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See detailCurrent options for the management of postmenopausal osteoporosis.
LECART, Marie-Paule ULg; Reginster, Jean-Yves ULg

in Expert Opinion on Pharmacotherapy (2011), 12(16), 2533-52

INTRODUCTION: Osteoporosis is a well-recognized disease with severe consequences if left untreated. The prevention of osteoporosis-associated fractures should include fall prevention, calcium ... [more ▼]

INTRODUCTION: Osteoporosis is a well-recognized disease with severe consequences if left untreated. The prevention of osteoporosis-associated fractures should include fall prevention, calcium supplementation and life-style advice, as well as pharmacological therapy using agents with proven antifracture efficacy. AREAS COVERED: This manuscript offers an evidence-based critical assessment of the currently available efficacy data on all new chemical entities that have been granted a marketing authorization for the management of primary osteoporosis in women. EXPERT OPINION: The availability of new therapeutic agents makes clinical decision making in osteoporosis more complex. Therapeutic decisions should be based on a balance between the benefits and risks of treatment, which must be carefully considered in each particular case, both by the physician and the patient. Indeed, no single agent is appropriate for all patients. Therefore, treatment decisions should be made on a tailor-made basis, taking into account all measures of treatment effect and risk, before making informed judgments about the best individual treatment option. [less ▲]

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See detailCurrent Pericopsis elata (Fabaceae) patches in southeastern Cameroon: remnants of a long and rich Human-rainforest relationship?
Bourland, Nils ULg; Cerisier, François; Livingstone Smith, Alexandre et al

Poster (2012, June 23)

Pericopsis elata is one of the most valuable African timber species. This IUCN Red Listed tree suffers from a lack of regeneration, thus its current presence provokes questioning. Our work aimed at ... [more ▼]

Pericopsis elata is one of the most valuable African timber species. This IUCN Red Listed tree suffers from a lack of regeneration, thus its current presence provokes questioning. Our work aimed at understanding its origins so as to help securing its future. This study, lead away from engineering works, was conducted in four different sites located within the natural distribution area of the species and taking into account the different growing conditions were the species occurs. Our observations are based on an analysis of charcoal elements and pottery fragments discovered in subsurface layers of soils as well as current botanical and pedological surveys. Evidence of past human activities we found led to the assumption that this part of the Congo Basin was much more inhabited than previously thought. Some of the results obtained for P. elata could apply for other long lived light demanding species growing in the same environment [less ▲]

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See detailCurrent perspectives on developmental dysphasias
Rondal, Jean-Adolphe ULg; Comblain, Annick ULg

in Journal of Neurolinguistics (1999), 12(3-4), 181-212

This paper documents the major difficulties observed in the oral language development of individuals with mental retardation of genetic origin. The extent of inter- and within-syndrome variability is ... [more ▼]

This paper documents the major difficulties observed in the oral language development of individuals with mental retardation of genetic origin. The extent of inter- and within-syndrome variability is evaluated. More specifically, a comparative analysis of typical language phenotypes in several genetic syndromes is attempted and the possible brain underpinnings of the observed differences are envisaged. Recent cases of favorable language development in individuals with mental retardation are summarized and explanatory variables are discussed. [less ▲]

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See detailCurrent perspectives on microwave-enhanced reactions of monosaccharides promoted by heterogeneous catalysts.
Richel, Aurore ULg; Laurent, Pascal ULg; Wathelet, Bernard ULg et al

in Catalysis Today (2011), 167

Involvment of heterogeneous catalysts as promoters of carbohydrate conversions, in synergy with microwaves as the heating source, is reported. This paper deals with the application of ion-exchange resins ... [more ▼]

Involvment of heterogeneous catalysts as promoters of carbohydrate conversions, in synergy with microwaves as the heating source, is reported. This paper deals with the application of ion-exchange resins, zeolites, clays and metal oxides as convenient mediators for key transformations of carbohydrates. A special emphasis is placed on the use of (doped) mineral supports, in solventless conditions, as clean promoters in combination with microwave dielectric heating. [less ▲]

