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Peer Reviewed
See detailA critical cysteine residue of bovine leukemia virus SU protein interacts with zinc and plays a role in viral infectivity.
GATOT, Jean-Stéphane ULg; Kerkhofs, Pierre; Burny, Arsène et al

in The 2001 meeting on Retroviruses. (2001, May)

Detailed reference viewed: 17 (4 ULg)
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See detailCritical evaluation of serum uric acid levels in acute myocardial infarction.
Chapelle, Jean-Paul ULg; Albert, Adelin ULg; Boland, Jean et al

in Clinica Chimica Acta (1982), 121(2), 147-157

Serial measurements of serum uric acid were performed on patients suffering from acute myocardial infarction. Nearly 80 percent of the cases demonstrated a fall in uric acid concentrations during the ... [more ▼]

Serial measurements of serum uric acid were performed on patients suffering from acute myocardial infarction. Nearly 80 percent of the cases demonstrated a fall in uric acid concentrations during the first two days of hospitalization and a subsequent return to initial levels within six to eight days. There was a relationship between the decrease in uric acid levels and the serum lactate dehydrogenase activity. No evidence could be found that male patients were hyperuricemic as compared to control subjects. However, female patients between 40 and 60 years of age demonstrated significantly higher uric acid levels than healthy women of corresponding ages, even after adjustment for diuretic use. [less ▲]

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See detailCritical Evaluation of the DNA-methyl Green Assay: Application to Some Indole Alkaloids
Bonjean, K.; Gillet, Marie-Claire ULg; Bassleer, R. et al

in Phytotherapy Research (1996), 10

A DNA-methyl green colorimetric microassay for the detection of agents that interact with DNA was assessed with reference molecules (doxorubicin, ellipticine, melinonine F, dihydroflavopereirine, cis-Pt ... [more ▼]

A DNA-methyl green colorimetric microassay for the detection of agents that interact with DNA was assessed with reference molecules (doxorubicin, ellipticine, melinonine F, dihydroflavopereirine, cis-Pt, mitomycin C, emetine or colchicine). This test showed some promise as a screening technique for substances that intercalate partly or totally into the DNA helix but it is not suitable for substances that bind covalently to DNA. An application of this test to a number of indole alkaloids was also performed. Cryptolepine, serpentine, alstonine and matadine induced a reduction of the colour of the solution, so indicating an interaction with DNA. [less ▲]

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See detailCritical field enhancement in hybrid superconductor/ferromagnet mesoscopic disks
Schildermans, N.; Silhanek, Alejandro ULg; Sautner, J. et al

in Journal of Applied Physics (2009), 105(2),

We investigated experimentally the nucleation of superconductivity in a mesoscopic hybrid structure, consisting of a thin superconducting disk covered with a ferromagnetic layer with an in-plane magnetic ... [more ▼]

We investigated experimentally the nucleation of superconductivity in a mesoscopic hybrid structure, consisting of a thin superconducting disk covered with a ferromagnetic layer with an in-plane magnetic moment. By applying a magnetic field in the plane of the structure, the remanent magnetic state of the ferromagnet can be switched from a flux-closure state where field lines are confined inside the ferromagnet to a polarized state with nonzero stray fields at the edges. This change in the magnetic state causes a drastic modification on the superconductor/normal-state phase boundary of the hybrid sample. In the polarized state a re-entrant transition line and a strong broadening of the phase boundary are observed. [less ▲]

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See detailCritical issues in translational and clinical research for the study of new technologies to enhance bone repair.
Goldhahn, Jorg; Mitlak, Bruce; Aspenberg, Per et al

in Journal of Bone & Joint Surgery. American Volume (2008), 90 Suppl 1

Osteoporosis increases fracture risk, especially in metaphyseal bone. Fractures seriously impair function and quality of life and incur large direct and indirect costs. Although the prevention of ... [more ▼]

Osteoporosis increases fracture risk, especially in metaphyseal bone. Fractures seriously impair function and quality of life and incur large direct and indirect costs. Although the prevention of fractures is certainly the option, a fast and uneventful healing process is optimal when fractures do occur. Many new therapeutic strategies have been developed to accelerate fracture-healing or to diminish the complication rate during the course of fracture-healing. However, widely accepted guidelines are needed to demonstrate the positive or negative interactions of bioactive substances, drugs, and other agents that are being used to promote fracture-healing. For each study design, the primary study goal should be indicated. Outcome variables should include both objective and subjective parameters. The guidelines should be harmonized between European and American regulatory authorities to ensure comparability of results of studies and to foster global harmonization of regulatory requirements. [less ▲]

