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See detailContribution au développement de méthodes minéralogiques et géochimiques pour la caractérisation d'un gazogène souterrain
Antenucci, Diano; Jacquemin, Christiane; Brasseur, D. et al

Report (1996)

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See detailContribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament (acronyme : DEV-AQM)
Marini Djang'Eing'A, Roland ULg; Hubert, Philippe ULg

Report (2011)

Contribution to the development of teaching capacity and training for the improvement of quality of the medicines. Contextualisation: The quality of medicines is a major problem of public health in the ... [more ▼]

Contribution to the development of teaching capacity and training for the improvement of quality of the medicines. Contextualisation: The quality of medicines is a major problem of public health in the development countries. Since 1990, this situation has deteriorated becoming worried mainly in the Central African region due to the degradation of social, economic and politic life, consequence of a long period of conflict and war. The resurgence of non-controlled drugs, the sale of illicit, deteriorated and even falsified drugs are real examples in the current practices, that is making difficult and even practically impossible an access to a safe, reliable and efficient medical treatment. It is known that even if a diagnosis is correctly made and a medical treatment is correctly prescribed, this treatment is doomed to failure if the medicine is not of a good quality. Democratic Republic of Congo (DRC) and Rwanda are among the countries that are facing such situations. Description of project purpose: The principal objective of this project is to contribute to the improvement of the quality of medicines and thus, of the public health in DRC and in Rwanda. More precisely, the project aims to strengthen the local capacity in order to respond to the need in the quality of medicines and to develop a platform of people in the pharmaceutical sector in the field of quality assurance and control. According to this main objective, the project aims in one hand to train people working in the pharmaceutical sector including the academic, the legal and the industrial, and in another hand to develop the tools to contribute to the improvement of the quality of medicines. Training and qualification of people, improvement of the teaching and making available the control documentation on quality are the sub-objectives pursued in the framework of this project. Chapter 2 : Six main activities are undergone in this project: The first activity is the seminar that is organised in order to promote the project and to initiate the importance of knowledge of the quality of medicine by awareness of the different authorities from government, from the churches and from the health sectors. The seminar is the preliminary step of this project that is done to select the different candidates. The second activity concerns the theoretical training, focused on the basis of the quality of drugs, the drug manufacturing and drug control / analysis taking into account the activity sector of each candidate. This activity is important since most of the candidates have been graduated a long time ago while working for a long time. This activity as well as the seminar is held in the beneficiary countries for one month. The trainers are among the Professors and Researchers from the “University of Liège”, the “University Libre de Bruxelles” and the “University Catholique de Louvain”, in Belgium. They are selected on basis of their expertise. The topics considered are the Quality Assurance, the Regulatory, the Statistical applied in the pharmaceutical industry, The Manufacturing and The Quality control of medicines, the Management in the Pharmaceutical sector. The theoretical training by e-learning using internet occurs in the third place. It is done as a complement to the second activity since it allows the candidate to have access to different and more documents available through the web site platform created for this purpose. This mode of teaching allows also the candidates to interact with other trainers concerning a particular subject of their working sector. The fourth activity is the practices that are done in Belgium in the different facilities of the laboratories associated to this project. This allows the different candidates to materialize the knowledge acquired during the theoretical teaching while considering their working sector, and to familiarize with the procedures dealing with their sector. The fifth activity is related to a specific training for auditor or evaluator. Indeed, this training is a specific requirement namely the creation of Federal Agency of Drug in DRC. The need is to improve the capacity of such organism to carry out efficiently the audits and evaluations of drug registration files before their commercialization. Finally, the sixth activity is the reintegration of the candidates within their professional environment. Considering the importance of this aspect, an accompanying is necessary to ensure that the acquired knowledge is valued in the professional environment. Chapter 3 : The expected impact At the end of this project, we expect that the different Authorities are aware with regard to the quality of drugs, the activities in the pharmaceutical sectors namely, the legal and industrial are improved since the actors are trained, qualified and gained competence. We expect also the improvement of teaching capacity in Pharmacy Schools taking into account the need of the pharmaceutical market, with the possibility of starting the post-university teaching programs. Finally, we expect the efficiency of activities in the pharmaceutical sector for the benefit of the DRC and Rwanda populations. Contact person : Philippe Hubert (ph.hubert@ulg.ac.be) / Roland Marini Djang’eing’a (rmarini@ulg.ac.be) Address : Service de Chimie Analytique, Département de Pharmacie, Bât. B36, Avenue de l'Hôpital, 1, 4000 Liège 1, Belgium. Tel. + 00 32 4 366 43 15 [less ▲]

