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See detailCurrent research in Sport Pedagogy
Cloes, Marc ULg

Conference (2012, October 20)

Sport pedagogy is a discipline aimed at providing scientific data on the education and training in the different contexts in the field of sport and physical activity: education, coaching, recreation ... [more ▼]

Sport pedagogy is a discipline aimed at providing scientific data on the education and training in the different contexts in the field of sport and physical activity: education, coaching, recreation, rehabilitation … Using traditionally descriptive, correlational and experimental approaches, it is focused as much on the main actors (participants and educators) than on contents or on curricula. Its main objectives consist to improve the knowledge and the field practice of the physical educators and their trainers. Most studies in sport pedagogy are conducted in the school context as physical education remains a central concern of researchers. Nevertheless, since two decades, the place of the science of coaching grows slowly while researches in leisure and rehabilitation are still quite rare. In parallel, physical activity and the fight against one sedentary lifestyle became really important in the preoccupations of most of the researchers. Moreover, two important concepts are developing nowadays: accountability and literacy. This underlines that physical educators are expected to meet the goals that modern society emphasizes: efficiency and effectiveness. Quality is now regularly identified as a priority or even a prerequisite. Current researches in sport pedagogy is become complex as they mobilize more and more often complementary approaches taking into account all the involved actors and environment. Moreover, subjects became central with the development of action researches and communities of practices. [less ▲]

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See detailCurrent role of glucosamine in the treatment of osteoarthritis
Reginster, Jean-Yves ULg; Bruyère, Olivier ULg; Neuprez, Audrey

in Rheumatology (2007), 46(5), 731-735

Objectives. To evaluate the interest of using the various preparations of glucosamine for symptomatic and structural management of osteoarthritis (OA). Methods. A critical analysis of the literature based ... [more ▼]

Objectives. To evaluate the interest of using the various preparations of glucosamine for symptomatic and structural management of osteoarthritis (OA). Methods. A critical analysis of the literature based on an exhaustive search (Medline, PubMed and manual search within the bibliography of retrieved manuscripts) from 1980 to 2005. Results. Despite multiple controlled clinical trials of the use of glucosamine in OA (mainly of the knee), controversy on efficacy related to symptomatic improvement continues. Differences in results originate from the differences in products, study design and study populations. Symptomatic efficacy described in multiple studies performed with glucosamine sulphate (GS) support continued consideration in the OA therapeutic armamentarium. The most compelling evidence of a potential for inhibiting the progression of OA is also obtain with GS. Conclusions. GS has shown positive effects on symptomatic and structural outcomes of knee OA. These results should not be extrapolated to other glucosamine salts [hydrochloride or preparations (over-the-counter or food supplements)] in which no warranty exists about content, pharmacokinetics and pharmacodynamics of the tablets. [less ▲]

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See detailCurrent roles for allogeneic hematopoietic cell transplantation following nonmyeloablative or reduced-intensity conditioning.
Baron, Frédéric ULg; Storb, Rainer

in Clinical Advances in Hematology & Oncology (2005), 3(10), 799-819

Nonmyeloablative and reduced-intensity conditioning regimens followed by allogeneic hematopoietic cell transplantation (HCT) have been evaluated in patients with hematologic malignancies who were not ... [more ▼]

Nonmyeloablative and reduced-intensity conditioning regimens followed by allogeneic hematopoietic cell transplantation (HCT) have been evaluated in patients with hematologic malignancies who were not considered candidates for conventional HCT because of age or medical comorbidities and in selected patients with metastatic renal cell carcinoma. The regimens have relied more on graft-versus-tumor effects than on chemoradiation therapy to facilitate engraftment and eradicate malignant cells. While nonmyeloablative HCT has been associated with reduced regimen-related toxicities and has been curative for a number of patients with hematologic malignancies, challenges have remained in regard to graft-versus-host disease, infections, and disease progression. In this article, we review data from a number of published phase I and II studies that describe the results of allogeneic HCT after nonmyeloablative conditioning. [less ▲]

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See detailThe current situation of pesticides use in developing countries: problems and solutions
Wynn, Nigel; Deuse, J.P.L.; Schiffers, Bruno ULg et al

Report (1996)

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See detailThe current situation of wild mammals in Belgium: an outline
Libois, Roland ULg

in Hystrix: the Italian Journal of Mammalogy (1996), 8(1-2), 35-41

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better ... [more ▼]

The distrbution of the wild mammals of Belgium has been intensively stutied during the years '78-81'. It was the first time that such a work was undertaken in Belgium and could lead to a better understanding of the current status of the different species. Conservation measures were olso proposed to the political authorities who thereafter edicted a legal protection of the most vulnerable species. Unfortunately, habitat protection is rather unachieved and the situation of the most endangered species is still getting worse. [less ▲]

