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See detailContribution of Pet Scanning to the Evaluation of Abdominal Aortic Aneurysm
Sakalihasan, Natzi ULg; Hustinx, Roland ULg; Limet, Raymond ULg

in Seminars in Vascular Surgery (2004), 17(2), 144-53

The size of abdominal aortic aneurysms (AAA) is the most usual predictor of the risk for rupture. Because chronic metalloproteinases production and activation by inflammatory cells causes degradation of ... [more ▼]

The size of abdominal aortic aneurysms (AAA) is the most usual predictor of the risk for rupture. Because chronic metalloproteinases production and activation by inflammatory cells causes degradation of elastin and collagen in the aneurysmal wall, the detection of an increased metabolic process preceding fissuration and rupture could be a more sensitive predictor of rupture risk. We investigated the metabolic activity of the aneurysmal wall by whole-body positron emission tomography (PET) in 26 patients with a documented AAA (mean diameter 63 mm, extremes 45 mm and 78 mm). A positive (18)F-fluorodeoxyglucose ((18)F-FDG) uptake at the level of the AAA was observed in 38% of the cases (10 of 26 patients). Nine of these 10 patients required emergent or urgent aneurysmectomy for ruptured (n = 1), leaking (n = 1), rapidly expanding (n = 2), or painful (n = 5) aneurysms; the negative (18)F-FDG uptake patients had a more benign course. This preliminary study suggests a possible correlation between (18)F-FDG uptake by the aneurysm wall and the triggering of processes leading to rupture. The (18)F-FDG uptake in the aneurysm wall may correspond to the accumulation of inflammatory cells responsible for the production and activation of degrading enzymes. PET scan seems useful in high-risk patients. Positive PET imaging in these cases would help us to decide to proceed with surgery, despite factors favoring a surveillance strategy. [less ▲]

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See detailContribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions.
Cosemans, Judith M E M; Kuijpers, Marijke J E; Lecut, Christelle ULg et al

in Atherosclerosis (2005), 181(1), 19-27

Collagens (types I and III) are among the strongest thrombus-forming components of the vascular subendothelium. We compared the thrombogenic effects of four collagen-containing advanced atherosclerotic ... [more ▼]

Collagens (types I and III) are among the strongest thrombus-forming components of the vascular subendothelium. We compared the thrombogenic effects of four collagen-containing advanced atherosclerotic lesions with those of purified types I and III collagen fibers. Cell-free homogenates from the human plaques effectively promoted platelet adhesion and aggregate formation under high-shear flow conditions, as well as exposure of procoagulant phosphatidylserine (PS) on platelets. With all plaques, blocking of the glycoprotein VI (GPVI) receptor for collagen abolished aggregation and PS exposure. Blocking of platelet ADP receptors resulted in similar, but less complete inhibitory effects. Type I collagen was more potent than type III collagen in inducing aggregation and PS exposure under flow, via stimulation of GPVI and ADP receptors. Type I collagen also more strongly enhanced thrombin generation with platelets and tissue factor, again via GPVI activation and PS exposure. The plaque material enhanced thrombin generation, partly due to the presence of tissue factor and partly via GPVI and ADP receptors. Together, these results indicate that in advanced plaques collagen type I is a major trigger of thrombus formation and PS exposure, acting via GPVI and ADP release, while tissue factor directly enhances coagulation. [less ▲]

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See detailContribution of polyalky(meth)acrylates to the design of PVC melt viscosity
Vankan, R.; Fayt, Roger; Jérôme, Robert ULg et al

in Polymer Engineering & Science (1996), 36(12), 1675-1684

The shear viscosity of poly(vinylchloride) (PVC) at 200°C can be decreased by at least one order of magnitude by the addition of as little as 5 wt% poly n-alkyl-(meth)acrylates (PMA) of a much lower ... [more ▼]

The shear viscosity of poly(vinylchloride) (PVC) at 200°C can be decreased by at least one order of magnitude by the addition of as little as 5 wt% poly n-alkyl-(meth)acrylates (PMA) of a much lower dynamic viscosity than PVC. For this effect to be observed, the polymeric additive must be immiscible with PVC at 200°C. The average size of the dispersed phases is observed in the range of 0.5 to 5 m; size fluctuation in this domain has no significant effect. When these conditions are met, there is a linear increase in the shear viscosity ratio blend/PVC from 0.2 to 1.0 with increasing logarithmic values of the dynamic viscosity ratio of the additive over PVC [(log(/)) from -4 to -1]. [less ▲]

