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See detailConformational and thermodynamic changes of the repressor/DNA operator complex upon monomerization shed new light an regulation mechanisms of bacterial resistance against beta-lactam antibiotics
Boudet, J.; Duval, V.; Van Melckebeke, H. et al

in Nucleic Acids Research (2007), 35(13), 4384-4395

In absence of beta-lactam antibiotics, Blal and Mecl homodimeric repressors negatively control the expression of genes involved in P-lactam resistance in Bacillus licheniformis and in Staphylococcus ... [more ▼]

In absence of beta-lactam antibiotics, Blal and Mecl homodimeric repressors negatively control the expression of genes involved in P-lactam resistance in Bacillus licheniformis and in Staphylococcus aureus. Subsequently to P-lactam presence, Blal/Mecl is inactivated by a single-point proteolysis that separates its N-terminal DNA-binding domain to its C-terminal domain responsible for its dimerization. Concomitantly to this proteolysis, the truncated repressor acquires a low affinity for its DNA target that explains the expression of the structural gene for resistance. To understand the loss of the high DNA affinity of the truncated repressor, we have determined the different dissociation constants of the system and solved the solution structure of the B. licheniformis monomeric repressor complexed to the semi-operating sequence OP1, of blaP (1/20P(1)blaP) by using a de novo docking approach based on inter-molecular nuclear Overhauser effects and chemical-shift differences measured on each macromolecular partner. Although the N-terminal domain of the repressor is not subject to internal structural rearrangements upon DNA binding, the molecules adopt a tertiary conformation different from the crystallographic operator-repressor dimer complex, leading to a 300 rotation of the monomer with respect to a central axis extended across the DNA. These results open new insights for the repression and induction mechanisms of bacterial resistance to beta-lactams. [less ▲]

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See detailConformational-Analysis Of The Calcium Complexes Formed By Meglitinide Analogs
Lins, Laurence ULg; Brasseur, Robert ULg; Malaisse, Wj.

in Research Communications In Molecular Pathology and Pharmacology (1995), 90(1), 153-64

The conformation of calcium complexes formed with meglitinide and its hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a semi-empirical procedure, which includes calculation ... [more ▼]

The conformation of calcium complexes formed with meglitinide and its hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a semi-empirical procedure, which includes calculation of the molecular hydrophobicity potential. The calcium complexes formed with KAD-1229, A-4166, repaglinide or its enantiomer, displayed favourable attributes to act as ionophores. Such was not the case for the poorly efficient insulinotropic agent meglitinide and the biologically inactive enantiomer of A-4166. The configuration of the calcium complex formed with S 3075 also failed to display the features required for a high ionophoretic capacity. [less ▲]

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See detailConformationally driven gas-phase H/D exchange of dinucleotide negative ions
Balbeur, Dorothée ULg; Dehareng, Dominique ULg; De Pauw, Edwin ULg

in Journal of the American Society for Mass Spectrometry (2007), 18(10), 1827-1834

Gas-phase hydrogen/deuterium exchange of six deprotonated dinucleoticles with CD3OD was performed in the second hexapole of a Fourier transform ion-cyclotron resonance (FTICR) mass spectrometer. To ... [more ▼]

Gas-phase hydrogen/deuterium exchange of six deprotonated dinucleoticles with CD3OD was performed in the second hexapole of a Fourier transform ion-cyclotron resonance (FTICR) mass spectrometer. To complete these experiments, dynamic simulations were carried out to investigate the different conformations adopted by the dinucleotides. In the experimental conditions and in integrating the experimental and theoretical results, H/D exchange was shown to be controlled by hydrogen accessibility and not by the chemical nature of the heteroatom bearing the exchangeable hydrogen. A model including simultaneous H/D exchanges at the experimental time scale was used to reproduce the dinucleotide H/D exchange kinetic plots. The relay mechanism was not relevant for dinucleotides. This allowed the H/D exchange rates to be directly linked to conformations. [less ▲]

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See detailConformations of protected oligo(gamma-methyl-L-glutamates) at the air-water interface.
Hecq, W.; Brasseur, Robert ULg; Caspers, J. et al

in Biopolymers (1976), 15(7), 1425-30

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See detailA conforming finite element for plate bending
Fraeijs de Veubeke, Baudouin ULg

in International Journal for Solids ans Structures (1968), 4

In this paper, the celeber CQ (conforming quadrilateral) element of plate is presented for the first time.

