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See detail2 years of existence... Lessons learnt from CSDP modules for young officers
Paile, Sylvain ULg

Scientific conference (2011, September 28)

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See detail2,4,7-Trimethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazinium 1,1-dioxide iodide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detail2,7-dihydroapogeissoschizine from root bark of strychnos Gossweileri
Quetin-Leclercq, Joëlle; Dive, Georges ULg; Delaude, Clément et al

in Phytochemistry (1994), 35(2), 533-536

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based ... [more ▼]

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on 1D and 2D NMR studies; its conformation was optimized by energy minimization. This type of skeleton is related to geissoschizine but with the notable diffrence that the 1 and 17 positions are joined giving an additional fused ring. Such a seven-membered ring has ,to our knowledge, only been observed in apogeissoschizine, obtained after chemical tratment of two alkaloids ( geissospermine and geissoschizine). 2,7-dihydroxyapogeissoschizine is therefore, the first natural product possessing this skeleton. According to a preliminary test, this new alkaloid shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.THese results have to be confirmed by further tests. [less ▲]

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See detail2- and 4-[18F]fluorotropapride, two specific D2 receptor ligands for positron emission tomography: N.C.A. syntheses and animal studies.
Damhaut, Philippe; Cantineau, Robert; Lemaire, Christian ULg et al

in International Journal of Radiation Applications and Instrumentation. Part A : Applied Radiation and Isotopes (1992), 43(10), 1265-74

Tropapride, (exo)-2,3-dimethoxy-N-[8-(phenylmethyl)-8- azabicyclo[3.2.1]oct-3-yl]benzamide hydrochloride, has been labeled with fluorine-18 at the 2- and 4-positions of its benzylic group. Two synthetic ... [more ▼]

Tropapride, (exo)-2,3-dimethoxy-N-[8-(phenylmethyl)-8- azabicyclo[3.2.1]oct-3-yl]benzamide hydrochloride, has been labeled with fluorine-18 at the 2- and 4-positions of its benzylic group. Two synthetic pathways were investigated: the first one required the alkylation of the norbenzyl precursor with 2- or 4-[18F]fluorobenzyl bromide (radiochemical yield of 5% EOB, 180 min); the second method consisted of a reductive amination of norbenzyl tropapride with 2- or 4-[18F]fluorobenzaldehyde (20% EOB, 110 min). In both cases, the specific activity was found to be greater than 1 Ci/mumol (EOS). Animal studies in rats showed the percentage of the injected dose localizing in the whole brain to be 0.6 +/- 0.09 and 0.2 +/- 0.03 at 2 h post injection for the para- and the ortho-[18F]fluoro analogs of tropapride respectively. Cerebral biodistribution studies showed at 4 h a striatum uptake of 5 +/- 0.7% of the injected dose per gram of striatum for the para derivative with a low fixation into the frontal cortex and the cerebellum (% ID/g FC < 0.4 and % ID/g Cb < 0.3). The selectivity of 4-[18F]fluorotropapride for D2 dopaminergic sites was demonstrated through blocking experiments with ketanserin, spiperone and halopemide. The saturability was confirmed by the use of variable specific activities. These preliminary results showed that 4-[18F]fluorotropapride can be considered as a potent radiopharmaceutical for the study of the dopaminergic system with PET. [less ▲]

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See detail2-(2-Oxoimidazolidinyl)Ethyl 2-Methylprop-2-Enoate
Spirlet, Marie-Rose ULg; Desreux, Jean-François ULg; Riondel, A. et al

in Acta Crystallographica Section C-Crystal Structure Communications (2000), 56((Pt 10)), 1258-9

In the crystal structure of the title compound, C(9)H(14)N(2)O(3), the molecules are linked by N-H.O=C bonds into chains parallel to [001]. Large crystals are readily obtained, presumably because of the ... [more ▼]

In the crystal structure of the title compound, C(9)H(14)N(2)O(3), the molecules are linked by N-H.O=C bonds into chains parallel to [001]. Large crystals are readily obtained, presumably because of the hydrogen bonds and an energetically stable conformation of the molecule. [less ▲]

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See detail2-, 3- and 4-substituted pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers
De Tullio, Pascal ULg; Pirotte, Bernard ULg; Ouedraogo, R. et al

in Journal de Pharmacie de Belgique (1996), 51

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See detail2-18F-Fluoro-L-tyrosine in the suspicion of recurrence of previously treated gliomas.
AGIUS, C.; NAMUR, Gauthier ULg; COUTURIER, O. et al

in European Journal of Nuclear Medicine and Molecular Imaging (2011), 38(SUPPL), 219

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See detailThe 2-3 minutes periodicity in the polar aurora and the magnetosphere of Jupiter
Bonfond, Bertrand ULg; Grodent, Denis ULg; Gérard, Jean-Claude ULg et al

Poster (2013, December 10)

The main aurora at Jupiter is related to the middle magnetosphere and the corotation breakdown of the magnetospheric plasma. On the other hand, the polar regions either magnetically map to the outer ... [more ▼]