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See detailContribution au développement des capacités d’enseignement et de formation pour l’amélioration de la qualité du médicament (acronyme : DEV-AQM)
Marini Djang'Eing'A, Roland ULg; Hubert, Philippe ULg

Report (2011)

Project title: Contribution to the development of teaching capacity and training for the improvement of quality of the medicines. Contextualisation: The quality of medicines is a major problem of public ... [more ▼]

Project title: Contribution to the development of teaching capacity and training for the improvement of quality of the medicines. Contextualisation: The quality of medicines is a major problem of public health in the development countries. Since 1990, this situation has deteriorated becoming worried mainly in the Central African region due to the degradation of social, economic and politic life, consequence of a long period of conflict and war. The resurgence of non-controlled drugs, the sale of illicit, deteriorated and even falsified drugs are real examples in the current practices, that is making difficult and even practically impossible an access to a safe, reliable and efficient medical treatment. It is known that even if a diagnosis is correctly made and a medical treatment is correctly prescribed, this treatment is doomed to failure if the medicine is not of a good quality. Democratic Republic of Congo (DRC) and Rwanda are among the countries that are facing such situations. Description of project purpose: The principal objective of this project is to contribute to the improvement of the quality of medicines and thus, of the public health in DRC and in Rwanda. More precisely, the project aims to strengthen the local capacity in order to respond to the need in the quality of medicines and to develop a platform of people in the pharmaceutical sector in the field of quality assurance and control. According to this main objective, the project aims in one hand to train people working in the pharmaceutical sector including the academic, the legal and the industrial, and in another hand to develop the tools to contribute to the improvement of the quality of medicines. Training and qualification of people, improvement of the teaching and making available the control documentation on quality are the sub-objectives pursued in the framework of this project. Chapter 2 : Six main activities are undergone in this project: The first activity is the seminar that is organised in order to promote the project and to initiate the importance of knowledge of the quality of medicine by awareness of the different authorities from government, from the churches and from the health sectors. The seminar is the preliminary step of this project that is done to select the different candidates. The second activity concerns the theoretical training, focused on the basis of the quality of drugs, the drug manufacturing and drug control / analysis taking into account the activity sector of each candidate. This activity is important since most of the candidates have been graduated a long time ago while working for a long time. This activity as well as the seminar is held in the beneficiary countries for one month. The trainers are among the Professors and Researchers from the “University of Liège”, the “University Libre de Bruxelles” and the “University Catholique de Louvain”, in Belgium. They are selected on basis of their expertise. The topics considered are the Quality Assurance, the Regulatory, the Statistical applied in the pharmaceutical industry, The Manufacturing and The Quality control of medicines, the Management in the Pharmaceutical sector. The theoretical training by e-learning using internet occurs in the third place. It is done as a complement to the second activity since it allows the candidate to have access to different and more documents available through the web site platform created for this purpose. This mode of teaching allows also the candidates to interact with other trainers concerning a particular subject of their working sector. The fourth activity is the practices that are done in Belgium in the different facilities of the laboratories associated to this project. This allows the different candidates to materialize the knowledge acquired during the theoretical teaching while considering their working sector, and to familiarize with the procedures dealing with their sector. The fifth activity is related to a specific training for auditor or evaluator. Indeed, this training is a specific requirement namely the creation of Federal Agency of Drug in DRC. The need is to improve the capacity of such organism to carry out efficiently the audits and evaluations of drug registration files before their commercialization. Finally, the sixth activity is the reintegration of the candidates within their professional environment. Considering the importance of this aspect, an accompanying is necessary to ensure that the acquired knowledge is valued in the professional environment. Chapter 3 : The expected impact At the end of this project, we expect that the different Authorities are aware with regard to the quality of drugs, the activities in the pharmaceutical sectors namely, the legal and industrial are improved since the actors are trained, qualified and gained competence. We expect also the improvement of teaching capacity in Pharmacy Schools taking into account the need of the pharmaceutical market, with the possibility of starting the post-university teaching programs. Finally, we expect the efficiency of activities in the pharmaceutical sector for the benefit of the DRC and Rwanda populations. Contact person : Philippe Hubert (ph.hubert@ulg.ac.be) / Roland Marini Djang’eing’a (rmarini@ulg.ac.be) Address : Service de Chimie Analytique, Département de Pharmacie, Bât. B36, Avenue de l'Hôpital, 1, 4000 Liège 1, Belgium. Tel. + 00 32 4 366 43 15 [less ▲]

