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See detailContribution of ATP-gated P2X1 ion channels to the control of neutrophil chemotaxis.
Lecut, Christelle ULg; Frederix, Kim ULg; Johnson, Daniel et al

in Purinergic Signalling (2008), 4

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See detailContribution of cobalt-mediated radical polymerization to macromolecular engineering and photodynamic therapy
Hurtgen, Marie ULg

Doctoral thesis (2011)

Cobalt-mediated radical polymerization (CMRP) is an emerging class of controlled radical polymerization technique based on the reversible deactivation of the propagating radicals by a cobalt complex. This ... [more ▼]

Cobalt-mediated radical polymerization (CMRP) is an emerging class of controlled radical polymerization technique based on the reversible deactivation of the propagating radicals by a cobalt complex. This thesis aims at broadening the nature, the structure, the properties and the end-use of (co)polymers accessible by CMRP. The first part of this work is devoted to the synthesis of novel statistical, graft and block copolymers by CMRP. First, the statistical copolymerization of conjugated (n-butyl acrylate) with a non-conjugated one (vinyl acetate) has been successfully controlled by bis(acetylacetonato)cobalt(II). The optimal experimental conditions were then implemented to the copolymerization of vinyl acetate with poly(ethylene glycol) acrylate, which yielded (quasi-)diblock amphiphilic graft copolymers for potential biomedical applications in one step. CMRP also revealed successful for the synthesis of well-defined thermo-responsive copolymers based on poly(N-vinylcaprolactam), either amphiphilic or double-hydrophilic at room temperature. In the second part of this thesis, we investigated the potential of CMRP for the synthesis of new agents for cancer photodynamic therapy. The synthesis of such photosensitizers relied on the chain-end functionalization by [60]fullerene of water-soluble (co)polymers (or precursors) prepared by CMRP. The photodynamic activity of poly(vinyl alcohol)/C60, poly(N-vinylpyrrolidone-co-vinyl acetate)/C60 and poly(PEG acrylate-co-vinyl acetate)/C60 nanohybrids were assessed through photophysical and in vitro experiments. Also, the ability of the nanohybrids to avoid recognition by the immune system was evaluated by a protein adsorption test. Finally, some hints on how to improve the synthesis of the nanohybrids - and therefore, their photodynamic activity - were provided by a mechanistic study of the grafting onto C60 of macroradicals released by cobalt end-capped polymers [less ▲]

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See detailContribution of combined carbohydrates to dissolved and particulate organic carbon after the spring bloom in the northern Bay of Biscay (North-Eastern Atlantic Ocean)
Engel, Anja; Harlay, Jérôme ULg; Piontek, Judith et al

in Continental Shelf Research (2012), 45

Two cruises were conducted after the diatom spring bloom in the northern Bay of Biscay (2006, 2007), to assess the contribution of combined carbohydrates to organic carbon partitioning. Partitioning of ... [more ▼]

Two cruises were conducted after the diatom spring bloom in the northern Bay of Biscay (2006, 2007), to assess the contribution of combined carbohydrates to organic carbon partitioning. Partitioning of total organic carbon (TOC) into particulate organic carbon (POC) and dissolved organic carbon (DOC) differed between the two years, particularly for depths above 60 m, and was related to the vernal development of the system: a post spring-bloom system in 2007, and a more stratified summer system with higher coccolithophore abundance in 2006. In general, contribution of POC to TOC ranged between 4 and 28% and decreased with depth. Concentration of high molecular weight (>1 kDa) dissolved combined carbohydrates (dCCHO) ranged from 0.6 to 1.4 µmol L−1 and contributed between 4 and 11% to DOC. Concentration of particulate combined carbohydrates (pCCHO) varied between 0.03 and 1.3 µmol L−1. A high contribution of pCCHO to POC was observed in 2007, i.e. 22–60% C compared to 3–10% C in 2006, and coincided with a higher abundance of transparent exopolymer particles (TEP). TEP accounted for 0.4–2.0 µmol C L−1 in 2007 and 0.5–1.5 µmol C L−1 in 2006. Above 60 m, differences in contribution of TEP-C to POC were most pronounced yielding 15.4±3.0% in 2007 compared to relatively low 4.8±1.4%, in 2006. TEP-C could explain about 60% in 2007 and about 40% of pCCHO-C in 2006. Hence, TEP were identified as a substantial component of pCCHO and POC, particularly in the wake of the spring bloom. Molecular composition of CCHO, i.e. HMW-dCCHO+pCCHO, revealed little difference between the years but strong variation over depth. Uronic acids (URA) were identified as a major component of CCHO (20–40%). Our study indicates that the distribution and composition of CCHO in surface seawater are determined by biogeochemical processes on a seasonal scale. A better knowledge of CCHO cycling and molecular signature has therefore a high potential for a better tracing of carbon dynamics in shelf sea ecosystems. [less ▲]

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See detailContribution of CT scan for lesions affecting the spine
Deudon, Pauline ULg; Peeters, Dominique ULg; Balligand, Marc ULg et al

Poster (2011, January 22)

