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See detailComparative effectiveness of silvicultural interventions for increasing timber production and sustaining conservation values in natural tropical production forests. A systematic review protocol
Petrokofsky, Gillian; Sist, Plinio; Blanc, Lilian et al

in Environmental Evidence (2015), 4(8),

Background: Currently, about 400 million hectares of tropical moist forests worldwide are designated production forests, about a quarter of which are managed by rural communities and indigenous peoples ... [more ▼]

Background: Currently, about 400 million hectares of tropical moist forests worldwide are designated production forests, about a quarter of which are managed by rural communities and indigenous peoples. There has been a gradual impoverishment of forest resources inside selectively logged forests in which the volume of timber extracted over the first cutting cycle was mostly from large, old trees that matured over a century or more and grew in the absence of strong anthropological pressures. In forests now being logged for a second and third time, that volume has not been reconstituted due in part to the lack of implementation of post-logging silvicultural treatments. This depletion of timber stocks renders the degraded forests prone to conversion to other land uses. Although it is essential to preserve undisturbed primary forests through the creation of protected areas, these areas alone will not be able to ensure the conservation of all species on a pan-tropical scale, for social, economic and political reasons. The conservation of tropical forests of tomorrow will mostly take place within human-modified (logged, domesticated) forests. In this context, silvicultural interventions are considered by many tropical foresters and forest ecologists as tools capable of effectively conserving tropical forest biodiversity and ecosystem services while stimulating forest production. This systematic review aims to assess past and current evidence of the impact of silviculture on tropical forests and to identify silvicultural practices appropriate for the current conditions in the forests and forestry sectors of the Congo Basin, Amazonia and Southeast Asia. Methods: This systematic review will undertake an extensive search of literature to assess the relative effectiveness of different silvicultural interventions on timber production and the conservation value of forests, and to determine whether there is a relationship between sustainability of timber harvesting and the maintenance/conservation of other ecosystem services and biodiversity in production forests. Data will be extracted for meta-analysis of at least sub-sets of the review questions. Findings are expected to help inform policy and develop evidence-based practice guidelines on silvicultural practices in tropical forests. [less ▲]

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See detailComparative Effects Of Deltamethrin And Neem Kernel Solution Treatments On Diamondback Moth And Cotesia Plutellae (Hym., Braconidae) Parasitoid Populations In The Cotonou Peri-Urban Area In Benin
Goudegnon, Ae.; Kirk, Aa.; Schiffers, Bruno ULg et al

in Journal of Applied Entomology-Zeitschrift Fur Angewandte Entomologie (2000), 124(3-4), 141-144

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See detailComparative effects of IL-1beta and hydrogen peroxide (H2O2) on catabolic and anabolic gene expression in juvenile bovine chondrocytes.
Martin, G.; Andriamanalijaona, R.; Mathy, Marianne ULg et al

in Osteoarthritis and Cartilage (2005), 13(10), 915-24

OBJECTIVE: To compare the effects of hydrogen peroxide (H(2)O(2)) to those of interleukin-1beta (IL-1beta) on gene expression in juvenile bovine articular chondrocytes (BAC). The study analyses the ... [more ▼]

OBJECTIVE: To compare the effects of hydrogen peroxide (H(2)O(2)) to those of interleukin-1beta (IL-1beta) on gene expression in juvenile bovine articular chondrocytes (BAC). The study analyses the activation of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) transcription factors, and the mRNA steady-state levels of the type II collagen, aggrecan core protein matrix, metalloproteinases (MMP-1, -3), and transforming growth factor-beta1 (TGF-beta1) genes. METHODS: Confluent BAC cultures were treated for 3 and 24h with IL-1beta and/or different concentrations of H(2)O(2) (Protocol 1). Following initial treatment, a part of the cells was further subjected to another 24h with medium, in the presence of IL-1beta, to determine the effect of the cytokine on H(2)O(2) pre-treated cells (Protocol 2). Total RNA and nuclear protein extractions were performed to study mRNA steady-state levels (real-time polymerase chain reaction) and AP-1/NF-kappaB DNA binding (Electrophoretic Mobility Shift Assays), respectively. RESULTS: IL-1beta enhanced both AP-1 and NF-kappaB binding, whereas H(2)O(2) only activated AP-1. H(2)O(2) pre-treatment decreased the IL-1beta activation of NF-kappaB. Both H(2)O(2) and IL-1beta down-regulated type II collagen and aggrecan expression and increased that of MMP-1 and -3. When cells were pre-treated with H(2)O(2), followed by IL-1beta, the effects were the same as those observed with H(2)O(2) alone. However, although H(2)O(2) and IL-1beta were capable of increasing TGF-beta1 expression separately, subsequent incubation with both factors led to a partial or total abolition of TGF-beta1 up-regulation. CONCLUSION: The different regulation of NF-kappaB and AP-1 by H(2)O(2) and IL-1beta underlines the distinct roles played by the two transcription factors in the regulation of gene expression. H(2)O(2) and IL-1beta exert similar effects on matrix, MMPs and TGF-beta1 gene expression. However, the association of H(2)O(2) and IL-1beta does not cause synergic effect, and rather leads, in some cases, to an opposite effect. These data provide further insights into the respective roles of reactive oxygen species and cytokine in the pathophysiology of joint diseases. [less ▲]

