Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailCholesterol interaction with proteins that partition into membrane domains: an overview.
Epand, Richard M; Thomas, Annick ULg; Brasseur, Robert ULg et al

in Sub Cellular Biochemistry (2010), 51

Biological membranes are complex structures composed largely of proteins and lipids. These components have very different structural and physical properties and consequently they do not form a single ... [more ▼]

Biological membranes are complex structures composed largely of proteins and lipids. These components have very different structural and physical properties and consequently they do not form a single homogeneous mixture. Rather components of the mixture are more enriched in some regions than in others. This can be demonstrated with simple lipid mixtures that spontaneously segregate components so as to form different lipid phases that are immiscible with one another. The segregation of molecular components of biological membranes also involves proteins. One driving force that would promote the segregation of membrane components is the preferential interaction between a protein and certain lipid components. Among the varied lipid components of mammalian membranes, the structure and physical properties of cholesterol is quite different from that of other major membrane lipids. It would therefore be expected that in many cases proteins would have very different energies of interaction with cholesterol vs. those of other membrane lipids. This would be sufficient to cause segregation of components in membranes. The factors that facilitate the interaction of proteins with cholesterol are varied and are not yet completely understood. However, there are certain groups that are present in some proteins that facilitate interaction of the protein with cholesterol. These groups include saturated acyl chains of lipidated proteins, as well as certain amino acid sequences. Although there is some understanding as to why these particular groups favour interaction with cholesterol, our knowledge of these molecular features is not sufficiently developed to allow for the design of agents that will modify such binding. [less ▲]

Detailed reference viewed: 47 (0 ULg)
Full Text
See detailCholinergic Transmission and Acetylcholine release enhancers
Francotte, Pierre ULg; De Tullio, Pascal ULg; Pirotte, Bernard ULg

in Protein Misfolding in neuro degenerative Diseases : Mechanisms and Therapeutic Strategies (2007)

Detailed reference viewed: 20 (5 ULg)
Full Text
See detailCHOLTIC Epidémies de choléra au lac Tanganyika induites par les changements climatiques ?
Plisnier, Pierre-Denis; Bompangue, Didier; Piarroux, Renaud et al

in Sciences Connection (2011), 35(Juillet-Août), 38-42

Detailed reference viewed: 123 (15 ULg)
Full Text
See detailLe chômage des jeunes
Robert, Jocelyne ULg

in Van Haecht Anne (Ed.) Socialisations scolaires-socialisations professionnelles: nouveaux enjeux, nouveaux débats: actes du colloque de Bruxelles (1986, October 09)

Detailed reference viewed: 39 (10 ULg)
See detailChômeur Blaster, jeu vidéo liégeois créé en atelier
Hurel, Pierre-Yves ULg

Article for general public (2014)

"Chômeur Blaster, jeu vidéo conçu à Liège par une dizaine de néophytes en programmation, se situe à la croisée du jeu vidéo traditionnel et du serious game militant. Il prend au premier degré la « chasse ... [more ▼]

"Chômeur Blaster, jeu vidéo conçu à Liège par une dizaine de néophytes en programmation, se situe à la croisée du jeu vidéo traditionnel et du serious game militant. Il prend au premier degré la « chasse aux chômeurs » pour la dénoncer. Explications de Pierre-Yves Hurel, animateur du premier atelier Média dédié au jeu de l'association d'éducation permanente D'une Certaine Gaieté." [less ▲]

Detailed reference viewed: 27 (2 ULg)
Full Text
See detailChondrogenic Differentiation in the growth Plate: a Computational Modelling Approach
Kerkhofs, Johan ULg

Doctoral thesis (2015)

The specialization of cartilage cells, or chondrogenic differentiation, is an intricate and meticulously regulated process that plays a vital role in both bone formation and cartilage regeneration. This ... [more ▼]

