers, the growing number of overweight/obese students seems to represent a real challenge. Indeed, these students require specialized attention that, in the same time, cannot result in a stigmatization of the students’ characteristics. It first appears that PE teachers experience some difficulties in clearly identifying those students who need real intervention. Moreover, PE teachers express real concern over what can be done without causing harm to the overweight/obese student, this situation being especially relevant with the adolescent student (Cloes & Ziant, 2009; Rukavina et al., 2010). The presentation will focus on the current state of the research on PE teachers’ potential actions with overweight/obese students. The aim is to illustrate the avenues that are currently being explored. The presentation will offer a review of the steps of a research program addressing student obesity in PE developed at the University of Liege over the past several years. [less ▲]

Detailed reference viewed: 48 (7 ULg)
Full Text
Peer Reviewed
See detailCurrent Developments of Alloyed Steels for Hot Strip Roughing Mills : Characterization of High-Chromium Steel and Semi-High Speed Steel
Lecomte-Beckers, Jacqueline ULg; Sinnaeve, Mario; Tchuindjang, Jérôme Tchoufack ULg

in Iron and Steel Technology (2012)

Two alloys grades for work rolls used in the roughing stand of Hot Strip Mill - high chromium steel (HCS) and semi-high-speed steel (semi-HSS), In this paper, the new semi-high-speed steel grade is studied

Detailed reference viewed: 57 (10 ULg)
Full Text
Peer Reviewed
See detailCurrent evidence and indications for Prolotherapy with Platelet Rich Plasma in chronic musculoskeletal conditions
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

in Regional Anesthesia & Pain Medicine (2012, September), 37(5 - Suppl 1), 104-106

Detailed reference viewed: 77 (10 ULg)
See detailCurrent generation arrays: current status, getting the most out of them and future development
Akeson, R.; ten Brummelaar, T.; Eisner, J. et al

in “Future Directions for Interferometry” (2006)

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailCurrent impact and future directions of high throughput sequencing in plant virus diagnostics.
Massart, Sébastien ULg; Olmos, Antonio; Jijakli, Haissam ULg et al

in Virus Research (2014), 188

The ability to provide a fast, inexpensive and reliable diagnostic for any given viral infection is a key parameter in efforts to fight and control these ubiquitous pathogens. The recent developments of ... [more ▼]

The ability to provide a fast, inexpensive and reliable diagnostic for any given viral infection is a key parameter in efforts to fight and control these ubiquitous pathogens. The recent developments of highthroughput sequencing (also called Next Generation Sequencing – NGS) technologies and bioinformatics have drastically changed the research on viral pathogens. It is now raising a growing interest for virus diagnostics. This review provides a snapshot vision on the current use and impact of high throughput sequencing approaches in plant virus characterization. More specifically, this review highlights the potential of these new technologies and their interplay with current protocols in the future of molecular diagnostic of plant viruses. The current limitations that will need to be addressed for a wider adoption of high-throughput sequencing in plant virus diagnostics are thoroughly discussed. [less ▲]

Detailed reference viewed: 7 (2 ULg)
Peer Reviewed
See detailCurrent issues : varicella
Stouvenakers, Nadine ULg; Sadzot-Delvaux, Catherine ULg; Rentier, Bernard ULg

in Vaccines : Children and Practice (2001), 4

Detailed reference viewed: 32 (5 ULg)
Full Text
Peer Reviewed
See detailCurrent levels of drug resistance among therapy-naive HIV-infected patients have significant impact on treatment response
Derdelinckx, Inge; Van Laethem, Kristel; Maes, Bart et al

in Journal of Acquired Immune Deficiency Syndromes [=JAIDS] (2004), 37(5), 1664-1666

Detailed reference viewed: 11 (3 ULg)
Full Text
Peer Reviewed
See detailCurrent management strategies for coexisting diabetes mellitus and obesity.
Scheen, André ULg

in Drugs (2003), 63(12), 1165-84

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus. Weight reduction has been shown to markedly improve blood glucose control and vascular ... [more ▼]