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See detailComparative effects of ketamine on Bispectral Index and spectral entropy of the electroencephalogram under sevoflurane anaesthesia
Hans, Pol ULg; Dewandre, Pierre-Yves; Brichant, Jean-François ULg et al

in British Journal of Anaesthesia (2005), 94(3), 336-340

BACKGROUND: The Bispectral Index (BIS) and spectral entropy of the electroencephalogram can be used to assess the depth of hypnosis. Ketamine is known to increase BIS in anaesthetized patients and may ... [more ▼]

BACKGROUND: The Bispectral Index (BIS) and spectral entropy of the electroencephalogram can be used to assess the depth of hypnosis. Ketamine is known to increase BIS in anaesthetized patients and may confound that index as a guide to steer administration of hypnotics. We compared the effects of ketamine on BIS, response entropy (RE) and state entropy (SE) during surgery under sevoflurane anaesthesia. METHODS: Twenty-two women undergoing gynaecological surgery were enrolled in this double-blind, randomized study. Anaesthesia was induced i.v. and maintained with sevoflurane. Under stable surgical and anaesthetic conditions, patients were assigned to receive either a bolus of ketamine 0.5 mg kg(-1) or the same volume of saline. Blood pressure, heart rate, BIS, RE and SE were measured every 2.5 min from 10 min before (baseline) until 15 min after ketamine or saline administration. The maximum relative increase in BIS, RE and SE compared with baseline was calculated for each patient. Values are mean (sd). RESULTS: Baseline values were BIS 33 (4), RE 31 (5), SE 30 (5) for the ketamine patients and BIS 35 (3), RE 33 (5) and SE 32 (6) for the patients receiving saline. BIS, RE and SE increased significantly from 5 min (BIS) and 2.5 min (RE and SE) after ketamine administration, peaking at 46 (8) (BIS), 52 (12) (RE) and 50 (12) (SE) respectively. The maximum relative increase in RE [42.2 (10.4%)] and SE [41.6 (10.9)%] was higher than that of BIS [29.4 (10.4%)]. Blood pressure, heart rate and RE-SE gradient did not change in either group. CONCLUSIONS: Ketamine administered under sevoflurane anaesthesia causes a significant increase in BIS, RE and SE without modification of the RE-SE gradient. This increase is paradoxical in that it is associated with a deepening level of hypnosis. [less ▲]

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See detailComparative effects of nimesulide, nimesulide L-lysine and nimesulide L-lysine L-arginine on human articular chondrocytes in vitro
De Leval, X.; Dogné, Jean-Michel ULg; Delarge, J. et al

in Mediators of Inflammation (2000), 9

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See detailComparative effects of nimesulide, nimesulide L-lysine and nimesulide L-lysine L-arginine on human articular chondrocytes in vitro
De Leval, X.; Dogne, J. M.; Delarge, J. et al

Poster (1999, September 17)

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See detailComparative Effects of University of Wisconsin and Euro-Collins Solutions on Pulmonary Mitochondrial Function after Ischemia and Reperfusion
Detry, Olivier ULg; Willet, K.; Lambermont, Bernard ULg et al

in Transplantation (1998), 65(2), 161-6

BACKGROUND: The aim of this study was to compare the effects of Euro-Collins and University of Wisconsin solutions on pulmonary mitochondrial function after cold ischemia and subsequent warm reperfusion ... [more ▼]

