24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.

in Journal of Clinical Investigation (1995), 95(4), 1464-71

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in ... [more ▼]

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in reducing blood glucose levels than continuous administration, nine normal young men were each studied on two occasions during a 28-h period including a period of polygraphically recorded sleep. Endogenous insulin secretion was suppressed by somatostatin, a constant intravenous glucose infusion was administered, and exogenous insulin was infused either at a constant rate or in a sinusoidal pattern with a period of 120 min. The mean glucose level over the 28-h period was 0.72 +/- 0.31 mmol/liter lower when insulin was infused in an oscillatory pattern than when the rate of infusion was constant (P < 0.05). The greater hypoglycemic effect of oscillatory versus constant infusion was particularly marked during the daytime, with the difference averaging 1.04 +/- 0.38 mmol/liter (P < 0.03). Serum insulin levels tended to be lower during oscillatory than constant infusion, although the same amount of exogenous insulin was administered under both conditions. Ultradian insulin oscillations appear to promote more efficient glucose utilization. [less ▲]

25-OH vitamin D deficiencies and secondary hyperparathyroidism in elderly women living at home or in nursing/retirement homes

in Osteoporosis International (1996), 6(S1), 119

2500 years record of trace element metal in the Misten peat bog (Hautes Fagnes), Belgium

Poster (2011, April 08)

The Misten peat bog provides a record of atmospheric deposition in the Hautes Fagnes Plateau (East Belgium). A composite 185cm core (W01/01b) was studied for its trace metal content (TM) and its lead ... [more ▼]

The Misten peat bog provides a record of atmospheric deposition in the Hautes Fagnes Plateau (East Belgium). A composite 185cm core (W01/01b) was studied for its trace metal content (TM) and its lead isotopic signature. The peat bog accumulation allows following the history of atmospheric TM deposition during the last 2500 years. TM enrichment factors coupled with a continuous decrease in 206Pb/204Pb, 207Pb/204Pb,208Pb/204Pb isotopic ratios from 494-732AD to1969-1977 AD evidence the increasing importance of TM released by anthropogenic activities. The highest concentrations of TM are found near the surface of the bog; at depths from 30 to 19 cm. Historical records of Cu, Zn, As, Sb, and Pb atmospheric flux during the Industrial Revolution and pre-industrial periods were derived. Maximum fluxes (up to 7.3, 89, 2.4, 1.5, and 116 mg.m-2.y-1, respectively) occurred in peat layers dated from 1619-1877AD to 1992-2000AD, reflecting anthropogenic emissions from diverse sources such as mining, coal combustion, and emissions from the use of leaded gasoline. The TM enrichment factors also increased significantly during the Industrial Revolution until a reduction at the end of the 70’S due to the progressive abolition of the leaded gasoline. [less ▲]

26. Assessment of Cleanliness requirements for space optical instruments; Proc. of the Third International Symposium on Environmental Testing for Space Programmes, ESTEC, 24-27-6-97, SP-408, August 1997.

(1997)

26th Chicago Annual Gospel Music Festival

Article for general public (2010)

28 milliards d’euros, c’est grand comment ?

Article for general public (2009)

J’ouvre mon quotidien. Fortis : 28 milliards d’euros de pertes en 2008. Ma fille de sept ans qui commence à lire et pose sans cesse des questions sur tout me lance : « Dis-moi, papa : 28 milliards d’euros ... [more ▼]

J’ouvre mon quotidien. Fortis : 28 milliards d’euros de pertes en 2008. Ma fille de sept ans qui commence à lire et pose sans cesse des questions sur tout me lance : « Dis-moi, papa : 28 milliards d’euros, c’est grand comment ? ». Grande question… Je réfléchis et tente de trouver une parade parlante pour un enfant qui, in fine, se pose les mêmes questions que les grandes personnes. [less ▲]

29. Lessons learned from the thermal design of an instrument (EIT, the Extreme-UV Imaging Telescope) on board SOHO

in IAF (1997)

A 295-Kda Intermediate Filament-Associated Protein in Radial Glia and Developing Muscle Cells in Vivo and in Vitro

in Developmental Dynamics : An Official Publication of the American Association of Anatomists (2000), 219(4), 514-25

The RC2 antibody is frequently used to label mouse radial glial cells in all parts of the nervous system where neuronal migration occurs during embryonic and early postnatal life. The antigen recognized ... [more ▼]

The RC2 antibody is frequently used to label mouse radial glial cells in all parts of the nervous system where neuronal migration occurs during embryonic and early postnatal life. The antigen recognized by this antibody still needs to be identified. We have characterized further its localization in vivo, its expression and subcellular localization in vitro, as well as its molecular nature. Histologic investigations of whole mouse embryos reveal an equally intense expression of RC2 immunostaining in radial glial cells in brain and spinal cord and in skeletal muscle. In glial cells cultures, the RC2 antibody recognizes an epitope located on the glial cytoskeleton and identified as an intermediate filament associated protein (IFAP) at the ultrastructural level. RC2 immunostaining in those cells is strongly dependent on the presence of a serum-derived activity. Serum-removal causes a decrease of the staining while adding serum back to the cells induces reexpression of RC2 immunoreactivity. By Western blotting, we find that in intermediate filament (IF) preparations obtained from cultured cerebellar glia, the RC2 antibody recognizes a 295-kDa protein whose expression is also dependent on the presence of serum in culture medium. In developing muscle cells, RC2 immunostaining is observed from the myoblast stage and disappears after complete myotube fusion. Both in vivo and in vitro, staining is first seen as a loose capping around myoblasts nuclei and progressively concentrates into Z-disks in association with the muscle IF protein desmin. The RC2 antibody also recognizes a 295-kDa protein band in muscle tissue protein extracts. Thus, the RC2 antibody recognizes a developmentally regulated cytoskeletal protein that is expressed, like other previously identified IFAPs, by cells of the glial and myogenic lineages and whose expression in vitro seems to be controlled by a signaling mechanism known to modulate astroglial morphology. [less ▲]

2D and 3D groundwater simulations to interpret tracer tests results in heterogeneous geological contexts

in Kranjc, A. (Ed.) Tracer Hydrology 97 (1997)

2D cellular automata for turbulent convection

in Gruber, R.; Tomassini, M. (Eds.) Proceedings of the 6th Joint EPS-APS International Conference on Physics Computing. PC'94. Physics Computing '94 (1994)

A cellular automaton (CA) formulation is devised to simulate 2-dimensional Rayleigh-Benard convection. The model is tested in the case of a standard plane-parallel shallow configuration for which ... [more ▼]

A cellular automaton (CA) formulation is devised to simulate 2-dimensional Rayleigh-Benard convection. The model is tested in the case of a standard plane-parallel shallow configuration for which analytical solutions of the hydrodynamical formulation are available at low enough Rayleigh numbers. If we use a measure of the intensity of gravity, k, as our free parameter (the analogue of the Rayleigh number), all other model parameters being fixed, then we can reproduce the well-known stationary roll-pattern predicted by the hydrodynamic theory at low k values. At higher k values the model exhibits a nonstationary turbulent flow pattern. Our formulation is extended to less trivial geometries for which an analytic treatment in the usual hydrodynamic context is not feasible. Besides geometry-constrained stationary patterns of motion in a range of low k values, this model exhibits again turbulent motions at higher k values [less ▲]