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See detailCorrelation between Nuclear Factor-Kappab Activity in Bronchial Brushing Samples and Lung Dysfunction in an Animal Model of Asthma
Bureau, Fabrice ULg; Bonizzi, G.; Kirschvink, N. et al

in American Journal of Respiratory & Critical Care Medicine (2000), 161(4, Pt 1), 1314-1321

Asthma is a chronic inflammatory disease of the airways, in which many inflammatory genes are overexpressed. Transcription factor, nuclear factor-kappaB (NF-kappaB), which is thought to control the ... [more ▼]

Asthma is a chronic inflammatory disease of the airways, in which many inflammatory genes are overexpressed. Transcription factor, nuclear factor-kappaB (NF-kappaB), which is thought to control the transcriptional initiation of inflammatory genes, has been poorly investigated in asthma. In the present report, bronchial cells (BCs), recovered by bronchial brushing in healthy and heaves-affected horses (i.e., an animal model of asthma), were assessed for NF-kappaB activity. Small amounts of active NF-kappaB were present in BCs of healthy horses, whereas high levels of NF-kappaB activity was found during crisis (i.e., acute airway obstruction) in all heaves-affected horses. Three weeks after the crisis, the level of NF-kappaB activity found in BCs of heaves-affected horses was highly correlated (p < 0.01) to the degree of residual lung dysfunction. Unexpectedly, active NF- kappaB complexes found in BCs of heaves-affected horses were mainly p65 homodimers, rather than classic p65-p50 heterodimers. At last, intercellular adhesion molecule-1 (ICAM-1) expression paralleled p65 homodimers activity in these cells. These results demonstrate that the kinetics of NF-kappaB activity is strongly related to the course of the disease and confirm the relevance of NF-kappaB as a putative target in asthma therapy. Moreover, uncommon p65 homodimers could transactivate, in BCs, a subset of genes, such as ICAM-1, characteristic of chronic airway inflammation. [less ▲]

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See detailCorrelation between optical constants and crystal chemical parameters of ZrW2O8
Shannon, Robert D; Fischer, Reinhard X; Medenbach, Olaf et al

in Journal of Solid State Chemistry (2009), 182(10), 2762-2768

The refractive indices of ZrW2O8, measured at wavelengths of 435.8-643.8 nm, were used to calculate n(D) at lambda = 589.3 nm and n(infinity) at lambda = infinity from a one-term Sellmeier equation ... [more ▼]

The refractive indices of ZrW2O8, measured at wavelengths of 435.8-643.8 nm, were used to calculate n(D) at lambda = 589.3 nm and n(infinity) at lambda = infinity from a one-term Sellmeier equation. Refractive indices, n(D) and dispersion values, A, are, respectively, 1.8794 and 114 x 10(-16) m(2). The high dispersion, relative to other molybdates, tungstates and Zr-containing compounds, is attributed to the low value of E-o = 7.7 eV and mean cation coordination number. Total electronic polarizabilities, alpha(total), were calculated from n(infinity) and the Lorenz-Lorentz equation. The unusually large difference between the observed polarizability of 20.087 angstrom(3) and the calculated total polarizability alpha(T) of 17.59 angstrom(3) (Delta = +12.4%) is attributed to (1) a large M-O-W angle, (2) a high degree of W 5d-O(terminal) 2p and Zr nd-O 2p hybridization, and (3) unusually high oxygen displacement factors, B(O), normalized to B(W). (C) 2009 Elsevier Inc. All rights reserved. [less ▲]

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See detailCorrelation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate.
Bruyère, Olivier ULg; Honore, Aline; Ethgen, Olivier ULg et al

in Osteoarthritis and Cartilage (2003), 11(1), 1-5

OBJECTIVE: To investigate the relationship between baseline radiographic severity of knee osteoarthritis (OA) and the importance of long-term joint space narrowing. DESIGN: Sub-analysis from a three-year ... [more ▼]