BACKGROUND: The aim of this study was to compare the effects of Euro-Collins and University of Wisconsin solutions on pulmonary mitochondrial function after cold ischemia and subsequent warm reperfusion. METHODS: Seventeen pigs underwent lung harvesting after classical lung flush with either University of Wisconsin or Euro-Collins solutions. The mitochondria were isolated from fresh swine lungs, from swine lungs subjected to 24 hr of cold ischemia, and from swine lungs subjected to 24 hr of ischemia followed by 30 min of subsequent ex vivo reperfusion at 37 degrees C with Krebs-Henseleit buffer solution and air ventilation. Mitochondrial oxidative phosphorylation parameters were determined in isolated mitochondria by in vitro measurement of oxygen consumption rates. During reperfusion, the lung function was assessed by the pulmonary aerodynamic parameters and the pulmonary vascular resistance. RESULTS: Relative to controls, mitochondria submitted to cold ischemia showed an alteration in the oxidoreductase activities of the respiratory chain. However, the yield of oxidative phosphorylation was conserved. After reperfusion, pulmonary mitochondria underwent a significant worsening in the oxidoreductase activities of the respiratory chain, and a decrease in the respiratory control and the efficiency of oxidative phosphorylation. Meanwhile, the reperfused lungs showed evidence of early dysfunction, assessed by the aerodynamic parameters and pulmonary vascular resistance. In this model, there was no advantage of University of Wisconsin solution over Euro-Collins solution. CONCLUSIONS: The mild mitochondrial alterations after cold ischemia were not sufficient to explain the limited tolerance of lung to ischemia. After reperfusion, the mitochondrial damage was more severe and could be involved in the posttransplant lung dysfunction. [less ▲]

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See detailComparative efficacy of eletriptan 40 mg versus sumatriptan 100 mg
Mathew, N. T.; Schoenen, Jean ULg; Winner, P. et al

in Headache (2003), 43(3), 214-222

Objective.-To confirm the efficacy advantage of eletriptan 40 mg over sumatriptan 100 mg. Background.-Eletriptan 80 mg has demonstrated significantly greater efficacy when compared to both sumatriptan 50 ... [more ▼]

Objective.-To confirm the efficacy advantage of eletriptan 40 mg over sumatriptan 100 mg. Background.-Eletriptan 80 mg has demonstrated significantly greater efficacy when compared to both sumatriptan 50 mg and 100 mg in two studies. Eletriptan 40 mg demonstrated significantly greater efficacy than sumatriptan 100 mg in one previous trial. Methods.-Two thousand one hundred thirteen patients with a diagnosis of migraine according to International Headache Society criteria were randomized using a double-blind, double-dummy, parallel-group design, and treated for a single migraine attack with either eletriptan 40 mg, sumatriptan 100 mg, or placebo. The primary endpoint was 2-hour headache response. Secondary endpoints included headache response rates at 1 hour, pain-free rates, absence of associated symptoms, functional response at 1 and 2 hours, and sustained headache response. Results.-Headache response rates at 2 hours postdose were significantly higher for eletriptan 40 mg (67%) than for sumatriptan 100 mg (59%; P<.001) and placebo (26%; P <.0001). Eletriptan 40 mg consistently showed significant (P<.01) efficacy over sumatriptan 100 mg across secondary clinical outcomes, including 1-hour headache response; 2-hour pain-free response; absence of nausea, photophobia, and phonophobia; functional improvement; use of rescue medication; treatment acceptability; and sustained headache response (P<.05). Overall, treatment-related adverse events were low, nausea being the only adverse event with an incidence of 2% or higher (4.9% with eletriptan, 4.2% sumatriptan, 2.8% placebo). Conclusion.-This trial confirmed that eletriptan 40 mg offers superior efficacy in treating migraine pain and associated symptoms and in restoring patient functioning when compared with sumatriptan 100 mg. [less ▲]

