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Peer Reviewed
See detailCrossroads Poetics, Frank Zappa and the Loop
Delville, Michel ULg

Conference (2013, May 11)

Detailed reference viewed: 9 (0 ULg)
See detailCrossroads Poetics: Text, Image, Music, Film & Beyond
Delville, Michel ULg

Book published by Presses Universitaires de Prague (2013)

Detailed reference viewed: 18 (1 ULg)
Peer Reviewed
See detailCrosstalk Modeling of Wnt, BMP and ERK Pathways during osteochondrogenic differentiation
Geris, Liesbet ULg; Vandeput, Maarten; Roberts, Scott et al

in proceedings of the International Symposium on Biomechanics and Biology of Bone Regeneration “From Functional Assessment To Guided Tissue Formation (2009, November)

The in vitro engineering of tissues may be achieved by mimicking in vivo tissue development. Although multiple skeletal tissue engineering applications already exist, the underlying mechanisms at protein ... [more ▼]

The in vitro engineering of tissues may be achieved by mimicking in vivo tissue development. Although multiple skeletal tissue engineering applications already exist, the underlying mechanisms at protein level are often poorly understood. Growth factors and protein pathways precisely navigate mesenchymal stem cells trough the correct cascades. A detailed understanding of these cascades will enable us to develop efficient and robust production methods, which are required for large scale tissue engineering applications. Multiple studies hypothesize that the Wnt/β-catenin pathway acts as a switching mechanism to determine the differential fate of esenchymal cells in osteoblasts or chondrocytes during skeletogenesis. The concentration of β-catenin is a key factor in this mechanism. Wnt upregulates the productionof β-catenin which in turn upregulates Runx2 and downregulates Sox9. High concentrations of Runx2 relative to Sox9 lead to osteoblasts, while the opposite situation leads to chondrocytes. Crosstalks of the Wnt pathway with other pathways such as that of BMP and ERK expand the amount of factors that can influence β-catenin, turning the linear signaling cascade into a complex network with multiple starting conditions. A mathematical model was derived from literature describing the pathways of BMP, Wnt and ERK as well as various crosstalks between these pathways that were suggested in literature. CellDesigner™ was used to formulate, solve and visualize the Ordinary Differential Equations describing the temporal evolution of the various model constituents. Multiple starting conditions (various concentrations of BMP, Wnt and ERK) were examined to clarify the crosstalk effect. Modeling various crosstalks proposed in literature resulted in a mutual inhibitory effect between Wnt and BMP signaling, an effect independently described in literature. Experiments are ongoing to corroborate the model predictions. [less ▲]

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See detailCrowdsourced Monitoring, Citizen Empowerment and Data Credibility: The case of Observations.be
Farah, Jihad ULg

in Murgante, Beniamino; Sanjay, Misra; Rocha, Anna Maria (Eds.) et al Computational Science and its applications - ICCSA 2014 (2014)

Crowdsourcing is today a revolutionary phenomenon changing pro- foundly our ways of communicating and producing. This article is interested in two issues that are crucial to its development and impacts ... [more ▼]

Crowdsourcing is today a revolutionary phenomenon changing pro- foundly our ways of communicating and producing. This article is interested in two issues that are crucial to its development and impacts. On one hand, it in- vestigates the forms and limits of crowdsourcing-related citizen empowerment. It is less concerned by the now recognized fact that crowdsourcing is empower- ing, but rather focuses on the ways it does so and the architecture of the rela- tions between citizens, scientists and institutions in this new context. On the other, it discusses the question of credibility of data produced through crowd- sourcing. This question represents, in fact, the Achilles’ heel that destabilizes the rise of citizen power in the face of experts and institutions. In its discussion of these two issues, the article relies on a particularly interesting case study: the online platform of participatory monitoring of biodiversity in Belgium Observa- tions.be. The creation of databases is an occasion here for reflexivity, learning and mobilisation. It is also an occasion for the liberation of the lay citizen, as an individual, from the straightjackets delimiting the institutional, scientific and associative spaces where he remains a subject, a collaborator or a member – al- ways in a subordinate position. He becomes a peer producer, partner and discussant. More important, learning and action networks that develop in the platform cut transversally through the three spheres. We find unexpected and new cooperations between citizen, scientists and civil servants. Likewise, ac- tions developed through the platform, mainly reporting, counting campaigns and early alert systems attest new modes of action that transgress the functional and ontological division of the three spheres. [less ▲]

