Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
See detailCross-linked pH sensitive polymer micelles for drug delivery systems
Cajot, Sébastien ULg; Jérôme, Christine ULg

Poster (2009, December 08)

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block ... [more ▼]

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block copolymers are supramolecular core-shell type assemblies of tens of nanometers in diameter. In principle, the micelles core is usually constructed with biodegradable hydrophobic polymers such as aliphatic polyesters, e.g. poly(ɛ-caprolactone) (PCL), which serves as a reservoir for the incorporation of various lipophilic drugs. Water soluble poly(ethylene oxide) (PEO) is most frequently used to build the micelle corona because it is very efficient in preventing protein adsorption at surfaces and in stabilizing the micelles in the blood compartment, giving rise to particles invisible to the body defence system (so-called stealthy or long circulating particles). The tumour targeting of a cytotoxic agent refers to the passive accumulation of polymer nanocarriers to solid tumours (EPR effect) followed by active internalization in tumor cells. The internalization of the drug is required for cell death because most cytotoxic drugs act intracellularly. Accordingly, polymer micelles are usually modified by specific ligands. No-specific ligands can be used if their exposition is modulated by the pH decrease typical of tumour tissues. The release of the drug is ruled by diffusion and degradation of the biodegradable polymer used as reservoir. Even if micelles get a high stability in aqueous media thanks to their low critical micellar concentration, the dissociation of micelles is not always preserved when they are injected in the blood compartment. The cross-linking of the core of micelles by disulfide bridges will provide the stability of micelles after the administration and will release the drugs intracellularly by enzymatic breaking of disulfide bridges. This work consists in the development of new macromolecular architectures for the targeting of tumour cells. pH sensitive copolymers able to micellize so as non-specific ligand like biotin is exposed on their surface in response to pH decrease typical for tumour tissues will be synthesized by the incorporation of pH-sensitive linkers, e.g. imine benzoïc linkers. In addition, the core of these new micelles will be cross-linked by disulfide bridges to prevent dissociation around healthy cells and trigger the drug release inside tumour cells. [less ▲]

Detailed reference viewed: 103 (16 ULg)
Full Text
Peer Reviewed
See detailCross-modal facilitation is not specific to self-face recognition
Brédart, Serge ULg

in Consciousness & Cognition (2004), 13(3), 610-612

Detailed reference viewed: 37 (9 ULg)
Full Text
Peer Reviewed
See detailCross-reactive T cell responses in HIV CRF01_AE and B'-infected intravenous drug users: implications for superinfection and vaccines.
Promadej-Lanier, Nattawan; Thielen, Caroline ULg; Hu, Dale J et al

in AIDS Research and Human Retroviruses (2009), 25(1), 73-81

Abstract We previously observed limited cross-reactive T cell responses in two HIV-1-superinfected injection drug users (IDUs) before superinfection [Ramos A, et al.: J Virol 2002;76(15):7444-7452]. To ... [more ▼]

Abstract We previously observed limited cross-reactive T cell responses in two HIV-1-superinfected injection drug users (IDUs) before superinfection [Ramos A, et al.: J Virol 2002;76(15):7444-7452]. To elucidate the role of such responses in superinfection we examined cross-reactive T cell responses in IDUs infected with a single HIV-1 subtype. In this study, IFN-gamma ELISPOT assays were performed using recombinant vaccinia constructs and peripheral blood mononuclear cells (PBMCs) from 43 IDUs singly infected with CRF01_AE or B' from the same cohort as the superinfected IDUs. PBMCs were from time points corresponding to pre- (early) or post- (late) superinfection in the superinfected IDUs. We observed that most singly infected IDUs had cross-reactivity in samples from early (84% of CRF01_AE and 78% of B'-infected IDUs) and late (96% of CRF_01AE and 77% of B'-infected IDUs) time points. Frequent homologous reactivity at early (67% of CRF-01AE and 100% of B') and late (84% of CRF01_AE-infected and 100% of B'-infected IDUs) time points was also observed. Cross-reactive responses were predominantly to Pol and were broader and higher in CRF01_AE than in B'-infected IDUs (medians of 825 vs. 90 and 585 vs. 60 spot-forming units/10(6) PBMCs at early and late time points, respectively). Our results show that cross-reactive responses were more prevalent with greater height and breadth in singly infected IDUs than previously observed in corresponding collection time points of superinfected IDU. Thus, low or absent cross-reactivity may have contributed to the previously observed superinfections. These data are relevant for understanding superinfection and improving vaccine design. [less ▲]