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See detailComparative efficacy of eletriptan and zolmitriptan in the acute treatment of migraine
Steiner, T. J.; Diener, H. C.; MacGregor, E. A. et al

in Cephalalgia : An International Journal of Headache (2003), 23(10), 942-952

Eletriptan 40 mg and 80 mg have shown greater efficacy in acute migraine than oral sumtriptan 100 mg and naratriptan 2.5 mg. This study continues the systematic series of active comparator trials in the ... [more ▼]

Eletriptan 40 mg and 80 mg have shown greater efficacy in acute migraine than oral sumtriptan 100 mg and naratriptan 2.5 mg. This study continues the systematic series of active comparator trials in the eletriptan clinical development programme. In a multicentre double-blind, double-dummy, parallel-groups trial, 1587 outpatients with migraine by IHS criteria were randomised in a 3: 3: 3: 1 ratio to eletriptan 80 mg, eletriptan 40 mg, zolmitriptan 2.5 mg or placebo. Of these, 1312 treated a single migraine attack and recorded baseline and outcome data to be included in the intention-to-treat population. The primary analysis was between eletriptan 80 mg and zolmitriptan. For the primary efficacy end-point of 2-h headache response, rates were 74% on eletriptan 80 mg, 64% on eletriptan 40 mg, 60% on zolmitriptan (P < 0.0001 vs. eletriptan 80 mg) and 22% on placebo (P < 0.0001 vs. all active treatments). Eletriptan 80 mg was superior to zolmitriptan on all secondary end-points at 1, 2 and 24 h, in most cases with statistical significance. Eletriptan 40 mg had similar efficacy to zolmitriptan 2.5 mg in earlier end-points, and significantly (P < 0.05) lower recurrence rate and need for rescue medication over 24 h. All treatments were well tolerated; 30-42% of patients on active treatments and 40% on placebo reported all-causality adverse events that were mostly mild and transient. On patients' global ratings of treatment, both eletriptan doses scored significantly better than zolmitriptan. [less ▲]

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See detailComparative efficacy of everolimus plus exemestane versus fulvestrant for hormone-receptor-positive advanced breast cancer following progression/recurrence after endocrine therapy: a network meta-analysis.
Bachelot, Thomas; McCool, Rachael; Duffy, Steven et al

in Breast cancer research and treatment (2013)

Postmenopausal women with advanced breast cancer recurring/progressing on or after initial (adjuvant or first-line) endocrine therapy may be treated multiple times with one of several endocrine or ... [more ▼]

Postmenopausal women with advanced breast cancer recurring/progressing on or after initial (adjuvant or first-line) endocrine therapy may be treated multiple times with one of several endocrine or combinatorial targeted treatment options before initiating chemotherapy. In the absence of direct head-to-head comparisons of these treatment options, an indirect comparison can inform treatment choice. This network meta-analysis compared the efficacy of everolimus plus exemestane with that of fulvestrant 250 and 500 mg in the advanced breast cancer setting following adjuvant or first-line endocrine therapy. The reported hazard ratios (HRs) for progression-free survival (PFS) or time to progression from six studies that formed a network to compare everolimus plus exemestane (BOLERO-2 trial) with fulvestrant were analyzed by means of a Bayesian network meta-analysis. In the primary comparison (PFS analysis based on the local review of disease progression from BOLERO-2 with the data from the other studies), everolimus plus exemestane appeared to be more efficacious than both fulvestrant 250 mg (HR = 0.47; 95 % credible interval [CrI] 0.38-0.58) and 500 mg (HR = 0.59; 95 % CrI 0.45-0.77). Similar results were obtained in an alternate comparison based on central review of disease progression from BOLERO-2 with the data from the other studies (HR = 0.40; 95 % CrI 0.31-0.51 and HR = 0.50; 95 % CrI 0.37-0.67, respectively), and in a subgroup analysis of patients who had received prior aromatase inhibitor therapy (HR = 0.47; 95 % CrI 0.38-0.58 and HR = 0.55; 95 % CrI 0.40-0.76, respectively). These results suggest that everolimus plus exemestane may be more efficacious than fulvestrant in patients with advanced breast cancer who progress on or after adjuvant or first-line therapy with a nonsteroidal aromatase inhibitor. [less ▲]