The specialization of cartilage cells, or chondrogenic differentiation, is an intricate and meticulously regulated process that plays a vital role in both bone formation and cartilage regeneration. This PhD work centers on the development of computational models to study the molecular regulation of this process. First, we investigate how individual genes and their defects contribute to the overall change in functionality of the growth plate, where chondrogenic differentiation fuels bone growth. As each gene is influenced by a myriad of feedback mechanisms that keep its expression in a desirable range, predicting what will happen if one of these genes defaults is challenging. Therefore, we constructed a qualitative model, focusing on the process of bone formation, that simulates how the intricate interplay between the genes results in a functional growth plate morphology. This model allows the effect of gene knockouts or overexpression to be evaluated from a network perspective, and hence relates this genetic deficiency to the impairment of the gross bone formation on a tissue level. This knowledge can be of great assistance in the design and control of \textit{in vitro} bone tissue engineering processes. A framework with increased temporal and quantitative resolution is then used to study chondrocyte hypertrophy in an expanded network. Chondrocyte hypertrophy, a process in which cartilage cells enlarge and change their secretion profile to attract bone forming cells and blood vessels, is orchestrated on a molecular level by a switch between two ‘genetic programs’. In this switch, one set of transcription factors that represents chondrocyte proliferation competes with, and is ultimately replaced by, another set that represents hypertrophy. Since hypertrophy plays a vital role not only in the development the skeleton, but is also thought to be involved in several bone-related diseases, it has been studied extensively. We combine information of how individual factors that prevent or contribute to the hypertrophic switch interact in a computational model to develop a more global view of the regulatory network underlying hypertrophy. Through simulations of this regulatory network model we can perform an in silico screening for factors that greatly impact, positively or negatively, the decision to undergo hypertrophy. The results of this screening are checked for consistency using an ensemble approach. Specifically, a genetic algorithm is used to generate an ensemble of models, differing only in parameter values, whose qualitative dynamics match those observed in the growth plate. The range of behaviour exhibited by individual factors throughout this ensemble is mostly consistent. Additionally, a subset of the network topology is compared to that obtained by inference from growth plate expression profiles. Understanding how individual factors contribute to the hypertrophic switch in the context of the regulatory network has important repercussions in both cartilage and bone tissue engineering. Our approach further suggests several putative targets for intervention in disease processes where hypertrophy plays a role. In summary, this PhD offers and explores a series of tools that form a first step to a rigorous and systems-level understanding of chondrogenic differentiation. [less ▲]

Detailed reference viewed: 29 (2 ULg)
Full Text
Peer Reviewed
See detailChondrogenic potential of mesenchymal stromal cells derived from equine bone marrow and umbilical cord blood.
Berg, Luc ULg; Koch, T.; Heerkens, T. et al

in Veterinary and Comparative Orthopaedics and Traumatology (2009), 22(5), 363-70

OBJECTIVE: Orthopaedic injury is the most common cause of lost training days or premature retirement in the equine athlete. Cell-based therapies are a potential new treatment option in musculo-skeletal ... [more ▼]

OBJECTIVE: Orthopaedic injury is the most common cause of lost training days or premature retirement in the equine athlete. Cell-based therapies are a potential new treatment option in musculo-skeletal diseases. Mesenchymal stromal cells (MSC) have been derived from multiple sources in the horse including bone marrow and umbilical cord blood. The objective of this study was to provide an in vitro comparison of the chondrogenic potential in MSC derived from adult bone marrow (BM-MSC) and umbilical cord blood (CB-MSC). RESULTS: MSC from both sources produced tissue with cartilage-like morphology that stained positive for proteoglycans and expressed cartilage markers. The CB-MSC pellets were larger and showed hyaline-like cartilage morphology as early as day six. Gene expression of collagen type 21, aggrecan and CD-RAP was higher in CB- than BM-MSC pellets. Expression of Sox9 mRNA was similar between CB- and BM-MSC pellets. Protein concentration of cartilage-derived retinoic acid sensitive protein was higher in culture medium from CB- than BM-MSC pellets. CONCLUSION: CB-MSC and BM-MSC were both capable of producing hyaline-like cartilage in vitro . However, in this study the MSC from umbilical cord blood appeared to have more chondrogenic potential than the BM-MSC based on the cells tested and parameters measured. [less ▲]