OBJECTIVE: To investigate the relationship between baseline radiographic severity of knee osteoarthritis (OA) and the importance of long-term joint space narrowing. DESIGN: Sub-analysis from a three-year randomized, placebo-controlled, prospective study, of 212 patients with knee OA, recruited in an osteoarthritic outpatient clinic and having been part of a study evaluating the effect of glucosamine sulfate on symptom and structure modification in knee OA. MATERIAL AND METHODS: Measurements of mean joint space width (JSW), assessed by a computer-assisted method, were performed at baseline and after 3 years, on weightbearing anteroposterior knee radiographs. RESULTS: In the placebo group, baseline JSW was significantly and negatively correlated with the joint space narrowing observed after 3 years (r=-0.34, P=0.003). In the lowest quartile of baseline mean JSW (<4.5mm), the JSW increased after 3 years by (mean (S.D.)) 3.8% (23.8) in the placebo group and 6.2% (17.5) in the glucosamine sulfate group. The difference between the two groups in these patients with the most severe OA at baseline was not statistically significant (P=0.70). In the highest quartile of baseline mean JSW (>6.2mm), a joint space narrowing of 14.9% (17.9) occurred in the placebo group after 3 years while patients from the glucosamine sulfate group only experienced a narrowing of 6.0% (15.1). Patients with the most severe OA at baseline had a RR of 0.42 (0.17-1.01) to experience a 0.5mm joint space narrowing over 3 years, compared to those with the less affected joint. In patients with mild OA, i.e. in the highest quartile of baseline mean JSW, glucosamine sulfate use was associated with a trend (P=0.10) towards a significant reduction in joint space narrowing. CONCLUSION: These results suggest that patients with the less severe radiographic knee OA will experience, over 3 years, the most dramatic disease progression in terms of joint space narrowing. Such patients may be particularly responsive to structure-modifying drugs. [less ▲]

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See detailCorrelation between RNA and protein levels in a large european series from the LYSA
Bossard, C.; Dobay, M.P.; Lamant, L. et al

in Hematological Oncology (2013), 31 Suppl.1

Introduction: CD22 is expressed on most B-non-Hodgkin lymphomas (NHL); inotuzumab ozogamicin (INO) is an anti-CD22 antibody conjugated to calicheamicin. This study evaluated the safety and tolerability of ... [more ▼]

Introduction: CD22 is expressed on most B-non-Hodgkin lymphomas (NHL); inotuzumab ozogamicin (INO) is an anti-CD22 antibody conjugated to calicheamicin. This study evaluated the safety and tolerability of INO plus R-CVP in patients (pts) with relapsed/refractory CD22+ B-NHL. Efficacy data were also collected. Methods: Part 1 of this open-label study identified a maximum tolerated dose (MTD) of INO 0.8mg/m,2 on day 2 plus R-CVP (rituximab 375mg/m,2 cyclophosphamide 750mg/m,2 and vincristine 1.4mg/m,2 on day 1; prednisone 40mg/m,2 on days 1-5) every 21 days. Subsequently, pts were enrolled in the MTD confirmation cohort (part 2, n = 10), which required a dose-limiting toxicity rate of <33% in cycle 1 and <4 pts discontinuing prior to cycle 3 due to an adverse event (AE) in the MTD expansion cohort (part 3, n = 22), which explored preliminary activity. Results: Parts 2 and 3 enrolled 32 pts: 16 pts with diffuse large B-cell lymphoma, 15 with follicular lymphoma and one with mantle cell lymphoma. Median age was 64.5 years (range 44-81 years); 34% of pts had 1 prior regimen, 34% had 2, 28% had ≥3 and 3% had none (median 2; range 0-6).Median treatment duration was five cycles (range 1-6). Part 2 confirmed the MTD as standard dose R-CVP plus INO 0.8mg/m,2; 2/10 pts had a dose-limiting toxicity (grade 3 increased ALT/AST, grade 4 neutropenia requiring G-CSF). One pt discontinued because of an AE prior to cycle 3. Common treatment-related AEs were thrombocytopenia (78%), neutropenia (66%), fatigue (50%), leukopenia (50%), nausea (41%) and lymphopenia (38%); common grade 3/4 AEs were neutropenia (63%), thrombocytopenia (53%), leukopenia (38%) and lymphopenia (31%). There was one case of treatment-related fatal pneumonia with grade 4 neutropenia. Ten pts discontinued treatment due to AEs; thrombocytopenia/delayed platelet recovery was the leading cause (grade 1/2, n = 6; grade 3/4, n = 3). Objective response rate (ORR) was 77% (n = 24/31 evaluable pts), including 26% (n=8/31) with complete response (CR); three pts had stable disease. Of the pts with follicular lymphoma, ORR was 100% (n = 15/15), including seven pts with CR. Of the pts with diffuse large B-cell lymphoma, ORR was 60% (n = 9/16), including one pt with CR. Conclusions: Results suggest that INOplus R-CVP has acceptable toxicity and promising activity in relapsed/refractory CD22+ B-NHL. The most common grade 3/4 AEs were hematologic. Follow-up for progression-free and overall survival is ongoing. [less ▲]

