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Peer Reviewed
See detailCusum techniques in clinical chemistry quality control
Albert, Adelin ULg

in Clinical research centre (1972)

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See detailCutaneous adverse reactions following anti-infective vaccinations.
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2005), 6(2), 79-87

Although widely administered, anti-infective vaccinations are rarely responsible for cutaneous adverse effects. In this context, hepatitis B and bacillus Calmette-Guerin vaccines are the most frequently ... [more ▼]

Although widely administered, anti-infective vaccinations are rarely responsible for cutaneous adverse effects. In this context, hepatitis B and bacillus Calmette-Guerin vaccines are the most frequently incriminated products. Cutaneous adverse effects are less frequently encountered following administration of vaccines against varicella, diphtheria/tetanus/pertussis (primary and booster doses), measles, poliomyelitis, rubella, pneumococcus, tick-borne encephalitis, smallpox, Meningococcus and influenza. The adverse effects can occur at the site of or at a distance from the injection. The patho-mechanisms of local adverse cutaneous reactions include predominantly nonspecific lymphoid or granulomatous reactions. Allergic reactions to the vaccine strain, adjuvants, conservatives or other components are less frequently involved in local vaccine adverse effects. Systemic reactions are mainly mediated by immediate type or immune complex-related allergic reactions to toxoid-, ovalbumin-, gelatin- or pneumococcal-containing vaccines. Systemic reactions are sometimes related to a specific vaccine strain. Other cutaneous reactions may also occur through unknown patho-mechanisms. No vaccine type or strain is specifically associated with a particular type of cutaneous adverse effect. This article presents seven case reports of cutaneous adverse effects following anti-infective vaccination then reviews the relevant literature on this subject. [less ▲]

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See detailCutaneous and basophilic sensitivity to substance P and gastrin in non-atopic versus atopic subjects.
Louis, Renaud ULg; Radermecker, Maurice ULg

in Allergy (1991), 46(1), 30-4

We compared the cutaneous reaction to intradermal injection of substance P, gastrin and histamine in asymptomatic atopic subjects with a history of hay fever and/or asthma versus non-atopic healthy ... [more ▼]

We compared the cutaneous reaction to intradermal injection of substance P, gastrin and histamine in asymptomatic atopic subjects with a history of hay fever and/or asthma versus non-atopic healthy volunteers. We also studied in these two groups the basophilic histamine release induced by substance P and gastrin with that obtained with anti-human IgE and Con A. Intradermal injection of substance P (3-300 pM) and gastrin (3-30 pM) caused a wheal and flare reaction which was comparable in both groups of subjects. Substance P 10(-4)M caused a mean basophilic histamine release of about 15% in atopic and non-atopic subjects. Gastrin was not effective in this model. Anti-IgE and Con A-induced histamine release was significantly higher in atopic than in non-atopic volunteers. [less ▲]

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See detailCutaneous and preputial candidiasis in a guinea pig
Mignon, Bernard ULg; Losson, Bertrand ULg

Conference (2001)

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See detailCutaneous infection by Alternaria infectoria in a renal transplant patient.
Segner, S.; JOURET, François ULg; Durant, J.-F. et al

in Transplant Infectious Disease : An Official Journal of the Transplantation Society (2009), 11(4), 330-2

Skin lesions are common in renal transplant recipients (RTR) and the clinical distinction of malignancy versus infection may be difficult in this patient population, with the need for further histological ... [more ▼]

Skin lesions are common in renal transplant recipients (RTR) and the clinical distinction of malignancy versus infection may be difficult in this patient population, with the need for further histological and biological investigations. We report here on a 73-year-old male RTR who presented with Alternaria infectoria phaeohyphomycosis of 1 year's duration. Mycological cultures were negative, and the diagnosis was performed by real-time polymerase chain reaction assay and direct sequencing. The extension of the lesion under itraconazole treatment required its surgical excision. Alternaria are ubiquitous plant-inhabiting saprobes, which are increasingly associated with opportunistic phaeohyphomycosis in immunocompromised individuals. [less ▲]

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See detailCutaneous mucormycosis.
Flagothier, Caroline ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Journal de Mycologie Médicale (2006), 16

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See detailCutaneous myospherulosis and membranous lipodystrophy: extensive presentation in a patient with severe steroid-induced dermal atrophy.
Flagothier, Caroline ULg; Pierard, Gérald ULg; Quatresooz, Pascale ULg

in Journal of the European Academy of Dermatology & Venereology (2006), 20(4), 457-60

Myospherulosis is a rare disorder that may develop in various organs including the skin. It is characterized by a typical histological presentation resulting from the interaction between erythrocytes and ... [more ▼]

