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See detailLe complexe du Lincombien-Ranisien-Jerzmanowicien
Flas, Damien ULg

in Depaepe, Pascal (Ed.) La France au Paléolithique (2009)

Detailed reference viewed: 21 (0 ULg)
See detailComplexe I mitochondrial dysfunction in HDAC5 depleted cancer cells induces glucose-dependent metabolic reprogrammation.
Hendrick, Elodie ULg; Matheus, Nicolas ULg; Peixoto, Paul ULg et al

Poster (2013, September 13)

Introduction: Histone deacetylases (HDAC) is a family of eighteen enzymes, which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure ... [more ▼]

Introduction: Histone deacetylases (HDAC) is a family of eighteen enzymes, which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure. Broad-spectrum inhibitors of these enzymes such as SAHA can inhibit tumor growth both in vitro and in vivo and are currently used as anti-cancer agents in clinic. For many years, we are investigating the specific role of individual HDAC members in cancer biology and we have recently demonstrated that specific depletion of HDAC5 using siRNA technology reduced cancer cells proliferation and survival1. Aims: The goal of this study is to further understand the metabolic response of cancer cells to HDAC5 depletion. Results: Screening transcriptomic study demonstrated that HDAC5 depletion induces a deregulation of genes encoding subunits of complex I of the mitochondrial respiratory chain leading to a significant increase of ROS production and inducing uncoupled mitochondrial respiration. In addition, this HDAC5 depletion-induced mitochondrial dysfunction provokes metabolic adaptation associated with increased importance of glucose. Indeed, interference with glucose supply in HDAC5-depleted cancer cells significantly increases apoptotic cell death suggesting that glucose deprivation might be combined to HDAC5 inhibition as a therapeutic strategy to kill cancer cells. Conclusion: Our study demonstrated for the first time that specific HDAC5 inhibition induces alteration of gene expression encoding mitochondrial proteins in cancer cells and provide insight into a valuable experimental strategy for manipulation of specific HDAC5 inhibition and glucose metabolism in therapy against cancer. 1.Peixoto, P. et al. HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells. Cell death and differentiation, 2012; 1-14. elodie.hendrick@student.ulg.ac.be [less ▲]

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See detailLe complexe respiratoire bovin
Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1996), 140

Respiratory disease is the principal cause of loss of young cattle worldwide. The syndrome arises from a number of factors, including those involving the animal, e.g., age, general condition and immune ... [more ▼]

Respiratory disease is the principal cause of loss of young cattle worldwide. The syndrome arises from a number of factors, including those involving the animal, e.g., age, general condition and immune status; its environment, e.g. changes in food, temperature and humidity that lead to stress; and the presence of infectious agents, e.g., bacteria, viruses and mycoplasmas. The syndrome, in a method proposed by the author, can be classified into four grades: Grade 1, subclinical disease; Grade 2, compensated clinical disease; Grade 3, noncompensated clinical disease; and Grade 4, irreversible clinical disease. The increase in frequency and economic impact of bovine respiratory disease complex can be correlated with the escalating industrialisation of cattle produc-tion. In intensive operations, commingling of animals from multiple sources, exposure to many orga-nisms, stress and management practices are all factors that can lead to disease. The predisposition of cattle, espe-cially beef calves, to respiratory problems is related to their lack of functional pulmonary hardiness. Selection of breeds that demons-trate adequate pulmonary function and sufficient ventilatory reserve may help in the control of the bovine respiratory disease complex, but this approach is difficult to implement and slow to produce results. Prophylactic measures, including vaccination programmes and modifying management practices to reduce stress, also have a place in preventing the bovine respiratory disease complex. Unfortunately, these measures are not always easy to put into operation and cannot completely eradicate the problem. Therapeutic strategies to minimise the economic impact of the syndrome include use of appropriate antibacterial therapy, modulation of the pulmonary inflammatory reaction and correction of mechanical disorders [less ▲]