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See detailContribution of cyclodextrins in the developement of different pharmaceutical formulations of a nex matrix metalloproteinase inhibitor
Evrard, Brigitte ULg; Bertholet, Pascal; Guéders, Maud ULg et al

in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry (2007), 57(1-4), 303-308

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors ... [more ▼]

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors progression and is potentially effective against bronchial remodeling in asthma and BPCO. Ro 28-2653 is very poorly soluble in water. This low solubility estimated at about 0.56 lg/ml in water at 25 C gives rise to difficulties in pharmaceutical formulation of oral, injectable or <br />nebulizable solutions. The purpose of our study is to prepare and to characterize inclusion complexes between Ro 28-2653 and cyclodextrins and to investigate the biopharmaceutical repercussion of the inclusion of the active substance.The complex formation was investigated by phase solubility studies. 1H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion <br />complex between Ro 28-2653 and cyclodextrin. Oral, intravenous and nebulizable solutions of Ro 28-2653 were developed with cyclodextrin. The in vivo studies were performed on healthy sheep for the pharmacokinetic evaluation of the oral and intravenous formulations while the nebulization of the complex solution was studied by using an asthma model in mouse. [less ▲]

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See detailContribution Of Delayed Autonomous Selfing To Reproductive Success In Kosteletzkya Virginica
Ruan, Cj.; Zhou, Lj.; Zeng, Fy. et al

in Belgian Journal of Botany (2008), 141(1), 3-13

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See detailContribution of dendrochronology to the study of droughts in northwestern France (late XIX-XXth century)
Planchon, Olivier; Dubreuil, Vincent; Bernard, Vincent et al

in Geophysical Research Abstracts (2007)

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See detailContribution of diversified farming systems to the delivery of ecosystem services
Boeraeve, Fanny ULg; Dufrêne, Marc ULg; Dendoncker, Nicolas

Conference (2015, May)

The present contribution introduces an innovative research project analyzing farms which have encompassed a transition towards more sustainability. The project being at its premise, we shall focus the ... [more ▼]

The present contribution introduces an innovative research project analyzing farms which have encompassed a transition towards more sustainability. The project being at its premise, we shall focus the presentation on the innovative aspects of the methodology and expected outcomes with a first introduction on the context and the theoretical framework relied on. [less ▲]

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See detailContribution of donors after cardiac death to the deceased donor pool: 2002 to 2009 university of liege experience.
Ledinh, H.; Meurisse, Nicolas ULg; Delbouille, Michèle ULg et al

in Transplantation Proceedings (2010), 42(10), 4369-72

OBJECTIVE: In this study, we have evaluated the organ procurement and transplantation activity from donors after cardiac death (DCD) at our institution over an 8-year period. Our aim was to determine ... [more ▼]

OBJECTIVE: In this study, we have evaluated the organ procurement and transplantation activity from donors after cardiac death (DCD) at our institution over an 8-year period. Our aim was to determine whether this program influenced transplantation programs, or donation after brain death (DBD) activity. METHODS: We prospectively collected our procurement and transplantation statistics in a database for retrospective review. RESULTS: We observed an increasing trend in potential and actual DCD number. The mean conversion rate turning potential into effective donors was 58.1%. DCD accounted for 16.6% of the deceased donor (DD) pool over 8 years. The mean age for effective DCD donors was 53.9 years (range, 3-79). Among the effective donors, 63.3% (n = 31) came from the transplant center and 36.7% (n = 18) were referred from collaborative hospitals. All donors were Maastricht III category. The number of kidney and liver transplants using DCD sources tended to increase. DCD kidney transplants represented 10.8% of the DD kidney pool and DCD liver transplants made up 13.9% of the DD liver pool over 8 years. The DBD program activity increased in the same time period. In 2009, 17 DCD and 33 DBD procurements were performed in a region with a little >1 million inhabitants. CONCLUSION: The establishment of a DCD program in our institution enlarged the donor pool and did not compromise the development of the DBD program. In our experience, DCD are a valuable source for abdominal organ transplantation. [less ▲]

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See detailContribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum
Dent, G.; Hadjicharalambous, C.; Yoshikawa, T. et al

in American Journal of Respiratory & Critical Care Medicine (2004), 169(10), 1110-1117

The CC chemokine eotaxin-1 (CCL11) is chemotactic for eosinophils, basophils, and type 2 helper T cells and may play a role in allergic inflammation. We investigated its contribution as an eosinophil ... [more ▼]