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See detailCurrent status of brain imaging in sleep medicine
Maquet, Pierre ULg

in Sleep Medicine Reviews (2005), 9(3), 155-156

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See detailCurrent Status of fluoride salts to treat postmenopausal osteoporosis
Reginster, Jean-Yves ULg; Paul, I.; Gosset, Christiane ULg

in Current Opinion in Orthopaedics (1998), 9(V), 7-10

Fluoride has been used over the past 25 years as a potential treatment of established osteoporosis. Notwithstanding a consensus over its ability to stimulate bone formation, discrepant results were ... [more ▼]

Fluoride has been used over the past 25 years as a potential treatment of established osteoporosis. Notwithstanding a consensus over its ability to stimulate bone formation, discrepant results were published relating to its antifracture efficacy. Differences in the published results are likely to be linked to therapeutic regimens, fluoride formulation, and the nature of the treated populations. A critical review of the published data evaluating the antifracture efficacy of fluoride leads to the conclusion that this substance should be mainly used in postmenopausal women with low bone mineral density without prevalent fracture, that low-dose fluoride for a prolonged period should be preferred to high doses for short-term treatment, and that gastroresistant preparations are likely to be better tolerated than fluoride. [less ▲]

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See detailCurrent status of hematopoietic stem cell transplantation after nonmyeloablative conditioning
Baron, Frédéric ULg; Sandmaier, B. M.

in Current Opinion in Hematology (2005), 12(6), 435-443

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See detailCurrent status of scrapie. CAB review for Perspectives in Agriculture
Saegerman, Claude ULg; Vanopdenbosch, E.; Berkvens, D.

in CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources (2007), 2(027),

Despite being controlled in many developed countries, scrapie remains endemic in many parts of the world. Economic losses result from mortality and culling of small ruminants and from market restrictions ... [more ▼]

Despite being controlled in many developed countries, scrapie remains endemic in many parts of the world. Economic losses result from mortality and culling of small ruminants and from market restrictions. Moreover, it is difficult to develop all-inclusive guidelines that could establish a scrapie-free status for a country. Unfortunately, the global picture remains incomplete because in many countries confusion still remains regarding the clinical picture of scrapie and information is not available owing to the absence of adequate epidemiosurveillance networks. Currently, the predominant theory is that PrPSc is the infectious agent where host genetic factors play a central role. The precise transmission routes of scrapie and their relative contributions to the overall transmission intensity remain poorly documented and the physiopathology is not fully understood. However, it is evident that the purchase of female sheep from scrapie flocks, sharing pastures with scrapie flocks, sharing breeding rams and genetic host susceptibility are the main risk factors for the spread of the disease. A better understanding of the epidemiology of scrapie would greatly aid the development and evaluation of control and eradication strategies that were mainly based on selective depopulation of infected animals and genetically susceptible and/or related animals and also on the biosecurity and the use of selective genetic breeding programmes in healthy flocks. Some numbers of a new transmissible spongiform encephalopathy (TSE) form in small ruminants (atypical scrapie) have meanwhile been identified by TSE rapid testing using an assay, which also recognizes comparatively less proteinase K-resistant PrPSc. Uncertainties remain regarding the pathogenesis of this new TSE form, as well as regarding its potential transmissibility within the affected species and to other species. Thus far, no bovine spongiform encephalopathy (BSE) cases have been confirmed in sheep under natural conditions (a report of vertical transmission after experimental infection merits attention), but two historical cases of BSE in goats born in the 1990s have been identified. Currently BSE must also be considered in the differential diagnosis of scrapie. The development of prevention and control programmes should be assisted by new scientific findings. [less ▲]

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See detailCurrent status of transmissible spongiform encephalopathies in ruminants
Thiry, Etienne ULg; Saegerman, Claude ULg; Xambeu, Laurence et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2004), 8

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See detailCurrent systematic carbon-cycle observations and the need for implementing a policy-relevant carbon observing system
Ciais, P.; Dolman, A. J.; Bombelli, A. et al

in Biogeosciences (2014), 11(13), 3547--3602

A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify ... [more ▼]

