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See detailComment j'explore ... les secrets d'une meta-analyse.
Scheen, André ULg

in Revue Médicale de Liège (2003), 58(1), 41-6

Meta-analysis is becoming a key partner of Evidence-Based Medicine. This statistical tool is currently used in most systematic reviews and allows to quantitatively synthesize the results of several ... [more ▼]

Meta-analysis is becoming a key partner of Evidence-Based Medicine. This statistical tool is currently used in most systematic reviews and allows to quantitatively synthesize the results of several studies by a single weighted average whose precision is indicated by the confidence interval. A standardized graphical representation allows, at first glance, to derive a lot of useful information, especially the number of studies taken into account for the analysis, the mean effect observed in each study with its confidence interval, the relative size (number of subjects) of each study, the homogeneity/heterogeneity of between-study results, finally the overall mean effects with its confidence interval. The meta-analysis plays a key-role in epidemiology, for the evaluation of a risk or a protective factor, and in therapeutics, for summarizing the results of numerous clinical trials with a specific drug or a pharmacological class in a given disease. [less ▲]

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See detailComment j'explore ... les troubles de la calcémie
Janssens, Lise; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1999), 54(9), 764-769

Mechanisms for calcium homeostasis are complex but their understanding is important before investigating the calcium disorders. Hypercalcaemia is often due to hyperparathyroidism or cancers. The ... [more ▼]

Mechanisms for calcium homeostasis are complex but their understanding is important before investigating the calcium disorders. Hypercalcaemia is often due to hyperparathyroidism or cancers. The diagnostis must thus be rapid and a treatment decided in a global approach. Hypocalcaemia, more frequently noted, is often due to a general disorder with hypoalbuminemia or chronic renal failure. [less ▲]

Detailed reference viewed: 343 (32 ULg)
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See detailComment j'explore ... nouveaux critères pour le diagnostic du diabète sucré
Scheen, A. J.; Paquot, Nicolas ULg; Lefebvre, P. J.

in Revue Médicale de Liège (1997), 52(9), 606-9

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See detailComment j'explore ... Sur le plan coronarien, un patient avant chirurgie non cardiaque
Hoffer, E.; Pierard, Luc ULg

in Revue Médicale de Liège (1997), 52(3), 178-82

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See detailComment j'explore ... un cancer broncho-pulmonaire par imagerie metabolique (TEP-18-FDG).
Bury, Thierry ULg; DUYSINX, Bernard ULg; CORHAY, Jean-Louis ULg et al

in Revue Médicale de Liège (2000), 55(3), 178-83

Continuing advances in PET imaging have resulted in an improved ability to evaluate thoracic malignancies. Published reports demonstrate that PET provides accurate noninvasive detection of malignancy that ... [more ▼]

Continuing advances in PET imaging have resulted in an improved ability to evaluate thoracic malignancies. Published reports demonstrate that PET provides accurate noninvasive detection of malignancy that is useful in the characterization of a pulmonary solitary nodule and in the mediastinal or extrathoracic staging of known lung cancer. Preliminary studies suggest that PET may also be able to assess the therapeutic response after surgery or radiation therapy. [less ▲]

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See detailComment j'EXPLORE ... un hypogonadisme hypogonadotrope congenital isole
Valdes-Socin, H.; Debray, François-Guillaume ULg; Parent, Anne-Simone ULg et al

in Revue Médicale de Liège (2010), 65(11), 634-41

Congenital Isolated hypogonadotropic hypogonadism (CIHH) is caused by an inherited mechanism of impairment of the pituitary-gonadal axis, interfering with gonads' control. Currently, different forms of ... [more ▼]

