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See detailComparative analysis of cancer vaccine settings for the selection of an effective protocol in mice.
Conteduca, Giuseppina ULg

in Journal of Translational Medicine (2013), 12(11),

Background: Cancer vaccines are considered a promising therapeutic approach. However, their clinical results are not yet satisfactory. This may be due to the the difficulty of selection of an efficient ... [more ▼]

Background: Cancer vaccines are considered a promising therapeutic approach. However, their clinical results are not yet satisfactory. This may be due to the the difficulty of selection of an efficient tumor associated antigen (TAA) and immunization protocol. Indeed, the weak antigenicity of many TAA impairs the design of robust procedures, therefore a systematic analysis to identify the most efficient TAA is mandatory. Here, we performed a study to compare different gp100 vaccination strategies to identify the best strategy to provide a 100% protection against experimental melanoma in a reproducible manner. Methods: C57BL/6J mice were challenged subcutaneously with B16F10 melanoma cells, after vaccination with: a) mouse or human gp10025-33 peptide plus CpG adjuvant; b) mouse or human gp100 gene; c) mouse or human gp10025-33 peptide-pulsed dendritic cells (DC). Alternatively, a neutralizing anti-IL-10 monoclonal antibody (mAb) was subcutaneously administered at the site of tumor challenge to counteract regulatory cells. Finally, combinatorial treatment was performed associating human gp10025-33 peptide-pulsed DC vaccination with administration of the anti-IL-10 mAb. Results: Vaccination with human gp10025-33 peptide-pulsed DC was the most effective immunization protocol, although not achieving a full protection. Administration of the anti-IL-10 mAb showed also a remarkable protective effect, replicated in mice challenged with a different tumor, Anaplastic Large Cell Lymphoma. When immunization with gp10025-33 peptide-pulsed DC was associated with IL-10 counteraction, a 100% protective effect was consistently achieved. The analysis on the T-cell tumor infiltrates showed an increase of CD4+granzyme+ T-cells and a decreased number of CD4+CD25+Foxp3+ Treg elements from mice treated with either gp10025-33 peptide-pulsed DC vaccination or anti-IL-10 mAb administration. These data suggest that processes of intratumoral re-balance between effector and regulatory T cell subpopulations may play a critical protective role in immunotherapy protocols. Conclusions: Here we demonstrate that, in the setting of a cancer vaccine strategy, a comparative analysis of different personalized approaches may favour the unveiling of the most effective protocol. Moreover, our findings suggest that counteraction of IL-10 activity may be critical to revert the intratumoral environment promoting Treg polarization, thus increasing the effects of a vaccination against selected TAA. [less ▲]

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See detailA Comparative Analysis of Coffee Fair Trade Arena in Tanzania and Nicaragua
Pirotte, Gautier ULg; Pleyers, Geoffrey; Poncelet, Marc ULg

in Development in Practice (2006), 16(5),

Les activités de commerce équitable dans le Sud sont en général étudiées par rapport aux buts internes des organisations de commerce équitable elles-mêmes. Cet article soutient qu’il est également ... [more ▼]

Les activités de commerce équitable dans le Sud sont en général étudiées par rapport aux buts internes des organisations de commerce équitable elles-mêmes. Cet article soutient qu’il est également essentiel de prendre en compte l’“arène” ou ensemble d’interactions plus générales de commerce équitable. Les auteurs se concentrent sur les “arènes” du café commerce équitable de la Tanzanie et du Nicaragua et étudient le rôle de quatre acteurs clés : les petits producteurs, les coopératives, les partenaires de développement et les autorités publiques. En utilisant des données comparatives issues d’études sur le terrain menées en 2002 et 2003, cet article fait ressortir des questions clés nationales et internationales qui affectent les producteurs locaux. Illustrant l’évolution différente du commerce équitable selon le contexte, cet article examine la manière dont le mouvement des coopératives au Nicaragua a été consolidé par la production du commerce équitable, à la différence de la situation en Tanzanie. Il conclut en se penchant sur certains des défis auxquels se confronte le commerce équitable, y compris comment concilier les exigences du marché et le renforcement de la solidarité. [less ▲]

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See detailComparative analysis of kisspeptin-immunoreactivity reveals genuine differences in the hypothalamic Kiss1 systems between rats and mice.
Overgaard, Agnete; Tena-Sempere, Manuel; Franceschini, Isabelle et al

in Peptides (2013), 45

Kiss1 mRNA and its corresponding peptide products, kisspeptins, are expressed in two restricted brain areas of rodents, the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (ARC). The ... [more ▼]