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See detailContribution of positron emission tomography in pleural disease.
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Larock, Marie-Paule ULg et al

in Revue des Maladies Respiratoires (2010), 27(8), 47-53

INTRODUCTION: Positron emission tomography (PET) now plays a clear role in oncology, especially in chest tumours. We discuss the value of metabolic imaging in characterising pleural pathology in the light ... [more ▼]

INTRODUCTION: Positron emission tomography (PET) now plays a clear role in oncology, especially in chest tumours. We discuss the value of metabolic imaging in characterising pleural pathology in the light of our own experience and review the literature. BACKGROUND: PET is particularly useful in characterising malignant pleural pathologies and is a factor of prognosis in mesothelioma. Metabolic imaging also provides clinical information for staging lung cancer, in researching the primary tumour in metastatic pleurisy and in monitoring chronic or recurrent pleural pathologies. CONCLUSIONS: PET should therefore be considered as a useful tool in the diagnosis of liquid or solid pleural pathologies. [less ▲]

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See detailContribution of postero-anterior cephalometry in obstructive sleep apnea.
POIRRIER, Anne-Lise ULg; Pire, Sylvie; Raskin, Sylviane et al

in The Laryngoscope (2012), 122(10), 2350-4

OBJECTIVES/HYPOTHESIS: Lateral cephalometry has been widely used to characterize facial and maxillary morphology in obstructive sleep apnea (OSA) patients. It is a useful tool to assess orthodontic and ... [more ▼]

OBJECTIVES/HYPOTHESIS: Lateral cephalometry has been widely used to characterize facial and maxillary morphology in obstructive sleep apnea (OSA) patients. It is a useful tool to assess orthodontic and maxillofacial procedures, but transverse dimensions of the airway (e.g., nasal framework) have not been well described yet by cephalometry. We explored whether postero-anterior cephalometry could refine the analysis of the facial morphology, with a special attention paid to nasal morphology. We validated cephalometric measurements relevant to the diagnosis of OSA. STUDY DESIGN: Controlled study. METHODS: We explored postero-anterior and lateral cephalometric bony structures in OSA patients and in control subjects to determine which were predictive of an association with OSA. Healthy volunteers paired for age and sex to OSA patients underwent polysomnography and cephalometry. Data were analyzed by Shapiro-Wilk, Fisher, Wilcoxon, and paired t tests where appropriate. RESULTS: Nasal fossae and maxillary bone proportions were positively and independently associated with the absence of OSA. Measurements of maxillary width, nasal fossae angle, and anterior skull base contributed to the characterization of OSA patients. CONCLUSIONS: Postero-anterior cephalometry is an easy, rapid, informative, and reliable technique, which is complementary to the lateral cephalometry in the assessment of OSA patients. Our study may also suggest the negative impact of the nasal resistance on the upper airway resistance in sleep disorders. [less ▲]

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See detailThe contribution of primary care to health and health systems in low- and middle-income countries: a critical review of major primary care initiatives.
Kruk, Margaret Elizabeth; Porignon, Denis ULg; Rockers, Peter C. et al

in Social science & medicine (1982) (2010), 70(6), 904-11

It has been 30 years since the Declaration of Alma Ata. During that time, primary care has been the central strategy for expanding health services in many low- and middle-income countries. The recent ... [more ▼]

It has been 30 years since the Declaration of Alma Ata. During that time, primary care has been the central strategy for expanding health services in many low- and middle-income countries. The recent global calls to redouble support for primary care highlighted it as a pathway to reaching the health Millennium Development Goals. In this systematic review we described and assessed the contributions of major primary care initiatives implemented in low- and middle-income countries in the past 30 years to a broad range of health system goals. The scope of the programs reviewed was substantial, with several interventions implemented on a national scale. We found that the majority of primary care programs had multiple components from health service delivery to financing reform to building community demand for health care. Although given this integration and the variable quality of the available research it was difficult to attribute effects to the primary care component alone, we found that primary care-focused health initiatives in low- and middle-income countries have improved access to health care, including among the poor, at reasonably low cost. There is also evidence that primary care programs have reduced child mortality and, in some cases, wealth-based disparities in mortality. Lastly, primary care has proven to be an effective platform for health system strengthening in several countries. Future research should focus on understanding how to optimize the delivery of primary care to improve health and achieve other health system objectives (e.g., responsiveness, efficiency) and to what extent models of care can be exported to different settings. [less ▲]

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See detailThe contribution of processing fluency to preference : a comparison with familiarity-based recognition
Willems, Sylvie ULg; Van der Linden, Martial ULg; Bastin, Christine ULg

in European Journal of Cognitive Psychology (2007), 19(1), 119-140

There is a great deal of evidence supporting the idea that, when a stimulus is processed fluently, it is more likely to be judged as pleasant. However, this influence of fluency on preference judgement ... [more ▼]

