Diabète, hypertension artérielle et insuffisance rénaleKrzesinski, Jean-Marie ![]() Conference (2003, April 17) Le diabete: de la connaissance clinique a la preoccupation de sante publique.Scheen, André ![]() in Journal de la Société de Biologie (2007), 201(2), 133-40 Diabetes mellitus is a chronic disease whose prevalence is increasing worldwide. It remains associated with a high risk of severe complications, essentially micro- and macro-vascular complications. Type 1 ... [more ▼] Diabetes mellitus is a chronic disease whose prevalence is increasing worldwide. It remains associated with a high risk of severe complications, essentially micro- and macro-vascular complications. Type 1 diabetes is an auto-immune disease that leads to the destruction of insulin-secreting B cells and therefore requires an intensive optimised exogenous insulin therapy. Type 2 diabetes is a polygenic disease whose expression is favoured by inadequate lifestyle, leading to obesity. It combines a relative insulin secretory defect and insulin resistance, the latter being associated with various other cardiovascular risk factors. Treatment consists of lifestyle modifications first, then the prescription of various glucose-lowering oral drugs and finally, when requested, insulin therapy. A multi-risk intervention is mandatory to improve the cardiovascular prognosis. The prevention of diabetes and its complications is a major public health objective. [less ▲] Detailed reference viewed: 33 (0 ULg) Diabetes is still a risk factor for restenosis after drug-eluting stent in coronary arteries.Scheen, André ; Warzee, Fabian ![]() in Diabetes Care (2004), 27(7), 1840-1 Detailed reference viewed: 5 (0 ULg) Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?Scheen, André ![]() in Diabètes & Métabolism (2005), 31 Spec No 2 Elderly people are more glucose intolerant and insulin resistant than young individuals, and many of them will develop type 2 diabetes. It remains, however, controversial whether this decrease in function ... [more ▼] Elderly people are more glucose intolerant and insulin resistant than young individuals, and many of them will develop type 2 diabetes. It remains, however, controversial whether this decrease in function is due to an inevitable consequence of "biological aging" or due to environmental or lifestyle variables. Indeed, increased adiposity/altered fat distribution, decreased fat free mass/abnormal muscle composition, poor dietary habits and physical inactivity all contribute to reduce insulin sensitivity. Insulin resistance in elderly people appears to predominate in skeletal muscle, whereas hepatic glucose output seems to be almost unaffected. Several abnormalities in islet beta-cell and insulin secretion were also pointed out in elderly people such as increased amyloid deposition and decreased amylin secretion, impaired insulin secretion pulsatility, decreased insulin sensitivity of pancreatic beta-cells to insulinotropic gut hormones and diminished insulin response to non-glucose stimuli such as arginine. Controversial results were reported concerning the effects of aging on absolute insulin secretion in response to oral or intravenous glucose. However, insulin secretion appears to decrease with age, with significantly diminished beta-cell sensitivity and acute insulin response to glucose, provided it is analyzed relative to concomitant decreased insulin sensitivity. Thus, there is an interplay between decreased insulin secretion and increased insulin resistance that largely explains the abnormal glucose metabolism seen in elderly. Weight loss, especially reduction of abdominal adiposity, and increased physical activity may contribute to improve insulin sensitivity and glucose tolerance, and prevent the development of type 2 diabetes in elderly people. [less ▲] Detailed reference viewed: 33 (0 ULg) Diabètes secondaires à une endocrinopathie.; Betea, Daniela ; Daly, Adrian et alin Revue Médicale de Liège (2005), 60(5-6), 442-447 Diabetes mellitus may occur in association with endocrine disorders and is termed "other causes of diabetes" by the American Diabetes Association. Hyperglycaemia results from sustained excessive hormonal ... [more ▼] Diabetes mellitus may occur in association with endocrine disorders and is termed "other causes of diabetes" by the American Diabetes Association. Hyperglycaemia results from sustained excessive hormonal secretion, which alters insulin secretion or action. It is characterized by the absence of ketosis because of the persistence of endogenous insulin secretion. Diabetes is usually reversible with successful treatment of the underlying endocrine disorder and the correction of hormonal overproduction. Most important endocrine diseases associated with diabetes mellitus are briefly described and the underlying mechanisms of glucose abnormalities are discussed. [less ▲] Detailed reference viewed: 75 (0 ULg) Diabetogenic coxsackievirus B4 modifies cytokine secretion by human thymic epithelial cells; ; et al in Diabetologia (2000), 43 (Suppl. 