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See detailComparative value of post-remission treatment in cytogenetically normal AML subclassified by NPM1 and FLT3-ITD allelic ratio.
Versluis, J.; In 't Hout, F. E. M.; Devillier, R. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2016)

Post-remission treatment (PRT) in patients with cytogenetically normal (CN) acute myeloid leukemia (AML) in first complete remission (CR1) is debated. We studied 521 patients with CN-AML in CR1, for whom ... [more ▼]

Post-remission treatment (PRT) in patients with cytogenetically normal (CN) acute myeloid leukemia (AML) in first complete remission (CR1) is debated. We studied 521 patients with CN-AML in CR1, for whom mutational status of NPM1 and FLT3-ITD was available, including the FLT3-ITD allelic ratio. PRT consisted of reduced intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (alloHSCT) (n=68), myeloablative conditioning (MAC) alloHSCT (n=137), autologous hematopoietic stem cell transplantation (autoHSCT) (n=168) or chemotherapy (n=148). Favorable overall survival (OS) was found for patients with mutated NPM1 without FLT3-ITD (71+/-4%). Outcome in patients with a high FLT3-ITD allelic ratio appeared to be very poor with OS and relapse-free survival (RFS) of 23+/-8% and 12+/-6%, respectively. Patients with wild-type NPM1 without FLT3-ITD or with a low allelic burden of FLT3-ITD were considered as intermediate-risk group because of similar OS and RFS at 5 years, in which PRT by RIC alloHSCT resulted in better OS and RFS as compared with chemotherapy (hazard ratio (HR) 0.56, P=0.022 and HR 0.50, P=0.004, respectively) or autoHSCT (HR 0.60, P=0.046 and HR 0.60, P=0.043, respectively). The lowest cumulative incidence of relapse (23+/-4%) was observed following MAC alloHSCT. These results suggest that alloHSCT may be preferred in patients with molecularly intermediate-risk CN-AML, while the choice of conditioning type may be personalized according to risk for non-relapse mortality.Leukemia advance online publication, 15 July 2016; doi:10.1038/leu.2016.183. [less ▲]

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See detailComparative virucidal efficacy of seven disinfectants against murine norovirus and feline calicivirus, surrogates of human norovirus
Zonta, William ULg; Mauroy, Axel ULg; Farnir, Frédéric ULg et al

in Food and Environmental Virology (2016)

Human noroviruses (HuNoV) are the leading cause of acute nonbacterial gastroenteritis in humans and can be transmitted either by person-to-person contact or by consumption of contaminated food. Knowledge ... [more ▼]

Human noroviruses (HuNoV) are the leading cause of acute nonbacterial gastroenteritis in humans and can be transmitted either by person-to-person contact or by consumption of contaminated food. Knowledge of an efficient disinfection for both hands and food contact surfaces is helpful for the food sector and provides precious information for public health. The aim of this study was to evaluate the effect of seven disinfectants belonging to different groups of biocides (alcohol, halogen, oxidizing agents, quaternary ammonium compounds, aldehyde and biguanide) on infectious viral titre and on genomic copy number. Due to the absence of a cell culture system for HuNoV, two HuNoV surrogates such as murine norovirus (MNV) and feline calicivirus (FCV), were used and the tests were performed in suspension, on gloves and on stainless steel discs. When, as criteria of efficacy, a log reduction > 3 of the infectious viral titre on both surrogates and in the three tests is used, the most efficacious disinfectants in this study appear to be biocidal products B, C and D, representing the halogens, the oxidizing agents group and a mix of QAC, alcohol and aldehyde, respectively. In addition, these three disinfectants also elicited a significant effect on genomic copy number for both surrogate viruses and in all three tests. The results of this study demonstrate that a halogen compound, oxidizing agents and a mix of QAC, alcohol and aldehyde are advisable for HuNoV disinfection of either potentially contaminated surfaces or materials in contact with foodstuffs. [less ▲]