Myospherulosis is a rare disorder that may develop in various organs including the skin. It is characterized by a typical histological presentation resulting from the interaction between erythrocytes and lipids. We present a case of cutaneous myospherulosis associated with membranous lipodystrophy. The lesions were supervening on severe steroid-induced skin atrophy upon which ointments had been applied. [less ▲]

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See detailCutaneous papules in a patient with AIDS.
Quatresooz, Pascale ULg; Franchimont, Claudine ULg; Paquet, Philippe ULg et al

in Dermatology Reports (2010), 2(e2), 4-5

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See detailCutaneous psammomatous melanotic schwannoma: non-recurrence with surgical excision.
Claessens, Nadine; Heymans, Olivier; Arrese Estrada, Jorge ULg et al

in American Journal of Clinical Dermatology (2003), 4(11), 799-802

BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which ... [more ▼]

BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which consists of various, but specific, tumors. OBJECTIVE: We report two cases of subcutaneous melanotic schwannoma localized on the trunk in two men aged 37 and 45 years. METHODS: Conventional histology and immunohistochemistry were performed. RESULTS: One melanotic schwannoma was associated with a cutaneous atypical myxoma and multiple melanocytic lesions, all being part of the Carney complex. The other case had no associated signs. In both cases, the melanotic schwannoma was completely excised and did not recur. CONCLUSION: Melanotic schwannoma is rare and curable by surgery. It must not be confused with malignant melanoma and other pigmented neoplasms. The Carney complex should be carefully ruled out. [less ▲]

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See detailCutaneous side effects of antiosteoporosis treatments
Musette, P.; Kaufman, J.-M.; Rizzoli, R. et al

in Therapeutic Advances in Musculoskeletal Disease (2011), 3(1), 31-41

Cutaneous adverse reactions are reported for many therapeutic agents and, in general, are observed in between 0% and 8% of treated patients depending on the drug. Antiosteoporotic agents are considered to ... [more ▼]

Cutaneous adverse reactions are reported for many therapeutic agents and, in general, are observed in between 0% and 8% of treated patients depending on the drug. Antiosteoporotic agents are considered to be safe in terms of cutaneous effects, however there have been a number of case reports of cutaneous adverse reactions which warrant consideration. This was the subject of a working group meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis in April 2009, which focused on the impact of cutaneous adverse reactions and drug-induced hypersensitivity in the management of postmenopausal osteoporosis. This position paper was drafted following these discussions and includes a flowchart for their recognition. Cutaneous adverse reactions observed with antiosteoporotic agents were reviewed and included information from case reports, regulatory documents and pharmacovigilance. These reactions ranged from benign effects including exanthematous or maculopapular eruption (drug rash), photosensitivity and urticaria, to the severe and potentially life-threatening reactions of angioedema, drug rash with eosinophilia and systemic symptoms (DRESS), Stevens Johnson syndrome and toxic epidermal necrolysis. A review of the available evidence demonstrates that cutaneous adverse reactions occur with all commonly used antiosteoporotic treatments. Notably, there are reports of Stevens Johnson syndrome and toxic epidermal necrolysis for bisphosphonates, and of DRESS and toxic epidermal necrolysis for strontium ranelate. These severe reactions remain very rare (<1 in 10,000 cases). In general, with proper management and early recognition, including immediate and permanent withdrawal of the culprit agent, accompanied by hospitalization, rehydration and systemic corticosteroids if necessary, the prognosis is positive. © The Author(s), 2011. [less ▲]

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See detailCutaneous spherulosis (myospherulosis).
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2007), 8(2), 117-9

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See detailCutting balloon angioplasty for the prevention of restenosis: Results of the cutting balloon global randomized trial
Mauri, L.; Bonan, R.; Weiner, B. H. et al

in American Journal of Cardiology (2002), 90(10), 1079-1083

The cutting balloon (CB) is a specialized device designed to create discrete longitudinal incisions in the atherosclerotic target coronary segment during balloon inflation. Such controlled dilatation ... [more ▼]

