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See detailLe CRP et ses opérateurs : les usages de la confiance
Remy, Céline ULg

Conference (2013, December 12)

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See detailCrp of Streptomyces Coelicolor Is the Third Transcription Factor of the Large Crp-Fnr Superfamily Able to Bind Camp
Derouaux, Adeline ULg; Dehareng, Dominique ULg; Lecocq, Elke et al

in Biochemical and Biophysical Research Communications (2004), 325(3), 983-90

The chromosomal inactivation of the unique transcription factor of Streptomyces coelicolor that displays a cyclic-nucleotide-binding domain, Crp(Sco), led to a germination-defective phenotype similar to ... [more ▼]

The chromosomal inactivation of the unique transcription factor of Streptomyces coelicolor that displays a cyclic-nucleotide-binding domain, Crp(Sco), led to a germination-defective phenotype similar to the mutant of the adenylate cyclase gene (cya) unable to produce cAMP. By means of cAMP affinity chromatography we demonstrate the specific cAMP-binding ability of Crp(Sco), which definitely demonstrate that a Cya/cAMP/Crp system is used to trigger germination in S. coelicolor. However, electromobility shift assays with the purified Crp(Sco)-cAMP complex and the CRP-like cis-acting element of its own promoter failed. Moreover, we were unable to complement an Escherichia coli crp mutant in trans with Crp(Sco). The fact that Vfr from Pseudomonas aeruginosa and GlxR from Corynebacterium glutamicum could complement such an E. coli mutant suggests that the way Crp(Sco) interacts with DNA should mechanistically differ from its most similar members. This hypothesis was further supported by homology modelling of Crp(Sco) that confirmed an unusual organisation of the DNA-binding domain compared to the situation observed in Crp(Eco). [less ▲]

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See detailA crucial role forlung interstitial macrophages in preventing airway allergy
Bedoret, Denis; Wallemacq, Hugues ULg; Marichal, Thomas ULg et al

in Short book of the Annual Congress of the European Respiratory Society (ERS), Vienne (2009)

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See detailCrucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channel
Weatherall, Kate; Seutin, Vincent ULg; Liégeois, Jean-François ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2011), 108(45), 18488-18493

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See detailCrucial role of reversible phosphorylation in the mechanisms governing the biological functions of class IIa Histone Deacetylases
Martin, Maud ULg

Doctoral thesis (2009)

Regulation of class IIa histone deacetylases (HDACs) phosphorylation is crucial because it provides the opportunity to control important developmental processes associated with these key enzymes. Indeed ... [more ▼]

Regulation of class IIa histone deacetylases (HDACs) phosphorylation is crucial because it provides the opportunity to control important developmental processes associated with these key enzymes. Indeed, the transcriptional repressor activity of class IIa HDAC is controlled via their phosphorylation-dependent nucleo-cytoplasmic shuttling. While a lot of efforts have been directed towards the identification of the inactivating kinases that phosphorylate class IIa HDACs, the identity of the antagonist phosphatase remained an open question. During this work, we found that protein phosphatase 2A (PP2A) is responsible for dephosphorylating the class IIa HDACs member HDAC7, thereby regulating its subcellular localization and repressor activity. In order to validate our model, functional consequences of these findings was illustrated during the two main biological processes involving HDAC7, i.e. T-cells apoptosis during negative selection and endothelial cells angiogenic activities during vascular network formation. Cellular PP2A represents a large population of trimeric holoenzymes containing a variable regulatory subunit, whose identity has a crucial role in determining the specificity of PP2A catalytic activity. In an effort to characterize the regulation of HDAC7 dephopshorylation, we identified the relevant PP2A holoenzyme regulating HDAC7 function during vasculogenesis and we found that, among diverse regulatory subunit isoforms, PP2A-Bα uniquely regulates endothelial cell angiogenic properties. PP2A-Bα silencing using small interfering RNAs results in a significant inhibition of endothelial cell tube formation and migration. These results establish PP2A, and more precisely the Bα containg PP2A holoenzyme, as an essential element in the regulation of the class IIa HDACs HDAC7 and unravel a first developmental function for the PP2A regulatory subunit Bα in the genesis of blood vessels. [less ▲]

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See detailCrucial role of the amino-terminal tyrosine residue 42 and the carboxy-terminal PEST domain of IkappaBalpha in NF-kappaB activation by an oxidative stress
Schoonbroodt, Sonia; Ferreira, V.; Best-Belpomme, Martin et al

in Journal of Immunology (2000)

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See detailCrude oil bioremediation in sub-Antarctic intertidal sediments: chemistry and toxicity of oiled residues
Pelletier, Emilien; Delille, Daniel; Delille, Bruno ULg

in Marine Environmental Research (2004), 57(4), 311-327

The effectiveness of fertilizers for crude oil bioremediation in sub-Antarctic intertidal sediments was tested over a one-year period in a series of ten (10) experimental enclosures. Chemical, microbial ... [more ▼]