There is a great deal of evidence supporting the idea that, when a stimulus is processed fluently, it is more likely to be judged as pleasant. However, this influence of fluency on preference judgement seems to depend on several experimental conditions. So we tried to better understand these conditions via a comparison with recognition and by manipulating some aspects of the procedure (test format) and material (similarity and figure-ground contrast of the stimuli). Two experiments showed that some conditions maximally induce the use of processing fluency in a preference judgement, as in a recognition task. We discuss the implications of these findings for the well-documented discrepancy-attribution hypothesis (Whittlesea [less ▲]

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See detailThe contribution of recollection and familiarity to recognition memory : A study of the effects of test format and aging
Bastin, Christine ULg; Van der Linden, Martial ULg

in Neuropsychology (2003), 17(1), 14-24

Whether the format of a recognition memory task influences the contribution of recollection and familiarity to performance is a matter of debate. The authors investigated this issue by comparing the ... [more ▼]

Whether the format of a recognition memory task influences the contribution of recollection and familiarity to performance is a matter of debate. The authors investigated this issue by comparing the performance of 64 young (mean age = 21.7 years; mean education = 14.5 years) and 62 older participants (mean age = 64.4 years; mean education = 14.2 years) on a yes–no and a forced-choice recognition task for unfamiliar faces using the remember– know–guess procedure. Familiarity contributed more to forced-choice than to yes–no performance. Moreover, older participants, who showed a decrease in recollection together with an increase in familiarity, performed better on the forced-choice task than on the yes–no task, whereas younger participants showed the opposite pattern. [less ▲]

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See detailThe contribution of recollection and familiarity to recognition memory performance in chronic pain patients
Grisart, Jacques; Van der Linden, Martial ULg; Bastin, Christine ULg

in Behaviour research and therapy (2007), 45

This study examines the selective impact of chronic pain on memory functioning in a recognition task. Thirty chronic pain patients and 30 healthy control subjects performed a yes–no word recognition test ... [more ▼]

This study examines the selective impact of chronic pain on memory functioning in a recognition task. Thirty chronic pain patients and 30 healthy control subjects performed a yes–no word recognition test. The contribution of recollection and familiarity to both groups’ performance was compared by means of the Remember/Know (R/K) procedure, which distinguishes recognition based on the recollection of the encoding episode (R responses) and recognition accompanied by a feeling of familiarity (K responses). Chronic pain patients showed a decrease in recollection together with an increase in familiarity: indeed, they reported less R and more K responses than control subjects. This pattern of performance was not related to the overall recognition ability. These findings are consistent with the hypothesis of the attentional cost of chronic pain, suggesting a selective impact of chronic pain on the most attention-demanding cognitive processes, such as recollection. This study emphasises the relevance of specific procedures distinguishing the underlying components of memory functioning rather than solely global indicators. [less ▲]

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See detailContribution of reticular nuclei in the pathophysiology of parkinsonian rigidity
Delwaide, Paul ULg; PEPIN, Jean-Louis ULg; MAERTENS DE NOORDHOUT, Alain ULg

in Narabayashi, H.; Nagatsu, T.; yanagisawa, N. (Eds.) et al Advances in Neurology - Vol 60 (1993)

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See detailContribution of Revised International Prognostic Scoring System Cytogenetics to Predict Outcome After Allogeneic Stem Cell Transplantation for Myelodysplastic Syndromes: A Study From the Socie 0 te0 FranO´ aise de Greffe de Moelle et The 0 rapies Cellulaires
Gauthier, Jordan; Damaj, Gandhi; Langlois, Carole et al

in Transplantation (in press)

Background. The prognosis of myelodysplastic syndromes (MDS) after allogeneic stem cell transplantation is critically determined by cytogenetic abnormalities, as previously defined by International ... [more ▼]