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See detailCorrelation between superhydrophobicity and the power spectral density of randomly rough surfaces
Awada, Houssein; Grignard, Bruno ULg; Jérôme, Christine ULg et al

in Langmuir (2010), 26(23), 17798-17803

We show experimentally and analytically that for single-valued, isotropic, homogeneous, randomly rough surfaces consisting of bumps randomly protruding over a continuous background, superhydrophobicity is ... [more ▼]

We show experimentally and analytically that for single-valued, isotropic, homogeneous, randomly rough surfaces consisting of bumps randomly protruding over a continuous background, superhydrophobicity is related to the power spectral density of the surface height, which can be derived from microscopy measurements. More precisely, superhydrophobicity correlates with the third moment of the power spectral density, which is directly related to the notion of Wenzel roughness (i.e., the ratio between the real area of the surface and its projected area). In addition, we explain why randomly rough surfaces with identical root-mean-square roughness values may behave differently with respect to water repellence and why roughness components with wavelength larger than 10 μm are not likely to be of importance or, stated otherwise, why superhydrophobicity often requires a contribution from submicrometer-scale components such as nanoparticles. The analysis developed here also shows that the simple thermodynamic arguments relating superhydrophobicity to an increase in the sample area are valid for this type of surface, and we hope that it will help researchers to fabricate efficient superhydrophobic surfaces based on the rational design of their power spectral density. [less ▲]

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See detailCorrelation between the acoustic noise field measured in a Posidonia oceanica bed and the photosynthetic activity
Felisberto, P; Zabel, F; Rodriguez, O et al

Poster (2014, May 05)

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See detailCorrelation between the neutralizing response to BRSV vaccinal strains and the prevention of pulmonary dysfunction induced by a challenge strain
Bureau, Fabrice ULg; Genicot, B.; Coghe, J. et al

in Proceedings: Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques (1999)

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See detailCorrelation between the roughness of the substrate surface and the debonding risk
Perez, Fabien; Morency, Maxim; Bissonnette, Benoît et al

in Alexander, M. G.; Beushausen, H.-D.; Dehn, F. (Eds.) et al Concrete Repair, Rehabilitation and Retrofitting II (2009)

This paper presents the influence of substrate surface preparation on the adhesion strength of repaired beams system. Bond between new and old concrete has been the subject of a number of investigations ... [more ▼]