The main aurora at Jupiter is related to the middle magnetosphere and the corotation breakdown of the magnetospheric plasma. On the other hand, the polar regions either magnetically map to the outer magnetosphere or correspond to field lines open to the interplanetary medium and most of the auroral emissions from this region are still poorly understood. Among these polar auroral emissions are the flares, dramatic brightenings of several million square kilometers over a couple of minutes. Two previously reported observations of the southern hemisphere showed that these flares can be quasi-periodic with a re-occurrence time of 2-3 minutes. Here we report results from the Hubble Space Telescope campaign carried out in 2012-2013 with the STIS FUV instrument in time-tag mode (PI: D. Grodent). This campaign consisted in alternating observations of the two hemispheres. Based on the analysis of this dataset, we confirm that these quasi-periodic flares are ubiquitous and occur in both hemispheres. Moreover, in at least one case, these flares appear to occur in phase in both hemispheres. We compare the characteristics of these flares with those of the relativistic electron bursts observed by the Ulysses spacecraft with the HET instrument. We find that 2-3 minutes quasi-periodic burst are much more frequent than previously reported and that they magnetically map to the same auroral area as the flares. We conclude that these two phenomena are most probably related and arise from a common origin. [less ▲]

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See detail2-abelian complexity of the Thue-Morse sequence
Rigo, Michel ULg; Vandomme, Elise ULg

Scientific conference (2012, December 14)

Let k be an integer. Two words u and v of the same length are k-abelian equivalent, if they have the same prefix (resp. suffix) of length k-1 and if, for all words x of length k, the numbers of ... [more ▼]

Let k be an integer. Two words u and v of the same length are k-abelian equivalent, if they have the same prefix (resp. suffix) of length k-1 and if, for all words x of length k, the numbers of occurrences of x in u and v are the same. This notion has received some recent interest, see the works of Karhumäki et al. The k-abelian complexity of an infinite word x maps an integer n to the number of k-abelian classes partitioning the set of factors of length n occurring in x. The Thue-Morse word is a well-known and extensively studied 2-automatic sequence. It is trivially abelian periodic and its (1)-abelian complexity takes only two values. The aim of this talk is to explain how to compute the 2-abelian complexity a(n) of the Thue-Morse word, showing in particular that it is unbounded. We conjecture that a(n) is 2-regular in the sense of Allouche and Shallit. This question can be related to a recent work of Madill and Rampersad where the (1)-abelian complexity of the paper folding word is shown to be 2-regular. We will also explain why the usual logical framework introduced by Büchi and popularized by Bruyère (indeed, automatic sequences can be characterized in an extension of the Presburger arithmetic) and the recent work of Charlier et al. about "automatic theorem-proving" of properties of automatic sequences cannot be applied to these questions related to abelian complexity. [less ▲]

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See detail2-Alkyl-3-alkylamino-2H-benzo- and pyridothiadiazine 1,1-dioxides: Ca++ channel blockers rather than K+ATP channel openers?
De Tullio, Pascal ULg; Becker, B.; Ouedraogo, R. et al

Poster (2001, December 08)

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See detail2-Alkyl-3-alkylamino-2H-benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers?
Ouedraogo, R.; Becker, B.; Boverie, S. et al

in Biological Chemistry (2002), 383

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See detail2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis.
Beck, Josephine; Sauvage, Eric ULg; Charlier, Paulette ULg et al

in Bioorganic & Medicinal Chemistry Letters (2008), 18(13), 3764-8

The title compound 4 has been prepared in four steps from ethylglycinate in 63% overall yield. This amino analog of citric acid has been co-crystallized with the class A beta-lactamase BS3 of Bacillus ... [more ▼]

The title compound 4 has been prepared in four steps from ethylglycinate in 63% overall yield. This amino analog of citric acid has been co-crystallized with the class A beta-lactamase BS3 of Bacillus licheniformis and the structure of the complex fully analyzed by X-ray diffraction. Tris-ethyl aminocitrate 3 and the free tris-acid 4 have been tested against a member beta-lactamase from all distinct subgroups. They are novel inhibitors of class A beta-lactamases, still modest but more potent than citrate and isocitrate. [less ▲]

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See detail(+/-)-2-Benzoyl-8-ethyl-1,2-dihydro-isoquinoline-1-carbonitrile: an original Reissert compound
Graulich, Amaury ULg; Norberg, B.; Liégeois, Jean-François ULg et al

in Acta Crystallographica Section E-Structure Reports Online (2007), 63(Part 7), 3161-3073

The title compound, C19H16N2O, is a Reissert compound. The heterocyclic fragment of the molecule exhibits a 1,3-diplanar conformation. The phenyl ring is connected to the isoquinoline ring system via an ... [more ▼]

The title compound, C19H16N2O, is a Reissert compound. The heterocyclic fragment of the molecule exhibits a 1,3-diplanar conformation. The phenyl ring is connected to the isoquinoline ring system via an amide bond that adopts an anti conformation with respect to the adjacent C-N bond in the adjacent heterocyclic ring. Intra-and intermolecular C-H center dot center dot center dot O hydrogen bonds are present in the crystal structure. [less ▲]

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See detail2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties
Olive, Gilles ULg; Mercier, Anne; Le Moigne, François et al

in Free Radical Biology & Medicine (2000), 28(3), 403-408

The 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-l-oxide (EMPO), an easily prepared pyrroline-Noxide has been tested as a free radical scavenger. Spin adducts of superoxide, hydroxyl radical, and ... [more ▼]

The 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-l-oxide (EMPO), an easily prepared pyrroline-Noxide has been tested as a free radical scavenger. Spin adducts of superoxide, hydroxyl radical, and other free radicals were characterized in phosphate buffer at pH 7.0 and 5.6. At pH 7 in phosphate buffer, the EMPO/O2 2• spin adduct was estimated to be about five times more persistent than its DMPO analogue. Furthermore, its decay does not produce the EMPO/HO• adduct. [less ▲]

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