Background. The prognosis of myelodysplastic syndromes (MDS) after allogeneic stem cell transplantation is critically determined by cytogenetic abnormalities, as previously defined by International Prognostic Scoring System (IPSS) cytogenetics. It has been shown that a new cytogenetic classification, included in the IPSS-R (cytogenetic-IPSS-R [C-IPSS-R]), can better predict the outcome of untreated MDS patients.Methods. In this study, we assessed the impact of the IPSS-R cytogenetic score (C-IPSS-R) on the outcome of 367 MDS patients transplanted from HLA-identical siblings or HLA allele-matched unrelated donors. Results. According to the C-IPSS-R, 178 patients (48%) fell in the good risk, 102 (28%) in the intermediate risk, 77 (21%) in the poor risk, and 10 (3%) in the very poor risk group. In multivariate analysis, after a median follow-up of 4 years, the poor and very poor-risk categories correlated with shorter overall survival (OS) (4-year OS, 32%; hazard ratio [HR], 1.59; P = 0.009 and OS, 10%; HR, 3.18; P = 0.002, respectively) and higher cumulative incidence of relapse (CIR) (CIR, 52%; HR, 1.82; P = 0.004 and CIR, 60%; HR, 2.44; P = 0.060, respectively). Conclusions. Overall, the C-IPSS-R changed the IPSS cytogenetic risk only in 8% of cases but identified a new risk group, the very poor C-IPSS-R category, with dismal outcome after allogeneic stem cell transplantation (10% 4-year OS, 60% 4-year CIR). Posttransplantation maintenance therapy should be investigated in prospective trials for patients with high-risk C-IPSS-R karyotypes. [less ▲]

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See detailContribution of Robotic Surgery to Gynecologic Oncology
GOFFIN, Frédéric ULg

Conference (2012, September 14)

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See detailContribution of SAR interferometry (from ERS1/2) in the study of aeolian transport processes : The cases of Niger, Mauritania and Morocco
Bodart, Catherine; Gassani, Jean; Salmon, Marc ULg et al

in Marini, Alberto; Talbi, Mohamed (Eds.) Desertification and risk analysis using high and medium resolution satellite data (2009)

In order to face desertification and sand encroachment of inter dunes depressions, as well as to protect soils in the area of Gouré (Southeast Niger) where it is possible to have food plantations, it is ... [more ▼]

In order to face desertification and sand encroachment of inter dunes depressions, as well as to protect soils in the area of Gouré (Southeast Niger) where it is possible to have food plantations, it is essential to localize the origin and drift of sands. This paper shows that radar satellite remote sensing and interferometry offers the opportunity to gather all the required information. Digital Elevation Models (DEM) generated by interferometry on ERS 1-2 SAR images (a tandem pair acquired on April 25 and 26 1996) helped to collect information on relief and provided an aeolian model, while giving some insight into the spatial distribution of sand formations. Interpreting the interferometric coherent image by means of a color composite allowed detecting and locating sand movements in the areas under study. This project mainly highlights the contribution of SAR interferometry in the study of sand movements by developing added-value products. Interpretations were validated using highresolution satellite data (SPOT 5, IKONOS, and QUICKBIRD) and field observations made during a campaign in Niger in March 2004. The same procedure was also applied in Mauritania using two tandem pairs (2–3 November 1995 and 7–8 December 1995) and in Southern Morocco (18–19 May 1996) in order to identify active dunes in these regions. These observations will be taken into account when analyzing ENVISAT-ASAR data. [less ▲]

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See detailContribution of Services of General Interest
Gathon, Henry-Jean ULg; Sluse, Myriam ULg; Anghinelli, Stefania et al

Report (2004)

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See detailThe contribution of short-term memory for serial order to early reading acquisition: Evidence from a longitudinal study
Martinez Perez, Trecy ULg; Majerus, Steve ULg; Poncelet, Martine ULg

in Journal of Experimental Child Psychology (2012), 111

Early reading acquisition skills have been linked to verbal short-term memory (STM) capacity. However, the nature of this relationship remains controversial, since verbal STM, like reading acquisition ... [more ▼]

Early reading acquisition skills have been linked to verbal short-term memory (STM) capacity. However, the nature of this relationship remains controversial, since verbal STM, like reading acquisition, depends upon the complexity of underlying phonological processing skills. This longitudinal study addressed the relation between STM and reading decoding acquisition by distinguishing between STM for item and STM for order information, based on recent studies showing that STM for item information recruits underlying phonological representations, but not STM for order information. If there is a specific link between STM and reading decoding acquisition, STM for order information should be an independent predictor of reading decoding acquisition. Tasks maximizing STM for serial order or item information, measures of phonological abilities and reading tests were administered to children followed from kindergarten through 1st grade. We observed that order STM capacity but not item STM capacity predicted independent variance in reading decoding abilities one year later. These results highlight the specific role of STM for order in reading decoding acquisition, and argue for a causal role of order STM capacity in reading acquisition. Mechanisms relating STM for order information and reading acquisition will be discussed. [less ▲]

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See detailContribution of sleep to memory consolidation
Shaffii-Le Bourdiec, Anahita; Muto, Vincenzo ULg; Mascetti, Laura et al

in Future Neurology (2010), 5(2), 325-338

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