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See detailCurrent position of information technology applications in agricultural information dissemination - Belgium
Carletti, G.; Claustriaux, Jean-Jacques ULg

in Houseman, C. I. (Ed.) Agriculture : the green telematics challenge (1989)

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See detailCurrent Post Harvest Practices to Avoid Insect Attacks on Stored Grains in Northern Cameroon
Ngamo, Tinkeu S.L.; Ngassoum, Martin B.; Mapongmestsem, Pierre M. et al

in Agricultural Journal (2007), 2(2), 242-247

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See detailCurrent practices in antinuclear antibody testing: results from the Belgian External Quality Assessment Scheme.
Van Blerk, Marjan; Van Campenhout, Christel; Bossuyt, Xavier et al

in Clinical Chemistry & Laboratory Medicine (2009), 47(1), 102-8

BACKGROUND: This study aimed to assess the state-of-the-art of antinuclear antibody (ANA) testing as practiced in the Belgian and Luxembourg laboratories, using the results obtained in the Belgian ... [more ▼]

BACKGROUND: This study aimed to assess the state-of-the-art of antinuclear antibody (ANA) testing as practiced in the Belgian and Luxembourg laboratories, using the results obtained in the Belgian National External Quality Assessment Scheme from 2000 to 2005. METHODS: During this period, nine samples with different specificities were sent for analysis. Participants were surveyed for methodology used and were asked to report staining pattern and titer of ANAs. In 2002, an attempt was made to improve the comparability of quantitative ANA results by the provision of a commercial reference material and to relate observed differences to methodology. RESULTS: With one exception, all participants employed a microscope-based indirect immunofluorescence assay with human epithelial cell line 2 cells. Most laboratories were accurate in describing the pattern. The percentage of unacceptable answers was greater for samples with borderline levels of antibody and for samples showing a cytoplasmic pattern. An improvement in the detection of anticentromere antibodies was observed. For all samples, a wide range of titers was reported. The provision of the secondary reference preparation led to improved inter-laboratory concordance. Comparison of methodology variables revealed a correlation between unstandardized titers and the power of the lamp of the microscope and the use of a dark room. CONCLUSIONS: The EQAS results presented in this work provide valuable insights into the state of the art of ANA testing as practiced in the Belgian and Luxembourg Laboratories and illustrate the important value of a national EQAS for ANA testing as a tool to improve performance and interlaboratory comparability of laboratory results. [less ▲]

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See detailCurrent Practices of Organ Donation and Transplantation Among Different French-Speaking Countries and Regions
SQUIFFLET, Jean-Paul ULg; Barrou, B.; Rifle, G.

in Transplantation Proceedings (2011), 43

The aim of the “Transplantation Sans Frontières” (TSF) questionnaire, which was sent to <br />French-speaking centers in 6 different countries and regions, was to establish the current <br />status of ... [more ▼]

The aim of the “Transplantation Sans Frontières” (TSF) questionnaire, which was sent to <br />French-speaking centers in 6 different countries and regions, was to establish the current <br />status of organ donation and transplantation in their environments. It was also to examine <br />ways to collaborate and exchange scientific information, teaching, and training in the field <br />of organ transplantation. The French Society of Transplantation and the Agency of <br />Biomedicine already offer specific programs to expand local activities, and the World <br />Health Organization (WHO) regulates them. Therefore, TSF could be a coordinating <br />platform in the near future. [less ▲]

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See detailThe current quark mass and the regularisation of the Nambu-Jona-Lasinio action
Jaminon, Martine ULg; Ripka, Georges; Stassart, Pierre ULg

in Physics Letters B (1989), 227

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See detailCurrent research in Sport Pedagogy
Cloes, Marc ULg

Conference (2012, October 20)

Sport pedagogy is a discipline aimed at providing scientific data on the education and training in the different contexts in the field of sport and physical activity: education, coaching, recreation ... [more ▼]