The CC chemokine eotaxin-1 (CCL11) is chemotactic for eosinophils, basophils, and type 2 helper T cells and may play a role in allergic inflammation. We investigated its contribution as an eosinophil chemoattractant in asthmatic airway secretions (sampled as induced sputum), which possess chemotactic activity for eosinophils and T cells. Sputum samples collected from healthy subjects and subjects with mild, stable-moderate, unstable-moderate, and severe asthma were processed with phosphate-buffered saline and assayed for eotaxin by ELISA and for eosinophil chemotactic activity by fluorescence-based chemotaxis assay. The contribution of eotaxin to chemotactic activity was studied by using a high-affinity neutralizing human anti-eotaxin antibody, CAT-213. Sputum eotaxin concentration was significantly raised in moderate and severe asthma (p < 0.05 versus healthy control subjects) but not in mild asthma. Chemotactic activity was significantly increased in all asthmatic groups relative to healthy subjects (p < 0.05) and was significantly inhibited by CAT-213 (1100 nM) in subjects with moderate and severe asthma, with median inhibition of 52% (p < 0.05), 78% (p < 0.0001), and 86% (p < 0.0001), respectively, in samples representing stable-moderate, unstable-moderate, and severe asthma. Eotaxin contributed to the eosinophil chemotactic activity of sputum from subjects with more severe forms of asthma but not mild asthma, suggesting that its contribution is more important in more severe disease. This activity is inhibited significantly by CAT-213. [less ▲]

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See detailContribution of epigenetic alteration of BRCA1 and BRCA2 genes in breast carcinomas in Tunisian patients
Ben Gacem, Riadh; Hachana, Mohamed Ridha ULg; Ziadi, Sonia et al

in Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology (2011)

Objective: The aim of this study was to evaluate the contribution of the BRCA1 and BRCA2 promoter methylation in the pathogenesis of sporadic breast cancer in Tunisian patients. Methods: Breast carcinoma ... [more ▼]

Objective: The aim of this study was to evaluate the contribution of the BRCA1 and BRCA2 promoter methylation in the pathogenesis of sporadic breast cancer in Tunisian patients. Methods: Breast carcinoma tissues (n=117) and available paired normal breast tissues (n=65) from Tunisian women who had no family history were investigated for the methylation status of BRCA1 and BRCA2 promoters using methylation-specific PCR. Breast specimens from women without carcinoma (16 fibroadenomas and 5 mastopathies) were used as control. Results: Hypermethylation of BRCA1 and BRCA2 promoters was detected respectively in 60.7% and 69.2% of the carcinoma tissues, and in only 7.7% and 4.6% of the paired normal breast tissues. None of the fibroadenomas and mastopathies showed hypermethylation. Correlations were found between BRCA1 and BRCA2 hypermethylation and decrease in their mRNA expression (p=0.02 and p=0.009, respectively). Moreover, BRCA1 methylation correlates with patients age (p=0.01) and triple negative (ER-, PR-, HER2-) tumors (p=0.01). Patients with methylated BRCA1 and/or BRCA2 had a significant prolonged survivals compared to those with unmethylated tumors (p=0.002). Conclusion: Our results suggest an important role of BRCA1 and BRCA2 promoter methylation in breast cancer development in the Tunisian population. [less ▲]

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See detailThe contribution of ERS1 SAR data in neotectonics
Cornet, Yves ULg; Ozer, Pierre ULg

in Guyenne, T. D. (Ed.) Proceedings of the Second ERS Applications Workshop, London, UK, 6-8 December 1995 (1996)

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See detailThe contribution of ethnoarchaeological macro- and microscopic wear traces to the understanding of archaeological hide-working processes
Beyries, Sylvie; Rots, Veerle ULg

in Longo, Laura; Della Riva, Martina (Eds.) Proceedings of the Congress "Prehistoric Technology: 40 years later. Functional Studies and the Russian Legacy" (2008)

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See detailThe contribution of familiarity to within- and between-domain associative recognition memory: Use of a modified remember/know procedure
Bastin, Christine ULg; Van der Linden, Martial ULg; Schnakers, Caroline ULg et al

in European Journal of Cognitive Psychology (2010), 22(6), 922-943

The purpose of the present study was to determine the extent to which familiarity can support associative recognition memory as a function of whether the associations are within- or between-domain ... [more ▼]

The purpose of the present study was to determine the extent to which familiarity can support associative recognition memory as a function of whether the associations are within- or between-domain. Standard recognition and familiarity only performance were compared in different participants, using a new adaptation of the remember/know procedure. The results indicated that within-domain (face face) associative recognition was mainly supported by familiarity. In contrast, familiarity provided relatively poor support to between-domain (face name) associative recognition for which optimal performance required a major recollection contribution. These findings suggest that familiarity can support associative recognition memory, particularly for within-domain associations, and contrast with the widely held view that associative recognition depends largely on recollection. [less ▲]

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See detail[Contribution of functional neuroimaging studies to the understanding of the mechanisms of general anesthesia]
Boveroux, P.; Bonhomme, V.; Kirsch, M. et al

in Revue medicale de Liege (2008), 64

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See detailContribution of GC×GC TOFMS to tobacco analysis
Brokl, Michal ULg; Bishop, Louise; Wright, Christopher et al

Scientific conference (2011, September 21)

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See detailContribution of GC×GC-TOFMS to tobacco analysis
Brokl, Michal ULg; Bishop; Liu et al

Conference (2012, January)

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See detailContribution of glycoproteomics in the search for accessible biomarkers in human lymphoma
Kischel, Philippe; Greffe, Yannick; Waltregny, David ULg et al

Scientific conference (2008)

Detailed reference viewed: 15 (2 ULg)