A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify the effectiveness of policies aiming to reduce greenhouse gas emissions and increase carbon sequestration. Building an integrated carbon observation system requires transformational advances from the existing sparse, exploratory framework towards a dense, robust, and sustained system in all components: anthropogenic emissions, the atmosphere, the ocean, and the terrestrial biosphere. The paper is addressed to scientists, policymakers, and funding agencies who need to have a global picture of the current state of the (diverse) carbon observations.We identify the current state of carbon observations, and the needs and notional requirements for a global integrated carbon observation system that can be built in the next decade. A key conclusion is the substantial expansion of the ground-based observation networks required to reach the high spatial resolution for CO2 and CH4 fluxes, and for carbon stocks for addressing policy-relevant objectives, and attributing flux changes to underlying processes in each region. In order to establish flux and stock diagnostics over areas such as the southern oceans, tropical forests, and the Arctic, in situ observations will have to be complemented with remote-sensing measurements. Remote sensing offers the advantage of dense spatial coverage and frequent revisit. A key challenge is to bring remote-sensing measurements to a level of long-term consistency and accuracy so that they can be efficiently combined in models to reduce uncertainties, in synergy with groundbased data. Bringing tight observational constraints on fossil fuel and land use change emissions will be the biggest challenge for deployment of a policy-relevant integrated carbon observation system. This will require in situ and remotely sensed data at much higher resolution and density than currently achieved for natural fluxes, although over a small land area (cities, industrial sites, power plants), as well as the inclusion of fossil fuel CO2 proxy measurements such as radiocarbon in CO2 and carbon-fuel combustion tracers. Additionally, a policy-relevant carbon monitoring system should also provide mechanisms for reconciling regional top-down (atmosphere-based) and bottom-up (surface-based) flux estimates across the range of spatial and temporal scales relevant to mitigation policies. In addition, uncertainties for each observation data-stream should be assessed. The success of the system will rely on long-term commitments to monitoring, on improved international collaboration to fill gaps in the current observations, on sustained efforts to improve access to the different data streams and make databases interoperable, and on the calibration of each component of the system to agreed-upon international scales. [less ▲]

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See detailCurrent themes in social economy research
Fecher-Bourgeois, Fabienne ULg; Lévesque, Benoît; McPherson, Ian

in Annals of Public and Cooperative Economics = Annales de l'Economie Publique, Sociale et Coopérative (2009), 80(2), 163-344

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See detailCurrent therapies for shingles
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Expert Opinion on Investigational Drugs (1996), 5

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but ... [more ▼]

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but its moderate bioavailability renders five oral daily doses mandatory. Recent anti-VZV drug research has been oriented towards agents with increased oral bioavailability. Famciclovir and valaciclovir were originally developed as oral prodrugs for^penciclovir and acyclovir, respectively, but, together with the new antivirals, sorivudine and brovavir, they appear to be effective as oral therapy for shingles. Ongoing clinical trials will determine their relative merits in the management of shingles. The experimental agents H2G, HPMPC, mappicine ketone and A-73209 have potential in the treatment of VZV and are undergoing further investigation and development. [less ▲]

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See detailCurrent thinking about Jupiter's magnetic anomaly
Grodent, Denis ULg; Gérard, Jean-Claude ULg; Gustin, Jacques ULg et al

Conference (2006)

Repeated imaging of Jupiter's aurora has shown that the northern main oval has a distorted 'kidney bean' shape in the general range of 90-150o System III longitude, which appears unchanged since 1994 ... [more ▼]

Repeated imaging of Jupiter's aurora has shown that the northern main oval has a distorted 'kidney bean' shape in the general range of 90-150o System III longitude, which appears unchanged since 1994. While it is more difficult to observe the conjugate regions in the southern aurora, no corresponding distortion appears in the south. Recent improved accuracy in locating the auroral footprint emission of Io has provided new information about the geometry of Jupiter's magnetic field in this and other areas. The persistent pattern of the main oval implies a disturbance of the local magnetic field, and the increased latitudinal separation of the locus of the Io footprint from the main oval implies a locally weaker field strength. The most recent images obtained with the Hubble Space Telescope Advance Camera for Surveys (ACS) allow us to complement previous observations with the location of the auroral footprints of Io, Europa, and Ganymede in the region of interest. Their footpaths vary in parallel and form a kink in the 90-150° S3 sector which strongly suggests the presence of a magnetic anomaly in this region. [less ▲]

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See detailCurrent treatment of respiratory inflammatory disorders in the horse
Lekeux, Pierre ULg; Van Erck, Emmanuelle; Art, Tatiana ULg

in XVII. Tagung über Pferdekrankheiten im Rahmen der EQUITANA (2007)

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See detailCurrent treatments of muco-cutaneous herpes simplex virus infections
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Current Medicinal Chemistry - Anti-Infective Agents (2002), 1(1), 83-98

Infection by Herpes Simplex Virus (HSV) types I and II represent a worldwide medical problem. After the primary infection the virus establishes a life-long latency in the dorsal root ganglia and ... [more ▼]