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailChondroitin and glucosamine in the management of osteoarthritis: an update.
Henrotin, Yves ULg; Lambert, Cécile ULg

in Current Rheumatology Reports (2013)

Detailed reference viewed: 22 (4 ULg)
Full Text
Peer Reviewed
See detailChondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations
Henrotin, Yves ULg; Mathy, Marianne ULg; Sanchez, Christelle ULg et al

in Therapeutic Advances in Musculoskeletal Disease (2010), 2(6), 335-348

Detailed reference viewed: 12 (6 ULg)
Full Text
Peer Reviewed
See detailLa chondroitine sulfate stimule la production des facteurs anti angiogéniques TSP-1 et VEGI par les synoviocytes arthrosiques : un nouveau mécanisme d’action pour cette molécule.
Mathy, Marianne ULg; Lambert, Cécile ULg; Dubuc, Jean Emile et al

in Revue du Rhumatisme (2010), 77

La chondroïtine sulfate (CS), la glucosamine sulfate (GS), la glucosamine HCl (GH) et l’acide hyaluronique (AH) sont des anti-arthrosiques symptomatiques d’action lente (AASAL) dont l’utilisation est ... [more ▼]

La chondroïtine sulfate (CS), la glucosamine sulfate (GS), la glucosamine HCl (GH) et l’acide hyaluronique (AH) sont des anti-arthrosiques symptomatiques d’action lente (AASAL) dont l’utilisation est recommandée dans le traitement de l’arthrose. Les mécanismes d’action de ces molécules demeurent mal compris. Notre étude a comme objectif d’étudier les effets de ces molécules sur la production de médiateurs impliqués dans l’angiogenèse de la membrane synoviale (MS) arthrosique [less ▲]

Detailed reference viewed: 27 (0 ULg)
Full Text
Peer Reviewed
See detailLa chondroitine sulfate stimule la production des facteurs anti angiogéniques TSP-1 et VEGI par les synoviocytes arthrosiques : un nouveau mécanisme d’action pour cette molécule.
Mathy, Marianne ULg; Lambert, Cécile ULg; Dubuc, Jean Emile et al

Poster (2010, September)

: La chondroïtine sulfate (CS), la glucosamine sulfate (GS), la glucosamine HCl (GH) et l’acide hyaluronique (AH) sont des anti-arthrosiques symptomatiques d’action lente (AASAL) dont l’utilisation est ... [more ▼]

: La chondroïtine sulfate (CS), la glucosamine sulfate (GS), la glucosamine HCl (GH) et l’acide hyaluronique (AH) sont des anti-arthrosiques symptomatiques d’action lente (AASAL) dont l’utilisation est recommandée dans le traitement de l’arthrose. Les mécanismes d’action de ces molécules demeurent mal compris. Notre étude a comme objectif d’étudier les effets de ces molécules sur la production de médiateurs impliqués dans l’angiogenèse de la membrane synoviale (MS) arthrosique. [less ▲]

Detailed reference viewed: 57 (4 ULg)
Peer Reviewed
See detailChondroïtine-sulfate in Heberden's and Bouchard's osteoarthritis
WANG, François-Charles ULg; Collignon, Laurent; REGINSTER, Jean-Yves ULg et al

Conference (1991)

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailChondromodulation en 2003: reve ou realite?
Reginster, Jean-Yves ULg

in Revue Médicale de la Suisse Romande (2004), 124(2), 85-7

The use of drugs for the treatment of osteoarthritis, with a view to obtain a long-term symptomatic as well as structural benefit, is still in a preliminary state. Nowadays, matricial precursors, such as ... [more ▼]