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See detailThe Critical Neighbourhood Range for Asymptotic Overlay Connectivity in Ad Hoc Networks
Calomme, Sandrine; Leduc, Guy ULg

in Ad Hoc & Sensor Wireless Networks (2006), 2(2), 169-187

We first motivate the use of ad hoc overlays. In particular, we argue that overlay routing could play a role in the spreading of ad hoc networks. We then define a simple criterion for neighbourhood: two ... [more ▼]

We first motivate the use of ad hoc overlays. In particular, we argue that overlay routing could play a role in the spreading of ad hoc networks. We then define a simple criterion for neighbourhood: two overlay nodes are neighbours if and only if there exists a path between them of at most R hops, and R is called the (overlay) neighbourhood range. A small R may result in a disconnected overlay, while an unnecessarily large R would generate extra control traffic. We are interested in the minimum R ensuring overlay connectivity, the so-called critical R. We study conditions on R to achieve asymptotic connectivity of the overlay almost surely, i.e. connectivity with probability 1 when the number of nodes in the underlying ad hoc network tends to infinity (so-called dense networks) or when the size of the field tends to infinity (socalled sparse networks), under the hypothesis that the underlying ad hoc network is itself asymptotically almost surely connected. For dense networks, we derive a necessary and sufficient condition on R, and for sparse networks we derive distinct necessary and sufficient conditions that are however asymptotically tight. These conditions, though asymptotic, shed some light on the relation linking the critical R to the number of nodes n, the field size the radio transmission range r and the overlay density D (i.e., the proportion of overlay nodes). These conditions can be considered as approximations when the number of nodes (resp. the field) is large enough. Since r is considered as a function of n or l , we are able to study the impact of topology control mechanisms, by showing how the shape of this function impacts the critical R. [less ▲]

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See detailThe Critical Neighbourhood Range for Asymptotic Overlay Connectivity in Dense Ad Hoc Networks
Calomme, Sandrine; Leduc, Guy ULg

in Challenges in Ad Hoc Networking (2005, June)

We define, for an overlay built on top of an ad hoc network, a simple criterion for neighbourhood: two overlay nodes are neighbours if and only if there exists a path between them of at most R hops, and R ... [more ▼]

We define, for an overlay built on top of an ad hoc network, a simple criterion for neighbourhood: two overlay nodes are neighbours if and only if there exists a path between them of at most R hops, and R is called the (overlay) neighbourhood range. A small R may result in a disconnected overlay, while an unnecessarily large R would generate extra control traffic. We are interested in the minimum R ensuring overlay connectivity, the so-called critical R. We derive a necessary and sufficient condition on R to achieve asymptotic connectivity of the overlay almost surely, i.e. connectivity with probability 1 when the number of overlay nodes tends to infinity, under the hypothesis that the underlying ad hoc network is itself asymptotically almost surely connected. This condition, though asymptotic, sheds some light on the relation linking the critical R to the number of nodes n, the normalized radio transmission range r and the overlay density D (i.e., the proportion of overlay nodes). This condition can be considered as an approximation when the number of nodes is large enough. Since r is considered as a function of n, we are able to study the impact of topology control mechanisms, by showing how the shape of this function impacts the critical R. [less ▲]

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See detailCritical opalescence points to thermodynamic instability:relevance to small-angle X-ray scattering of resorcinol–formaldehyde gel formation at low pH
Gommes, Cédric ULg; Job, Nathalie ULg; Pirard, Jean-Paul ULg et al

in Journal of Applied Crystallography (2008), 41(4), 663-668

During the formation at low pH of resorcinol–formaldehyde gels with a structure in the micrometre range, small-angle X-ray scattering exhibits a nonmonotonic intensity variation as a function of reaction ... [more ▼]

During the formation at low pH of resorcinol–formaldehyde gels with a structure in the micrometre range, small-angle X-ray scattering exhibits a nonmonotonic intensity variation as a function of reaction time. The data are analyzed in terms of scattering by statistical fluctuations of polymer concentration, the amplitude of which is maximal close to the critical point for phase separation between polymer and solvent. The data do not carry any morphological information, but they unambiguously show that the driving force of the gel formation is a thermodynamic instability of the polymerizing solution. [less ▲]

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See detailCritical parameters for the partial coalescence of a droplet
Gilet, Tristan ULg; Mulleners, Karen; Lecomte, Jean-Paul et al

in Physical Review E (2007), 75(3, Pt 2), 36303

The partial coalescence of a droplet onto a planar liquid-liquid interface is investigated experimentally by tuning the viscosities of both liquids. The problem mainly depends on four dimensionless ... [more ▼]