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See detailContribution au développement et à la mise en place d’une approche innovante dans une formation en handball pour les éducateurs sportifs. Exploitation en milieu universitaire d’un projet développé pour des entraîneurs
Theunissen, Catherine; Cloes, Marc ULg

in Eid, C. (Ed.) Les programmes de formation universitaire. Actes du Colloque Didactique et TICE IV (2011)

In the context of education of the beginning Belgian handball coaches, we are currently developing a project based on a mixed program (presential and e-learning) and on the use of a competencies based ... [more ▼]

In the context of education of the beginning Belgian handball coaches, we are currently developing a project based on a mixed program (presential and e-learning) and on the use of a competencies based framework. We wish to test tools that could be, in a long term perspective, extended to the entire course of this level of preparation but also to other contexts. For this, we are analyzing processes aiming to transfer the technology developed to the physical education teacher education. Gradually, changes are made in order to offer training ever closer to the professsional reality, more consistent, with more meaning for the participants and involving them more in a process of knowledge building. [less ▲]

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See detailContribution au diagnostic et à la correction des carences en iode et sélénium chez les bovins
Guyot, Hugues ULg

Doctoral thesis (2007)

Deficiencies of selenium (Se) and iodine (I) are widespread in livestock all over Europe. They have an impact on the animals’ health. Since the clinical signs of the deficiencies are rarely pathognomic ... [more ▼]

Deficiencies of selenium (Se) and iodine (I) are widespread in livestock all over Europe. They have an impact on the animals’ health. Since the clinical signs of the deficiencies are rarely pathognomic, auxiliary exams, based on blood and milk samples are needed for the confirmation of the diagnosis. To evaluate the Se and I status, the plasmatic Se content, the erythrocytic glutathione peroxydase activity (GPX), and the inorganic plasmatic I (IIP) content are measured routinely. Other analyses, like e.g. the dosage of tri-iodothyronine (T3) or thyrotropine (bTSH) can be used. Once the deficiency is diagnosed, it can be corrected by several methods. The first aim of the study was to evaluate the zinc, copper, Se, and I status of Wallonian dairy and beef herds and to correlate their trace element status to their health. The trace element status of the herds with pathologies was less good than that of healthy herds. Further, more herds with pathologies had deficiencies when compared to healthy ones. Dairy herds had a better trace element status than beef herds. Se and I deficiencies are among the most important ones and have the most severe sequels. Therefore, the subsequent parts of the study focussed on these two trace elements. The second aim was the establishment of a technique for the dosage of bTSH and of reference values in healthy cattle. Reference ranges for bTSH and for thyroxine (T4) have been determined in healthy adult cows and in healthy calves. Thereafter, the next aim was to compare the concentration of bTSH in newborn calves with goitre to those obtained in healthy calves, in order to validate a diagnostic test for this pathology. The bTSH allowed the discrimination of the two groups and to approve the diagnosis of hypothyroidism in some of the calves. The threshold value of bTSH for the diagnosis of hypothyroidism in the newborn calf has been fixed at 35 µU/ml. The fourth aim was to compare the I (IIP) and Se (plasmatic Se, GPX) status as well as the thyroid status (bTSH, T4, T3, rT3) in dried pregnant cows and their calves and in non-pregnant cows, that received normal diet and a diet enriched in Se and I. In those receiving a Se and I enriched diet, the T4 and the bTSH decreased while the IIP, the T3, and the GPX activity increased. In the group that received a diet with normal Se and I contents, only the GPX activity increased. At birth, calves from mothers receiving the Se and I enriched diet, had a higher IPP content and GPX activity, and a lower bTSH concentration than calves from the other group. The last aim was to compare the effects of two different forms of Se (sodium selenite versus seleno-methionine) and two different doses of Se (0.1 versus 0.5 ppm) on the health and the Se status of Se deficient Belgian Blue cows and their calves. The first two groups of cows received a ration with 0.1 and 0.5 ppm, respectively, of Se in the form of sodium selenite (Na-Se 0.1 and Na-Se 0.5), while the third group received 0.5 ppm of Se in the form of seleno-methionine (Y-Se 0.5). The Se content of plasma, colostrum, and milk was higher in the cows of group Y-Se 0.5 when compared to the two other groups. The Se content of the plasma was higher in calves from group Y-Se 0.5 when compared to the two other groups. The daily weight gain of the Y-Se 0.5 group was higher than those of the group Na-Se 0.1. The incidence of diarrhoea among calves in group Na-Se 0.1 was higher than in group Y-Se 0.5. In conclusion, trace elements deficiencies are common in Wallonia and often they are multiple. They play a major role in the aetiology of multifactorial diseases diagnosed in the cattle herds. Deficiencies in Se and in I are most commonly implicated in clinical problems. The diagnosis of these deficiencies is determined by blood analyses. Therefore, the tests need to be differentiated according to their capacity to test the nutritional or the thyroid status. A simultaneous supplementation with I and Se, as well as the form of the supplemented Se, may modify the interpretation of the nutritional and the thyroid status. Better reproduction performances and a better health have been observed in herds with a normal trace element status. Furthermore, the advantage of the supplementation with Se in the form of seleno-methionine has been demonstrated in comparison to sodium selenite in deficient Belgian Blue cattle. This study opened numerous perspectives. The measurement of bTSH should be implemented in laboratories in order to offer it as a routine analysis to the practitioning veterinarian, who could use this tool in the framework of many diseases other than goitre. From a fundamental point of view, the dosage of deiodinases would allow the understanding of the regulation and of the synthesis of the thyroid hormones in bovines, and identifying the role of Se and I in this process. Finally, following the discoveries concerning the seleno-methionine, the effect of organic forms of other trace elements in bovine supplementation should be investigated. [less ▲]