This paper presents the influence of substrate surface preparation on the adhesion strength of repaired beams system. Bond between new and old concrete has been the subject of a number of investigations, but in most cases, only adhesion strength was addressed. This parameter was used to estimate the durability and/or the debonding risk for repaired structure and it’s a generally accepted auditing standards. Usually, surface preparation of the substrate concrete is considered essential to achieve a durable repair because of its influence on the bond strength. To better understand debonding mechanism, in particular these related to surface preparation, roughness parameters were calculated to quantify the influence of surface preparation on the structural behaviour. Using this approach, repair beams prepared by way of four (4) concrete surface preparations were characterized. Results obtained show that repaired beams presenting a substrate with a rough surface permit to achieve a monolithic behaviour of the repaired system. Opposite structural behaviour, with large debonding, was recorded for those having smooth surface. However, all surface preparations used have promoted the same bond strength regardless the roughness of the substrate. The resulting analysis highlights the relation between roughness parameter αrough and the debonding mechanism of repaired beams. Such results will be useful to better predict the performance of concrete repairs. [less ▲]

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See detailCorrelation between the Sexually Dimorphic Aromatase of the Preoptic Area and Sexual Behavior in Quail: Effects of Neonatal Manipulations of the Hormonal Milieu
Balthazart, Jacques ULg

in Archives Internationales de Physiologie et de Biochimie (1989), 97(6), 465-81

The aromatase of the preoptic area is significantly more active in males than in females. This sex dimorphism in enzyme activity is still found in birds that have been gonadectomized and treated with a ... [more ▼]

The aromatase of the preoptic area is significantly more active in males than in females. This sex dimorphism in enzyme activity is still found in birds that have been gonadectomized and treated with a same dose of testosterone. This suggests that the sex difference is not the result of a differential activation by the adult hormonal environment but rather is organized neonatally by steroid hormones. As the central aromatization of testosterone is a limiting step in the activation of copulatory behavior by testosterone, the lower aromatase activity in the preoptic area of females might be responsible, at least in part, for their lower sensitivity to the activating effects of testosterone on behavior. Three experiments were carried out to determine whether early manipulations of the hormonal environment, which are known to differentiate sexual behavior, also affect in a permanent way the aromatase activity in the preoptic area. Injection of estradiol benzoate into male embryos on day 9 of incubation decreased the preoptic aromatase activity in parallel to its demasculinizing effect on behavior. Unexpectedly the same treatment tended to increase enzyme activity in females so that the physiological relevance of the observed enzymatic change remains questionable. In two independent experiments, we confirmed that neonatal ovariectomy of female quail interferes with their behavioral differentiation. Females gonadectomized at 4 days post-hatch showed significantly more male-type sexual behavior as adult in response to testosterone than females gonadectomized at the age of 5 weeks. These experiments also confirmed that the preoptic aromatase activity is higher in males than in females but no evidence for an effect of the age of gonadectomy on the enzyme activity could be obtained. The sex difference and experimental modifications observed in the aromatase activity of the preoptic area were not seen in the posterior hypothalamus demonstrating that these effects are specific. The mechanisms controlling the sex difference in aromatase activity are discussed. The difference might be organized by the action of embryonic steroids as suggested by the changes observed in males injected with estradiol benzoate in egg. Alternatively, activational mechanisms cannot be ruled out at present. In one experiment, the activity of the preoptic aromatase was positively correlated with the sexual activity of the birds.(ABSTRACT TRUNCATED AT 400 WORDS) [less ▲]

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See detailCorrelation between thoracic ct-scan angiography findings and echocardiographic right pulmonary vein to pulmonary artery ratio in west highland white terriers with idiopathic pulmonary fibrosis.
Roels, Elodie ULg; Merveille, Anne-Christine ULg; Couvreur, T. et al

in Proceedings of the 24th Ecvim Meeting, Mainz, Germany - 4-6 September 2014 (2014, September)

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See detailLa corrélation canonique : principes et application
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1990), (1), 28

This note describes the different stages in interpreting a canonical correlation analysis. It is based on an example analysed by SAS software. Relationship with some other multivariate statistical methods ... [more ▼]

This note describes the different stages in interpreting a canonical correlation analysis. It is based on an example analysed by SAS software. Relationship with some other multivariate statistical methods is also pointed out. [less ▲]

