Dexamethasone compared to prednisolone for adults with acute lymphoblastic leukemia or lymphoblastic lymphoma : final results of the ALL-4 randomized, phase III trial of the EORTC Leukemia Group
; ; et al
in Haematologica (2010), 95Detailed reference viewed: 2 (0 ULg)
Dexamethasone Ester Treatment Alters Insulin-Like Growth Factor-I, Its Binding Proteins And Thyroid Status In Finishing Calves
; Portetelle, Daniel ; et al
in Canadian Journal of Animal Science (2000), 80(2),Detailed reference viewed: 17 (5 ULg)
Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells.
Robe, Pierre ; Nguyen-Khac, Minh-Tuan ; Jolois, Olivier et al
in BMC Cancer (2005), 5
BACKGROUND: HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. Large studies have however failed to demonstrate ... [more ▼]
BACKGROUND: HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. Large studies have however failed to demonstrate any significant benefit of this strategy in the treatment of human brain tumors. Since dexamethasone is a frequently used symptomatic treatment for malignant gliomas, its interaction with the bystander effect and the overall efficacy of HSV-TK gene therapy ought to be assessed. METHODS: Stable clones of TK-expressing U87, C6 and LN18 cells were generated and their bystander effect on wild type cells was assessed. The effects of dexamethasone on cell proliferation and sensitivity to ganciclovir were assessed with a thymidine incorporation assay and a MTT test. Gap junction mediated intercellular communication was assessed with microinjections and FACS analysis of calcein transfer. The effect of dexamethasone treatment on the sensitivity of TK-expressing to FAS-dependent apoptosis in the presence or absence of ganciclovir was assessed with an MTT test. Western blot was used to evidence the effect of dexamethasone on the expression of Cx43, CD95, CIAP2 and BclXL. RESULTS: Dexamethasone significantly reduced the bystander effect in TK-expressing C6, LN18 and U87 cells. This inhibition results from a reduction of the gap junction mediated intercellular communication of these cells (GJIC), from an inhibition of their growth and thymidine incorporation and from a modulation of the apoptotic cascade. CONCLUSION: The overall efficacy of HSV-TK gene therapy is adversely affected by dexamethasone co-treatment in vitro. Future HSV-tk/ GCV gene therapy clinical protocols for gliomas should address this interference of corticosteroid treatment. [less ▲]Detailed reference viewed: 14 (1 ULg)
Dexamethasone pretreatment provides antiinflammatory and myocardial protection in neonatal arterial switch operation.
; ; SCHUMACHER, Katharina et al
in Annals of Thoracic Surgery (2012), 93(3), 869-76
BACKGROUND: This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the ... [more ▼]
BACKGROUND: This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the systemic inflammatory reaction upon cardiac operation, and provide organ protection in neonates. METHODS: Twenty neonates (age, 8 to 21 days) with transposition of the great arteries scheduled for arterial switch operation were included. Nine received dexamethasone (1 mg/kg body weight) 4 hours before cardiopulmonary bypass, and 11 received natrium chloride. We studied intramyocardial messenger RNA expression of interleukin (IL)-6, IL-8, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha), as well as IL-10 and expression of TNF-alpha on protein level in right atrial tissue taken before institution of CPB. We measured plasma levels of IL-6, IL-10, lipopolysaccharide binding protein, and cardiac troponin T. Cytokine expression was related to postoperative outcome. RESULTS: Pretreatment with dexamethasone led to a significant decrease in myocardial expression of IL-6, IL-8, IL-1beta, and TNF-alpha messenger RNA and to a decrease in protein synthesis of TNF-alpha. Plasma concentrations of IL-6 were significantly lower and those of IL-10 significantly higher in pretreated patients. This was associated with lower cardiac troponin T values and lower dobutamine requirement. Levels of lipopolysaccharide binding protein were significantly higher postoperatively in pretreated neonates. CONCLUSIONS: Dexamethasone administration before arterial switch operation leads to a shift in the myocardial and systemic cytokine expression profile in neonates with transposition of the great arteries, with downregulation of proinflammatory and upregulation of antiinflammatory cytokines. Lower myocardial cell damage and lower catecholamine requirement suggest myocardial protection in treated patients. [less ▲]Detailed reference viewed: 20 (10 ULg)
Dexamethasone suppression test and prediction of treatment response to selective antidepressants
ANSSEAU, Marc ; PAPART, Patrick ; PITCHOT, William et al
in European Psychiatry (1992)Detailed reference viewed: 4 (0 ULg)
The dexamethasone suppression test in violent suicide attempters with major depression.
Pitchot, William ; Hansenne, Michel ; et al
in Biological Psychiatry (1995), 37(4), 273-4Detailed reference viewed: 6 (0 ULg)
Dexamethasone-induced accumulation of a fibronectin and collagen extracellular matrix in transformed human cells.
; ; et al
in Nature (1979), 277(5695), 393-5Detailed reference viewed: 4 (0 ULg)
The dexamethasone-induced inhibition of proliferation, migration and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors.