Kiss1 mRNA and its corresponding peptide products, kisspeptins, are expressed in two restricted brain areas of rodents, the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (ARC). The concentration of mature kisspeptins may not directly correlate with Kiss1 mRNA levels, because mRNA translation and/or posttranslational modification, degradation, transportation and release of kisspeptins could be regulated independently of gene expression, and there may thus be differences in kisspeptin expression even in species with similar Kiss1 mRNA profiles. We measured and compared kisspeptin-immunoreactivity in both nuclei and both sexes of rats and mice and quantified kisspeptin-immunoreactive nerve fibers. We also determined Kiss1 mRNA levels and measured kisspeptin-immunoreactivity in colchicine pretreated rats. Overall, we find higher levels of kisspeptin-immunoreactivity in the mouse compared to the rat, independently of brain region and gender. In the female mouse AVPV high numbers of kisspeptin-immunoreactive neurons were present, while in the rat, the female AVPV displays a similar number of kisspeptin-immunoreactive neurons compared to the level of Kiss1 mRNA expressing cells, only after axonal transport inhibition. Interestingly, the density of kisspeptin innervation in the anterior periventricular area was higher in female compared to male in both species. Species differences in the ARC were evident, with the mouse ARC containing dense fibers, while the rat ARC contains clearly discernable cells. In addition, we show a marked sex difference in the ARC, with higher kisspeptin levels in females. These findings show that the translation of Kiss1 mRNA and/or the degradation/transportation/release of kisspeptins are different in mice and rats. [less ▲]

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See detailComparative analysis of large Nc QCD and quark model approaches to baryons
Buisseret, F.; Semay, C.; Stancu, Floarea ULg et al

in Acta Physica Polonica. B, Proceedings Supplement (2009), 2(2), 223-228

We show that a remarkable compatibility exists between the results of a potential model with constituent quarks and the 1/Nc expansion mass formula for strange and nonstrange baryon resonances. Such ... [more ▼]

We show that a remarkable compatibility exists between the results of a potential model with constituent quarks and the 1/Nc expansion mass formula for strange and nonstrange baryon resonances. Such compatibility brings support to the basic assumptions of relativistic quark models and sheds light on the physical content of the model-independent large Nc mass formula. Good agreement between both approaches is also found for heavy baryons, made of one heavy and two light quarks, in the ground state band. [less ▲]

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See detailComparative analysis of melting properties, polymorphic behavior and triacylglycerol composition of palm oil and fractions
Braipson, Sabine ULg; Gibon, Véronique; Deroanne, Claude

Conference (2007)

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See detailA comparative analysis of non-fickean thermodiffusion by EIT and GENERIC
Lebon, Georgy ULg; Desaive, Thomas ULg; Colinet, P.

in 1st international exergy, energy and environment symposium (2003)

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See detailComparative analysis of painting recipes: a new contribution to the study of the texts of the Strasbourg family
Neven, Sylvie ULg

in HERMENS, Erma; TOWNSEND, Joyce (Eds.) Sources and Serendipity. Testimonies of Artists’ Practice (2009)

For many years, the Strasbourg Manuscript was believed to be the oldest German-language source for the study of Northern European painting techniques. Unfortunately, the manuscript was lost in the 1870 ... [more ▼]

For many years, the Strasbourg Manuscript was believed to be the oldest German-language source for the study of Northern European painting techniques. Unfortunately, the manuscript was lost in the 1870 fire at the Strasbourg Library, and the text only survives in a 19th-century transcription made for Eastlake (1847). Studies such as those of Ploss and more recently those of Oltrogge have already highlighted the existence of texts with very similar contents, grouping them under the name of the ‘Strasbourg family’. Since these studies, a clearly defined corpus of manuscripts has been established as belonging to this family. This paper shows the different degrees of connection between the texts and presents some suggestions concerning their compilation process. The possibility of collating different versions of an identical text and cross-checking recipes can also be exploited to learn more about the ways in which recipe books were compiled, and to provide information concerning their use and function. [less ▲]

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See detailComparative analysis of the energy dissipation on a stepped spillway downstream of a Piano Key Weir
Silvestri, Aurélien ULg; Archambeau, Pierre ULg; Pirotton, Michel ULg et al

in Erpicum, Sébastien; Laugier, Frédéric; Pfister, Michael (Eds.) et al Labyrinth and Piano Key Weirs II - PKW 2013 (2014)

A systematic experimental study has been carried out to compare the residual energy at the toe of a stepped spillway of varied length considering a classical ogee-crested weir (OCW) or two different piano ... [more ▼]