Congenital Isolated hypogonadotropic hypogonadism (CIHH) is caused by an inherited mechanism of impairment of the pituitary-gonadal axis, interfering with gonads' control. Currently, different forms of HHCI with (Kallmann syndrome or KS) or without anosmia-hyposmia are known. There are six forms of KS already described but in several cases no genetic mutation is found. The genetic anomalies already described are: KAL1 (locus Xp23) coding for anosmine-1, KAL-2 or FGFRI (8p11. locus 2 - p11.1) coding for Fibroblast Growth Factor Receptor 1 (FGFR1), KAL4 or PROk2 (locus 3p21.1) and KAL3 or ProKR2 (locus 20p13) coding respectively for the Prokinecitin-2 and its receptor, KAL5 or CHD7 (locus_8q12.1) coding for a chromodomain helicase DNA-binding protein-7 gene (CHD7) and lastly KAL6 or FGF8 (10Q 24 loci) coding for Fibroblast Growth Factor 8. The other genetic anomalies without anosmia are less frequent. These are associated either with Gnrhl gene (8p2-11. 2), GnRHR (4q21.2), GPR54 (19p13),TAC3R or neurokinine receptor 3 (4 q 25), LH (19q13.32) or FSH (11p13). The isolated congenital hypogonadotrophic hypogonadism phenotype is variable depending on gender, the importance of the deficit, and ultimately, according to a specific regulatory mechanism of the axis, affected by an inherited genetic anomaly. In this review, we describe the essential aspects of the different phenotypes and genotypes of HHCI, in order to assess clinicians an early disease's diagnosis and management. [less ▲]

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See detailComment j'explore ... un nez rouge.
Pierard, Claudine ULg; Henry, Frédérique ULg; Rakic, L. et al

in Revue Médicale de Liège (2003), 58(7-8), 515-8

A red nose is a semiological sign shared in common by a series of diseases. The differential diagnosis is important to establish. A careful clinical examination often allows to reach the precise diagnosis ... [more ▼]

A red nose is a semiological sign shared in common by a series of diseases. The differential diagnosis is important to establish. A careful clinical examination often allows to reach the precise diagnosis. A skin biopsy is required when erythema is accompanied by a cutaneous infiltration suggesting some granulomatous and tumoral processes. [less ▲]

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See detailComment j'explore ... un patient atteint de mélanome: actualisation d'un algorithme.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(12), 837-43

Cutaneous melanoma is a cancer affecting an ever growing proportion of young adults. Currently, the best approach for a prolonged remission or cure relies on early detection of the primary neoplasm and of ... [more ▼]

Cutaneous melanoma is a cancer affecting an ever growing proportion of young adults. Currently, the best approach for a prolonged remission or cure relies on early detection of the primary neoplasm and of its first possible metastases. Some therapies can bring much hope at this stage of the disease. The early detection of lymph node metastases is therefore essential in the global management strategy. The excision and the microscopic examination of the sentinel lymph node are important in this evaluation. Echography of the draining lymph nodes is a non invasive procedure which may also prove to be informative. PET-scan brings additional information, particularly when the dissemination risk is beyond the first group of lymph nodes. [less ▲]

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See detailComment j'explore ... un patient avec diabète de type 1 inaugural ou a risque de développer la maladie
Philips, J. C.; Letiexhe, M. R.; Paquot, Nicolas ULg et al

in Revue Médicale de Liège (1997), 52(5), 363-6

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See detailComment j'explore ... un patient avec hypotension orthostatique.
Scheen, André ULg; De Fooz, Geoffroy; Marchand, Monique ULg

in Revue Médicale de Liège (1997), 52(2), 116-9

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See detailComment j'explore ... un prurit souvenir de vacances sous les tropiques.
Bourguignon, Raphaël; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60(7-8), 676-9

Any journey or stay in a tropical country can lead to a variety of diseases with exotic background. One of the symptoms is represented by localized or generalized pruritus. It is associated or not ... [more ▼]

Any journey or stay in a tropical country can lead to a variety of diseases with exotic background. One of the symptoms is represented by localized or generalized pruritus. It is associated or not associated with primary cutaneous lesions. [less ▲]

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See detailComment j'explore ... un sujet avec un exces ponderal ou une obesite.
Scheen, André ULg; Luyckx, Françoise ULg

in Revue Médicale de Liège (1999), 54(6), 553-6

The evaluation of an obese subject aims at better understanding the disease, its causes and consequences, in order to optimize its management. Schematically, this task can be done in three successive ... [more ▼]

The evaluation of an obese subject aims at better understanding the disease, its causes and consequences, in order to optimize its management. Schematically, this task can be done in three successive steps. First, it is necessary to analyse data from the past, by asking about family and personal history. Then, the present data should be carefully analysed, especially the severity of overweight, its type of distribution and the importance of associated complications. Finally, it is mandatory to project these data into the future, in order to assess the final prognosis of the obese patient allowing a better definition of the goals and the therapeutical strategies. [less ▲]

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See detailComment j'explore ... un sujet avec une concentration basse de cholesterol HDL.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(11), 711-4