Detailed reference viewed: 16 (3 ULg)
Peer Reviewed
See detailcrown rot disease of bananas
Lassois, Ludivine ULg; de Lapeyre de Bellaire

in Bautista-Banos, Silvia (Ed.) Postharvest Decay, control strategies (2014)

Detailed reference viewed: 28 (18 ULg)
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Peer Reviewed
See detailCrown rot of banana: Preharvest factors involved in postharvest disease development and integrated control methods
Lassois, Ludivine ULg; Jijakli, Haissam ULg; Chillet, M. et al

in Plant Disease (2010), 94(6), 648-658

Detailed reference viewed: 53 (11 ULg)
Peer Reviewed
See detailCroyances métacognitives et hallucinations
Laroi, Frank ULg

Conference (2010, November 18)

Detailed reference viewed: 15 (1 ULg)
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See detailLes croyances partagées et la question du lien social
Melice, Anne ULg

Conference given outside the academic context (2013)

Detailed reference viewed: 83 (7 ULg)
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See detailCroyances, pratiques et utilisations des tortues marines en médecine traditionnelle sur la côte ouest africaine: Bénin et Sénégal
Dossa, Justine; Diez, Marianne ULg; Hornick, Jean-Luc ULg et al

in Chéloniens : Biologie, écologie, Elevage, Conservation (2009), 14

Detailed reference viewed: 78 (21 ULg)
See detailLe CRP et ses opérateurs : les usages de la confiance
Remy, Céline ULg

Conference (2013, December 12)

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See detailCrp of Streptomyces Coelicolor Is the Third Transcription Factor of the Large Crp-Fnr Superfamily Able to Bind Camp
Derouaux, Adeline ULg; Dehareng, Dominique ULg; Lecocq, Elke et al

in Biochemical and Biophysical Research Communications (2004), 325(3), 983-90

The chromosomal inactivation of the unique transcription factor of Streptomyces coelicolor that displays a cyclic-nucleotide-binding domain, Crp(Sco), led to a germination-defective phenotype similar to ... [more ▼]

The chromosomal inactivation of the unique transcription factor of Streptomyces coelicolor that displays a cyclic-nucleotide-binding domain, Crp(Sco), led to a germination-defective phenotype similar to the mutant of the adenylate cyclase gene (cya) unable to produce cAMP. By means of cAMP affinity chromatography we demonstrate the specific cAMP-binding ability of Crp(Sco), which definitely demonstrate that a Cya/cAMP/Crp system is used to trigger germination in S. coelicolor. However, electromobility shift assays with the purified Crp(Sco)-cAMP complex and the CRP-like cis-acting element of its own promoter failed. Moreover, we were unable to complement an Escherichia coli crp mutant in trans with Crp(Sco). The fact that Vfr from Pseudomonas aeruginosa and GlxR from Corynebacterium glutamicum could complement such an E. coli mutant suggests that the way Crp(Sco) interacts with DNA should mechanistically differ from its most similar members. This hypothesis was further supported by homology modelling of Crp(Sco) that confirmed an unusual organisation of the DNA-binding domain compared to the situation observed in Crp(Eco). [less ▲]

Detailed reference viewed: 99 (17 ULg)
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Peer Reviewed
See detailA crucial role forlung interstitial macrophages in preventing airway allergy
Bedoret, Denis; Wallemacq, Hugues ULg; Marichal, Thomas ULg et al

in Short book of the Annual Congress of the European Respiratory Society (ERS), Vienne (2009)

Detailed reference viewed: 38 (14 ULg)
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Peer Reviewed
See detailCrucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channel
Weatherall, Kate; Seutin, Vincent ULg; Liégeois, Jean-François ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2011), 108(45), 18488-18493

Detailed reference viewed: 36 (8 ULg)
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See detailCrucial role of reversible phosphorylation in the mechanisms governing the biological functions of class IIa Histone Deacetylases
Martin, Maud ULg