1) Detailed reference viewed: 11 (0 ULg) Le Diable et les viergesDor, Juliette ![]() in Carruthers, Leo (Ed.) Anges et démons dans la littérature anglaise du Moyen Âge (2002) Detailed reference viewed: 13 (0 ULg) "Diabolo Manques" - Une exploration à la découverte de soi - Rapport d'évaluation de la première annéeGrignard, Sophie ; Vandoorne, Chantal ![]() Report (2000) Detailed reference viewed: 11 (7 ULg) "Diabolo Manques" - Une exploration à la découverte de soi - Rapport d'évaluation de la troisième année; Grignard, Sophie ; Vandoorne, Chantal ![]() Report (2002) Detailed reference viewed: 29 (5 ULg) "Diabolo-Manques" - Une exploration à la découverte de soi - L'évaluation d'un programme de prévention des assuétudes en Province de LiègeGrignard, Sophie ; ; et alReport (2006) Detailed reference viewed: 22 (13 ULg) "Diabolo-Manques", histoire d'une évaluationGrignard, Sophie ; Vandoorne, Chantal ![]() in Education Santé (2008), (236), 2-3 Cet article présente les grandes lignes d’une brochure, coéditée par l’APES-ULg et par la Maison du Social de la Province de Liège, et intitulée «Diabolo-Manques - Une exploration à la découverte de soi ... [more ▼] Cet article présente les grandes lignes d’une brochure, coéditée par l’APES-ULg et par la Maison du Social de la Province de Liège, et intitulée «Diabolo-Manques - Une exploration à la découverte de soi - L'évaluation d'un programme de prévention des assuétudes en Province de Liège». Cette brochure d’une vingtaine de pages décrit de façon synthétique et intégrée les différentes phases d’évaluation de ce programme ainsi que leurs résultats. [less ▲] Detailed reference viewed: 59 (20 ULg) Diacerein by its Metabolite Rhein, Down-Regulates Stromelysins and Nitric Oxide Productions and Up-Regulates Aggrecan Production by Human Chondrocytes in Alginate BeadsHenrotin, Yves ; Sanchez, Christelle ; Deberg, Michelle et alin Tissue Engineering (2001), 7(5), 648 Detailed reference viewed: 24 (10 ULg) Diacerein by its Metabolite Rhein, Down-Regulates Stromelysins and Nitric Oxide Productions and Up-Regulates Aggrecan Production by Human Chondrocytes in Alginate BeadsHenrotin, Yves ; Sanchez, Christelle ; Deberg, Michelle et alPoster (2001) Detailed reference viewed: 17 (5 ULg) Diacerein by its Metabolite Rhein, Down-Regulates Stromelysins and Nitric Oxide Productions and Up-Regulates Aggrecan Production by Human Chondrocytes in Alginate BeadsHenrotin, Yves ; Sanchez, Christelle ; Deberg, Michelle et alin Clinical Rheumatology (2001), 20(5), 414 Detailed reference viewed: 36 (6 ULg) Diagenèse des monticules micritiques de la partie supérieure du Frasnien du Synclinorium de Dinant (Belgique, France)Boulvain, Frédéric ; ; in Comptes Rendus de l'Académie des Sciences. Série II, Mécanique, Physique, Chimie, Sciences de l'Univers, Sciences de la Terre (1992), 315 Detailed reference viewed: 8 (0 ULg) Diagenèse osseuse et genèse de nodules phosphatés, associés aux sédiments fluvio-lacustres de sites à hominidés miocène (Kenya); ; et al Poster (2010) Detailed reference viewed: 25 (4 ULg) Diagenetic and paleogeographic significance of clay and other sedimentary components in the middle Devonian limestones of Western Ardennes, France; ; et al in Palaeogeography, Palaeoclimatology, Palaeoecology (1997), 129 Givetian deposits accumulated in a more than 300-m-thick succession on a carbonate platform developed on the passive margin of the so-called Rheic ocean. These rocks crop out in the Ardenne massif at ... [more ▼] Givetian deposits accumulated in a more than 300-m-thick succession on a carbonate platform developed on the passive margin of the so-called Rheic ocean. These rocks crop out in the Ardenne massif at Glageon in a structural context marked by small fault-controlled basins subjected to moderate overburden, tectonic and metamorphic constraints. Data on the clay mineral distribution, associated with detailed information on limestone facies/microfacies, as well as data on the depositional profile and sequence stratigraphic evolution of these rocks indicate strong carbonate diagenesis and moderate clay diagenesis, the latter being favoured by the early occurrence of the former, which prevented further fluid-rock interaction. The clay assemblage distribution, which roughly parallels the palaeomorphologic and palaeobathymetric shape of the Givetian continental margin, is organized in five successive zones indicating large-scale sequence stratigraphic evolution and the control of regional sea-level fluctuations. The clay and other sedimentary components provide additional information on the warm and variably humid climate, northern, relative to southern, terrigenous sources, the open sea relative to restricted depositional environments, the temporary tectonic rejuvenation of the continental hinterland and the chemical conditions allowing early diagenetic modifications. [less ▲] Detailed reference viewed: 20 (0 ULg) Diagnosing Cardiac Dysfunction and Guiding Therapy in Critical Care; ; et al in Proceedings of the NZBio 2008 Conference & Exposition, (2008) Detailed reference viewed: 12 (1 ULg) Diagnosing entrapment neuropathies: probes and magnets instead of electrodes and needles?MAERTENS DE NOORDHOUT, Alain ![]() in Clinical Neurophysiology (2006), 117(3), 484-5 Detailed reference viewed: 5 (2 ULg) Diagnosing pulmonary embolism from a model-based cardiac driver function; ; et al in Proceedings of ANZICS 2011 (2011) Detailed reference viewed: 9 (0 ULg) |
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