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See detailComparison of the amnesic, ataxic and hypothermic effects of ethanol and acetaldehyde in mice
Closon, Catherine ULg; Quertemont, Etienne ULg

in Alcoholism, Clinical & Experimental Research (2010), 34(8), 92-92

Acetaldehyde, the first metabolite of ethanol, has been suggested to be involved in many behavioral effects of ethanol. However, very few studies have been published on the role of acetaldehyde in the ... [more ▼]

Acetaldehyde, the first metabolite of ethanol, has been suggested to be involved in many behavioral effects of ethanol. However, very few studies have been published on the role of acetaldehyde in the amnesic and ataxic effects of ethanol. The aim of the present studies was to compare the profiles of ethanol and acetaldehyde in several behavioral tests, measuring motor coordination, learning and memory in mice. Female Swiss mice were injected intraperitoneally with ethanol (0-3g/kg) and acetaldehyde (100-300mg/kg). The effects of these substances on a series of representative behaviors were investigated. The amnesic effects were tested with an object recognition task and a one-trial passive avoidance test. Additionally, the rectal temperatures were used to evaluate the hypothermic effects of the two substances. Finally, motor coordination was assessed using the accelerating rotarod test. The results showed that acetaldehyde, like ethanol, altered memory as shown by a reduced performance in the passive avoidance test and the object recognition task. In addition, acetaldehyde at doses between 100 and 300 mg/kg induced significant hypothermic effects, but that was of shorter duration than ethanol-induced hypothermia. Finally, significant ataxic effects of both acetaldehyde and ethanol were observed in the accelerating rotarod test. Overall, the results of the present study clearly show that acetaldehyde, like ethanol, has amnesic, hypothermic and ataxic properties in mice at least at relatively high concentrations. [less ▲]

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See detailComparison of the antihypertensive efficacy and tolerability of candesartan cilexetil and angiotensin-converting enzyme inhibitor therapy in primary hypertension: the champion study
Lins, R.; Krzesinski, Jean-Marie ULg; Vandenhoven, G. et al

in American Journal of Hypertension : Journal of the American Society of Hypertension (2001), 4

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See detailComparison of the candesartan cilexetil and angiotensin-converting enzyme inhibitor therapy in mild to moderate hypertension
Krzesinski, Jean-Marie ULg; Lins, R.; Vandenhoven, G. et al

in Journal of hypertension (2001)

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See detailComparison of the cardiac pumping capability and cardiac pumping reserve in double muscled and conventional calves
Amory, Hélène ULg; Mc Entee, Kathleen ULg; Linden, Annick ULg et al

in Canadian Journal of Physiology & Pharmacology (1993), 71(12), 946-951

Hereditary muscular hypertrophy is a character that has been selected in several animal species for industrial meat production. The selection of this character in cattle produces animals of exceptional ... [more ▼]

Hereditary muscular hypertrophy is a character that has been selected in several animal species for industrial meat production. The selection of this character in cattle produces animals of exceptional commercial value but ones with a lower aerobic capacity than that of conventional cattle. The purpose of this work was to study the role of cardiac function as a potential limiting factor of aerobic capacity in double-muscled calves. Two groups of healthy calves were studied, one consisting of nine calves of conventional conformation and the other of nine double-muscled calves. Pulmonary arterial and capillary wedge, central venous, and systemic arterial pressures were measured by fluid-filled catheters and recorded together with the electrocardiogram. Cardiac output was measured by the thermodilution technique. From these measurements, the heart rate, the cardiac and the stroke indices, the pulmonary and the systemic vascular resistances, and the cardiac power output were calculated. The parameters were recorded under basal resting conditions and during incremental dobutamine challenge, which allowed determination of the resting cardiac power output, the cardiac pumping capability, and the cardiac reserve. Dobutamine challenge induced a significant rise in cardiac and stroke indices, heart rate, and cardiac power output, a significant decrease in pulmonary and systemic vascular resistances, and no change in systemic and pulmonary arterial pressures. The cardiac reserve obtained in the present study was low in comparison with those previously reported in humans, dogs, and horses. This may be related to the poor running capability of bovine species relative to that of the former species.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailComparison of the collision-induced dissociation of duplex DNA at different collision regimes: Evidence for a multistep dissociation mechanism
Gabelica, Valérie ULg; De Pauw, Edwin ULg

in Journal of the American Society for Mass Spectrometry (2002), 13(1), 91-98

The dissociation mechanism of duplex DNA has been investigated in detail by collision-induced dissociation experiments at different collision regimes. MS/MS experiments were performed either in a ... [more ▼]