Sport pedagogy is a discipline aimed at providing scientific data on the education and training in the different contexts in the field of sport and physical activity: education, coaching, recreation, rehabilitation … Using traditionally descriptive, correlational and experimental approaches, it is focused as much on the main actors (participants and educators) than on contents or on curricula. Its main objectives consist to improve the knowledge and the field practice of the physical educators and their trainers. Most studies in sport pedagogy are conducted in the school context as physical education remains a central concern of researchers. Nevertheless, since two decades, the place of the science of coaching grows slowly while researches in leisure and rehabilitation are still quite rare. In parallel, physical activity and the fight against one sedentary lifestyle became really important in the preoccupations of most of the researchers. Moreover, two important concepts are developing nowadays: accountability and literacy. This underlines that physical educators are expected to meet the goals that modern society emphasizes: efficiency and effectiveness. Quality is now regularly identified as a priority or even a prerequisite. Current researches in sport pedagogy is become complex as they mobilize more and more often complementary approaches taking into account all the involved actors and environment. Moreover, subjects became central with the development of action researches and communities of practices. [less ▲]

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See detailCurrent role of glucosamine in the treatment of osteoarthritis
Reginster, Jean-Yves ULg; Bruyère, Olivier ULg; Neuprez, Audrey

in Rheumatology (2007), 46(5), 731-735

Objectives. To evaluate the interest of using the various preparations of glucosamine for symptomatic and structural management of osteoarthritis (OA). Methods. A critical analysis of the literature based ... [more ▼]

Objectives. To evaluate the interest of using the various preparations of glucosamine for symptomatic and structural management of osteoarthritis (OA). Methods. A critical analysis of the literature based on an exhaustive search (Medline, PubMed and manual search within the bibliography of retrieved manuscripts) from 1980 to 2005. Results. Despite multiple controlled clinical trials of the use of glucosamine in OA (mainly of the knee), controversy on efficacy related to symptomatic improvement continues. Differences in results originate from the differences in products, study design and study populations. Symptomatic efficacy described in multiple studies performed with glucosamine sulphate (GS) support continued consideration in the OA therapeutic armamentarium. The most compelling evidence of a potential for inhibiting the progression of OA is also obtain with GS. Conclusions. GS has shown positive effects on symptomatic and structural outcomes of knee OA. These results should not be extrapolated to other glucosamine salts [hydrochloride or preparations (over-the-counter or food supplements)] in which no warranty exists about content, pharmacokinetics and pharmacodynamics of the tablets. [less ▲]

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See detailCurrent roles for allogeneic hematopoietic cell transplantation following nonmyeloablative or reduced-intensity conditioning.
Baron, Frédéric ULg; Storb, Rainer

in Clinical Advances in Hematology & Oncology (2005), 3(10), 799-819

Nonmyeloablative and reduced-intensity conditioning regimens followed by allogeneic hematopoietic cell transplantation (HCT) have been evaluated in patients with hematologic malignancies who were not ... [more ▼]

Nonmyeloablative and reduced-intensity conditioning regimens followed by allogeneic hematopoietic cell transplantation (HCT) have been evaluated in patients with hematologic malignancies who were not considered candidates for conventional HCT because of age or medical comorbidities and in selected patients with metastatic renal cell carcinoma. The regimens have relied more on graft-versus-tumor effects than on chemoradiation therapy to facilitate engraftment and eradicate malignant cells. While nonmyeloablative HCT has been associated with reduced regimen-related toxicities and has been curative for a number of patients with hematologic malignancies, challenges have remained in regard to graft-versus-host disease, infections, and disease progression. In this article, we review data from a number of published phase I and II studies that describe the results of allogeneic HCT after nonmyeloablative conditioning. [less ▲]

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See detailThe current situation of pesticides use in developing countries: problems and solutions
Wynn, Nigel; Deuse, J.P.L.; Schiffers, Bruno ULg et al

Report (1996)

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See detailThe current situation of wild mammals in Belgium: an outline
Libois, Roland ULg

in Hystrix: the Italian Journal of Mammalogy (1996), 8(1-2), 35-41

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better ... [more ▼]