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See detail. Le complexe tourbeux du Grand-Bongard.
Bonhomme, JM; Gavray, L; Lejeune, I et al

in Hautes Fagnes (1985), 179

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See detailComplexes à multicomposants de miconazole avec différents acides et cyclodextrines
Piel, Géraldine ULg; Evrard, Brigitte ULg; Delattre, Luc ULg

in Journal de Pharmacie de Belgique (1997), 52(3), 124

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See detailComplexes et complexions de Mach à Meinong
Zincq, Aurélien ULg

Conference (2015, April 27)

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See detailComplexes I in the green lineage.
Remacle, Claire ULg; Hamel, Patrice; Larosa, Véronique ULg et al

in Sazanov, Leonid (Ed.) A structural perspective on complex I. (2012)

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See detailLa complexification du droit des marchés et contrats publics : lancement de la nouvelle revue juridique OOO/MCP
Durviaux, Ann-Lawrence ULg

in 1er numéro de la revue MCP/ OOO (2011, April 01)

Detailed reference viewed: 40 (2 ULg)
See detailComplexions et relations. Sur les objets d’ordre supérieur I
Zincq, Aurélien ULg

Conference (2014, September 22)

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See detailComplexité : Sciences humaines et promotion de la santé. A quelles conditions ?
Absil, Gaëtan ULg

Scientific conference (2016, September 09)

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See detailLa complexité d’Héraclès, entre Hérodote et les cultes de Thasos
Pitz, Zoé ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (in press), 29

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See detailComplexité et incertitude de la/en didactique du FLE
Defays, Jean-Marc ULg; Meunier, Deborah ULg

in Dumortier, Jean-Louis; Van Beveren, Julien; Vrydaghs, David (Eds.) Curriculum et progression en français. Actes du 11e colloque de l'AIRDF, Université de Liège, 26-28 août 2010 (2012)

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See detailComplexity markers in morphosyntactic productions in French-speaking children with specific language impairment (SLI)
Prigent, Gaïd ULg; Parisse, Christophe; Leclercq, Anne-Lise ULg et al

in Clinical Linguistics & Phonetics (2015)

The usage-based theory considers that the morphosyntactic productions of children with SLI are particularly dependent on input frequency. When producing complex syntax, the language of these children is ... [more ▼]

The usage-based theory considers that the morphosyntactic productions of children with SLI are particularly dependent on input frequency. When producing complex syntax, the language of these children is, therefore, predicted to have a lower variability and to contain fewer infrequent morphosyntactic markers than that of younger children matched on morphosyntactic abilities. Using a spontaneous language task, the current study compared the complexity of the morphological and structural productions of 20 children with SLI and 20 language-matched peers (matched on both morphosyntactic comprehension and mean length of utterance). As expected, results showed that although basic structures were produced in the same way in both groups, several complex forms (i.e. tenses such as Imperfect, Future or Conditional and Conjunctions) were less frequent in the productions of children with SLI. Finally, we attempted to highlight complex linguistic forms that could be good clinical markers for these children. [less ▲]

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See detailA complexity metric for practical ship design
Caprace, Jean-David ULg; Rigo, Philippe ULg

in Proceeding of PRADS 2010 (2010, September)

The paper introduces an innovative complexity metric for practical ship design taking into account the shape complexity of steel parts, the assembly complexity of steel components and the material ... [more ▼]

The paper introduces an innovative complexity metric for practical ship design taking into account the shape complexity of steel parts, the assembly complexity of steel components and the material complexity of the structure. The goal is to provide the designer with such information throughout the design process so that an efficient design is obtained at the first design run. Real-time assessment of complexity and quality measure-ments is rather imperative to ensure efficient and effec-tive optimality search, and to allow real-time adjustment of requirements during the design. Application and validation on a real passenger ship show that the new method is effective in giving a complementary aid to decision process for ship designers. [less ▲]

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See detailComplexity of a polyphenism: Facultative paedomorphosis in newts and salamanders
Denoël, Mathieu ULg

Scientific conference (2010)

Detailed reference viewed: 24 (8 ULg)