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See detailA comparative, Randomized trial of Concentration-Controlled Sirolimus Combined With Reduced-Dose Tacrolimus or Standard-Dose Tacrolimus in Renal Allograft Recipients
Bechstein, W.O; Paczeck, L; Wramner, L et al

in Transplantation Proceedings (2013), 45

The clinical safety and efficacy of sirolimus plus reduced-dose tacrolimus was evaluated in de novo renal allograft recipients enrolled in a comparative, open-label study. Methods. One hundred twenty ... [more ▼]

The clinical safety and efficacy of sirolimus plus reduced-dose tacrolimus was evaluated in de novo renal allograft recipients enrolled in a comparative, open-label study. Methods. One hundred twenty-eight renal allograft recipients were randomly assigned (1:1) to receive reduced-dose tacrolimus plus sirolimus (rTAC) or standard-dose tacrolimus and sirolimus (sTAC) for 6 months. The primary efficacy endpoint was calculated creatinine clearance values at 6 months. Results. Demographic variables were similar between groups. At 6 months, mean ( standard deviation) calculated creatinine clearance was significantly improved in the rTAC group (63.8 vs 52.7 mL/min, P ¼ .005), although mean serum creatinine values were not significantly different. Patient survival (95.2% and 96.9%) and graft survival (93.7% and 98.5%) were similar between the rTAC and sTAC groups, respectively. Acute rejection rates were 17.5% with rTAC and 7.7% with sTAC (P ¼ .095). Conclusions. The rTAC regimen provided effective immunosuppression and was associated with improved creatinine clearance. Adequate immunosuppressant exposure must be achieved in the early postoperative period to minimize the risk of acute rejection. [less ▲]

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See detailCOMPARATIVE-STUDY OF DIFFERENT BAMBOO PULPS
TSHIAMALA, T.; FRAIPONT, L.; Paquot, Michel ULg et al

in Holzforschung : International Journal of the Biology, Chemistry, Physics, & Technology of Wood (1984), 38(5), 281-288

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See detailComparator selection for RPC with many labels
Hiard, Samuel ULg; Geurts, Pierre ULg; Wehenkel, Louis ULg

in ECAI 2012 : 20th European Conference on Artificial Intelligence : 27-31 August 2012, Montpellier, France (2012, August)

The Ranking by Pairwise Comparison algorithm (RPC) is a well established label ranking method. However, its complexity is of O(N²) in the number N of labels. We present algorithms for selection, before ... [more ▼]

The Ranking by Pairwise Comparison algorithm (RPC) is a well established label ranking method. However, its complexity is of O(N²) in the number N of labels. We present algorithms for selection, before model construction, a subset of comparators of size O(N), to reduce the computational complexity without loss in accuracy. [less ▲]

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See detailCompared anatomy of the locomotor system : a website
Noble, Prisca ULg; Collin, Bernard ULg; Denoix, Jean-Marie

in Anatomia, Histologia, Embryologia (2010, July 28), 39(4), 275

Introduction: This website is a multi-dimensional approach of the locomotor system in domestic animals. The first objective of this anatomical presentation is to establish relation between systemic ... [more ▼]

Introduction: This website is a multi-dimensional approach of the locomotor system in domestic animals. The first objective of this anatomical presentation is to establish relation between systemic anatomy and topographic anatomy. The second objective is to teach a practical anatomy that must be adapted to the clinician work. Methods: From the dissection of equine, bovine and canine specimens, osteology, arthrology and myology (OAM) were photographed and filmed. All photos and movies were captioned and designed using Fireworks (Adobe CS4, USA), AVS video converter 6 (MediaTechnologies Ltd, UK) and Divx Author (Divx Inc, USA). The website was designed using Dreamweaver (Adobe CS4, USA). Results: Compared anatomy site consists on dichotomously organised web pages. Each page is transversally and vertically connected with others, and always surmounted by a navigation barr. From the navigation barr we can travel through different drop-down menus (DDM). The first DDM corresponds to the lesson menu (it sends to general OAM) ; the second and third DDMs correspond to the equine picture menu and the bovine/canine picture menu (from them we can navigate in OAM per species and per system using clickable captioned photos and movies, the functional aspects being explained). For practical reasons, equine species is used as animal reference. Indeed only anatomical differences of the other species are detailed and compared. Finally the button Index corresponds to the surgeon view (all of the body is transversally cut, the clickable anatomical structures are sent back to their specific topic web page). Conclusions: Because of the numerous photos and movies, the three-dimensional view is better understood. Because of the transversal and vertical links, the navigation, in whatever level per species or per system or per anatomical cut, strengthens the cognitive process. This website is a fabulous multi-scale tool to teach and to learn the veterinary anatomy. [less ▲]