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See detailContribution au titre XI intitulé "Organismes de placement collectif et droit européen"
Partsch, Philippe-Emmanuel ULg

in Les organismes de placement collectif en droit luxembourgeois (2007)

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See detailContribution au titre XI intitulé "Organismes de placement collectif et droit européen"
Partsch, Philippe-Emmanuel ULg

in Les organismes de placement collectif en droit luxembourgeois (2001)

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See detailContribution au traitement de l’incontinence urinaire chez la chienne par soutènement urétral prothétique trans-obturateur
Claeys, Stéphanie ULg

Doctoral thesis (2009)

L’incompétence du sphincter urétral (ISU) est la cause la plus fréquente d’incontinence urinaire chez la chienne adulte. Elle affecte typiquement les chiennes stérilisées, d’âge moyen et de grande race ... [more ▼]

L’incompétence du sphincter urétral (ISU) est la cause la plus fréquente d’incontinence urinaire chez la chienne adulte. Elle affecte typiquement les chiennes stérilisées, d’âge moyen et de grande race. Son traitement est initialement médical. La phénylpropanolamine (PPA) est le traitement médical de choix et son taux de succès varie de 85 à 97 % de continence. Des études expérimentales antérieures ont démontré l’avantage urodynamique d’une administration de PPA une fois par jour par rapport à l’administration 3 fois par jour recommandée habituellement. Aucune étude clinique n’a cependant été réalisée jusqu’à présent pour confirmer l’efficacité de ce protocole de traitement chez la chienne incontinente. Un traitement chirurgical est recommandé en cas de non réponse ou de réponse partielle au traitement médical, si la chienne devient réfractaire au traitement ou développe des effets secondaires, ou si les propriétaires ne souhaitent pas administrer un médicament à long terme. De nombreuses techniques chirurgicales ont été décrites pour traiter l’ISU chez la chienne mais aucune à l’heure actuelle ne permet de garantir un taux de continence complète élevé et ce, à long terme et avec un faible taux de complications. Le traitement de l’incontinence urinaire d’effort chez la femme est principalement chirurgical et implique le placement d’une bandelette sous-urétrale par voie vaginale. Parmi les techniques décrites, la TVT-O offre un très bon taux de succès et présente très peu de complications postopératoires. Les objectifs de ce travail étaient donc d’évaluer l’efficacité clinique d’un dosage quotidien unique de PPA et d’adapter la technique TVT-O à la chienne en passant par une étude préliminaire sur cadavres et chiennes Beagles saines pour ensuite l’utiliser chez des chiennes incontinentes atteintes d’ISU, afin d’en évaluer les effets cliniques, urodynamiques et morphologiques. Dans la première étude, l’efficacité clinique de la PPA administrée une seule fois par jour à un dosage de 1.5 mg/kg a été démontrée. En effet, le suivi à long terme (23.9 mois en moyenne) montre que 8 chiennes sur 9 étaient continentes après traitement. Une chienne n’a pas répondu à la PPA et a été traitée chirurgicalement. Aucun effet secondaire n’a été observé chez les animaux traités. D’un point de vue urodynamique, l’administration de PPA augmente significativement les valeurs de pression urétrale maximale de fermeture (MUCP). L’administration de PPA 2 à 3 fois par jour, telle que recommandée habituellement, n’est donc pas utile puisqu’une administration quotidienne unique, plus pratique et moins coûteuse pour les propriétaires, suffit à maintenir la continence