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better understanding of the current status of the different species. Conservation measures were olso proposed to the political authorities who thereafter edicted a legal protection of the most vulnerable species. Unfortunately, habitat protection is rather unachieved and the situation of the most endangered species is still getting worse. [less ▲]

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See detailCurrent status of brain imaging in sleep medicine
Maquet, Pierre ULg

in Sleep Medicine Reviews (2005), 9(3), 155-156

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See detailCurrent Status of fluoride salts to treat postmenopausal osteoporosis
Reginster, Jean-Yves ULg; Paul, I.; Gosset, Christiane ULg

in Current Opinion in Orthopaedics (1998), 9(V), 7-10

Fluoride has been used over the past 25 years as a potential treatment of established osteoporosis. Notwithstanding a consensus over its ability to stimulate bone formation, discrepant results were ... [more ▼]

Fluoride has been used over the past 25 years as a potential treatment of established osteoporosis. Notwithstanding a consensus over its ability to stimulate bone formation, discrepant results were published relating to its antifracture efficacy. Differences in the published results are likely to be linked to therapeutic regimens, fluoride formulation, and the nature of the treated populations. A critical review of the published data evaluating the antifracture efficacy of fluoride leads to the conclusion that this substance should be mainly used in postmenopausal women with low bone mineral density without prevalent fracture, that low-dose fluoride for a prolonged period should be preferred to high doses for short-term treatment, and that gastroresistant preparations are likely to be better tolerated than fluoride. [less ▲]

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See detailCurrent status of hematopoietic stem cell transplantation after nonmyeloablative conditioning
Baron, Frédéric ULg; Sandmaier, B. M.

in Current Opinion in Hematology (2005), 12(6), 435-443

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See detailCurrent status of scrapie. CAB review for Perspectives in Agriculture
Saegerman, Claude ULg; Vanopdenbosch, E.; Berkvens, D.

in CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources (2007), 2(027),

Despite being controlled in many developed countries, scrapie remains endemic in many parts of the world. Economic losses result from mortality and culling of small ruminants and from market restrictions ... [more ▼]

Despite being controlled in many developed countries, scrapie remains endemic in many parts of the world. Economic losses result from mortality and culling of small ruminants and from market restrictions. Moreover, it is difficult to develop all-inclusive guidelines that could establish a scrapie-free status for a country. Unfortunately, the global picture remains incomplete because in many countries confusion still remains regarding the clinical picture of scrapie and information is not available owing to the absence of adequate epidemiosurveillance networks. Currently, the predominant theory is that PrPSc is the infectious agent where host genetic factors play a central role. The precise transmission routes of scrapie and their relative contributions to the overall transmission intensity remain poorly documented and the physiopathology is not fully understood. However, it is evident that the purchase of female sheep from scrapie flocks, sharing pastures with scrapie flocks, sharing breeding rams and genetic host susceptibility are the main risk factors for the spread of the disease. A better understanding of the epidemiology of scrapie would greatly aid the development and evaluation of control and eradication strategies that were mainly based on selective depopulation of infected animals and genetically susceptible and/or related animals and also on the biosecurity and the use of selective genetic breeding programmes in healthy flocks. Some numbers of a new transmissible spongiform encephalopathy (TSE) form in small ruminants (atypical scrapie) have meanwhile been identified by TSE rapid testing using an assay, which also recognizes comparatively less proteinase K-resistant PrPSc. Uncertainties remain regarding the pathogenesis of this new TSE form, as well as regarding its potential transmissibility within the affected species and to other species. Thus far, no bovine spongiform encephalopathy (BSE) cases have been confirmed in sheep under natural conditions (a report of vertical transmission after experimental infection merits attention), but two historical cases of BSE in goats born in the 1990s have been identified. Currently BSE must also be considered in the differential diagnosis of scrapie. The development of prevention and control programmes should be assisted by new scientific findings. [less ▲]

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See detailCurrent status of transmissible spongiform encephalopathies in ruminants
Thiry, Etienne ULg; Saegerman, Claude ULg; Xambeu, Laurence et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2004), 8

Detailed reference viewed: 33 (3 ULg)