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See detailCurcumin inhibits interleukin-6, -8, nitric oxide and prostaglandin E2 synthesis by bovine chondrocytes
Mathy, Marianne ULg; Sanchez, Christelle ULg; Priem, F. et al

in Osteoarthritis and Cartilage (2007), 15(Suppl C), 115

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See detailCurcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes
Mathy, Marianne ULg; Jacquemond-Collet, Ingrid; Priem, Fabian et al

in Inflammation research (2009), 58

Objective and Design. This study aims to investigate the effects of curcumin (Cur) on the production of inflammatory mediators and on the extracellular matrix proteins metabolism by articular chondrocytes ... [more ▼]

Objective and Design. This study aims to investigate the effects of curcumin (Cur) on the production of inflammatory mediators and on the extracellular matrix proteins metabolism by articular chondrocytes. Methods. Human chondrocytes in alginate beads and human cartilage explants were cultured in the absence or in the presence of interleukin (IL)-1beta(10-11 M) and with or without Cur (5 to 20 µM). Nitric oxide (NO) synthesis was measured by Griess spectrophotometric method, prostaglandin (PG) E2 by a specific radioimmunoassay and IL-6, IL-8, aggrecan (Agg), matrix metalloproteinase (MMP)-3 and tissue inhibitor of metalloproteinase (TIMP)-1 by specific enzyme-amplified immunoassays. Proteoglycans degradation was evaluated by the release of 35S-glycosaminoglycans (GAG) from human cartilage explants. Results. In alginate beads and cartilage explants models, Cur inhibited in a concentration dependent manner the basal and the IL-1beta stimulated NO, PGE2, IL-6, IL-8 and MMP-3 production by human chondrocytes. The TIMP-1 and the Agg productions were not modified. In basal condition, 35S-GAG release from cartilage explants was decreased by Cur. Conclusions. Cur was a potent inhibitor of the production of inflammatory and catabolic mediators by chondrocytes, suggesting that this natural compound could be efficient in the treatment of osteoarthritis. [less ▲]

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See detailCurcumin-cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer.
Rocks, Natacha ULg; Bekaert, Sandrine ULg; Coia, I et al

in British Journal of Cancer (2012), 107(7), 1083-92

Background:Overall clinical outcome for advanced lung cancer remains very disappointing despite recent advances in treatment. Curcumin has been reported as potentially active against cancer.Methods:Owing ... [more ▼]

Background:Overall clinical outcome for advanced lung cancer remains very disappointing despite recent advances in treatment. Curcumin has been reported as potentially active against cancer.Methods:Owing to poor curcumin solubility, we have used cyclodextrins (CD) as an excipient allowing a considerable increase of aqueous solubility and bioavailability of curcumin. The effects of solubilised curcumin have been evaluated in cell cultures as well as in an in vivo orthotopic lung tumour mouse model.Results:Cell proliferation was reduced while apoptosis rates were increased when lung epithelial tumour cells were cultured in the presence of curcumin-CD complexes. For in vivo experiments, cells were grafted into lungs of C57Bl/6 mice treated by an oral administration of a non-soluble form of curcumin, CDs alone or curcumin-CD complexes, combined or not with gemcitabine. The size of orthotopically implanted lung tumours was reduced upon curcumin complex administration as compared with treatments with placebo or non-solubilised curcumin. Moreover, curcumin potentiated the gemcitabine-mediated antitumour effects.Conclusion:Our data demonstrate that curcumin, when given orally in a CD-solubilised form, reduces lung tumour size in vivo. In vitro experiments show impaired tumour cell proliferation and increased cell apoptosis. Moreover, our data underline a potential additive effect of curcumin with gemcitabine thus providing an efficient therapeutic option for antilung cancer therapy. [less ▲]

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See detailLes cures de jeûne modifié, protidique ou glucido-protidique, dans le traitement de l'obésité morbide.
SCHEEN, André ULg; Henrivaux, Ph; SCHEEN, Myriam ULg et al

in Médecine et Nutrition (1988), 24

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See detailCurie temperature, exchange integrals, and magneto-optical properties in off-stoichiometric bismuth iron garnet epitaxial films
Vertruyen, Bénédicte ULg; Cloots, Rudi ULg; Abell, J. S. et al

in Physical Review b (2008), 78(9), 094429

We have studied the influence of the stoichiometry on the structural, magnetic, and magneto-optical properties of bismuth iron garnet (Bi3Fe5O12) thin films grown by pulsed laser deposition. Films with ... [more ▼]