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See detailConformités des paysages ruraux et parc naturels wallons : l’exemple du parc naturel de la Vallée de l’Attert
Christians, Charles ULg; Schmitz, Serge ULg

in Van Eetvelde, Veerle; Sevenant, Marjanne; Van de Velde, Lisa (Eds.) Re-Marc-able Landscape, Marc-ante Landschappen (2009)

The landscape of a nature park is not a relic landscape but a living cultural landscape. The paper questions the conformity of the landscape in the regional nature park of the Attert valley. It analyses ... [more ▼]

The landscape of a nature park is not a relic landscape but a living cultural landscape. The paper questions the conformity of the landscape in the regional nature park of the Attert valley. It analyses more specifically (1) the conformity to the natural environment and the economic context, (2) the conformity from a semiotic or cultural point of view, and (3) the recognition and the management of the landscape as heritage. It states that few landscape features are preserved from the past. Nevertheless the landscape of the Attert valley maintains an identity due to old settlements, and the influence of the natural environment. The rural policy of renovation since 1970, together with the regional nature park activities, and the coming landscape Charter are useful tools to manage the landscape. However, these tools experience trouble with restraining the increase of real-estate due to the proximity of the Great Duchy of Luxembourg. [less ▲]

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See detailConformity in landscape: a theoretical approach and the Attert Valley Belgian Nature Park case study
Schmitz, Serge ULg

in Pungetti, Gloria (Ed.) European culture expressed in agricultural landscapes, book of abstracts of the Eucaland Project Conference (Gloria Pungetti ed) : Corpus Christi College, Cambridge University 22-23 September 2009 (2009, September)

Maintaining or strengthening the value of the landscape is quite a new issue for the council boards of Walloon nature park. This issue was reinforced by the 2008 Walloon decree, which requires a landscape ... [more ▼]

Maintaining or strengthening the value of the landscape is quite a new issue for the council boards of Walloon nature park. This issue was reinforced by the 2008 Walloon decree, which requires a landscape charter to each nature park. This new topic poses the Park Council with the question of defining the type of landscape that should be in a nature park in Belgium. Two interesting viewpoints could be that of visual integrity and conformity. The paper questions the notion of “conformity” theoretically and empirically through the analysis of the Attert valley nature park (South Belgium). It analyzes more specifically the conformity with the natural environment and the economic context acknowledging the rule of the semiotic approach and of the management of landscape as an heritage. [less ▲]

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See detailConformity in Landscape: a theoretical approach and the Attert Valley Nature Park case study, Belgium
Schmitz, Serge ULg

Conference (2009, September)

Maintaining or strengthening the value of the landscape is quite a new issue for the council boards of Walloon nature park. This issue was reinforced by the 2008 Walloon decree, which requires a landscape ... [more ▼]

Maintaining or strengthening the value of the landscape is quite a new issue for the council boards of Walloon nature park. This issue was reinforced by the 2008 Walloon decree, which requires a landscape charter to each nature park. This new topic poses the Park Council with the question of defining the type of landscape that should be in a nature park in Belgium. Two interesting viewpoints could be that of visual integrity and conformity. The paper questions the notion of “conformity” theoretically and empirically through the analysis of the Attert valley nature park (South Belgium). It analyzes more specifically the conformity with the natural environment and the economic context acknowledging the rule of the semiotic approach and of the management of landscape as an heritage. [less ▲]