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See detailCompared sensitivities of VLT, JWST and ELT for direct exoplanet detection in nearby stellar moving groups
Hanot, Charles ULg; Absil, Olivier ULg; Surdej, Jean ULg et al

in Oschmann, J.; Clampin, M.; MacEwen, H. (Eds.) Space Telescopes and Instrumentation 2010: Optical, Infrared, and Millimeter Wave (2010, July)

In the context of exoplanet detection, a large majority of the 400 detected exoplanets have been found by indirect methods. Today, progress in the field of high contrast and angular resolution imaging has ... [more ▼]

In the context of exoplanet detection, a large majority of the 400 detected exoplanets have been found by indirect methods. Today, progress in the field of high contrast and angular resolution imaging has allowed direct images of several exoplanetary systems to be taken (cf. HR 8799, Fomalhaut and β Pic).[SUP]1-4[/SUP] In the near future, several new instruments are going to dramatically improve our sensitivity to exoplanet detection. Among these, SPHERE (Spectro Polarimetric High contrast Exoplanet REsearch) at the VLT, MIRI (Mid Infra-Red Instrument) onboard JWST and EPICS at the ELT will be equipped with coronagraphs to reveal faint objects in the vicinity of nearby stars. We made use of the Lyon group (COND) evolutionary models of young (sub-)stellar objects and exoplanets to compare the sensitivities of these different instruments using their estimated coronagraphic profiles. From this comparison, we present a catalogue of targets which are particularly well suited for the different instruments. [less ▲]

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See detailCompared sensitivity of VLT, JWST and ELT for direct exoplanet detection in nearby stellar moving groups
Hanot, Charles ULg; Absil, Olivier ULg; Surdej, Jean ULg et al

in Villegas, Daniela; Kissler-Patig, Markus (Eds.) JWST and the ELTs: An ideal Combination (2010)

In the context of exoplanet detection, a large majority of the 400 detected exoplanets have been found by indirect methods. Today, progress in the field of high contrast imaging has allowed direct images ... [more ▼]

In the context of exoplanet detection, a large majority of the 400 detected exoplanets have been found by indirect methods. Today, progress in the field of high contrast imaging has allowed direct images of several exoplanetary systems to be taken (cf. HR 8799, Fomalhaut). In the near future, several new instruments are going to dramatically improve our sensitivity to exoplanet detection. Among these, SPHERE ( Spectro Polarimetric High contrast Exoplanet REsearch ) at the VLT, MIRI ( Mid Infra-Red Instrument) onboard JWST and the ELT will be equipped with coronagraphs to reveal faint objects in the vicinity of nearby stars. We made use of the Lyon group (COND) evolutionary models of young (sub-) stellar objects and exoplanets to compare the sensitivity of these different instruments using their estimated coronagraphic profiles. From this comparison, we present a catalogue of targets which are particularilly well suited for the different instruments. [less ▲]

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See detailComparer et articuler les droits. L'exemple du démariage en 2015
Wautelet, Patrick ULg

in Droit de la famille (2015), 20(4), 63-66

Cette communication dresse un tableau succincts de l'état du droit comparé du divorce en Europe. L'analyse de droit comparé sert d'appui à une mise en perspective du droit international privé du divorce.