Detailed reference viewed: 40 (3 ULg)
Full Text
Peer Reviewed
See detailCross-reactivity of 25-hydroxy vitamin D2 from different commercial immunoassays for 25-hydroxy vitamin D: an evaluation without spiked samples.
CAVALIER, Etienne ULg; WALLACE, A. Michael; CARLISI, Ignazia ULg et al

in Clinical chemistry and laboratory medicine : CCLM / FESCC (2011), 49(3), 555-8

Detailed reference viewed: 35 (1 ULg)
Full Text
Peer Reviewed
See detailCross-reactivity of 25-hydroxyvitamin D2 in ADVIA Centaur Total Vitamin D
FORTUNATO, Antonio; LE GOFF, Caroline ULg; PEETERS, Stéphanie ULg et al

Poster (2012, May)

Detailed reference viewed: 30 (3 ULg)
Full Text
Peer Reviewed
See detailCross-sectional assessment of risk factors associated with breast cancer among French postmenopausal women being prescribed an antiosteoporotic treatment
Tancredi, Annalisa ULg; Bosio-Le Goux, B.; Augendre-Ferrante, B. et al

in Osteoporosis International (2005, March), 16(Suppl.3), 108

Detailed reference viewed: 12 (4 ULg)
Full Text
Peer Reviewed
See detailA cross-sectional epidemiological survey of bovine trypanosomosis and its vectors in the Savelugu and West Mamprusi districts of northern Ghana
Mahama, C. I.; Desquesnes, M.; Dia, M. L. et al

in Veterinary Parasitology (2004), 122(1), 1-13

The epidemiology of bovine trypanosomosis was investigated in two districts (Savelugu and West Mamprusi) of Northern Ghana with different land use and environmental characteristics. The land use intensity ... [more ▼]

The epidemiology of bovine trypanosomosis was investigated in two districts (Savelugu and West Mamprusi) of Northern Ghana with different land use and environmental characteristics. The land use intensity and environmental change was suspected to be higher in the Savelugu District. A cross-sectional entomological survey conducted along the White Volta river and its tributaries confirmed the presence of only Glossina palpalis gambiensis and G. tachinoides. The challenge index as measured by the product of tsetse density and tsetse infection rate was much higher in the West Mamprusi (19.6) than in the Savelugu district (4.7). A total of 10 13 cattle (508 in Savelugu and 505 in West Mamprusi) were bled from a random selection of 16 villages in the Savelugu District and 13 villaaes in the West Mamprusi District. Blood samples were examined for trypanosomes by the buffy coat technique (BCT). Blood samples that were positive in the BCT or negative in the BCT but with packed cell volume (PCV) values below 21 were further tested with a polymerase chain reaction for trypanosomal DNA. Plasma samples of all cattle were serologically tested with an indirect ELISA for trypanosomal antibodies. The parasitological and serological prevalence of bovine trypanosomoses was significantly higher in West Mamprusi (16 and 53%, respectively) than in Savelugu District (8 and 24%, respectively). An evaluation of animal health at the village herd level, using PCV as an index of anaemia, provided various epidemiological scenarios prevalent in the entire study-area. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailA cross-sectional evaluation of adiponectin plasma levels in patients with schizophrenia and schizoaffective disorder.
Hanssens, Linda; van Winkel, Ruud; Wampers, Martien et al

in Schizophrenia Research (2008), 106(2-3), 308-14

BACKGROUND: In recent years, several studies showed increased rates of hyperglycaemia, diabetes, dyslipidemia, metabolic syndrome as well as cardiovascular disease in schizophrenic patients. The ... [more ▼]