The use of drugs for the treatment of osteoarthritis, with a view to obtain a long-term symptomatic as well as structural benefit, is still in a preliminary state. Nowadays, matricial precursors, such as glucosamine sulfate, are an interesting approach in this indication. They have demonstrated a symptomatic efficacy comparable to that of N.S.A.I.D., with significantly reduced side-effects. Glucosamine sulfate also appears to positively interfere with the structural evolution of osteoarthritis by preventing joint space narrowing which characterizes the evolution of the disease. Encouraging results have also been obtained with chondroitin sulfate and diacerein. As for other molecules, new studies should be undertaken to confirm the results already obtained. [less ▲]

Detailed reference viewed: 10 (2 ULg)
Full Text
See detailChondropathie rotulienne
Kaux, Jean-François ULg

Learning material (2016)

Detailed reference viewed: 55 (24 ULg)
Full Text
See detailChondroprotective/structure-modifying drugs: a neverending story
Henrotin, Yves ULg

in Reumatissimo (2006), 58

Detailed reference viewed: 10 (2 ULg)
Full Text
Peer Reviewed
See detailChoosing an aphid partner: a matter of taste and smell
Detrain, Claire; Fischer, Christophe ULg; Lognay, Georges ULg et al

Conference (2012, August 27)

Honeydew is the keystone upon which ants and aphids build their mutualistic relationship. We have investigated how sugar and volatile compounds from honeydew are involved in the discovery, the recognition ... [more ▼]

Honeydew is the keystone upon which ants and aphids build their mutualistic relationship. We have investigated how sugar and volatile compounds from honeydew are involved in the discovery, the recognition and the exploitation of aphid colonies by the black garden ant Lasius niger. In addition to semiochemicals produced by aphids, honeydew volatile compounds are used by ant scouts to orient themselves and distantly recognize myrmecophilous species. Once discovered, aphid colonies producing sugars which are the most beneficial to the ants are preferentially tended. In this respect, the ways each sugar acts upon the feeding behavior of ant foragers and triggers the laying of a recruitment trail are essential to understand how their collective exploitation of aphid colonies proceeds and why mutualistic interactions between ants and aphids are maintained. Sensitivity of ant scouts to honeydew sugars was also investigated. Dose-response curves revealed between-sugar differences with foragers being very sensitive even to small amounts of melezitose, a sugar specifically produced by aphid colonies. We discuss about the relevance of honeydew cues used by ants in the selection of sugary resources, the recognition of their honeydew-producing partners as well as in the assessment of size and nutritive value of exploited aphid colonies. [less ▲]

Detailed reference viewed: 65 (6 ULg)
Full Text
See detailChoosing the right land managment strategy: innovations in land managment tools
van der Krabben, Erwin; Halleux, Jean-Marie ULg

in Tira, Maurizio; van der Krabben, Erwin; Zanon, Bruno (Eds.) Land managment for urban dynamics. Innovative methods and practices in a changing Europe (2011)

Detailed reference viewed: 131 (24 ULg)
Full Text
Peer Reviewed
See detailCHOP alone compared with CHOP plus radiotherapy for localized aggressive lymphoma in elderly patients: A study by the Groupe d'Etude des Lymphomes de I'Adulte
Bonnet, Christophe ULg; Fillet, Georges ULg; Mounier, N. et al

in Journal of Clinical Oncology (2007), 25(7), 787-792

Purpose Chemoradiotherapy has been considered standard treatment for patients with limited-stage aggressive lymphoma on the basis of trials conducted before the introduction of the International ... [more ▼]