Infection by Herpes Simplex Virus (HSV) types I and II represent a worldwide medical problem. After the primary infection the virus establishes a life-long latency in the dorsal root ganglia and recurrences may occur at unpredictable times and rate. The most frequent clinical presentation of HSV infection is recurrent herpes labialis and herpes genitalis. The clinical expression varies according to the body site, the infected cell type, the relationship between HSV and the host immune status. Viral identification techniques such as immunohistochemistry and in situ hybridization on Tzanck smears and muco-cutanenous biopsies are helpful in the diagnosis of atypical cutaneous lesions. The treatment modalities of HSV infections include the reduction of viral load using antiviral agents, the non-specific immune stimulation of the host and specific vaccination in order to prevent new acquisition and to mitigate symptoms in already infected individuals. This review addresses various therapeutic options, their mode of action, and clinical value as well as the indications of the various drugs. [less ▲]

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See detailCurrent trends in follow-up of trophoblastic function in ruminant species
Melo de Sousa, Noelita ULg; Beckers, Jean-François ULg; Gajewski, Z.

in Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society (2008), 59 Suppl 9

During the pregnancy of ruminants, different hormones and proteins are secreted by placenta or corpus luteum allowing the follow up of gestation. Among them, progesterone (P4) and pregnancy-associated ... [more ▼]

During the pregnancy of ruminants, different hormones and proteins are secreted by placenta or corpus luteum allowing the follow up of gestation. Among them, progesterone (P4) and pregnancy-associated glycoproteins (PAG) were proposed as laboratory tools to establish or to confirm pregnancy diagnosis. In last years, PAG assay also provided useful information for researchers working in programs focused on the follow up of trophoblastic function. Concentrations of PAG appeared as altered after the use of embryo biotechnology (in vitro fertilization, cloning by nuclear transfer, inter-specific pregnancies), according to nutritional status of pregnant females (overnourished or undernourished), or consecutive to infectious diseases leading to pathologies affecting the pregnancy in cows (Actynomyces pyogenes and Neospora caninum) and goats (Toxoplasma gondii, Listeria monocytogenes and Trypanosoma congolense). As well, in numerous studies, the association of repeated ultrasound examinations with P4 and PAG determinations allowed a better understanding of mechanisms related to embryonic and fetal mortalities: failure after artificial insemination or embryo transfer techniques, large offspring syndrome after in vitro fecundation and cloning. [less ▲]

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See detailCurrent Trends in the Research on Physical Education Teacher Education (PETE)
Cloes, Marc ULg

Conference (2008, July)

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See detailCurrent views on calcium phosphate osteogenicity and the translation into effective bone regeneration strategies.
Chai, Y. C.; Carlier, Aurélie ULg; Bolander, J. et al

in Acta Biomaterialia (2012), 8(11), 3876-87

Calcium phosphate (CaP) has traditionally been used for the repair of bone defects because of its strong resemblance to the inorganic phase of bone matrix. Nowadays, a variety of natural or synthetic CaP ... [more ▼]

Calcium phosphate (CaP) has traditionally been used for the repair of bone defects because of its strong resemblance to the inorganic phase of bone matrix. Nowadays, a variety of natural or synthetic CaP-based biomaterials are produced and have been extensively used for dental and orthopaedic applications. This is justified by their biocompatibility, osteoconductivity and osteoinductivity (i.e. the intrinsic material property that initiates de novo bone formation), which are attributed to the chemical composition, surface topography, macro/microporosity and the dissolution kinetics. However, the exact molecular mechanism of action is unknown. This review paper first summarizes the most important aspects of bone biology in relation to CaP and the mechanisms of bone matrix mineralization. This is followed by the research findings on the effects of calcium (Ca(2)(+)) and phosphate (PO(4)(3)(-)) ions on the migration, proliferation and differentiation of osteoblasts during in vivo bone formation and in vitro culture conditions. Further, the rationale of using CaP for bone regeneration is explained, focusing thereby specifically on the material's osteoinductive properties. Examples of different material forms and production techniques are given, with the emphasis on the state-of-the art in fine-tuning the physicochemical properties of CaP-based biomaterials for improved bone induction and the use of CaP as a delivery system for bone morphogenetic proteins. The use of computational models to simulate the CaP-driven osteogenesis is introduced as part of a bone tissue engineering strategy in order to facilitate the understanding of cell-material interactions and to gain further insight into the design and optimization of CaP-based bone reparative units. Finally, limitations and possible solutions related to current experimental and computational techniques are discussed. [less ▲]

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