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See detailCorals of the Upper Viséan Microbial-Sponge-Bryozoan-Coral Bioherm of Kongul Yayla (Taurides, S Turkey), Palaeobiogeographic Relations
Denayer, Julien ULg

in Turkish Association of Petroleum Geologists, Special Publication (2012), 6

Detailed reference viewed: 15 (2 ULg)
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See detailThe CORALS project: simulated Cosmic Radiations and Alternative Splicing.
Lambert, Charles ULg; Battout, S.; Van Oostveldt, P. et al

Conference (2009)

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See detailUn Coran liégeois
Martin, Aubert ULg; Bauden, Frédéric ULg

in La Vie Wallonne (1992), 56(417-418), 5-20

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See detailCord blood banking
Brand, A.; Rebulla, P.; Engelfriet, C. P. et al

in Vox Sanguinis (2008), 95

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See detailCord blood banking Introduction-State of the art
BAUDOUX, Etienne ULg

in Gluckman, Eliane; Cavazzana (Eds.) World Cord blood congress IV and innovative therapies for sickle cell disease (2013, October 25)

Since the early years 1990 when the first cord blood (CB) banks were created, the worldwide inventory has grown considerably to a current 590 thousand units that complement the 22 M donors to provide ... [more ▼]

Since the early years 1990 when the first cord blood (CB) banks were created, the worldwide inventory has grown considerably to a current 590 thousand units that complement the 22 M donors to provide hematopoietic progenitor cells (HPC) to patients in need of an allogeneic transplantation. The existing inventory shows a high degree of heterogeneity with a significant number of units below the current transplantation standards for adult patients. In the mean time, the use of CB as a HPC source has remained steady over the last years, leading to a relative decrease in the release activity in each individual bank. New challenges and innovations have emerged, such as: • More stringent regulations in the USA and in the EU • Upgrades in professional standards • Competing transplantation approaches such as easier access to adult unrelated donors (UD), use of haplo identical donors, single or multiple CB transplantation • CB collection safety becoming a concern since issues have been raised about the outcome of newborns linked to their iron status • The definition of clear criteria for transplant selection (HLA typing level, cell contents) • Potential role of CB banks in non hematological CB use (use of CB byproducts, generation of iPS from selected universal donors, immunotherapy, HIV therapy) • Financial restrictions The elements mentioned above have lead banking strategies, including recruitment, donor selection, CB collection, processing, storage and release to evolve considerably and to incorporate • Active volunteer accreditation processes for international recognition • Donor recruitment: more detailed and selective donor evaluation • Systematic nucleic acid (NAT) testing for infectious disease markers (IDM) • Extensive use of molecular HLA typing and widening range of loci to be taken into account • Evolving definition of acceptance criteria for incoming CB units, (i.e. stricter TNC requirements) • Well standardized processing and storage methods • Evaluation and adaptation of supply vs. needs in strategic approaches • Need to increase and optimize CB visibility through up to date electronic solutions • Methods to have a permanent and up to date overview of post transplantation outcomes, including elements relevant to the banking and clinical side Professional organizations (NetCord, WMDA, FACT, WBMT) are in the process of tightening their links in order to increase interactions and respond in time to upcoming challenges and evolutions of the field. [less ▲]

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See detailCord Blood Banking: Cord blood management and evaluation: International networking
Van Beckhoven, Jacqueline; BAUDOUX, Etienne ULg; Duffy, Merry et al

in Bart, Thomas; Hwang, William; Boo, Michael (Eds.) A gift for life, WMDA handbook for blood stem cell donation (2013)

Detailed reference viewed: 34 (1 ULg)
See detailCord blood for allogeneic use: Clinical and scientific aspects?
BAUDOUX, Etienne ULg; BEGUIN, Yves ULg; Benoit, Yves et al

Report (2012)

In this science-policy advisory report, the Superior Health Council issues advice on cord blood as an allogeneic source of stem cells for human clinical use

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See detailCord blood transplantation in a child with Pearson's disease.
Hoyoux, Claire; Dresse, Marie-Françoise ULg; Robinet, Sébastien ULg et al

in Pediatric Blood & Cancer (2008), 51(4), 566

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See detailCORD DONOR Safety
BAUDOUX, Etienne ULg; Lefebvre, Caroline ULg; FASTH, Anders

Conference (2014, May 16)

As for any cell donation, donor safety parameters must be included in the design of cord blood (CB) collection procedures. Until recently, CB donation has been regarded as a relatively safe procedure, and ... [more ▼]