Doctoral thesis (2009)

Regulation of class IIa histone deacetylases (HDACs) phosphorylation is crucial because it provides the opportunity to control important developmental processes associated with these key enzymes. Indeed ... [more ▼]

Regulation of class IIa histone deacetylases (HDACs) phosphorylation is crucial because it provides the opportunity to control important developmental processes associated with these key enzymes. Indeed, the transcriptional repressor activity of class IIa HDAC is controlled via their phosphorylation-dependent nucleo-cytoplasmic shuttling. While a lot of efforts have been directed towards the identification of the inactivating kinases that phosphorylate class IIa HDACs, the identity of the antagonist phosphatase remained an open question. During this work, we found that protein phosphatase 2A (PP2A) is responsible for dephosphorylating the class IIa HDACs member HDAC7, thereby regulating its subcellular localization and repressor activity. In order to validate our model, functional consequences of these findings was illustrated during the two main biological processes involving HDAC7, i.e. T-cells apoptosis during negative selection and endothelial cells angiogenic activities during vascular network formation. Cellular PP2A represents a large population of trimeric holoenzymes containing a variable regulatory subunit, whose identity has a crucial role in determining the specificity of PP2A catalytic activity. In an effort to characterize the regulation of HDAC7 dephopshorylation, we identified the relevant PP2A holoenzyme regulating HDAC7 function during vasculogenesis and we found that, among diverse regulatory subunit isoforms, PP2A-Bα uniquely regulates endothelial cell angiogenic properties. PP2A-Bα silencing using small interfering RNAs results in a significant inhibition of endothelial cell tube formation and migration. These results establish PP2A, and more precisely the Bα containg PP2A holoenzyme, as an essential element in the regulation of the class IIa HDACs HDAC7 and unravel a first developmental function for the PP2A regulatory subunit Bα in the genesis of blood vessels. [less ▲]

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See detailCrucial role of the amino-terminal tyrosine residue 42 and the carboxy-terminal PEST domain of IkappaBalpha in NF-kappaB activation by an oxidative stress
Schoonbroodt, Sonia; Ferreira, V.; Best-Belpomme, Martin et al

in Journal of Immunology (2000)

Detailed reference viewed: 11 (1 ULg)
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Peer Reviewed
See detailCrude oil bioremediation in sub-Antarctic intertidal sediments: chemistry and toxicity of oiled residues
Pelletier, Emilien; Delille, Daniel; Delille, Bruno ULg

in Marine Environmental Research (2004), 57(4), 311-327

The effectiveness of fertilizers for crude oil bioremediation in sub-Antarctic intertidal sediments was tested over a one-year period in a series of ten (10) experimental enclosures. Chemical, microbial ... [more ▼]

The effectiveness of fertilizers for crude oil bioremediation in sub-Antarctic intertidal sediments was tested over a one-year period in a series of ten (10) experimental enclosures. Chemical, microbial and toxicological parameters demonstrated the effectiveness of various fertilizers in a pristine environment where hydrocarbon degrading bacteria (HDB) had not been stimulated by previous accidental spills or human activities. The low temperature of seawater (3-4 degreesC) had no obvious effects on the HDB community and the bioremediation process. Over 90% of n-alkanes were degraded in the first six months and most light aromatics (2-3 rings) disappeared during the first year of observation. The toxicity of oiled residues (Microtox(R) SP) was significantly reduced in the first 6 months of the process, but it increased again in the last months of the experiment. One of the fertilizers containing fishbone compost enriched with urea, inorganic phosphorus and a lipidic surfactant reduced significantly the toxicity of oil residues in the last 3 months of the experiment. Interstitial waters collected below the oil slicks during the remediation showed no toxicity, and even stimulated Vibrio fischeri. When comparing all fertilizers to the control plots, a good correlation (r(2) = 0.82) was found between the growth rate of HDB and the degradation rate of n-alkanes in the first 90 days of the experiment only indicating that fertilizers were efficient for at least 3 months but their beneficial effects were lost after 6 months. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 29 (1 ULg)