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See detailCLANIMAE:Climatic and Anthropogenic Impacts on African Ecosystems. Final Report Phase 1 (2007-2008)
Verschuren, Dirk; Plisnier, Pierre-Denis; Hugues, Harold et al

Report (2009)

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See detailClap 48- Le 48è NO Jazz & Heritage Festival 2017 - Le festival de la démesure
Sacré, Robert ULiege

E-print/Working paper (2017)

Compte rendu du 48è Festival de la Nouvelle Orleans

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See detailCLARA WARD & THE FAMOUS WARD SINGERS ( CD sleeve notes)
Sacré, Robert ULiege

in GOSPEL FRIEND (Ed.) CLARA WARD & THE FAMOUS WARD SINGERS In Memory of Willa-Ward-Royster PN-1508 (2013)

The Ward Singers are considered as one of the best -if not the best- female gospel group ever. Gospel Friend and Per Notini gathered 25 rare tracks recorded between 1949-1958. The notes tell the story of ... [more ▼]

The Ward Singers are considered as one of the best -if not the best- female gospel group ever. Gospel Friend and Per Notini gathered 25 rare tracks recorded between 1949-1958. The notes tell the story of the group and of the recordings. [less ▲]

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See detailClarice Lispector et le concept d'écriture féminine
Petteni, Oriane ULiege

Scientific conference (2014, December 10)

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See detailClarifier les dimensions socio-économiques et politiques de l'agroécologie : au delà des principes, des compromis
Dumont, Antoinette; Stassart, Pierre M ULiege; Vanloqueren, Gaetan et al

Conference (2014)

Le concept d’agroécologie est de plus en plus mobilisé en Europe. Toutefois, les dimensions socio-économiques et politiques de cette alternative au modèle productiviste restent encore peu qualifiées dans ... [more ▼]

Le concept d’agroécologie est de plus en plus mobilisé en Europe. Toutefois, les dimensions socio-économiques et politiques de cette alternative au modèle productiviste restent encore peu qualifiées dans le monde académique. La présente étude contribue à clarifier les principes socio-économiques et politiques de l’agroécologie, en mettant les principes identifiés dans la littérature grise et scientifique à l’épreuve de l’étude qualitative de deux systèmes alimentaires belges : Agribio, une coopérative céréalière ; les Grosses Légumes un réseau de ménages, producteurs et citoyens membres qui organisent la production et la distribution de paniers de légumes. Des entretiens semi-directifs ont été effectués auprès des différents acteurs de ces systèmes alimentaires. Ils ont été analysés à la lumière de la théorie de la justification de Boltanski et Thévenot afin de mettre en évidence les principes que les acteurs rencontrés se donnent et tentent de mettre en application dans les différents projets qu’ils réalisent. Les principaux résultats obtenus sont explicités par l’analyse de quatre compromis (qui concernent les systèmes de commercialisation des deux systèmes alimentaires, un Système de Garantie Participative mis en place par les Grosses Légumes et la meunerie d’Agribio), plus spécifiquement étudiés via les objets qui matérialisent ces compromis et les controverses qui les remettent en question. Les deux études de cas illustrent l’écart qui existe entre les principes qui décrivent un horizon vers lequel l’agroécologie tend et les principes mis concrètement en oeuvre par les acteurs de terrain au travers des différentes trajectoires de transition. [less ▲]

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See detailClarifying the Socio-Economic Dimensions of Agroecology: Between Principles and Practices
Dumont, Antoinette M.; Vanloqueren, Gaëtan; Stassart, Pierre M ULiege et al

in Agroecology and Sustainable Food Systems (2016), 1(1), 24-47

AbstractThe concept of agroecology is being mobilized increasingly. However, its socio-economic dimensions receive little attention from academia. This study helps to clarify the socio-economic principles ... [more ▼]

AbstractThe concept of agroecology is being mobilized increasingly. However, its socio-economic dimensions receive little attention from academia. This study helps to clarify the socio-economic principles of agroecology by first identifying a list of principles in popular and scientific literature and, as a second step, by putting the principles to the test of a qualitative study of two Belgian organizations. Agribio is a grain cooperative, and Les Grosses L√©gumes is a network of consumers, farmers, and the members of an association set up to organize the production and distribution of vegetable boxes. Semi-directed interviews of the various actors linked to these organizations were conducted and then analyzed through an approach inspired by the convention theory in order to reveal the principles that the stakeholders have adopted. The main findings are then made explicit by analysis of four strong agreements (which concern the two organizations? marketing schemes, a Participatory Guarantee System set up by Les Grosses L√©gumes and Agribio?s flour mill). The two case studies show the gap that exists between the principles that describe the horizon of agroecology and the principles that are actually put into practice by the parties in the field through various transition pathways. [less ▲]