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See detailConfounding factors influencing serum dioxin concentrations in the French dioxin and incinerators study
Frery, N.; Zegnoun, N.; Sarter, H. et al

in Organohalogen Compounds (2007), 69

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See detailLes confraternités de l'abbaye de Stavelot-Malmedy au Moyen Age
George, Philippe ULg

in Actes du Congrès de la Fédération Archéologique & Historique de Belgique (1992)

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See detailLes confraternités de l'abbaye de Stavelot-Malmedy
George, Philippe ULg

in Bulletin de la Commission Royale d'Histoire (1995), CLXI

réseau de fraternités de Stavelot-Malmdy mis en parallèle avec tous les échanges humains observés dans toutes les sources

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See detailConfrontation anatomo-clinique. A propos d'un cas de carcinome renal a cellules claires
Daloze, A.; Delbecque, Katty ULg; Delvenne, Philippe ULg et al

in Revue Médicale de Liège (1999), 54(11), 859-63

The authors report the case of a patient with a history of hypertension and multiple intracerebral hemorrhages who was found at post mortem examination to have a renal cell carcinoma. The relationship ... [more ▼]

The authors report the case of a patient with a history of hypertension and multiple intracerebral hemorrhages who was found at post mortem examination to have a renal cell carcinoma. The relationship between renal carcinoma and hypertensive intracerebral hemorrhages is discussed. [less ▲]

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See detailConfrontation anatomo-clinique. Carcinome spinocellulaire de la jambe chez une octogenaire
Quatresooz, Pascale ULg; Letot, Bernard ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60(7-8), 680-2

An octogenarian woman developed lesions of the leg suggesting the diagnosis of cutaneous cancer at the dermatological examination. A biopsy revealed the carcinomatous nature of the neoplasm. An additional ... [more ▼]

An octogenarian woman developed lesions of the leg suggesting the diagnosis of cutaneous cancer at the dermatological examination. A biopsy revealed the carcinomatous nature of the neoplasm. An additional immunohistochemical examination was performed for scientific purposes. The neoplastic structures were not surrounded by a basement membrane and its framework of collagen IV. The dermal dendrocytes were abundant in the peritumoral stroma. This situation was previously interpreted as a favourable prognostic factor. [less ▲]

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See detailConfrontation anatomo-clinique. Le cancer cutané a-t-il été éradique?
Arrese Estrada, Jorge ULg; Pierard, Gérald ULg; Ruiz Ballon, M. et al

in Revue Médicale de Liège (2007), 62(9), 582-4

Distinguishing complete removal of a skin cancer and its partial destruction is frequently requested by the clinicians and their patients. The information is awaited from the laboratory, but it is not ... [more ▼]

Distinguishing complete removal of a skin cancer and its partial destruction is frequently requested by the clinicians and their patients. The information is awaited from the laboratory, but it is not always correctly interpreted by the information-seekers. The factors influencing this assessment include the combination of the nature of the antineoplastic therapy, the sampling modality of the area to be examined, and the quality of the dermatopathology procedure. In addition, the possibility of neoplastic regression linked to scarring or, conversely, the existence of a possible field cancerisation should be taken into consideration. [less ▲]

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See detailConfrontation anatomo-clinique. Mélanose vulvaire.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2004), 59(12), 731-3

Vulvar melanosis is a benign disorder that may suggest a malignant melanoma. We report the case of a woman in whom partial vulvectomy was performed to eradicate the melanotic macule. The lesion ... [more ▼]

Vulvar melanosis is a benign disorder that may suggest a malignant melanoma. We report the case of a woman in whom partial vulvectomy was performed to eradicate the melanotic macule. The lesion corresponds to increased accumulation of melanin inside keratinocytes in the absence of any melanocytic neoplasm. [less ▲]

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See detailConfrontation anatomo-clinique: a propos de deux cas de meningite bacterienne.
Deprez, Manuel ULg; Van Den Brule, Justine ULg; Degauque, C. et al

in Revue Médicale de Liège (1994), 49(11), 615-20

Detailed reference viewed: 37 (6 ULg)