BACKGROUND: In recent years, several studies showed increased rates of hyperglycaemia, diabetes, dyslipidemia, metabolic syndrome as well as cardiovascular disease in schizophrenic patients. The underlying mechanism, however, is poorly understood. Adiponectin is a recently identified adipocyte-derived protein, with low adiponectin levels being associated with metabolic abnormalities such as obesity, insulin resistance and type 2 diabetes. METHODS: Fasting adiponectin levels were assessed in a cross-sectional sample of 386 patients with schizophrenia or schizoaffective disorder. All patients were on monotherapy of second-generation antipsychotics (SGA) and underwent an extensive metabolic screening including an oral glucose tolerance test (OGTT). RESULTS: Adiponectin plasma levels were inversely correlated with BMI, and differed significantly between patients with normal weight, overweight or obesity (p<0.05). Patients who met criteria for the metabolic syndrome, according to adapted National Cholesterol Educational Program - Adult Treatment Panel criteria (NCEP-ATP III) (29.3%), had significantly lower adiponectin levels than patients not meeting metabolic syndrome criteria (p<0.0001). Patients without glucose abnormalities (78%) had significantly higher adiponectin levels than patients with diabetes (5.7%) (p<0.05). After controlling for components of metabolic syndrome and sex, antipsychotic medication independently influenced adiponectin levels (p<0.0001), with the lowest mean levels in patients on clozapine and olanzapine. CONCLUSIONS: Adiponectin levels in schizophrenic patients mirror what is observed in the general population, with the lowest levels in the most metabolically comprised subjects. However, antipsychotic medication may also influence adiponectin regulation independently, a finding that should be confirmed in longitudinal studies. [less ▲]

Detailed reference viewed: 62 (7 ULg)
Full Text
Peer Reviewed
See detailA cross-sectional study of adiponectin in patients with schizophrenia
Hanssens, L.; De Hert, M.; Van Eyck, D. et al

in Schizophrenia Research (2006, January), 81(Suppl. S), 135

Detailed reference viewed: 15 (5 ULg)
Full Text
Peer Reviewed
See detailA cross-sectional study of adiponectin in patients with schizophrenia
Hanssens, L.; De Hert, M.; Van Eyck, D. et al

in European Neuropsychopharmacology (2006, September), 16(Suppl. 4), 430-431

Detailed reference viewed: 20 (5 ULg)
Full Text
Peer Reviewed
See detailA cross-sectional study of biotechnology awareness and teaching in European high schools.
Vanderschuren, Hervé ULg; Heinzmann, Dominik; Faso, Carmen et al

in New biotechnology (2010), 27(6), 822-8

Undoubtedly, biotechnology has a tremendous impact on our daily lives. As a result of this and in parallel to the advancement of knowledge in this field of applied research, consumer awareness of the ... [more ▼]

Undoubtedly, biotechnology has a tremendous impact on our daily lives. As a result of this and in parallel to the advancement of knowledge in this field of applied research, consumer awareness of the potential benefits and risks of this technology has steadily increased, leading to a thorough investigation of the public perception of biotechnology in the past years. Indeed, it has become clear that it is in the general interest of science and especially of applied research to inform the public of its advances. A promising next step is to strengthen biotechnology communication in scholastic institutions. In this paper, we investigate the perception of biotechnology in a specific target group, namely high-school students in the 16-20-year-old age range. We conducted a questionnaire-based survey on a total of 1410 students in six European countries to investigate students' perception, concern, scientific knowledge, and awareness. Our data revealed some unexpected patterns of acceptance and concern about biotechnology. Knowledge analysis indicated that pupils lack specific knowledge about biotechnological applications and their interest in biotechnology appeared to be linked to knowledge. Analysis of specific questions about teaching practices at schools suggests that a better targeted choice in media as vehicles for information together with selected speakers could be instrumental in increasing students' interest in science and more specifically in biotechnology. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailCross-Sectional Study of the Association between Pathological Conditions and Myxoma-Virus Seroprevalence in Intensive Rabbit Farms in Europe
Marlier, Didier ULg; Herbots, J.; Detilleux, Johann ULg et al

in Preventive Veterinary Medicine (2001), 48(1), 55-64

Myxomatosis is a major viral disease of the European rabbit (Oryctolagus cuniculus). Two forms of the disease (nodular and amyxomatous) exist. The clinical diagnosis of the nodular form is easily ... [more ▼]