As for any cell donation, donor safety parameters must be included in the design of cord blood (CB) collection procedures. Until recently, CB donation has been regarded as a relatively safe procedure, and practices have evolved from the early stages of CB banking to make reasonable provisions to protect mothers and infant donors from harm linked to CB donation: informed consent, exclusion of complicated pregnancies and deliveries, as well as of pre-term births, non-interference with obstetrical practices, use of trained staff for CB collection, standardized aseptic collection practices, donation limited to single births. Besides, professional standards foresee careful record keeping of clinical side effects that may occur in the course of CB collection. Since 2011 time to cord clamping has become a concern in the light of publications on iron depletion and post natal outcome, including neurological development, and linked to early or late cord clamping at birth. As data show benefits of late clamping in low birth weight infants in terms of anemia and iron stores, it now admitted by professional organizations to delay cord clamping for 1 minute after birth, especially for pre-term births. However, in full term births after uncomplicated pregnancy, that are the target population for CB donation, there is no clear indication to confirm or refute benefits of late clamping. In some countries, sometimes emotional awareness has increased about optimal timing of cord clamping, leading to some resistance to CB donation and to questioning of the harmless reputation of CB donation. CB banking professionals however have not changed their recommendations, leaving up to obstetrical teams the decision to collect or not, after risk benefit assessment. However, CB bankers remain with the duty of providing transparent and up to date information to mothers, as well as of setting up accurate policies regarding informed consent. [less ▲]

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See detailCordon sanitaire : de l'éthique et de la responsabilité
Jamin, Jérôme ULg

Conference (2010)

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See detailCordon sanitaire et principes journalistiques: le point de vue de la réception
Devresse, Jenifer ULg

Diverse speeche and writing (2010)

L'objectif du séminaire est d'amener les acteurs présents (éditeurs de chaînes, journalistes, politiques) à débattre de la question du cordon sanitaire et ainsi mettre à plat les différentes ... [more ▼]

L'objectif du séminaire est d'amener les acteurs présents (éditeurs de chaînes, journalistes, politiques) à débattre de la question du cordon sanitaire et ainsi mettre à plat les différentes interprétations qui en sont données. A terme ces réflexions serviront de cadre au Collège d'avis du CSA qui devra revoir le règlement relatif aux programmes de radio et télévision en période électorale. Il s'agit de proposer des perspectives et questions par rapport au fait de donner ou non la parole à l'extrême droite dans les médias. Plus précisément, il s'agit d'interroger la responsabilité sociale et éditoriale des médias en éclairant le rôle que les médias et les journalistes jouent concrètement dans le succès électoral de l'extrême droite (à partir d'une analyse discursive de la couverture médiatique des présidentielles françaises de 2002). [less ▲]

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See detailLe cordon sanitaire: définition, enjeux, actualités
Devresse, Jenifer ULg

Learning material (2011)

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See detailThe core 2 beta-1,6-N-acetylglucosaminyltransferase-M encoded by bovine herpesvirus 4 is not essential for virus replication despite contributing to post-translational modifications of structural proteins.
Markine-Goriaynoff, Nicolas; Gillet, Laurent ULg; Karlsen, Odd A et al

in Journal of General Virology (The) (2004), 85(Pt 2), 355-67

The Bo17 gene of bovine herpesvirus 4 (BoHV-4) is the only virus gene known to date that encodes a homologue of the cellular core 2 beta-1,6-N-acetylglucosaminyltransferase-mucine type (C2GnT-M). Recently ... [more ▼]

The Bo17 gene of bovine herpesvirus 4 (BoHV-4) is the only virus gene known to date that encodes a homologue of the cellular core 2 beta-1,6-N-acetylglucosaminyltransferase-mucine type (C2GnT-M). Recently, our phylogenetic study revealed that the Bo17 gene has been acquired from an ancestor of the African buffalo around 1.5 million years ago. Despite this recent origin, the Bo17 sequence has spread to fixation in the virus population possibly by natural selection. Supporting the latter hypothesis, it has been shown by our group for the V. test strain that Bo17 is expressed during BoHV-4 replication in vitro, and that Bo17 expression product (pBo17) has all three enzymic activities exhibited by cellular C2GnT-M, i.e. core 2, core 4 and I branching activities. In the present study, firstly it was investigated whether encoding a functional C2GnT-M is a general property of BoHV-4 strains. Analysis of nine representative strains of the BoHV-4 species revealed that all of them express the Bo17 gene and the associated core 2 branching activity during virus replication in vitro. Secondly, in order to investigate the roles of Bo17, its kinetic class of expression was analysed and a deleted recombinant strain was produced. These experiments revealed that Bo17 is expressed as an early gene which is not essential for virus replication in vitro. However, comparison of the structural proteins, produced by the wild-type, the revertant and the deleted viruses, by 2D gels demonstrated that pBo17 contributes to the post-translational modifications of structural proteins. Possible roles of Bo17 in vivo are discussed. [less ▲]

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See detailThe core 2 beta-1,6-N-acetylglucosaminyltransferase-mucin encoded by bovine herpesvirus 4 was acquired from an ancestor of the African buffalo
Markine-Goriaynoff, N.; Georgin, J. P.; Goltz, M. et al

in Journal of Virology (2003), 77(3), 1784-1792

The Bo17 gene of bovine herpesvirus 4 (BoHV-4) is the only viral gene known to date that encodes a homologue of the cellular core 2 beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M). To ... [more ▼]