The effectiveness of fertilizers for crude oil bioremediation in sub-Antarctic intertidal sediments was tested over a one-year period in a series of ten (10) experimental enclosures. Chemical, microbial and toxicological parameters demonstrated the effectiveness of various fertilizers in a pristine environment where hydrocarbon degrading bacteria (HDB) had not been stimulated by previous accidental spills or human activities. The low temperature of seawater (3-4 degreesC) had no obvious effects on the HDB community and the bioremediation process. Over 90% of n-alkanes were degraded in the first six months and most light aromatics (2-3 rings) disappeared during the first year of observation. The toxicity of oiled residues (Microtox(R) SP) was significantly reduced in the first 6 months of the process, but it increased again in the last months of the experiment. One of the fertilizers containing fishbone compost enriched with urea, inorganic phosphorus and a lipidic surfactant reduced significantly the toxicity of oil residues in the last 3 months of the experiment. Interstitial waters collected below the oil slicks during the remediation showed no toxicity, and even stimulated Vibrio fischeri. When comparing all fertilizers to the control plots, a good correlation (r(2) = 0.82) was found between the growth rate of HDB and the degradation rate of n-alkanes in the first 90 days of the experiment only indicating that fertilizers were efficient for at least 3 months but their beneficial effects were lost after 6 months. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailCRUE DU GAZ CARBONIQUE DANS L'AIR DES GROTTES
Godissart, Jean; Ek, Camille ULg

in EcoKarst (2009)

Carbone dioxide in cave air is strongly increasing for at least forty years.

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See detailCrues, travaux d'aménagement, options futures et modélisations dynamiques
Lejeune, André ULg; Pirotton, Michel ULg

in Voies navigables intérieures et prévention des inondations (1995)

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See detailCrural artery bypass with the autogenous greater saphenous vein
Van Damme, Hendrik ULg; Zhang, Lihong ULg; Baguet, E. et al

in European Journal of Vascular and Endovascular Surgery : The Official Journal of the European Society for Vascular Surgery (2003), 26(6), 635-642

Objective. To evaluate the long-term outcome of greater saphenous vein (GSV) infrapopliteal revascularisation in a single centre over a 10 year period. Material and methods. Fourty-one variables relating ... [more ▼]

Objective. To evaluate the long-term outcome of greater saphenous vein (GSV) infrapopliteal revascularisation in a single centre over a 10 year period. Material and methods. Fourty-one variables relating to a consecutive series of 90 crural artery GSV(76% in situ) bypasses in 81 patients (1990-2000) were analysed. The mean age of the 47 men and 34 women was 70 years. Limb-threatening ischaemia was present in 96% of cases, claudication in four patients. In 18 patients, surgery was 'redo'. Results. The perioperative mortality was 3% (n = 3). Patient survival was 54% at 4 years. Independent risk factors affecting survival were chronic renal insufficiency (p = 0.04), hypertension (p = 0.02), and ischaemic heart disease (p = 0.01). Four bypasses thrombosed within 30 days. Three of them could be successfully reopened. Mean follow-up was 39 months. The primary patency rate at 4 years was 80%. Chronic renal insufficiency revealed to be the single independent risk factor for graft thrombosis (p = 0.03, RR = 12.4). The 4-year limb salvage rate was 88%. No independent risk factor affecting the limb salvage could be identified. Conclusion. Crural artery revascularisation is a valuable option for the management of limb threatening infrapopliteal arterial occlusive disease. [less ▲]

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See detailCrural or pedal artery revascularisation for limb salvage: is it justified
Van Damme, Hendrik ULg

in Acta Chirurgica Belgica (2004), 104(2), 148-157

With the ageing of population, the incidence of limb-threatening ischemia increases. In chronic critical limb ischemia, peripheral arterial occlusive disease almost always involves infrainguinal and ... [more ▼]

With the ageing of population, the incidence of limb-threatening ischemia increases. In chronic critical limb ischemia, peripheral arterial occlusive disease almost always involves infrainguinal and infragenicular vessels. Fortunately, recent advances in vascular surgery made arterial reconstruction of crural and pedal vessels possible. Should crural or pedal bypass surgery be offered to these frail, polyvascular patients, or is primary amputation a preferable treatment option in case of advanced limb-threatening ischemia? In order to answer this controversial question, the author analysed recent literature data on the feasibility and durability of infrapopliteal bypasses. The quality of life was also considered as an outcome measure. Finally, the cost-effectiveness of both treatment modalities (limb-saving distal bypass versus primary amputation) was assessed. [less ▲]

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See detailThe crustacean scavenger guild in Antarctic shelf, bathyal and abyssal communities
De Broyer, Claude; Nyssen, Fabienne ULg; Dauby, Patrick ULg

in Deep-Sea Research Part II, Topical Studies in Oceanography (2004), 51(14-16), 1733-1752

Peracarid crustaceans form a significant part of the macrobenthic community that is responsible for scavenging on large food falls onto the sea floor. Although several studies are available about ... [more ▼]