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See detailComparer la lutte contre les discriminations dans plusieurs pays
Lejeune, Aude ULg

Scientific conference (2013, February)

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See detailComparer les historiographies littéraires de la francophonie Nord. Repérages du repérable
Provenzano, François ULg

Master of advanced studies dissertation (2005)

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See detailComparer les systèmes éducatifs francophones à travers le monde grâce au PISA: pas si simple!
Baye, Ariane ULg; Demeuse, Marc; Friant, Nathanaël

in Education et Francophonie (2014), XLII(3), 102-122

The Program for International Student Assessment (PISA) compares the results of 15-year-old students from a growing number of countries, mainly industrialized. This recurring evaluation of student ... [more ▼]

The Program for International Student Assessment (PISA) compares the results of 15-year-old students from a growing number of countries, mainly industrialized. This recurring evaluation of student achievement has been the subject of numerous publications. However, if Francophone countries participate with more or less favourable results, there is still very little literature comparing countries that share the French language. There are several reasons for this. The first problem lies in the definition of what is meant by “Francophone countries”. Although several countries participating in PISA belong to the political Francophonie, few of them have effectively administered tests in French and use it as the language of instruction. The countries of Sub- Saharan Africa, in contrast, do not participate in PISA. It is therefore impossible to make comparisons among all the countries where French is actually the, or one of the, languages of instruction. It is also necessary to identify the performance of schools where French is actually practiced in the countries using several languages of instruction and compare similar situations outside of this variable. From this perspective, international publications do not always provide information, which must then be sought in national reports. The situation of students educated in French but not using the language at home, further complicating comparisons, should probably also be taken into account. [less ▲]

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See detailComparing Ape Densities and Habitats in Northern Congo: Surveys of Sympatric Gorillas and Chimpanzees in the Odzala and Ndoki Regions
Devos, Céline; Sanz, C.; Morgan, D. et al

in American Journal of Primatology (2008), 70(5), 438-451

The conservation status of western lowland gorillas and central chimpanzees in western equatorial Africa remains largely speculative because many remote areas have never been surveyed and the impact of ... [more ▼]

The conservation status of western lowland gorillas and central chimpanzees in western equatorial Africa remains largely speculative because many remote areas have never been surveyed and the impact of emergent diseases in the region has not been well documented. In this study, we compared ape densities and habitats in the Lokoue study area in Odzala National Park and the Goualougo Triangle in Nouabale-Ndoki National Park in northern Republic of Congo. Both of these sites have long been considered strongholds for the conservation of chimpanzees and gorillas, but supposedly differ in vegetative composition and relative ape abundance. We compared habitats between these sites using conventional ground surveys and classified Landsat-7 ETM+ satellite images. We present density estimates via both standing-crop and marked-nest methods for the first time for sympatric apes of the Congo Basin. The marked-nest method was effective in depicting chimpanzee densities, but underestimated gorilla densities at both sites. Marked-nest surveys also revealed a dramatic decline in the ape population of Lokoue which coincided with a local Ebola epidemic. Normal baseline fluctuations in ape nest encounter rates during the repeated passages of marked-nest surveys were clearly distinguishable from a 80% decline in ape nest encounter rates at Lokoue. Our results showed that ape densities, habitat composition, and population dynamics differed between these populations in northern Congo. We emphasize the importance of intensifying monitoring efforts and further refinement of ape survey methods, as our results indicated that even the largest remaining ape populations in intact and protected forests are susceptible to sudden and dramatic declines. Am. J. Primatol. 70:1-13, 2008. (c) 2008 Wiley-Liss, Inc. [less ▲]

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See detailComparing central western Europe Mesolithic and Neolithic plant processing microwear on flint tool
Linton, Jimmy ULg; Guéret, Colas; Gassin, Bernard

Conference (2015, May 30)

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See detailComparing Co-Parenting Among Gay- and Straight-Parented Triads
D'Amore, Salvatore ULg; Miscioscia, Marina ULg; Delvoye, Marie

in Psychology, Community & Heath (2013), 2(2), 87-88

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See detailComparing CO2 storage and advection conditions at night at different carboeuroflux sites
Aubinet, Marc ULg; Berbigier, P.; Bernhofer, C. H. et al

in Boundary-Layer Meteorology (2005), 116(1), 63-94

Anemometer and CO2 concentration data from temporary campaigns performed at six CARBOEUROFLUX forest sites were used to estimate the importance of non-turbulent fluxes in nighttime conditions. While ... [more ▼]