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See detailA clash of kings: The European Committee of Social Rights on the 'Lex Laval' ... and on the EU framework for the posting of workers
Rocca, Marco ULiege

in European Journal of Social Law (EJSL) (2013), 2013(3), 217-233

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See detailCLASIFICACIÓN ACÚSTICA DE PAVIMENTOS PARA CAPAS DE RODADURA CON CÁMARA SEMIANECOICA
Paje, S.E.; Luong, Jeanne ULiege

in XV Congreso Ibero Latino Americano do Asfalto (2010)

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See detailThe CLASS (CLinical and Angiographic analysis with a cobalt alloy coronary Stent (Driver(TM)) in stable and unstable angina pectoris) study
Legrand, Victor ULiege; Kelbaek, H.; Hauptmann, K. E. et al

in European Heart Journal (2004), 25(Suppl. S), 669-670

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See detailClass A β -Lactamases as Versatile Scaffolds to Create Hybrid Enzymes: Applications from Basic Research to Medicine
Huynen, Céline ULiege; Filée, Patrice; Matagne, André ULiege et al

in BioMed Research International (2013), 2013

Designing hybrid proteins is a major aspect of protein engineering and covers a very wide range of applications frombasic research to medical applications. This review focuses on the use of class A 𝛽 ... [more ▼]

Designing hybrid proteins is a major aspect of protein engineering and covers a very wide range of applications frombasic research to medical applications. This review focuses on the use of class A 𝛽-lactamases as versatile scaffolds to design hybrid enzymes (referred to as 𝛽-lactamase hybrid proteins, BHPs) in which an exogenous peptide, protein or fragment thereof is inserted at various permissive positions.We discuss how BHPs can be specifically designed to create bifunctional proteins, to produce and to characterize proteins that are otherwise difficult to express, to determine the epitope of specific antibodies, to generate antibodies against nonimmunogenic epitopes, and to better understand the structure/function relationship of proteins. [less ▲]

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See detailLa class action à la belge est arrivée
Boularbah, Hakim ULiege

in Justement (2014)

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See detailClass II histone deacetylases: versatile regulators.
Verdin, Eric; Dequiedt, Franck ULiege; Kasler, Herbert G

in Trends in Genetics (2003), 19(5), 286-93

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in eukaryotes. Histone deacetylases (HDACs) catalyze the deacetylation of lysine ... [more ▼]

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in eukaryotes. Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues in the histone N-terminal tails and are found in large multiprotein complexes with transcriptional co-repressors. Human HDACs are grouped into three classes based on their similarity to known yeast factors: class I HDACs are similar to the yeast transcriptional repressor yRPD3, class II HDACs to yHDA1 and class III HDACs to ySIR2. In this review, we focus on the biology of class II HDACs. These newly discovered enzymes have been implicated as global regulators of gene expression during cell differentiation and development. We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. [less ▲]

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See detailThe class IIa HDACs prevent degradation of RBFOX2 by Chaperone-Mediated Autophagy
Detiffe, Cécile ULiege; Dequiedt, Franck ULiege; Rambout, Xavier ULiege

Poster (2015, June)

By modulating the acetylation level of histones, histone deacetylases (HDACs) are enzymes playing a key role in the control of gene expression. In addition to histones, HDACs also have non-histone ... [more ▼]

By modulating the acetylation level of histones, histone deacetylases (HDACs) are enzymes playing a key role in the control of gene expression. In addition to histones, HDACs also have non-histone substrates, which may relate to potential roles for HDACs outside of gene regulation. Because HDACs are key regulators of major cellular processes such as cell division, apoptosis and differentiation, it is not surprising that these enzymes have emerged as attractive therapeutic targets for cancer. While the in vivo antitumoral activities of several small molecules HDACs inhibitors have generated a lot of hope, these molecules often showed dramatic side-effects. It is suspected that these side effects could be related to unknown functions of HDACs. The goal of this project is to identify novel, unsuspected functions of HDACs that will help developing more efficient and specific HDAC-based antitumoral therapies. To identify novel functions of HDACs, we used a high-throughput yeast two hybrid (Y2H) approach. This led to the first comprehensive interactomic map of class IIa HDACs that includes 84 protein partners. Among new HDACs partners, we identified several RNA-binding proteins (RBPs) involved in mRNA processing. In this work, we focused on one, the alternative splicing regulator RBFOX2, and investigated its regulation by class IIa HDACs. Through various approaches, we verified that HDAC7 interacts with RBFOX2. In addition, we found that silencing of HDAC7 correlates with a decrease in stability of RBFOX2. Because we identified a potential CMA-specific KFERQ motif in RBFOX2, we tested the possibility that RBFOX2 might be degraded through Chaperone-Mediated Autophagy (CMA). Supporting this hypothesis, we found that RBFOX2 interacts with the co-chaperone HSC70. RBFOX2 levels are sensitive to CMA inducers, including serum starvation and 6AN. Interestingly, we found that a lysine residue in the KFERQ motif of RBFOX2 is acetylated, suggesting that HDAC7 might control RBFOX2 degradation through reversible acetylation. Indeed, degradation of RBFOX2 following HDAC7 silencing was reverted with an inhibitor of autophagy, bafilomycin A1. Analysis of RNA splicing pattern in cells depleted for HDAC7 showed that absence of HDAC7 is associated with 159 alternative splicing events. These events mostly include exon skipping that is known to be the major splicing event in which RBFOX2 is involved. In addition, we observed a highly statistically overlap between splicing events associated with RBFOX2 and HDAC7 depletion. [less ▲]