Myxomatosis is a major viral disease of the European rabbit (Oryctolagus cuniculus). Two forms of the disease (nodular and amyxomatous) exist. The clinical diagnosis of the nodular form is easily performed on the basis of typical skin lesions whereas that of amyxomatous forms must be based on virus isolation or detection of specific antibodies to myxoma virus (MV). The seroprevalence of MV was studied between March 1998 and February 1999 in 16 farms from three European countries considered free of myxomatosis on the basis of the absence of typical clinical signs. MV antibodies were detected by enzyme-linked immunosorbent assay (ELISA) (sensitivity 100%, specificity 90%) in all 16 farms; the seroprevalences corrected for test inaccuracy (95% confidence interval) were 55+/-7.7% and 37+/-6.1% for does and broilers, respectively. The association between herd sizes, types of rabbitries, and presence of recurrent respiratory or digestive troubles and seroprevalence of MV antibodies was tested in logistic multiple regressions. In all models, the seroprevalence of MV antibodies was significantly higher in herds (does and broilers) with recurrent respiratory or digestive troubles than in herds without these problems. The seroprevalence was also higher in herds (does and broilers) where animals were housed totally or partially in outdoors rabbitries than in totally enclosed rabbitries. The effect of herd sizes on the presence of MV antibodies was the same in does and broilers; intermediate sizes were at lower risk than the smaller and larger ones. [less ▲]

Detailed reference viewed: 26 (1 ULg)
Full Text
Peer Reviewed
See detailA cross-sectional study to assess knowledge about HIV/AIDS transmission and prevention measures in company workers in Ecuador
Cabezas Guerra, Maria del Carmen ULg; Fornasini, Marco; Dardenne, Nadia ULg et al

in BMC Public Health (2013), 13

Background: HIV/AIDS was first reported in Ecuador in 1984 and its prevalence has been increasing ever since. In 2009, the National AIDS Program reported 21,810 HIV/AIDS cases and confirmed that the ... [more ▼]

Background: HIV/AIDS was first reported in Ecuador in 1984 and its prevalence has been increasing ever since. In 2009, the National AIDS Program reported 21,810 HIV/AIDS cases and confirmed that the worker population was amongst the most affected groups. The objective of this study was to assess knowledge about HIV transmission and prevention measures in company workers in Ecuador. Methods: A cross-sectional survey based on a random sample of 115 companies (1,732 workers), stratified by three large provinces and working sectors (commerce, manufacturing and real estate) was conducted. A validated instrument developed by Family Health International was used to evaluate HIV prevention knowledge and common local misconceptions about HIV transmission. Descriptive statistics, chi square test and logistic regression analysis were performed using SAS. Results: Incorrect knowledge about HIV/AIDS transmission were found in 49.1% (95% CI: 46.6-51.6) of subjects. Incorrect knowledge was higher among males (OR=1.73 [1.39 –2.15]), older subjects (OR=1.35 [1.02 – 1.77]), subjects with lower education (OR=3.72 [2.44 – 5.65]), manual labor workers (OR=2.93 [1.82 – 4.73]) and subjects without previous exposure to HIV intervention programs (OR=2.26 [1.79 – 2.86]). Incorrect knowledge about preventive measures was found among 32.9% (95%CI: 30.6-35.2) of respondents. This proportion was higher among subjects with lower education (OR=2.28 [1.52 – 3.43]), married subjects (OR=1.34 [1.07 – 1.68]), manual labor workers (OR=1.80 [1.34 – 2.42]), and subjects not previously exposed to HIV intervention programs (OR=1.44 [1.14 – 1.83]). Conclusions: HIV intervention programs targeting company workers are urgently needed to improve knowledge and reduce HIV transmission in Ecuador. [less ▲]