Anemometer and CO2 concentration data from temporary campaigns performed at six CARBOEUROFLUX forest sites were used to estimate the importance of non-turbulent fluxes in nighttime conditions. While storage was observed to be significant only during periods of both low turbulence and low advection, the advective fluxes strongly influence the nocturnal CO2 balance, with the exception of almost flat and highly homogeneous sites. On the basis of the main factors determining the onset of advective fluxes, the 'advection velocity', which takes net radiation and local topography into account, was introduced as a criterion to characterise the conditions of storage enrichment/depletion. Comparative analyses of the six sites showed several common features of the advective fluxes but also some substantial differences. In particular, all sites where advection occurs show the onset of a boundary layer characterised by a downslope flow, negative vertical velocities and negative vertical CO2 concentration gradients during nighttime. As a consequence, vertical advection was observed to be positive at all sites, which corresponds to a removal of CO2 from the ecosystem. The main differences between sites are the distance from the ridge, which influences the boundary-layer depth, and the sign of the mean horizontal CO2 concentration gradients, which is probably determined by the source/sink distribution. As a consequence, both positive and negative horizontal advective fluxes (corresponding respectively to CO2 removal from the ecosystem and to CO2 supply to the ecosystem) were observed. Conclusive results on the importance of non-turbulent components in the mass balance require, however, further experimental investigations at sites with different topographies, slopes, different land covers, which would allow a more comprehensive analysis of the processes underlying the occurrence of advective fluxes. The quantification of these processes would help to better quantify nocturnal CO2 exchange rates. [less ▲]

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See detailComparing control strategies using experimental and simulation results: Methodology and application to heating control of passive solar buildings
Kummert, M.; Andre, Philippe ULg; Argiriou, A.

in HVAC & R Research (2006), 12(3A Sp. Iss. SI), 553-575

Different heating system controllers for passive solar buildings are compared on two different buildings. The performance criterion combines energy performance and thermal comfort using the "cost function ... [more ▼]

Different heating system controllers for passive solar buildings are compared on two different buildings. The performance criterion combines energy performance and thermal comfort using the "cost function" paradigm. The experimental facilities did not allow a direct experimental comparison by using two identical buildings. The controllers were implemented alternately in one building and a performance comparison was obtained in two ways: first by identifying short periods that have similar driving variables (weather conditions and building occupancy) and comparing the experimental results obtained in both cases. The second method mixes experiments and simulation using a well-tuned model of the building and its occupants. This paper discusses the results obtained using the above methods and shows that both methods give consistent estimates of the difference between controllers and the second method allows extrapolation of useful information from the limited data available. [less ▲]

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See detailComparing conventional excellence: moral and technical features of "good research"
Charlier, Nathan ULg

Conference (2016, September)

During a stay at Lancaster University, I was struck to discover how the institutional branding relied on the rhetoric of excellence. Several flags scattered over the campus are displaying statements such ... [more ▼]

During a stay at Lancaster University, I was struck to discover how the institutional branding relied on the rhetoric of excellence. Several flags scattered over the campus are displaying statements such as: "our physicists helped discover the Higgs boson particle", "Lancaster University is ranked among the top 10 universities in the UK", "our volcanologists made the first observation of a rare type of lava", etc. These quotes convey technologies such as rankings, but also moral and epistemological aspects regarding the role and status of scientific knowledge. This fostered my reflection regarding the fieldwork I made in different research institutions located in Belgium: while academic excellence is not at the core of their branding per se, it is indeed a key issue for many actors concerned with research governance. My paper proposes to map the different ways to frame the notion of excellence in four institutions: two large biotech research centres and two universities in Flanders and Wallonia. It relies on 25 semi-structured interviews with tenured academics involved in their institution's research management. The paper will compare how "good research" is valued in different settings: what counts when one evaluates the "excellence" of a scientific production/career? To which technologies, indicators and to which "moral principles" are interviewees referring to when they discuss excellence? How do they engage in criticizing certain framings and praise others? Eligible for the rhetoric or comparative panel, my contribution will present four distinct institutional conventions that govern research practices and sorts the good scientist from the bad. [less ▲]

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