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See detailClass IIa histone deacetylases: conducting development and differentiation.
Martin, Maud ULiege; Kettmann, Richard ULiege; Dequiedt, Franck ULiege

in International Journal of Developmental Biology (2009), 53(2-3), 291-301

The emergence of specialized cell types and their organisation into organs and tissues involve the temporal modulation of many genes that are essential for coordinating the correct timing of instructive ... [more ▼]

The emergence of specialized cell types and their organisation into organs and tissues involve the temporal modulation of many genes that are essential for coordinating the correct timing of instructive signals. These transcriptional changes are orchestrated with a precision that reminds that of a classical symphony. Extracellular signals are transmitted to key integrators, which then orchestrate activation or repression of specific genes. In the last decade, class IIa HDACs have emerged as crucial regulators in various developmental and differentiation processes. This review focuses on the latest studies that have provided new insights into the biological functions of class IIa HDACs and discusses important aspects of their regulation. Elucidating cellular and molecular mechanisms by which functions of class IIa HDACs are modulated could potentially lead to new therapeutic opportunities for various diseases. [less ▲]

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See detailClass IIa histone deacetylases: regulating the regulators.
Martin, Maud ULiege; Kettmann, Richard ULiege; Dequiedt, Franck ULiege

in Oncogene (2007), 26(37),

n the last decade, the identification of enzymes that regulate acetylation of histones and nonhistone proteins has revealed the key role of dynamic acetylation and deacetylation in various cellular ... [more ▼]

n the last decade, the identification of enzymes that regulate acetylation of histones and nonhistone proteins has revealed the key role of dynamic acetylation and deacetylation in various cellular processes. Mammalian histone deacetylases (HDACs), which catalyse the removal of acetyl groups from lysine residues, are grouped into three classes, on the basis of similarity to yeast counterparts. An abundance of experimental evidence has established class IIa HDACs as crucial transcriptional regulators of various developmental and differentiation processes. In the past 5 years, a tremendous effort has been dedicated to characterizing the regulation of these enzymes. In this review, we summarize the latest discoveries in the field and discuss the molecular and structural determinants of class IIa HDACs regulation. Finally, we emphasize that comprehension of the mechanisms underlying class IIa HDAC functions is essential for potential therapeutic applications. [less ▲]

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See detailA Class of Methods for the Analysis of Blade Tip Timing Data from Bladed Assemblies Undergoing Simultaneous Resonances—Part I: Theoretical Development
Gallego-Garrido, Jon; Dimitriadis, Grigorios ULiege; Wright, Jan Robert

in International Journal of Rotating Machinery (2007), 2007

Blade tip timing is a technique for the measurement of vibrations in rotating bladed assemblies. Although the fundamentals of the technique are simple, the analysis of data obtained in the presence of ... [more ▼]

Blade tip timing is a technique for the measurement of vibrations in rotating bladed assemblies. Although the fundamentals of the technique are simple, the analysis of data obtained in the presence of simultaneously occurring synchronous resonances is problematic. A class of autoregressive-based methods for the analysis of blade tip timing data from assemblies undergoing two simultaneous resonances has been developed. It includes approaches that assume both sinusoidal and general blade tip responses. The methods can handle both synchronous and asynchronous resonances. An exhaustive evaluation of the approaches was performed on simulated data in order to determine their accuracy and sensitivity. One of the techniques was found to perform best on asynchronous resonances and one on synchronous resonances. Both methods yielded very accurate vibration frequency estimates under all conditions of interest. [less ▲]

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