A systematic experimental study has been carried out to compare the residual energy at the toe of a stepped spillway of varied length considering a classical ogee-crested weir (OCW) or two different piano key weirs (PKW) at the top of the structure. Four spillway lengths have been considered on a wide range of discharge. An indirect method has been used to compute the residual flow energy at the spillway toe from water depth measurements in a horizontal channel downstream. The results indicate that uniform flow conditions, i.e. flow energy at the spillway toe independent of the spillway length, are reached on significantly shorter spillways downstream of a PKW than downstream of an OCW. However, the uniform flow energy at constant discharge on the spillway is found to vary depending on the weir type. In particular, it is smaller downstream of the OCW than downstream of the PKWs. [less ▲]

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See detailA comparative analysis of the entrepreneurial profile of the rural entrepreneur: Moldavia region of Romania, Niger state in Nigeria and Camaguey region of Cuba
Paveliuc Olariu, Codrin ULg; Nwachukwu, Ifeanyi; Bover-Felices, Katia

in Advances in Agriculture & Botanics (2010), 2(1), 35-39

This paper presents a comparative analysis of the entrepreneurial profiles identified in three distinct regions from three countries: the historical region of Moldavia in Romania, known today as the ... [more ▼]

This paper presents a comparative analysis of the entrepreneurial profiles identified in three distinct regions from three countries: the historical region of Moldavia in Romania, known today as the North–East Development Region, Niger state in Nigeria and the Camaguey region in Cuba. In identifying the entrepreneurial profile of the rural entrepreneur statistical national, from every country, and international databases have been used (ex. INS, National Bureau of Statistics of Nigeria, La Oficina Nacional de Estadisticas de Cuba, EUROSTAT). Features regarding the environment of origin, level of studies, age, sex etc were identified. [less ▲]

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See detailComparative analysis of the lubricating power between a pure mineral oil and biodegradable oils of the same mean iso grade
Kabuya, A.; Bozet, Jean-Luc ULg

in Dowson, D.; Taylor, C. M.; Childs, T. H. C. (Eds.) et al Lubricants and lubrication : proceedings of the 21th Leeds-Lyon symposium on tribology held at the Institute of Tribology , University of Leeds U.K., 6th-9th September 1994 (1995)

n this paper, we compare the viscosimetric and tribological properties of some vegetable oils and one synthetic ester with a pure mineral oil. The viscosimetric characteristics of lubricants show that ... [more ▼]

n this paper, we compare the viscosimetric and tribological properties of some vegetable oils and one synthetic ester with a pure mineral oil. The viscosimetric characteristics of lubricants show that both vegetable oils and ester have a higher viscosity index than mineral oil. The test results show that all tested oils have a somewhat dilatant behaviour.The oiliness, antiwear and extreme pressure properties of lubricants have been studied respectively with a Stribeck machine and a four-ball machine. We have noted the following: On the four-ball machine, extreme pressure results expressed in terms of pressure wear index and mean hertz load show that the higher performance is obtained with the vegetable oils. Extreme pressure results expressed in terms of weld load, do not show a big difference between the tested oils. Antiwear results expressed in terms of wear scar show that die highest performances are obtained with vegetable oils. On the Stribeck machine, oiliness results expressed in terms of friction coefficient indicate that: in the regime of fluid lubrication, tested oils have me same behaviour; in die boundary lubrication regime, both vegetable oils and synthetic, ester have a better response uian mineral oil. [less ▲]

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See detailComparative analysis of the predictive capacity of breaching models for an overtopped rockfill dam
Dewals, Benjamin ULg; Archambeau, Pierre ULg; Erpicum, Sébastien ULg et al

in Proceedings of the International Workshop "Stability and Breaching of Embankment Dams" (2004)

The paper covers a brief description and a comprehensive comparative analysis of several state-of-the-art dam breaching models. The study is specifically focused on the applicability and on the predictive ... [more ▼]

The paper covers a brief description and a comprehensive comparative analysis of several state-of-the-art dam breaching models. The study is specifically focused on the applicability and on the predictive capacity of the models for the gradual breaching of an overtopped rockfill dam. A wide range of modelling techniques is reviewed, from process-oriented numerical simulations to empirical models. Comparisons are performed regarding various aspects, such as the applicability of the model without prior calibration or the possibility of coupling the breaching model with a quasi-3D flow solver such as WOLF. Finally, a sensitivity analysis of the downstream hydrograph to various parameters is conducted and the conclusions drawn are illustrated in the case of a large-scale real application in Belgium. [less ▲]

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See detailComparative analysis of the respiratory microbiota of healthy dogs and dogs with canine idiopathic pulmonary fibrosis
Roels, Elodie ULg; Taminiau, Bernard ULg; Darnis, Elodie ULg et al

in Journal of Veterinary Internal Medicine (2016, September)

Detailed reference viewed: 23 (3 ULg)