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus. Weight reduction has been shown to markedly improve blood glucose control and vascular risk factors associated with insulin resistance in obese individuals with type 2 diabetes. Therapeutic strategies for the obese diabetic patient include: (i) promoting weight loss, through lifestyle modifications (low-calorie diet and exercise) and antiobesity drugs (orlistat, sibutramine, etc.); (ii) improving blood glucose control, through agents decreasing insulin resistance (metformin or thiazolidinediones, e.g. pioglitazone and rosiglitazone) or insulin needs (alpha-glucosidase inhibitors, e.g. acarbose) in preference to agents stimulating defective insulin secretion (sulphonylureas, meglitinide analogues); and (iii) treating common associated risk factors, such as arterial hypertension and dyslipidaemias, to improve cardiovascular prognosis. Whenever insulin is required by the obese diabetic patient after failure to respond to oral drugs, it should be preferably prescribed in combination with an oral agent, more particularly metformin or acarbose, or possibly a thiazolidinedione. When morbid obesity is present, both restoring a good glycaemic control and correcting associated risk factors can only be obtained through a marked and sustained weight loss. This objective justifies more aggressive weight reduction programmes, including very-low-calorie diets and bariatric surgery, but only within a multidisciplinary approach and long-term strategy. [less ▲]

Detailed reference viewed: 28 (0 ULg)
Full Text
Peer Reviewed
See detailCurrent migraine management - patient acceptability and future approaches.
Fumal, Arnaud ULg; Schoenen, Jean ULg

in Neuropsychiatric Disease and Treatment (2008), 4(6), 1043-57

Despite its high prevalence and individual as well as societal burden, migraine remains underdiagnosed and undertreated. In recent years, the options for the management of migraine patients have greatly ... [more ▼]

Despite its high prevalence and individual as well as societal burden, migraine remains underdiagnosed and undertreated. In recent years, the options for the management of migraine patients have greatly expanded. A number of drugs belonging to various pharmacological classes and deliverable by several routes are now available both for the acute and the preventive treatments of migraine. Nevertheless, disability and satisfaction remain low in many subjects because treatments are not accessible, not optimized, not effective, or simply not tolerated. There is thus still considerable room for better education, for more efficient therapies and for greater support from national health systems. In spite of useful internationally accepted guidelines, anti-migraine treatment has to be individually tailored to each patient taking into account the migraine subtype, the ensuing disability, the patient's previous history and present expectations, and the co-morbid disorders. In this article we will summarize the phenotypic presentations of migraine and review recommendations for acute and preventive treatment, highlighting recent advances which are relevant for clinical practice in terms of both diagnosis and management. [less ▲]

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailThe Current N-15-Leucine Infusion Technique Is Not Suitable For Quantitative Measurements Of Ileal Endogenous Amino Acid Flows In Pigs
Leterme, Pascal; Seve, Bernard; Thewis, André ULg

in Journal of Nutrition (1998), 128(11), 1961-1968

The current 15N-leucine infusion technique may overestimate the ileal endogenous nitrogen losses in pigs. To determine the reason, we infused four cannulated pigs intravenously, fed them a pea-based diet ... [more ▼]

The current 15N-leucine infusion technique may overestimate the ileal endogenous nitrogen losses in pigs. To determine the reason, we infused four cannulated pigs intravenously, fed them a pea-based diet with 15N-leucine, and examined some methodological variables. Neither the blood sampling time nor the choice of precursor pool (total N or amino acid N of deproteinized plasma) or the method of estimation of the isotopic equilibrium level significantly affected the results. On the other hand, the 15N-enrichment of purified mucin, isolated from ileal digesta, was higher than that of the plasma amino acid pool (0.114 vs. 0.077 atom % excess). The endogenous proportion of the labeled amino acids (Ala, Gly, Ile, Leu and Val) in the ileal digesta ranged from 23 (Leu) to 74% (Ala), compared with 70% for total N. The low value of leucine was ascribed to the constant marker infusion condition. In pigs infused with 13C-leucine, a similar endogenous proportion was obtained for lumenal leucine with 13C-leucine and 15N-leucine infusion. However, the 13C-enrichment of the leucine bound to mucin was markedly lower than that of plasma leucine (38%). The endogenous amino acid flows were also estimated by combining the ileal N flow measured with 15N and the endogenous amino acid profile obtained by means of an N-free diet. They were different from those obtained with the 15N-amino acid dilution technique. We conclude that the precursor pool currently used (plasma total N or total a-amino acid N pools) is a poor indicator of the enrichment of the secretions and that the infusion of one labeled amino acid is not sufficient to extend the method at the amino acid level. [less ▲]

Detailed reference viewed: 21 (0 ULg)