We have studied the influence of the stoichiometry on the structural, magnetic, and magneto-optical properties of bismuth iron garnet (Bi3Fe5O12) thin films grown by pulsed laser deposition. Films with different stoichiometries have been obtained by varying the Bi/Fe ratio of the target and the oxygen pressure during deposition. Stoichiometry variations influence the Curie temperature T-C by tuning the (Fe)-O-[Fe] geometry: TC increases when the lattice parameter decreases, contrary to what happens in the case of stoichiometric rare-earth iron garnets. The thermal variation of the magnetization, the Faraday rotation, and the Faraday ellipticity have been analyzed in the frame of the Neel two-sublattice magnetization model giving energies of -48 K (4.1 meV), -29 K (2.5 meV), and 84 K (7.3 meV) for the three magnetic exchange integrals j(aa), j(dd), and j(ad), respectively. Magneto-optical spectroscopy linked to compositional analysis by Rutherford backscattering spectroscopy shows that Bi and/or Fe deficiencies also affect the spectral variation (between 1.77 and 3.1 eV). Our results suggest that bismuth deficiency has an effect on the magneto-optical response of the tetrahedral Fe sublattice, whereas small iron deficiencies affect predominantly the magneto-optical response of the octahedral sublattice. [less ▲]

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See detailUn curieux phénomène d'érosion famennienne: les "pains de grès" de Chambralles (Ardenne belge)
Macar, Paul; Ek, Camille ULg

in Sedimentology (1965), 4

Les carrières de Chambralles, ouvertes dans les bancs de grès verticaux du Famennien supérieur, montrent une grande variété de structures péné-contemporaines de la sédimentation. On y note en particulier ... [more ▼]

Les carrières de Chambralles, ouvertes dans les bancs de grès verticaux du Famennien supérieur, montrent une grande variété de structures péné-contemporaines de la sédimentation. On y note en particulier, sur un banc largement dégagé, des îlots souvent limités par des micro-falaises et de petites masses de grès isolées, de forme arrondie ("pains de grès"). [less ▲]

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See detailCurrative radiotherapy for early stage laryngeal carcinoma: results and technical considerations
Ozsahin; Zouhair; Rosset et al

in Radiotherapy & Oncology (1998), 48(Supp1), 27

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See detailCurrency Total Return Swaps: Valuation and Risk Factor Analysis
Cuchet, Romain; François, Pascal; Hübner, Georges ULg

in Quantitative Finance (2013), 13(7), 1135-1148

Currency total return swaps (CTRS) are hybrid derivatives instruments that allow to simultaneously hedge against credit and currency risks. We develop a structural credit risk model to evaluate CTRS ... [more ▼]

Currency total return swaps (CTRS) are hybrid derivatives instruments that allow to simultaneously hedge against credit and currency risks. We develop a structural credit risk model to evaluate CTRS premia. Empirical test on a sample of 23,005 price observations from 59 underlying issuers yields an average percentage error of around 10%. This indicates that, beyond interest rate risk, firm-specific factors are major drivers of the variations in the valuation of these instruments. Regression analysis of residuals shows that exchange rate determinants account for up to 40% of model pricing errors — indicating that a currency risk premium affects the CTRS price significantly but only marginally, which confirms the prevalence of credit risk in the pricing of CTRS. [less ▲]

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See detailCurrent analytical aspects of vitamin D
Cavalier, Etienne ULg

Conference (2010, October 07)

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See detailCurrent and future atmospheric circulation at 500 hPa over Greenland simulated by the CMIP3 and CMIP5 global models
Belleflamme, Alexandre ULg; Fettweis, Xavier ULg; Lang, Charlotte ULg et al

in Climate Dynamics (2013), 41(7-8),

The Greenland ice sheet is projected to be strongly affected by global warming. These projections are either issued from downscaling methods (such as Regional Climate Models) or they come directly from ... [more ▼]

The Greenland ice sheet is projected to be strongly affected by global warming. These projections are either issued from downscaling methods (such as Regional Climate Models) or they come directly from General Circulation Models (GCMs). In this context, it is necessary to evaluate the accuracy of the daily atmospheric circulation simulated by the GCMs, since it is used as forcing for downscaling methods. Thus, we use an automatic circulation type classification based on two indices (Euclidean distance and Spearman rank correlation using the daily 500 hPa geopotential height) to evaluate the ability of the GCMs from both CMIP3 and CMIP5 databases to simulate the main circulation types over Greenland during summer. For each circulation type, the GCMs are compared to three reanalysis datasets on the basis of their frequency and persistence differences. For the current climate (1961–1990), we show that most of the GCMs do not reproduce the expected frequency and the persistence of the circulation types and that they simulate poorly the observed daily variability of the general circulation. Only a few GCMs can be used as reliable forcings for downscaling methods over Greenland. Finally, when applying the same approach to the future projections of the GCMs, no significant change in the atmospheric circulation over Greenland is detected, besides a generalised increase of the geopotential height due to a uniform warming of the atmosphere. [less ▲]