The partial coalescence of a droplet onto a planar liquid-liquid interface is investigated experimentally by tuning the viscosities of both liquids. The problem mainly depends on four dimensionless parameters: The Bond number (gravity vs surface tension), the Ohnesorge numbers (viscosity in both fluids vs surface tension), and the density relative difference. The ratio between the daughter droplet size and the mother droplet size is investigated as a function of these dimensionless numbers. Global quantities such as the available surface energy of the droplet have been measured during the coalescence. The capillary waves propagation and damping are studied in detail. The relation between these waves and the partial coalescence is discussed. Additional viscous mechanisms are proposed in order to explain the asymmetric role played by both viscosities. [less ▲]

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See detailCritical points and reaction paths characterization on a potential energy hypersurface
Ramquet, Marie-Noëlle; Dive, Georges ULg; Dehareng, Dominique ULg

in Journal of Chemical Physics (2000), 112(11), 4923-4934

Most of the time, the definitions of minima, saddle points or more generally order p (p=0,...,n) critical points, do not mention the possibility of having zero Hessian eigenvalues. This feature reflects ... [more ▼]

Most of the time, the definitions of minima, saddle points or more generally order p (p=0,...,n) critical points, do not mention the possibility of having zero Hessian eigenvalues. This feature reflects some flatness of the potential energy hypersurface in a special eigendirection which is not often taken into account. Thus, the definitions of critical points are revisited in a more general framework within this context. The concepts of bifurcation points, branching points, and valley ridge inflection points are investigated. New definitions based on the mathematical formulation of the reaction path are given and some of their properties are outlined. (C) 2000 American Institute of Physics. [S0021-9606(00)01110-7]. [less ▲]

Detailed reference viewed: 26 (0 ULg)
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See detailCritical points for Salmonella contamination during slaughter process in Belgian slaughterhouses.
De Saedeleer, L.; Maes, D.; Dewulf, J. et al

in International Pig Veterinary Society Congress (2006, July)

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See detailCritical points in glucosinolates analysis in seed and plant tis Critical points in glucosinolates analysis in seed and plant tissues by HPLC of desulfo-derivatives
Leoni, O.; Iori, R.; Wathelet, Jean-Paul ULg et al

Poster (2004)

In the EU the ISO 9167-1 is the reference method for glucosinolates content determination in rapeseed. This method is widely used also for other seeds or Brassica plant tissues analysis also in order to ... [more ▼]

In the EU the ISO 9167-1 is the reference method for glucosinolates content determination in rapeseed. This method is widely used also for other seeds or Brassica plant tissues analysis also in order to the large diffusion of HPLC instrumentation in analytical laboratories. Anyway, in our experience the use of this method has revealed some critical points which can considerably affect the final result, thus when this method is used to analyse materials different from seeds of B. napus some methodological modifications must be done especially in reason of the kind of glucosinolate present in the sample. [less ▲]

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See detailCritical Re-Examination of the Distribution of Aromatase-Immunoreactive Cells in the Quail Forebrain Using Antibodies Raised against Human Placental Aromatase and against the Recombinant Quail, Mouse or Human Enzyme
Foidart, Agnès ULg; Reid, J.; Absil, Philippe ULg et al

in Journal of Chemical Neuroanatomy (1995), 8(4), 267-82

Mouse and quail aromatase cDNAs were isolated from libraries of mouse ovary and quail brain by using a human aromatase cDNA fragment (hA-24) as a probe. These three cDNAs were inserted into plasmid ... [more ▼]

Mouse and quail aromatase cDNAs were isolated from libraries of mouse ovary and quail brain by using a human aromatase cDNA fragment (hA-24) as a probe. These three cDNAs were inserted into plasmid vectors and expressed in Escherichia coli. Antisera against these purified recombinant proteins were raised in rabbit and purified by ammonium sulfate fractionation and affinity chromatography. The three antibodies directed against recombinant human, mouse and quail proteins were used to visualize aromatase-immunoreactive cells in the quail brain. They were compared with the antibody raised against human placental aromatase used in previous experiments and with another antibody recently developed by similar methods. The signal obtained with all antibodies was completely abolished by preadsorption with the homologous recombinant antigens and the signal produced by the two antibodies raised against placental aromatase was similarly abolished by a preadsorption with recombinant quail aromatase. The antibodies raised against recombinant proteins identified the major groups of aromatase cells previously described in the quail brain. The antibodies directed against the mouse and quail antigen identified more positive cells and stained them more densely than the antibodies raised against human recombinant antigen or purified placental aromatase. The new cell groups identified by the antibody raised against quail recombinant aromatase were located in an area ventral to the fasciculus prosencephali lateralis, the nucleus accumbens, the paleostriatum ventrale, the nucleus taeniae, the area around the nucleus ovoidalis, the caudal tuber and the mesencephalic central gray. A critical re-examination of the distribution and nomenclature of the aromatase-positive cells is proposed based on these new findings. [less ▲]

