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Peer Reviewed
See detailContrast enhanced nanoCT for volumetric analyses of in vitro manufactured tissue-engineered bone constructs: a soft tissue case study
Sonnaert, Maarten; Papantoniou, Ioannis; Geris, Liesbet ULg et al

Conference (2013)

Detailed reference viewed: 4 (1 ULg)
Peer Reviewed
See detailEen contrast in contrastief taalonderzoek
Hiligsmann, Philippe; Rasier, Laurent ULg

Conference (2006)

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See detailContrast-enhanced coded phase-inversion harmonic sonography of knee synovitis correlates with histological vessel density: 2 automated digital quantifications
Kaiser, Marie-Joëlle ULg; Hauzeur, Jean-Philippe ULg; Blacher, Silvia ULg et al

in Journal of Rheumatology (2009), 36(7), 1391-400

OBJECTIVE: To use contrast-enhanced coded phase-inversion harmonic B-mode sonography to assess the acoustic enhancement of the synovial area of the knee; and to compare the data with the histological ... [more ▼]

OBJECTIVE: To use contrast-enhanced coded phase-inversion harmonic B-mode sonography to assess the acoustic enhancement of the synovial area of the knee; and to compare the data with the histological vessel density. METHODS: Eleven patients eligible for a knee arthroscopy were studied. Acoustic quantification was carried out by a digital image analysis program that detects the time-dependent increase [intensity (time) = k x time + C] of gray-level intensity in all the pixels of a specific region of interest (ROI) following intravenous injection of the microbubble contrast agent sulfur hexafluoride. Echo-guided synovial biopsies were carried out in the same ROI. Synovial vessel areas were quantified after Factor VIII immunostaining of synovial biopsies using an automated digital image analysis. RESULTS: Significant (p < 0.05) correlations were observed between histological vessel density and percentage of the synovial area with a k value > 0.01 (r = 0.93) and k(max) values (r = 0.79), as well as between the 2 latter parameters (r = 0.72). The histological vessel density and the 2 acoustic parameters were also significantly correlated with the logarithm of erythrocyte sedimentation rate (r = 0.77, r = 0.87, r = 0.67, respectively) and with log C-reactive protein serum concentration (r = 0.69, r = 0.83, r = 0.62, respectively). CONCLUSION: Contrast-enhanced coded phase-inversion harmonic B-mode sonography coupled with an appropriate data analysis method is a new tool to identify and quantify vessel density in knee synovitis. [less ▲]

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See detailContrast-enhanced nanofocus computed tomography for virtual 3D histopathology and morphometric analysis of multiple skeletal tissues
Kerckhofs, Greet ULg; Papantoniou, Ioannis; Sonnaert, Maarten et al

Conference (2013)

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See detailContrast-enhanced nanofocus computed tomography images the cartilage subtissue architecture in three dimensions.
Kerckhofs, Greet ULg; Sainz, J.; Wevers, M. et al

in European cells & materials (2013), 25

We describe a non-destructive imaging method, named contrast-enhanced nanofocus X-ray computed tomography (CE-nanoCT), that permits simultaneously imaging and quantifying in 3D the (sub)tissue ... [more ▼]

We describe a non-destructive imaging method, named contrast-enhanced nanofocus X-ray computed tomography (CE-nanoCT), that permits simultaneously imaging and quantifying in 3D the (sub)tissue architecture and (biochemical) composition of cartilage and bone in small animal models at a novel contrast and spatial resolution. To demonstrate the potential of this novel methodology, a newborn mouse was scanned using CE-nanoCT. This allowed simultaneously visualising the bone and cartilage structure much like the traditional alcian blue-alizarin red skeletal stain. Additionally, it enabled a 3D visualisation at such a high spatial image resolution that internal, micro-scale structures could be digitally dissected and evaluated for size, structure and composition. Ex vivo treatment with papain, that is known to specifically remove the non-calcified cartilage layer but keep the calcified cartilage intact, proved CE-nanoCT to be applicable to visualise the subdivisions within the hyaline cartilage of the articular joint of mice. The quantitative power of CE-nanoCT in vivo was evaluated using a mouse model for osteoarthritis (OA), where OA-like cartilage lesions are induced by meniscus destabilisation surgery. The thickness of both the non-calcified and calcified cartilage layer in the knee joint of such mice was visualised and quantified in 3D and compared to unaffected mice. Finally, to show that different forms of cartilage and tissue combinations can be distinguished using CE-nanoCT, different cartilaginous body parts of the mouse were imaged. In conclusion, CE-nanoCT can provide novel insights in preclinical research by quantifying in a non-destructive 3D manner pathological differences, in particular in developing mice, newborns or adults. [less ▲]