The Bo17 gene of bovine herpesvirus 4 (BoHV-4) is the only viral gene known to date that encodes a homologue of the cellular core 2 beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M). To investigate the origin and evolution of the Bo17 gene, we analyzed its distribution among BoHV-4 strains and determined the sequences of Bo17 from nine representative strains and of the C2GnT-M gene from six species of ruminants expected to encompass the group within which the gene acquisition occurred. Of 34 strains of BoHV-4, isolated from four different continents, all were found to contain the Bo17 gene. Phylogenetic analyses indicated that Bo17 was acquired from a recent ancestor of the African buffalo, implying that cattle subsequently acquired BoHV-4 by cross-species transmission. The rate of synonymous nucleotide substitution in Bo17 was estimated at 5 x 10(-8) to 6 x 10(-8) substitutions/site/year, consistent with previous estimates made under the assumption that herpesviruses have cospeciated with their hosts. The Bo17 gene acquisition was dated to around 1.5 million years ago. Bo17 sequences from BoHV-4 strains from African buffalo and from cattle formed two separate clades, estimated to have split about 700,000 years ago. Analysis of the ratio of nonsynonymous to synonymous nucleotide substitutions revealed a burst of amino acid replacements subsequent to the transfer of the cellular gene to the viral genome, followed by a return to a strong constraint on nonsynonymous changes during the divergence of contemporary BoHV-4 strains. The Bo17 gene represents the most recent of the known herpesvirus gene acquisitions and provides the best opportunity for learning more about this important process of viral evolution. [less ▲]

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See detailCore Level Excitation in molecular Clusters.
Rühl, E.; Schmale, C.; Baumgärtel, H. et al

Book published by Berliner Elektronen Speicherring für Synchrotron Strahlung m.b.H (1991)

The photoionization of CO at the C-Kedge and that of its dimer are measured. The photodissociation of the cluster ion is investigated by PEPICO and PIPICO techniques.

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See detailCore Level Excitation of Atomic and Molecular Clusters.
Rühl, E.; Schmale, C.; Jochims, H. W. et al

in Beswick, A. (Ed.) Synchrotron Radiation and Dynamic Phenomena. (1992)

Core level excitation of weakly bonded atomic and molecular species is reported. Excitations into unoccupied orbitals with valence and Rydberg character as well as into the corresponding K- and L-continua ... [more ▼]

Core level excitation of weakly bonded atomic and molecular species is reported. Excitations into unoccupied orbitals with valence and Rydberg character as well as into the corresponding K- and L-continua are compared with the isolated and condensed species. Core level excitation of clusters is also accompagned with extensive fragmentation of singly and doubly charged clusters. Coincidence techniques such as photoelectron-photoion-coincidences (PEPICO) and photoion-photoion-coincidence (PIPICO) are used to study the photochemical fragmentation pathways of core excited clusters. Kinetic energy releases related to charge separation of cluster dications (Coulomb explosion) are derived from PIPICO spectra. The fragmentation energetics is discussed in relation to cluster dication threshold energies. [less ▲]

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See detailCore properties of α Centauri A using asteroseismology
de Meulenaer, P.; Carrier, F.; Miglio, A. et al

in Astronomy and Astrophysics (2010), 523

Context. A set of long and nearly continuous observations of α Centauri A should allow us to derive an accurate set of asteroseismic constraints to compare to models, and make inferences on the internal ... [more ▼]

Context. A set of long and nearly continuous observations of α Centauri A should allow us to derive an accurate set of asteroseismic constraints to compare to models, and make inferences on the internal structure of our closest stellar neighbour. <BR /> Aims: We intend to improve the knowledge of the interior of α Centauri A by determining the nature of its core. <BR /> Methods: We combined the radial velocity time series obtained in May 2001 with three spectrographs in Chile and Australia: CORALIE, UVES, and UCLES. The resulting combined time series has a length of 12.45 days and contains over 10 000 data points and allows to greatly reduce the daily alias peaks in the power spectral window. <BR /> Results: We detected 44 frequencies that are in good overall agreement with previous studies, and found that 14 of these show possible rotational splittings. New values for the large (Δν) and small separations (δν[SUB]02[/SUB], δν[SUB]13[/SUB]) have been derived. <BR /> Conclusions: A comparison with stellar models indicates that the asteroseismic constraints determined in this study (namely r[SUB]10[/SUB] and δν[SUB]13[/SUB]) allows us to set an upper limit to the amount of convective-core overshooting needed to model stars of mass and metallicity similar to those of α Cen A. [less ▲]

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See detailCore velocity dispersion and mass-to-light ratio of the old Magellanic globular cluster NGC 1835
Dubath, P.; Meylan, G.; Mayor, M. et al

in Astronomy and Astrophysics (1990), 239

Abstract image available at: http://adsabs.harvard.edu/abs/1990A&A...239..142D

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See detailCore Velocity Dispersion of the LMC Globular Cluster NGC 1835
Meylan, G.; Dubath, P.; Mayor, M. et al

in Bulletin of the American Astronomical Society (1989, January 01)

Not Available

Detailed reference viewed: 4 (0 ULg)