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See detailCritical Reflections on the Treaty on the Non-Proliferation of Nuclear Weapons
Michel, Quentin ULg

in Nuclear Law Bulletin (2007)

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See detailCritical Review of Near-Infrared Spectroscopic Methods Validations in Pharmaceutical Applications
De Bleye, Charlotte ULg; Chavez, Pierre-François ULg; Mantanus, Jérôme ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2012), 69

Based on the large number of publications reported over the past five years, near-infrared spectroscopy (NIRS) is more and more considered an attractive and promising analytical tool regarding Process ... [more ▼]

Based on the large number of publications reported over the past five years, near-infrared spectroscopy (NIRS) is more and more considered an attractive and promising analytical tool regarding Process Analytical Technology and Green Chemistry. From the reviewed literature, few of these publications present a thoroughly validated NIRS method even if some guidelines have been published by different groups and regulatory authorities. However, as any analytical method, the validation of NIRS method is a mandatory step at the end of the development in order to give enough guarantees that each of the future results during routine use will be close enough to the true value. Besides the introduction of PAT concepts in the revised document of the European Pharmacopoeia (2.2.40) dealing with near-infrared spectroscopy recently published in Pharmeuropa, it agrees very well with this mandatory step. Indeed, the latter suggests to use similar analytical performance characteristics than those required for any analytical procedure based on acceptance criteria consistent with the intended use of the method. In this context, this review gives a comprehensive and critical overview of the methodologies applied to assess the validity of quantitative NIRS methods used in pharmaceutical applications. [less ▲]

Detailed reference viewed: 148 (59 ULg)
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See detailA critical review of surgery techniques for implanting telemetry devices into the body cavity of fish
Baras, Etienne; Birtles, Cymon; Westerloppe, Luc et al

Conference (1996, August)

Based on literature survey and personal experience, this paper presents a critical review of surgery procedures to implant telemetry devices (transmitters, transponders) into the body cavity of fish ... [more ▼]

Based on literature survey and personal experience, this paper presents a critical review of surgery procedures to implant telemetry devices (transmitters, transponders) into the body cavity of fish species. It debates on the relative adequacy of techniques which may compromise or enhance tagging success with respect to fish health and transmitter retention: anaesthesia, incision (position and length of incision), transmitter features (size and weight ratios, coating), ways of closing the incision (stitches, staples, adhesives), prophylaxy, pre- and postoperative care. Behavioural and physiological biases originating from tagging or internal presence of the transmitter are reviewed, evaluated and integrated to determine the actual duration of the post-operative perturbation and subsequent validation of telemetry data. [less ▲]

Detailed reference viewed: 153 (10 ULg)
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See detailCritical Review: Biological functions of thiamine derivatives: Focus on non-coenzyme roles
Bettendorff, Lucien ULg; Wins, Pierre

in OA Biochemistry (2013), 1(1), 10

Thiamine (vitamin B1) is mainly known for its diphosphorylated derivatives (ThDP), an essential coenzyme in energy metabolism. However non-coenzyme roles have been suggested for this vitamin for many ... [more ▼]

Thiamine (vitamin B1) is mainly known for its diphosphorylated derivatives (ThDP), an essential coenzyme in energy metabolism. However non-coenzyme roles have been suggested for this vitamin for many years. Such roles have remained hypothetical, but recent data from various sources have shed a new light on this hypothesis. First, the existence of other phosphorylated thiamine derivatives, most prominently thiamine triphosphate (ThTP) and adenosine thiamine triphosphate (AThTP) can reach significant levels in E. coli, respectively during amino acid starvation and energy stress. Though much less is known about these compounds in animals, mammalian cells contain a highly specific soluble thiamine triphosphatase controlling cytosolic ThTP concentrations. Second, there is now growing evidence in favour of the existence of thiamine-binding proteins with specific roles in the nervous system, possibly in the regulation of in neurotransmitter release. Thiamine and some of its synthetic precursors with higher bioavailability have beneficial effects in several models of Alzheimer’s disease and may be beneficial for patients suffering from Alzheimer's or Parkinson's diseases. These effects might be related to non-coenzyme roles of thiamine, possibly involving thiamine-binding proteins. [less ▲]

Detailed reference viewed: 33 (3 ULg)