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See detailContrast-enhanced nanofocus computed tomography: a powerful technique enabling the combined visualization of the tissue architecture of cartilage and bone
Kerckhofs, Greet ULg; Sainz, Julie; Wevers, Martine et al

in Abstract book User Meeting Bruker MicroCT 2012 (2012)

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See detailContrast-enhanced nanofocus X-ray computed tomography allows virtual 3D histopathology and morphometric analysis of osteoarthritis in small animal models
Kerckhofs, Greet ULg; Sainz, J.; Maréchal, M. et al

in Cartilage (2013)

Objective: One of the early hallmarks of osteoarthritis (OA) is a progressive degeneration of the articular cartilage. Early diagnosis of OA-associated cartilage alterations would be beneficial for ... [more ▼]

Objective: One of the early hallmarks of osteoarthritis (OA) is a progressive degeneration of the articular cartilage. Early diagnosis of OA-associated cartilage alterations would be beneficial for disease prevention and control, and for the development of disease-modifying treatments. However, early diagnosis is still hampered by a lack of quantifiable readouts in preclinical models. Design: In this study, we have shown the potency of contrast-enhanced nanofocus x-ray computed tomography (CE-nanoCT) to be used for virtual 3-dimensional (3D) histopathology in established mouse models for OA, and we compared with standard histopathology. Results: We showed the equivalence of CE-nanoCT images to histopathology for the modified Mankin scoring of the cartilage structure and quality. Additionally, a limited set of 3D cartilage characteristics measured by CE-nanoCT image analysis in a user-independent and semiautomatic manner, that is, average and maximum of the noncalcified cartilage thickness distribution and loss in glycosaminoglycans, was shown to be predictive for the cartilage quality and structure as can be evaluated by histopathological scoring through the use of an empirical model. Conclusions: We have shown that CE-nanoCT is a tool that allows virtual histopathology and 3D morphological quantification of multitissue systems, such as the chondro-osseous junction. It provides faster and more quantitative data on cartilage structure and quality compared with standard histopathology while eliminating user bias. CE-nanoCT thus should allow capturing subtle differences in cartilage characteristics, carefully mapping OA progression and, ultimately, asses the beneficial changes when testing a candidate disease-modifying treatment. [less ▲]

Detailed reference viewed: 36 (1 ULg)
Peer Reviewed
See detailContraste et sensibilité lors de la scintigraphie thyroïdienne pratiquée avec les neuf caméras des trois principaux centres hospitaliers liégeois.
Seret, Alain ULg

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2005), 29(11), 711

Detailed reference viewed: 13 (1 ULg)
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See detailContrasted skin capacitance imaging of seborrheic keratoses and melanocytic nevi.
Xhauflaire, Emmanuelle ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2006), 212(4), 394-7

Detailed reference viewed: 18 (0 ULg)
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See detailContrasted views on environmental migration: the case of Tuvaluan migration to New Zealand
Shen, Shawn; Gemenne, François ULg

in International Migration (2011), 49

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See detailContrastief prosodieonderzoek Nederlands-Frans. Een contrastief-typologische kijk op de accentuering
Rasier, Laurent ULg

in Verslagen en Mededelingen van de Koninklijke Academie voor Nederlandse Taal- en Letterkunde (2008), 118(1), 49-67

Detailed reference viewed: 8 (0 ULg)
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See detailContrastief taalonderzoek geïntegreerd aanpakken: hoe en waarom?
Rasier, Laurent ULg; Hiligsmann, Philippe; Baelen, Mélanie et al

Poster (2008)

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See detailContrastief woordenboek Nederlands - Duits
Theissen, Siegfried ULg; Klein, Caroline

Book published by C.I.P.L. (2008)

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See detailContrastieve (tussen)taalkunde: nuttig, nodig of overbodig?
Hiligsmann, Philippe ULg; Rasier, Laurent ULg

in Verslagen en Mededelingen van de Koninklijke Academie voor Nederlandse Taal- en Letterkunde (2007), 117(2), 147-161

Detailed reference viewed: 13 (1 ULg)
See detailHet contrastieve element in Nederlandse en Duitse spreekwoorden en uitdrukkingen
Van Hoof, Florence ULg

Master's dissertation (1996)

Detailed reference viewed: 66 (4 ULg)
Peer Reviewed
See detailContrastieve onderzoeksmodellen onder de loep
Rasier, Laurent ULg; Hiligsmann, Philippe

Conference (2009)

Detailed reference viewed: 28 (1 ULg)