Purpose Chemoradiotherapy has been considered standard treatment for patients with limited-stage aggressive lymphoma on the basis of trials conducted before the introduction of the International Prognostic Index. To evaluate this approach in elderly patients with low-risk localized lymphoma, we conducted a trial comparing chemoradiotherapy with chemotherapy alone. Patients and Methods Previously untreated patients older than 60 years with localized stage I or II histologically aggressive lymphoma and no adverse prognostic factors of the International Prognostic Index were randomly assigned to receive either four cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus involved-field radiotherapy (299 patients) or chemotherapy alone with four cycles of CHOP (277 patients). Results With a median follow-up time of 7 years, event-free and overall survival did not differ between the two treatment groups (P =.6 and P =.5, respectively). The 5-year estimates of event-free survival were 61% for patients receiving chemotherapy alone and 64% for patients receiving CHOP plus radiotherapy; the 5-year estimates of overall survival were 72% and 68%, respectively. In a multivariate analysis, overall survival was affected by stage II disease (P <.001) and male sex (P =.03). Conclusion In this large prospective study, CHOP plus radiotherapy did not provide any advantage over CHOP alone for the treatment of low-risk localized aggressive lymphoma in elderly patients. [less ▲]

Detailed reference viewed: 69 (6 ULg)
Peer Reviewed
See detailCHORA L WORKS - "je ne suis pas sûr que cela tienne debout"
Bodart, Céline ULg

Conference (2014)

Dans le cadre d'une discussion à la croisée de l'architecture et de la philosophie, cette contribution propose de s'attarder à un moment précis de l'histoire récente de l'architecture : la rencontre ... [more ▼]

Dans le cadre d'une discussion à la croisée de l'architecture et de la philosophie, cette contribution propose de s'attarder à un moment précis de l'histoire récente de l'architecture : la rencontre orchestrée entre Jacques Derrida et Peter Eisenman. Deux hommes auxquels on propose de se rencontrer. Mais surtout, deux disciplines auxquelles on impose de se croiser. Pour revenir sur cet échange aux ambitions interdisciplinaires, nous choisissons de nous concentrer sur un moment précis ; leur Choral Works comme scène (réduite) de cette rencontre ; leur Choral Works en tant que livre, projet et événement médiatique. Mais ils ne faut pas aller très loin dans l'analyse de ce « travail commun » pour que très vite une première difficulté apparaisse : comment parler d'une rencontre des savoirs quand les protagonistes prétendent d'eux-même qu'elle n'a jamais eu lieu ? L'éloquente violence de leur correspondance ne suffit-elle pas pour conclure d'un non-lieu ? Ne s'agit-il pas au final de tout simplement reconnaitre qu'ils ne se sont pas compris ? Peut-être ; mais ce serait si facile. Choisissons plutôt de croire que cette histoire ne peut pas s'en arrêter là. Rejouons la scène. Remettons en jeu leurs attentes et ré-écrivons la fin de leur rencontre manquée. L'objectif est ici de redécouvrir ce qui semblait construire leur intérêt commun, et le mettre à l'épreuve de leurs reproches réciproques. De représenter le décalage entre leur premières admirations et leurs dernières accusations. En marquer l'écart ; le mesurer pour en faire une source de savoir. Pour travailler cet écart, nous planterons le décor depuis l'arrangement de la rencontre ; avec Bernard Tschumi dans le rôle de l'entremetteur et le projet pour le parc de La Villette comme lieu de rendez-vous. Nous nous consacrerons également aux premiers textes de Derrida sur l'architecture (Point de folie – Maintenant l'architecture, Cinquante-deux aphorismes pour un avant-propos) ; au texte du philosophe sur l'architecte américain (Pourquoi Peter Eisenman écrit de si bon livre) ; et à leurs réflexions communes sur khôra et leurs esquisses respectives pour un Choral Works. Bien sur, donner de l'intérêt à une énième relecture de ces textes, même si remis en perpective à partir de leur contexte médiatique, n'est pas un exercice gagné d'avance. Loin de là. Toutefois, si nous acceptons de prendre encore ce risque, c'est qu'il s'agit d'y défendre une intuition : l'intuition qu'il existe aujourd'hui une ré-actualité de la pensée derridienne en architecture. Alors la première étape pour soutenir cette intuition est ici de mesurer l'écart de nos erreurs passées en vue d'ajuster nos attentes en devenir. [less ▲]

Detailed reference viewed: 8 (0 ULg)