Piette, Caroline ; Deprez, Manuel ; et al
in Journal of Biological Chemistry (2009), 284(47), 32483-92
Glioblastomas (GBMs) are the most frequent and malignant brain tumors in adults. Glucocorticoids (GCs) are routinely used in the treatment of GBMs for their capacity to reduce the tumor-associated edema ... [more ▼]
Glioblastomas (GBMs) are the most frequent and malignant brain tumors in adults. Glucocorticoids (GCs) are routinely used in the treatment of GBMs for their capacity to reduce the tumor-associated edema. Few in vitro studies have suggested that GCs inhibit the migration and invasion of GBM cells through the induction of MAPK phosphatase 1 (MKP-1). Macrophage migration inhibitory factor (MIF), an endogenous GC antagonist is up-regulated in GBMs. Recently, MIF has been involved in tumor growth and migration/invasion and specific MIF inhibitors have been developed on their capacity to block its enzymatic tautomerase activity site. In this study, we characterized several glioma cell lines for their MIF production. U373 MG cells were selected for their very low endogenous levels of MIF. We showed that dexamethasone inhibits the migration and invasion of U373 MG cells, through a glucocorticoid receptor (GR)- dependent inhibition of the ERK1/2 MAPK pathway. Oppositely, we found that exogenous MIF increases U373 MG migration and invasion through the stimulation of the ERK1/2 MAP kinase pathway and that this activation is CD74 independent. Finally, we used the Hs 683 glioma cells that are resistant to GCs and produce high levels of endogenous MIF, and showed that the specific MIF inhibitor ISO-1 could restore dexamethasone sensitivity in these cells. Collectively, our results indicate an intricate pathway between MIF expression and GC resistance. They suggest that MIF inhibitors could increase the response of GBMs to corticotherapy. [less ▲]Detailed reference viewed: 53 (7 ULg)
Dexia Tower : prévision de l’effet à long terme du raccourcissement élastique et différé des colonnes de la tour et du noyau central
Report (2005)Detailed reference viewed: 14 (0 ULg)
Le déﬁ des générations, sous la direction de J. Grand’Maison, L. Baroni et J.-M. Gauthier (compte rendu)
in Recherches Sociographiques : Revue Pluridisciplinaire d'Etudes sur le Québec et le Canada français. (1999), XL(1)Detailed reference viewed: 4 (0 ULg)
DFT studies of solvation effects on the nanosize bare, thiolated and redox active ligated Au55 cluster
Periyasamy, Ganga ; ; Raty, Jean-Yves et al
in Journal of Physical Chemistry C: Nanomaterials, Interfaces, and Hard Matter (2010), Protected Metallic Clusters, Quantum Wells and Metal-Nanocrystal Molecules SymposiumDetailed reference viewed: 17 (7 ULg)
DG hat niemandem in Flandern geschadet (interview de presse)
Article for general public (2009)Detailed reference viewed: 20 (1 ULg)
DHEA et intracrinologie de jouvence pour la peau? Entre raison et magie.
; ; Henry, Frédérique et al
in Revue Médicale de Liège (2002), 57(7), 438-42
Slowing down ageing is a goal for a large part of the population. Some mercantile claims hold out bright prospects to DHEA. The effects of this hormone manifest themselves after intracrine conversion. In ... [more ▼]
Slowing down ageing is a goal for a large part of the population. Some mercantile claims hold out bright prospects to DHEA. The effects of this hormone manifest themselves after intracrine conversion. In the skin, sebaceous glands enlarge and seborrhoea increases in post-menopausal women. No other effect is clinically discernable on the skin. At this level, DHEA does not show efficacy comparable to that of other anti-ageing compounds. [less ▲]Detailed reference viewed: 59 (2 ULg)
(Di)-aminoguanidine Functionalization through Transamination: An Avenue to an Auspicious Class of Supramolecular Synthons
; ; Léonard, Alexandre et al
in Crystal Growth & Design (2011), 11Detailed reference viewed: 7 (0 ULg)
Diabatic molecular states and the shielded diatomic orbitals method. Evolution of two-interacting-state systems for molecular hydrogen
; Desouter, Michèle
in Chemical Physics (1977), 25Detailed reference viewed: 1 (1 ULg)
Le diabete de l'enfant et de l'adolescent. 1. Prise en charge par le Service Universitaire de Pediatrie et la Cellule "Education-Diabete en Pediatrie"
LEBRETHON, Marie-Christine ; ; et al
in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 313-9
The management and follow up of diabetes in youth is a multidisciplinary challenge due to both short and long term objectives. Awareness of the feelings and problems faced by the families is critical. The ... [more ▼]
The management and follow up of diabetes in youth is a multidisciplinary challenge due to both short and long term objectives. Awareness of the feelings and problems faced by the families is critical. The experience of our team has started in the 1960s and is briefly described and updated in this article. [less ▲]Detailed reference viewed: 97 (0 ULg)
Le diabete de type 1 et la maladie coeliaque.
Mathieu, Sandrine ; ; Paquot, Nicolas et al
in Revue Médicale de Liège (2006), 61(9), 637-42
Celiac disease is more prevalent in type 1 diabetic patients than in the general population. The exact reason for this association remains unknown. Two hypotheses are taken into consideration: either a ... [more ▼]
Celiac disease is more prevalent in type 1 diabetic patients than in the general population. The exact reason for this association remains unknown. Two hypotheses are taken into consideration: either a common genetic background or an immune response against Langerhans islets triggered by celiac disease. This review presents recent data about this association and its consequences in clinical practice. [less ▲]Detailed reference viewed: 175 (3 ULg)