A decrease in plasma HDL cholesterol concentration is considered as a major cardiovascular risk factor and is a prevalent lipid abnormality among patients with coronary heart disease. This condition is ... [more ▼]

A decrease in plasma HDL cholesterol concentration is considered as a major cardiovascular risk factor and is a prevalent lipid abnormality among patients with coronary heart disease. This condition is most often observed in the presence of hypertriglyceridaemia, generally linked to the insulin resistance syndrome, but may also be associated to elevated LDL cholesterol level or even be present alone (hypoalphalipoproteinaemia). The decision to treat a patient with low HDL level depends on the individual overall cardiovascular risk which should be evaluated as carefully as possible. The investigation should look for causes which may favour this metabolic condition, such as bad life habits or possible pharmacological interferences. [less ▲]

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See detailComment j'explore ... un trouble de la kaliémie
Neven, Ingrid; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1999), 54(12), 943-947

Potassium is the most important intracellular cation,playing a role in neuromuscular excitability. Dyskaliema is common. The consequence of this ionic perturbation could be serious related to its ... [more ▼]

Potassium is the most important intracellular cation,playing a role in neuromuscular excitability. Dyskaliema is common. The consequence of this ionic perturbation could be serious related to its magnitude. Thus a quick etiological approach and a medical intervention are needed to rapidly correct this potentially lethal ionic disturbance and prevent its recurrence. [less ▲]

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See detailComment j'explore ... un trouble de la magnésémie
Boman, Xavier ULg; Guillaume, Thierry; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2003), 58(2), 104-108

Magnesium (Mg) therapy is often proposed against stress and to correct asthenia. Thus our aim has been to review the role of Mg, the mechanisms of its homeostasis before detailing the clinical ... [more ▼]

Magnesium (Mg) therapy is often proposed against stress and to correct asthenia. Thus our aim has been to review the role of Mg, the mechanisms of its homeostasis before detailing the clinical presentations and etiologies of hypo- and hypermagnesemia and their exploration. Hypomagnesemia frequently occurs but is clinically rarely recognized without biological serum ionic determinations because causing atypical signs miming those of other ion deficiencies. Hypermagnesemia is uncommon but often occurs in the presence of renal insufficiency especially with excess of Mg administration. [less ▲]

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See detailComment j'explore ... une anemie (2eme partie).
Beguin, Yves ULg

in Revue Médicale de Liège (1995), 50(11), 487-8

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See detailComment j'explore ... Une anorexie mentale.
Scheen, André ULg

in Revue Médicale de Liège (1995), 50(12), 538-9

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See detailComment j'explore ... une bouche brulante
Claessens, N.; Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2000), 55(11), 1011-4

Burning mouth is a symptom typical for the oral mucosa. In contrast, pruritus is absent at this site. The situation which is the reverse on the skin can be explained by microanatomical differences in the ... [more ▼]

Burning mouth is a symptom typical for the oral mucosa. In contrast, pruritus is absent at this site. The situation which is the reverse on the skin can be explained by microanatomical differences in the sensorial innervation and by a different balance between neuromediators. Burning mouth sensation calls for the search of a series of diseases. However, it is most often a monosymptomatic expression of a minimal lichenoid stomatitis. [less ▲]

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See detailComment j'explore ... une grosse jambe rouge.
Goffin, Véronique ULg; Hermanns-Lê, Trinh ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(3), 155-7

A consultation motivated by an enlarged red leg is a common situation. The causes are multiple and the diagnosis primarily relies on case history and physical examination distinguishing inflammatory red ... [more ▼]

A consultation motivated by an enlarged red leg is a common situation. The causes are multiple and the diagnosis primarily relies on case history and physical examination distinguishing inflammatory red legs from erythemato-violaceous presentations. Additional diagnostic search cannot be described as a single standardized procedure. Each disease calls for specific and different paraclinical investigations. The most frequent cause is erysipelas or a thrombophlebitis. Some vascular malformations and some functional circulatory disturbances are also possible, as well as sequelae of panniculitis or borreliosis. [less ▲]

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See detailComment j'explore ... Une maladie de Basedow: de la clinique classique au diagnostic radio-immunologique.
Scheen, André ULg

in Revue Médicale de Liège (1997), 52(12), 788-91

Detailed reference viewed: 44 (5 ULg)