chez 89 % des chiennes traitées. La faisabilité de la technique TVT-O a ensuite été évaluée chez la chienne. La dissection de 12 cadavres de chiennes après mise en place de la bandelette montre que la TVT-O est faisable chez la chienne moyennant certaines adaptations. Une épisiotomie est notamment nécessaire chez la chienne contrairement à la femme. Les résultats montrent que la bandelette est située à une distance raisonnable des structures neuro-vasculaires importantes, y compris les vaisseaux fémoraux et le nerf obturateur, minimisant le risque de les léser. Elle est également localisée de manière constante en arrière du muscle élévateur de l’anus, en région périnéale, rendant ainsi le risque de lésion vésicale quasi inexistant. La technique apparaît donc peu risquée et reproductible chez la chienne. L’application de la TVT-O chez 2 chiennes Beagles continentes nous a ensuite permis d’observer l’absence de complications intra- et postopératoires. D’un point de vue urodynamique, la pression intégrée (aire sous la courbe d’UPP représentant la résistance urétrale) est augmentée jusqu’à 4 mois après l’intervention. Les vagino-urétrographies postopératoires montrent un déplacement ventral et un rétrécissement de l’urètre distal juste en avant du méat urinaire. D’un point de vue histologique, les tissus entourant la bandelette montrent une réaction fibroblastique modérée accompagnée d’une réaction inflammatoire lympho-plasmocytaire légère à modérée. La bandelette semble donc relativement inerte et bien tolérée chez le chien. La tolérance de la bandelette est d’une importance majeure puisqu’une réaction inflammatoire excessive peut induire une érosion vaginale ou urétrale pouvant entraîner une infection. La TVT-O a ensuite été réalisée sur 8 chiennes incontinentes atteintes d’ISU. Après un suivi de 2 semaines à 12 mois (moyenne, 7.3 mois), 7 des 8 chiennes sont continentes. Une chienne a récidivé 2 mois après la chirurgie et a été traitée à la PPA. D’un point de vue urodynamique, MUCP et la pression intégrée sont augmentées significativement après l’intervention. L’augmentation de pression se situe principalement au niveau de l’urètre moyen. Il apparaît donc que la localisation du pic de pression urétrale postopératoire ne correspond pas à la localisation anatomique de la bandelette. Les vagino-urétrographies, pour la plupart non remarquables, montrent que la bandelette ne modifie pas la position du col vésical puisque les vessies en position pelvienne en préopératoire le restent en postopératoire. Une complication intra-opératoire s’est produite chez une chienne chez qui une lésion urétrale caudale a été créée pendant l’intervention. Aucune complication postopératoire n’a été observée. Les résultats cliniques à court et moyen terme de l’utilisation de la TVT-O dans le traitement de l’ISU chez la chienne sont donc très favorables. L’hypothèse d’un rétablissement d’un support urétral déficient, entraînant une restauration de la fonction urétrale, reste à démontrer. [less ▲]

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See detailContribution d'un modèle à la détermination des zones de prévention autour d'un captage de sources à l’émergence dans les calcaires carbonifères du Condroz (Belgique)
Derouane, Johan; Dassargues, Alain ULg; Monjoie, Albéric ULg

in Actes du Colloque International Eau Souterraine en Région Agricole ESRA'96 (1996)

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See detailContribution de l’anthropologie des sens à une anthropologie des sensibilités
Colon, Paul-Louis ULg

Scientific conference (2010, February 26)

Detailed reference viewed: 22 (9 ULg)