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See detailCorrélation de la densité minérale osseuse de l’os spongieux du fémur et du T2* chez l’enfant
Schwartz, Cédric ULg

Master of advanced studies dissertation (2005)

La maladie de Legg-Calvé-Perthes est une maladie infantile qui a pour origine une ischémie du noyau épiphysaire fémoral supérieur. Cette pathologie évolue naturellement vers la guérison mais souvent avec ... [more ▼]

La maladie de Legg-Calvé-Perthes est une maladie infantile qui a pour origine une ischémie du noyau épiphysaire fémoral supérieur. Cette pathologie évolue naturellement vers la guérison mais souvent avec des déformations irréversibles de la tête fémorale. Le travail du médecin est de limiter au maximum ces complications. L’équipe d’imagerie vasculaire et biomécanique de l’UMR CNRS 6600 à l’Université de Technologie de Compiègne souhaite créer un modèle biomécanique de la hanche de l’enfant afin de proposer au médecin un outil de pronostic de l’évolution de la maladie et ainsi l’aider dans son choix de traitement. La création d’un modèle biomécanique implique la connaissance de la géométrie de la tête fémorale et des propriétés mécaniques des tissus qui la composent, c’est- à - dire de l’os cortical, de l’os spongieux et du cartilage. L’objet de cette étude est d’obtenir la densité minérale osseuse (DMO) de l’os spongieux à partir de la mesure du temps de relaxation transverse apparent T2*. L’interface de deux matériaux de susceptibilité magnétique différente (l’os et la moelle) crée des inhomogénéités dans le champ magnétique ayant pour conséquence un déphasage plus rapide des protons et donc un temps de relaxation plus petit. L’idée de ce travail est de proposer une méthode permettant de corréler la DMO au T2* au niveau de la hanche de l’enfant. Nous avons développé un modèle permettant de simuler en 2D et en 3D l’influence de différentes structures sur le T2*. Ces simulations nous ont conduit à appréhender les différents paramètres influant sur la valeur du T2* (l’orientation des travées, la différences de susceptibilité magnétique, ...). Ce travail nous a permis de mettre en avant l’importance qu’il y avait à prendre en compte la présence de deux types de moelle (jaune et rouge) dans la tête fémorale de l’enfant et l’orientation des travées. La corrélation en elle-même pourra être réalisée à l’aide d’un fantôme composé de cylindres de diamètre proche de l’épaisseur des travées osseuses. [less ▲]

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See detailCorrélation entre l'augmentation de la densité minérale osseuse et la réduction du risque fracturaire lors d'un traitement par ranélate de strontium
Bruyère, Olivier ULg; Cormier, C.; Fardellone, Patrice et al

in Revue du Rhumatisme (2006, December), 73

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See detailCorrelation entre l'echelle de Liege et un marqueur biochimique de la lesion cerebrale.
Born, J. D.; Hans, Pol ULg; Chapelle, Jean-Paul ULg et al

in Neuro-Chirurgie (1984), 30(5), 319-23

Brain type creatine kinase isoenzyme (CK.-1) was measured in the ventricular cerebrospinal fluid in a series of 42 patients within 7 +/- 3,4 hours following severe head injury (GCS less than or equal to 7 ... [more ▼]

Brain type creatine kinase isoenzyme (CK.-1) was measured in the ventricular cerebrospinal fluid in a series of 42 patients within 7 +/- 3,4 hours following severe head injury (GCS less than or equal to 7, LCS less than or equal to 12). The presence of the CK.-1 isoenzyme correlated with the degree of head injury as indexed by the Glasgow coma scale and the Liege coma scale. There was a significant logarithmic correlation between CK.-1 activity in the C.S.F. and the coma scores. However, the correlation with the Liege coma scale score (r = -0,84) is significantly better (Z = 1,97; p less than 0,05) than with the Glasgow coma scale score (r = -0,65). Thus, the Liege coma scale is a better index of neurological trauma. [less ▲]

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