The dissociation mechanism of duplex DNA has been investigated in detail by collision-induced dissociation experiments at different collision regimes. MS/MS experiments were performed either in a quadrupole collision cell (hybrid quadrupole-TOF instrument) or in a quadrupole ion trap with different activation times and energies. In addition to the noncovalent dissociation of the duplex into the single strands, other covalent bond fragmentation channels were observed. Neutral base loss from the duplex is favored by slow activation. In fast activation conditions, however, the major reaction channel is the noncovalent dissociation into single strands, which is highly entropy-favored. Fast activation regimes can favor the entropy-driven noncovalent dissociation, while in slow heating conditions the competition with enthalpy-driven covalent fragmentation can completely hinder the dissociation of the complex. We also evidence that the noncovalent dissociation of DNA duplex is a multistep process involving a progressive unzipping, preferentially at terminal positions. This is proposed to be a general feature for complexes containing a high number of contributing interactions organized at the interface of the ligands. The overall (observed) dissociation kinetics of noncovalent complexes can therefore depend on a complicated mechanism for which a single transition state description of the kinetics is too simplistic. [less ▲]

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See detailComparison of the current techniques used for the denoising of scintigraphic images
Kirkove, Murielle ULg; Seret, Alain ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(S2), 318

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See detailComparison of the Decomposition VOC Profile during Winter and Summer in a Moist, Mid-latitude (Cfb) Climate
Forbes, Shari L.; Perrault, Katelynn A.; Stefanuto, Pierre-Hugues ULg et al

in PLoS ONE (2014), 9(e113681), 1-11

The investigation of volatile organic compounds (VOCs) associated with decomposition is an emerging field in forensic taphonomy due to their importance in locating human remains using biological detectors ... [more ▼]

The investigation of volatile organic compounds (VOCs) associated with decomposition is an emerging field in forensic taphonomy due to their importance in locating human remains using biological detectors such as insects and canines. A consistent decomposition VOC profile has not yet been elucidated due to the intrinsic impact of the environment on the decomposition process in different climatic zones. The study of decomposition VOCs has typically occurred during the warmer months to enable chemical profiling of all decomposition stages. The present study investigated the decomposition VOC profile in air during both warmer and cooler months in a moist, mid-latitude (Cfb) climate as decomposition occurs year-round in this environment. Pig carcasses (Sus scrofa domesticus L.) were placed on a soil surface to decompose naturally and their VOC profile was monitored during the winter and summer months. Corresponding control sites were also monitored to determine the natural VOC profile of the surrounding soil and vegetation. VOC samples were collected onto sorbent tubes and analyzed using comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC6GC-TOFMS). The summer months were characterized by higher temperatures and solar radiation, greater rainfall accumulation, and comparable humidity when compared to the winter months. The rate of decomposition was faster and the number and abundance of VOCs was proportionally higher in summer. However, a similar trend was observed in winter and summer demonstrating a rapid increase in VOC abundance during active decay with a second increase in abundance occurring later in the decomposition process. Sulfur-containing compounds, alcohols and ketones represented the most abundant classes of compounds in both seasons, although almost all 10 compound classes identified contributed to discriminating the stages of decomposition throughout both seasons. The advantages of GC6GC-TOFMS were demonstrated for detecting and identifying trace levels of VOCs, particularly ethers, which are rarely reported as decomposition VOCs. [less ▲]

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See detailComparison of the effect of learning to read in English or in Dutch on the acquisition of the French orthographic code in French-speaking children attending immersion school programs.
Binamé, Florence ULg; Poncelet, Martine ULg; Guyon, Charline

Poster (2012, May 10)