Peracarid crustaceans form a significant part of the macrobenthic community that is responsible for scavenging on large food falls onto the sea floor. Although several studies are available about scavengers from tropical and temperate seas, very little information has been published about such species living in Antarctic waters, particularly at greater depths. The present paper is based on a collection of 31 baited trap sets deployed in the Weddell Sea, Scotia Sea, and off the South Shetland Islands, and presents results on the geographical and bathymetric distribution of the different taxa and on the eco-functional role of scavengers. <br /> <br />Some 68,000 peracarid crustaceans from 62 species were collected. About 98% of individuals belonged to the amphipod superfamily Lysianassoidea, and 2% to the isopod family Cirolanidae. Of these species, 31, including 26 lysianassoids (1400 individuals), were collected deeper than 1000 m. <br /> <br />High species richness was discerned for the eastern Weddell Sea shelf compared with other Antarctic areas. The Antarctic slope also seems to be richer in species than other areas investigated in the world, while in the abyss, scavenger species richness appears to be lower in Antarctica. A richness gradient was thus observed from the shelf to the deep. For amphipods, a number of species extend their distribution from the shelf to the slope and only one to the abyssal zone. <br /> <br />Amphipod species showed degrees of adaptation to necrophagy. The functional adaptations of the mandible and the storage function of the gut are discussed. Feeding experiments conducted on lysianassoid species collected at great depths and maintained in aquaria showed a mean feeding rate of about 1.4–4.1% dry body weight day−1, which is consistent with data obtained from other species. [less ▲]

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See detailThe crustal tongue melting model and the origin of massive anorthosites
Duchesne, Jean-Clair ULg; Liégeois, Jean-Paul ULg; Vander Auwera, Jacqueline ULg et al

in Terra Nova (1999), 11

Recent detailed field studies in several anorthosite complexes have shown that anorthosites are frequently linked with weakness zones in the crust which favour their emplacement at mid-crust levels ... [more ▼]

Recent detailed field studies in several anorthosite complexes have shown that anorthosites are frequently linked with weakness zones in the crust which favour their emplacement at mid-crust levels. Recent experimental data have also shown that the parent magma compositions of various anorthosite massifs lie on thermal highs in the relevant phase diagrams, indicating that these magmas cannot be derived by fractionation of peridotitic mantle melts but rather are produced by melting of gabbronoritic sources. In the Sveconorwegian province terrane boundaries have been traced in deep seismic profiles to Moho offsets or to tongues of lower crustal material underthrust to depths of 40-50 km. We therefore suggest that the parent magmas of anorthosite massifs are produced by melting of gabbronoritic rocks from the lower crust that had been thrust into the mantle by collision of terranes. [less ▲]

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See detailCryo-optical test of the PLANCK reflectors
Roose, Stéphane ULg; Cucchiaro, Antonio ULg

Conference (2006, March 20)

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See detailCryo-optical testing of large aspheric reflectors operating in the sub mm range
Roose, Stéphane ULg; Houbrechts, Yvette ULg; Mazzoli, Alexandra ULg et al

in Zhang, Y.; Jiang, W.; Cho, M. (Eds.) Proceedings of the 2nd SPIE symposium on Advanced Optical Manufacturing and Testing Technologies (2005, August)

The cryo-optical testing of the PLANCK primary reflector (elliptical off-axis CFRP reflector of 1550 mm x 1890 mm) is one of the major issue in the payload development program. It is requested to measure ... [more ▼]

The cryo-optical testing of the PLANCK primary reflector (elliptical off-axis CFRP reflector of 1550 mm x 1890 mm) is one of the major issue in the payload development program. It is requested to measure the changes of the Surface Figure Error (SFE) with respect to the best ellipsoid, between 293 K and 50 K, with a 1 μm RMS accuracy. To achieve this, Infra Red interferometry has been used and a dedicated thermo mechanical set-up has been constructed. This paper summarises the test activities, the test methods and results on the PLANCK Primary Reflector - Flight Model (PRFM) achieved in FOCAL 6.5 at Centre Spatial de Liege (CSL). Here, the Wave Front Error (WFE) will be considered, the SFE can be derived from the WFE measurement. After a brief introduction, the first part deals with the general test description. The thermo-elastic deformations will be addressed: the surface deformation in the medium frequency range (spatial wavelength down to 60 mm) and core-cell dimpling. [less ▲]

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See detailCryogenic and Thermal Control for Vacuum Facilities Development in KARI
Guiot, Marc ULg; Jamotton, Pierre ULg; Grodent, Christophe ULg et al

in CURRAN (Ed.) 26th Aerospace Testing Seminar 2011: Los Angeles, California, USA, 29 - 31 March 2011 (2011, March 29)

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See detailCryogenic Zone Compression for the Measurement of Dioxins
Focant, Jean-François ULg; Patterson Jr

Scientific conference (2010, April)

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See detailCryogenic Zone Compression for the Measurement of Dioxins in Human Serum at Attogram Level by GCxGC-IDHRMS.
Patterson Jr; Welch; Turner et al

Conference (2008, June)

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