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See detailComparative emergence phenology of the orange wheat blossom midge, Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae) and its parasitoids (Hymenoptera: Pteromalidae and Platygastridae) under controlled conditions
Chavalle, Sandrine ULg; Buhl, Peter Neerup; Censier, Florence ULg et al

in Crop Protection (2015), 76

The orange wheat blossom midge, Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae), is a wheat (Triticum aestivum L.) pest that can cause significant yield losses. Several hymenopterous parasitoids ... [more ▼]

The orange wheat blossom midge, Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae), is a wheat (Triticum aestivum L.) pest that can cause significant yield losses. Several hymenopterous parasitoids are known to attack S. mosellana. For the effective biological control of this pest by its parasitoids, the hostparasitoid synchrony is particularly important. The synchronization between the emergence of S. mosellana and its parasitoids was studied under controlled conditions with soils sampled from two locations. For both sites, three parasitoid species were identified: Macroglenes penetrans (Kirby) (Hymenoptera: Pteromalidae), Euxestonotus error (Fitch) (Hymenoptera: Platygastridae) and Platygaster tuberosula (Kieffer) (Hymenoptera: Platygastridae). The hypothesis that parasitoid emergence is triggered by the same rainfall that induces host emergence was tested by simulating three rainfall events, a week apart. The parasitoid M. penetrans emerged later than S. mosellana with a mean of 57 ± 7 DD (degree-days above 7 °C) for insects collected from Juprelle and 68 ± 10 DD for those from Veurne (i.e., 4-5 days after its host). M. penetrans was therefore closely synchronized with its host through the same inductive rainfall, but this was not the case for E. error or P. tuberosula. Depending on when the rainfall that triggered the emergence of S. mosellana occurred, E. error and P. tuberosula emerged either before or after their host. M. penetrans is a more effective biocontrol agent of S. mosellana compared to P. tuberosula and E. error. Greater knowledge about parasitoid emergence could lead to the better positioning of insecticide treatments against wheat midge that protect and conserve the parasitoid populations. [less ▲]

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See detailComparative enantiomer affinity pattern of beta-blockers in aqueous and non-aqueous CE using single-component anionic cyclodextrins
Feng, Y; Wang, T; Chankvetadze, B et al

Conference (2014)

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See detailComparative enantiomer affinity pattern of beta-blockers in aqueous and nonaqueous CE using single-component anionic cyclodextrins.
Feng, Ying; Wang, Tingting; Jiang, Zhengjin et al

in Electrophoresis (2015), 36(11-12), 1358-64

A series of eight chiral beta-blocker drugs, acebutolol, atenolol, carazolol, carteolol, carvedilol, propranolol, sotalol, and talinolol, have been enantioseparated using two single-component anionic beta ... [more ▼]

A series of eight chiral beta-blocker drugs, acebutolol, atenolol, carazolol, carteolol, carvedilol, propranolol, sotalol, and talinolol, have been enantioseparated using two single-component anionic beta-CD derivatives, namely heptakis (2,3-di-O-methyl-6-sulfo)-beta-CD (HDMS-beta-CD) and heptakis (2,3-di-O-acetyl-6-sulfo)-beta-CD (HDAS-beta-CD), in aqueous CE and NACE. The influence of the nature of substituents (methyl or acetyl) in positions 2 and 3 on the CD derivatives and of the electrophoretic medium (water or methanol) on the enantioselectivity and enantiomer affinity pattern (EAP) of these structurally related compounds was systematically studied. All eight beta-blockers could be enantioseparated at least partially in the four CE systems, except sotalol with HDMS-beta-CD in NACE. In general, lower affinity and enantioselectivity were obtained in the presence of HDMS-beta-CD compared to HDAS-beta-CD. Reversals of EAPs were observed for all compounds. EAPs toward these two CDs were found to be opposite to each other in NACE for all compounds except carvedilol and in aqueous CE for atenolol, carteolol, talinolol, and sotalol. It is particularly noteworthy that opposite EAPs were also observed using the same CD derivative when the aqueous BGE was replaced with the methanolic one: for carazolol, carvedilol, and propranolol in the presence of HDMS-beta-CD and for acebutolol and carvedilol with HDAS-beta-CD. [less ▲]