Most of the children attending bilingual immersion school programs in the French Community of Belgium learn to read in the immersion language before learning to read in their native language. This study ... [more ▼]

Most of the children attending bilingual immersion school programs in the French Community of Belgium learn to read in the immersion language before learning to read in their native language. This study aimed to explore the effect of learning to read in a second language having a transparent (Dutch) versus an opaque (English) orthographic code, on the later acquisition of French spelling. Because literacy acquisition depends on the orthographic depth of the code, the hypothesis is that learning to spell in a transparent language such as Dutch would promote the acquisition of the more opaque French spelling, by transferring the phonological recoding process. Contrariwise, the acquisition of French spelling would be less easy if learners were first immersed in very opaque spelling such as English. Participants were 182 third and fourth-graders immersed in Dutch or English, and monolingual French speakers (control group). Their French spelling skills were tested by words and non-words dictation. Results showed that the performance of Dutch immersed children was not significantly inferior to controls, which is not the case for English immersed children. This corroborates the fact that learning to spell in a more transparent orthographic code than French has a subsequent benefit on its acquisition. [less ▲]

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See detailComparison of the Effect of Morphine on Locus Coeruleus Noradrenergic and Ventral Tegmental Area Dopaminergic Neurons in Vitro
Seutin, Vincent ULg; Franchimont, Nathalie; Massotte, Laurent ULg et al

in Life Sciences (1990), 46(25), 1879-85

Extracellular single-cell recordings were performed on rat brain slices to compare the effects of morphine on noradrenergic neurons of the locus coeruleus (LC) and on dopaminergic neurons of the ventral ... [more ▼]

Extracellular single-cell recordings were performed on rat brain slices to compare the effects of morphine on noradrenergic neurons of the locus coeruleus (LC) and on dopaminergic neurons of the ventral tegmental area (VTA). Morphine inhibited the firing of LC neurons at very low concentrations. The mean IC50 was 13.4 +/- 1nM (mean +/- SEM) (n = 7). Moreover, the inhibitory effect of morphine was identical in slices obtained from rats anesthetized with chloral hydrate or from non-anesthetized rats. On the contrary, morphine did not have any influence on the firing of most VTA neurons (N = 20) up to 100 microM, and did not modify the sensitivity of their autoreceptors (N = 8). It is concluded that morphine potently inhibits the firing of LC neurons in vitro both in slices of anesthetized and not anesthetized animals and has no direct excitatory effect on VTA dopaminergic neurons of the rat. [less ▲]

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See detailComparison of the effects of a physiological and a pharmacological stress on plasma cortisol in sport horses
Linden, Annick ULg; Art, Tatiana ULg; Amory, Hélène ULg et al

in Archives Internationales de Physiologie et de Biochimie (1991)

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See detailA comparison of the effects of cathodal and anodal stimulation of the human motor cortex through the intact scalp
Day, B. L.; MAERTENS DE NOORDHOUT, Alain ULg; Marsden, C. D. et al

in Journal of Physiology (1987), 394

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See detailComparison of the effects of ethidium bromide and of ethidium bromide-deoxyribonucleic acid complex in fibroblasts cultivated in vitro.
Heinen, Ernst ULg; Bassleer, R.; Calberg, C.-M.

in Beitrage zur Pathologie (1976), 159(2), 207-18

Chick embryo fibroblasts cultivated in vitro were treated with ethidium bromide (E.B.) or with DNA-E.B. complex (DNA-E.B.). E.B. (5 mug/ml) provokes morphological alterations and cell death, inhibits DNA ... [more ▼]

Chick embryo fibroblasts cultivated in vitro were treated with ethidium bromide (E.B.) or with DNA-E.B. complex (DNA-E.B.). E.B. (5 mug/ml) provokes morphological alterations and cell death, inhibits DNA synthesis and mitotic activity. DNA-E.B. (E.B. 5 mug/ml) is less toxic to the fibroblasts as far as cell structure, DNA synthesis and mitotic activity are concerned. DNA alone has no apparent effect on the fibroblasts. As shown by fluorescence microscopy, the lower toxicity of DNA-E.B. seems to be related to its mode of penetration into the cells. [less ▲]

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