The cutting balloon (CB) is a specialized device designed to create discrete longitudinal incisions in the atherosclerotic target coronary segment during balloon inflation. Such controlled dilatation theoretically reduces the force needed to dilate an obstructive lesion compared with standard percutaneous transluminal coronary angioplasty (PTCA). We report a multicenter, randomized trial comparing the incidence of restenosis after CB angioplasty versus conventional balloon angioplasty in 1,238 patients. Six hundred seventeen patients were randomized to CB treatment, and 621 to PTCA. The mean reference vessel diameter was 2.86 +/- 0.49 mm, mean lesion length 8.9 +/- 4.3 mm, and prevalence of diabetes mellitus in patients was 13%. The primary end point, the 6-month binary angiographic restenosis rate, was 31.4% for CB and 30.4% for PTCA (p = 0.75). Acute procedural success, defined as the attainment of <50% diameter stenosis without in-hospital major adverse cardiac events, was 92.9% for CB and 94.7% for PTCA (p = 0.24). Freedom from target vessel revascularization was slightly higher in the CB arm (88.5% vs 84.6%, log-rank p = 0.04). Five coronary perforations occurred in the CB arm only (0.8% vs 0%, p = 0.03). At 270 days, rates of myocardial infarction, death, and total major adverse cardiac events for CB and PTCA were 4.7% versus 2.4% (p = 0.03), 1.3% versus 0.3% (p = 0.06), and 13.6% versus 15.1% (p = 0.34), respectively. In summary, the proposed mechanism of controlled dilatation did not reduce the rate of angiographic restenosis for the CB compared with conventional balloon angioplasty. CB angioplasty should be reserved for difficult lesions in which controlled dilatation is believed to provide a better acute result compared with balloon angioplasty alone. (C) 2002 by Excerpta Medica, Inc. [less ▲]

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See detailThe cutting edge of superabrasives quality control
Pirard, Eric ULg

in Industrial Diamond Review (2003), 03(3), 49-50

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See detailCutting planes and infeasibility certificates from lattice-point-free polyhedra
Louveaux, Quentin ULg

Conference (2007, July)

A central result in the theory of integer optimization states that a system of linear diophantine equations Ax = b has no integral solution if and only if there exists a vector in the dual lattice, yT A ... [more ▼]

A central result in the theory of integer optimization states that a system of linear diophantine equations Ax = b has no integral solution if and only if there exists a vector in the dual lattice, yT A integral such that yT b is fractional. We extend this result to systems that both have equations and inequalities {Ax = b, C x ≤ d}. We show that a certificate of integral infeasibility is a linear system with rank(C) variables containing no integral point. The result also extends to the mixed integer setting. [less ▲]

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See detailCutting planes from lattice-point-free polyhedra
Louveaux, Quentin ULg

Conference (2007, January)

In this talk, we generalize the concept of a split (that leads to split cuts) to any lattice-point-free polyhedron. We show how we can generate cutting planes for a polyhedron from these objects ... [more ▼]

In this talk, we generalize the concept of a split (that leads to split cuts) to any lattice-point-free polyhedron. We show how we can generate cutting planes for a polyhedron from these objects. Associated to any lattice-point-free polyhedron, we define a "split-dimension" (which is equal to 1 in the case of a split in the usual sense). We then consider the operation of adding to a polyhedron all cutting planes that we can obtain from considering all the lattice-point-free polyhedra with a split-dimension lower or equal to d. We call the obtained object the "d-dimensional split closure" of the initial polyhedron. We discuss whether this object is again a polyhedron or not. As an important illustration, we focus on objects of split-dimension equal to 1 or 2. [less ▲]

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See detailCutting planes from two rows of the simplex tableau (extended version)
Andersen, Kent; Louveaux, Quentin ULg; Weismantel, Robert et al

E-print/Working paper (2006)

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See detailCuttings of the non-rooting rac tobacco mutant overaccumulate phenolic compounds
Faivre-Rampant, Odile; Charpentier, Jean Paul; Kevers, Claire ULg et al

in Functional Plant Biology (2002), 29(1), 63-71

The auxin and phenolic contents, as well as phenylalanine ammonia-lyase (PAL) activity, were determined in in vitro cultured shoots of the recalcitrant-to-root rac mutant of tobacco, and compared with ... [more ▼]

The auxin and phenolic contents, as well as phenylalanine ammonia-lyase (PAL) activity, were determined in in vitro cultured shoots of the recalcitrant-to-root rac mutant of tobacco, and compared with wild-type shoots. The mutant and wild-type shoots showed similar auxin changes during the culture cycle, but with higher contents for the mutant. A transient peak of auxin (corresponding to the achievement of the rooting inductive phase) occurred at day 14 in both types of shoots, but earlier in the basal parts of the wild-type stems. The rac shoots contained more phenolics, corresponding with an increased PAL activity. The most abundant phenolic compound found in the two types of tobacco was chlorogenic acid, which was more abundant in the rac shoots. Rutin was also detected at a higher concentration in the mutant shoots. Basal parts of wild-type shoots treated with 10(-3) chlorogenic acid reacted by accumulating auxins and, unlike untreated controls, did not form adventitious roots. The relationships between those biochemical analyses in relation to the growth limitation of the rac mutant, and the inhibition of its root development, are discussed. [less ▲]

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