Detailed reference viewed: 79 (7 ULg)
Full Text
Peer Reviewed
See detailThe cross-talk between dendritic and regulatory T cells: good or evil?
Hubert, Pascale ULg; Jacobs, Nathalie ULg; Caberg, Jean-Hubert ULg et al

in Journal of Leukocyte Biology (2007), 82(4), 781-94

Immune responses against pathogens require fine regulation in order to avoid excessive inflammation, which could be harmful to the host. Moreover, the immune system must be tolerant to non-pathogenic ... [more ▼]

Immune responses against pathogens require fine regulation in order to avoid excessive inflammation, which could be harmful to the host. Moreover, the immune system must be tolerant to non-pathogenic antigens in order to prevent allergy, autoimmunity and transplant rejection. There is accumulating evidence that interactions between dendritic cells (DC) and regulatory T (Treg) cells play a crucial role in the balance between immune response and tolerance. Communications between these cells are complex, bi-directional and mediated by soluble or cell surface molecules. The maturation status of DC, which may be influenced by different microenvironmental factors, is considered as an important checkpoint for the induction of peripheral tolerance through modifications of the activation status of T cells. Moreover, several lines of experimental evidence suggest that different subsets or the functional status of DC are also involved in the promotion of Treg cell differentiation. A better knowledge of the regulatory mechanisms of the immune response induced or inhibited by DC via their interactions with Treg cells could be relevant for the development of new immunotherapeutic approaches. [less ▲]

Detailed reference viewed: 73 (13 ULg)
Peer Reviewed
See detailCross-talk Modeling of Wnt, BMP and ERK Pathways during Osteochondrogenic Differentiation
Geris, Liesbet ULg; Vandeput, M.; Roberts, S. et al

in Proceedings of the TERMIS-EU meeting (2010, June)

Detailed reference viewed: 17 (2 ULg)
Full Text
See detailA Cross-Validation Approach to Approximate Basis Function Selection of the Stall Flutter Response of a Rectangular Wing in a Wind Tunnel
Kukreja, Sunil L.; Vio, Gareth A.; Andrianne, Thomas ULg et al

in Proceedings of the 53rd AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics and Materials Conference (2012, April 25)

The stall flutter response of a rectangular wing in a low speed wind tunnel is modelled using a nonlinear difference equation description. Static and dynamic tests are used to select a suitable model ... [more ▼]

The stall flutter response of a rectangular wing in a low speed wind tunnel is modelled using a nonlinear difference equation description. Static and dynamic tests are used to select a suitable model structure and basis function. Bifurcation criteria such as the Hopf condition and vibration amplitude variation with airspeed were used to ensure the model was representative of experimentally measured stall flutter phenomena. Dynamic test data were used to estimate model parameters and estimate an approximate basis function. [less ▲]

Detailed reference viewed: 50 (12 ULg)
See detailCross-Words. Issues and Debates in Literary and Non-literary Translating
Pagnoulle, Christine ULg; Mason, Ian

Book published by L3 (1995)

Those sixteen contributions on the art of translating move from general considerations on what is involved in the process and specific strategies, to field-related topics such as legal translation ... [more ▼]

Those sixteen contributions on the art of translating move from general considerations on what is involved in the process and specific strategies, to field-related topics such as legal translation, teaching and assessing translations, to case studies in literary translation (Sinclair Lewis, nabokov, Queneau, Mistral, Lowell and Pound). [less ▲]

Detailed reference viewed: 130 (9 ULg)
Full Text
See detailA crossed random effects model to detect differential item functioning
Frederickx, Sofie; Magis, David ULg; Tuerlinckx, Francis et al

Conference (2008, June)

Detailed reference viewed: 7 (0 ULg)
Full Text
See detailCrossed random effects models for the detection of differential item functioning in psychometrics
Magis, David ULg; Frederickx, Sofie; Tuerlinckx, Francis et al

Conference (2008, October)

Detailed reference viewed: 2 (0 ULg)