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See detailCurrent and future perspectives on Recombinant GH for the treatment of Obesity
Rixhon, M.; Tikhomirova, M. A.; Tamagno, G. et al

in Expert Review of Endocrinology & Metabolism (2008), 3(1), 75-89

The similarities between patients with untreated growth hormone (GH) deficiency and those with the cardiometabolic syndrome and the beneficial effects of recombinant human GH (rhGH) on body composition ... [more ▼]

The similarities between patients with untreated growth hormone (GH) deficiency and those with the cardiometabolic syndrome and the beneficial effects of recombinant human GH (rhGH) on body composition have led to the hypothesis that rhGH treatment may have utility in obesity. GH release is reduced in the setting of obesity, primarily due to hyperinsulinism and increased free fatty acid levels. We reviewed the outcomes of 23 clinical studies carried out between 1987 and 2006 that examined the effects of rhGH administration in the obese state. Typically, changes in overall body weight do not occur with rhGH therapy; however, assessment of body composition demonstrates reductions in visceral abdominal fat. Data on the effects of rhGH on lipid and carbohydrate metabolic profiles in obese patients are less clear-cut, with a subset of studies showing a beneficial effect and others a neutral effect. Given the increasing burden of obesity in the general population and the current paucity of effective therapies, it is useful to consider the data on rhGH and obesity from a clinical perspective to highlight potential treatment strategies that harness the somatotropic axis. [less ▲]

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See detailCurrent and Future Trends in Dynamic and Mobile GIS
Drummond, Jane; Joao, Elsa; Billen, Roland ULg

in Drummond, Jane; Billen, Roland; Joao, Elsa (Eds.) et al Dynamic and Mobile GIS: Investigating Changes in Space and Time (2007)

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See detailCurrent and future trends in groundwater vulnerability assessment
Gogu, Radu; Dassargues, Alain ULg

in Environmental Geology (2000), 39(6), 549-559

The concept of groundwater vulnerability is a useful tool for environmental planning and decision-making. Many different methods have been developed for assessing this vulnerability. Hydrogeologists have ... [more ▼]

The concept of groundwater vulnerability is a useful tool for environmental planning and decision-making. Many different methods have been developed for assessing this vulnerability. Hydrogeologists have failed to reach a consensus concerning the definitions of and reference terms for groundwater vulnerability assessment. Therefore, a review of vulnerability assessment and mapping methods providing a new classification system is necessary. This is focused on techniques that use the overlay and index class methods. New research challenges in vulnerability assessment are identified, especially the need for developing dynamic links between numerical models and overlay and index methods. [less ▲]

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See detailCurrent approaches to phylogenomic reconstruction
Baurain, Denis ULg; Philippe, Hervé

in Caetano-Anollés, Gustavo (Ed.) Evolutionary Genomics and Systems Biology (2010)

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See detailThe current budget of NOy above the Jungfraujoch as derived from IR solar observations
Demoulin, Philippe ULg; Mahieu, Emmanuel ULg; Zander, Rodolphe ULg et al

in Harris, N. R. P.; Kilbane-Dawe, I.; Amanatidis, G. T. (Eds.) Polar stratospheric ozone 1997 (1998)

This paper reports on an investigations of a series of compounds of the NOy family, based on high resolution infrared solar observations made at the ISSJ (International Scientific Station of the ... [more ▼]

This paper reports on an investigations of a series of compounds of the NOy family, based on high resolution infrared solar observations made at the ISSJ (International Scientific Station of the Jungfraujoch), Switzerland (46.55ºN, 7.99ºE, 3580 m a.s.l.). These observations are part of a long-term monitoring effort undertaken by the Liège group since the mid-1970s, and integrated more recently as a contribution to the Network for the Detection of Stratospheric Change (NDSC). Currently, vertical column abundances of over 20 molecules are retrieved from solar spectra recorded under clear sky conditions as regularly as possible, using two high resolution Fourier transform infrared (2 to 15 microns) spectrometers. [less ▲]

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See detailThe current budjet of NOy above the Jungfraujoch as derived from IR Solar Observations.
Demoulin, Philippe ULg; Mahieu, Emmanuel ULg; Zander, Rodolphe ULg et al

in Air Pollution Research Report Nr 66 (1998). (1997)

Detailed reference viewed: 5 (1 ULg)