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See detailComparative enantioseparation of talinolol in aqueous and non-aqueous capillary electrophoresis and study of related selector-selectand interactions by nuclear magnetic resonance spectroscopy.
Chankvetadze, Lali; Servais, Anne-Catherine ULg; Fillet, Marianne ULg et al

in Journal of Chromatography. A (2012), 1267

The enantiomers of the chiral beta-blocker drug talinolol were separated with two single component sulfated beta-cyclodextrin (CD) derivatives, namely heptakis (2,3-di-O-methyl-6-sulfo)-beta-CD) (HDMS ... [more ▼]

The enantiomers of the chiral beta-blocker drug talinolol were separated with two single component sulfated beta-cyclodextrin (CD) derivatives, namely heptakis (2,3-di-O-methyl-6-sulfo)-beta-CD) (HDMS-beta-CD) and heptakis (2,3-di-O-acetyl-6-sulfo)-beta-CD) (HDAS-beta-CD), in aqueous and non-aqueous capillary electrophoresis (CE). The enantiomer affinity pattern of talinolol toward these two CDs was opposite in both aqueous and non-aqueous CE. However, the enantiomer affinity pattern for a given CD derivative did not change when aqueous buffer was replaced with non-aqueous background electrolyte. The structures of the analyte-selector complexes in both, aqueous and non-aqueous electrolytes were studied using rotating frame nuclear Overhauser effect (ROESY) NMR spectroscopy. Inclusion complex formation between the enantiomers of talinolol and HDAS-beta-CD was confirmed in aqueous buffer, while the complex between the enantiomers of talinolol and HDMS-beta-CD was of the external type. The complex of the talinolol enantiomers with HDAS-beta-CD in non-aqueous electrolyte was also of the external type. In spite of external complex formation excellent separation of the enantiomers was observed in non-aqueous CE. [less ▲]

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See detailComparative evaluation of a one-pot strategy for the preparation of beta-cyclodextrin-functionalized monoliths: Effect of the degree of amino substitution of beta-cyclodextrin on the column performance.
Zhang, Qiaoxuan; Guo, Jialiang; Xiao, Yuan et al

in Journal of separation science (2015), 38(11), 1813-21

To further evaluate the feasibility and applicability of the one-pot strategy in monolithic column preparation, two novel beta-cyclodextrin-functionalized organic polymeric monoliths were prepared using ... [more ▼]

To further evaluate the feasibility and applicability of the one-pot strategy in monolithic column preparation, two novel beta-cyclodextrin-functionalized organic polymeric monoliths were prepared using two beta-cyclodextrin derivatives, i.e. mono(6-amino-6-deoxy)-beta-cyclodextrin and heptakis(6-amino-6-deoxy)-beta-cyclodextrin. In this improved method, mono(6-amino-6-deoxy)-beta-cyclodextrin or heptakis(6-amino-6-deoxy)-beta-cyclodextrin reacted with glycidyl methacrylate to generate the corresponding functional monomers and were subsequently copolymerized with ethylene dimethacrylate. The polymerization conditions for both monoliths were carefully optimized to obtain satisfactory column performance with respect to column efficiency, reproducibility, permeability, and stability. The obtained poly(glycidyl methacrylate-mono(6-amino-6-deoxy)-beta-cyclodextrin-co-ethylene dimethacrylate) and poly(glycidyl methacrylate-heptakis(6-amino-6-deoxy)-beta-cyclodextrin-co-ethylene dimethacrylate) monoliths exhibited a uniform structure, good permeability, and mechanical stability as indicated by scanning electron microscopy and micro-high-performance liquid chromatography experimental results. Because of the probable existence of multi-glycidyl methacrylate linking spacers on the poly(glycidyl methacrylate-heptakis(6-amino-6-deoxy)-beta-cyclodextrin-co-ethylene dimethacrylate) monolith, the effect of the ratio of glycidyl methacrylate/heptakis(6-amino-6-deoxy)-beta-cyclodextrin was especially studied, and satisfactory reproducibility could still be achieved by strictly controlling the composition of the polymerization mixture. To investigate the effect of the degree of amino substitution of beta-cyclodextrin on column performance, a detailed comparison of the two monoliths was also carried out using series of analytes including small peptides and chiral acids. It was found that the beta-cyclodextrin-functionalized monolith with mono-glycidyl methacrylate linking spacers demonstrated better chiral separation performance than that with multi-glycidyl methacrylate linking spacers. [less ▲]

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