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See detailCompilation commentée de la littérature portant sur le soutien public et privé à la culture par d'autres voies et moyens que la subvention publique directe
Husson, Jean-François ULg; Paindavoine, Isabelle; Sepulchre, Vincent ULg

Report (2009)

Revue de la littérature et de sources officielles concernant les instruments budgétaires et fiscaux, autre que le financement budgétaire direct, concourant au financement de la culture. Le rapport aborde ... [more ▼]

Revue de la littérature et de sources officielles concernant les instruments budgétaires et fiscaux, autre que le financement budgétaire direct, concourant au financement de la culture. Le rapport aborde la situation en Belgique et dans plusieurs autres pays : France, Grande-Bretagne, Allemagne, Italie, Hongrie, Pays-Bas, Suisse, Etats-Unis et Canada. [less ▲]

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See detailCompilation of data collected and fed into a hydrogeological database in the Walloon Meuse catchment region
Batlle-Aguilar, Jordi; Wojda, Piotr; Brouyère, Serge ULg

Report (2005)

The objectives of this deliverable are to provide a general description of a hydrogeological database developed by HGULg, including specific adaptations made to meet the AQUATERRA project’s needs and to ... [more ▼]

The objectives of this deliverable are to provide a general description of a hydrogeological database developed by HGULg, including specific adaptations made to meet the AQUATERRA project’s needs and to provide a synthesis of available datasets for the selected test sites in the Meuse basin. First, a general description of the Walloon Meuse basin and the selected AQUATERRA test sites is provided. Then, the general concepts, the conceptual model and the developed interfaces of the HGULg hydrogeological database are presented. Finally, a summary of datasets available for the selected test sites is provided. [less ▲]

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See detailCompilation of data collected and fed into a hydrogeological database in the Walloon Meuse catchment region
Batlle-Aguilar, Jordi; Wojda, Piotr; Brouyère, Serge ULg

Report (2005)

Based on a first inventory of available case studies, test sites have been selected in the Walloon part of the Meuse Basin in Belgium. These sites meet the requirements and objectives of the researches ... [more ▼]

Based on a first inventory of available case studies, test sites have been selected in the Walloon part of the Meuse Basin in Belgium. These sites meet the requirements and objectives of the researches performed by different partners in AquaTerra. Available information and datasets have been collected for these sites and complementary investigations and experiments have been organized. Existing data and recently collected data have been compiled into a hydrogeological database developed by HGULg for the Walloon region and adapted to the specificities and needs of the AquaTerra project. The deliverable provides a general description of the hydrogeological database developed by HGULg: the conceptual model, specific adaptations performed for the AquaTerra project and interfaces for encoding, querying and exporting hydrogeological information stored in the database. A synthesis of datasets available in the HGULg Hydrogeological Database for the selected test sites in the Meuse basin is also provided. [less ▲]

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See detailCompiling polymorphic miRNA-target interactions: the Patrocles database.
Hiard, Samuel ULg; Tordoir, Xavier ULg; Coppieters, Wouter ULg et al

Poster (2007, November 12)

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of ... [more ▼]

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of muscle growth - and creates an illegitimate target site for miRNA expressed in the same tissue. This causes miRNA-mediated translation inhibition of mutant GDF8 transcripts which leads to muscle hypertrophy. We followed up on this finding by searching for common polymorphisms and mutations that affect either (i) RNAi silencing machinery components, (ii) miRNA precursors or (iii) target sites. These might likewise alter miRNA-target interaction and could be responsible for substantial differences in gene expression level. They have been compiled in a public database (“Patrocles”: www.patrocles.org), where they are classified in (i) DNA sequence polymorphisms (DSP) affecting the silencing machinery, (ii) DSP affecting miRNA structure or expression and (iii) DSP affecting miRNA target sites. DSP from the last category were organized in four classes: destroying a target site conserved between mammals (DC), destroying a non-conserved target site (DNC), creating a non-conserved target site (CNC), or shifting a target site (S). To aid in the identification of the most relevant DSP (such as those were a target site is created in an antitarget gene), we have quantified the level of coexpression for all miRNA-gene pairs. Analysis of the numbers of Patrocles-DSP as well as their allelic frequency distribution indicates that a substantial proportion of them undergo purifying selection. The signature of selection was most pronounced for the DC class but was significant for the DNC and CNC class as well, suggesting that a significant proportion of non-conserved targets is truly functional. The Patrocles database allowed for the selection of DSP that are likely to affect gene function and possibly disease susceptibility. The effect of these DSP is being studied both in vitro and in vivo. In conclusion, Patrocles-DSP could be widespread and underlie an appreciable amount of phenotypic variation, including common disease susceptibility. [less ▲]

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See detailCompiling polymorphic miRNA-target interactions: the Patrocles database.
Hiard, Samuel ULg; Tordoir, Xavier ULg; Coppieters, Wouter ULg et al

Poster (2007, February 15)

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of ... [more ▼]

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of muscle growth - and creates an illegitimate target site for miRNA expressed in the same tissue. This causes miRNA-mediated translation inhibition of mutant GDF8 transcripts which leads to muscle hypertrophy. We followed up on this finding by searching for common polymorphisms and mutations that affect either (i) RNAi silencing machinery components, (ii) miRNA precursors or (iii) target sites. These might likewise alter miRNA-target interaction and could be responsible for substantial differences in gene expression level. They have been compiled in a public database (“Patrocles”: www.patrocles.org), where they are classified in (i) DNA sequence polymorphisms (DSP) affecting the silencing machinery, (ii) DSP affecting miRNA structure or expression and (iii) DSP affecting miRNA target sites. DSP from the last category were organized in four classes: destroying a target site conserved between mammals (DC), destroying a non-conserved target site (DNC), creating a non-conserved target site (CNC), or shifting a target site (S). To aid in the identification of the most relevant DSP (such as those were a target site is created in an antitarget gene), we have quantified the level of coexpression for all miRNA-gene pairs. Analysis of the numbers of Patrocles-DSP as well as their allelic frequency distribution indicates that a substantial proportion of them undergo purifying selection. The signature of selection was most pronounced for the DC class but was significant for the DNC and CNC class as well, suggesting that a significant proportion of non-conserved targets is truly functional. The Patrocles database allowed for the selection of DSP that are likely to affect gene function and possibly disease susceptibility. The effect of these DSP is being studied both in vitro and in vivo. In conclusion, Patrocles-DSP could be widespread and underlie an appreciable amount of phenotypic variation, including common disease susceptibility. [less ▲]

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See detailComplement activation during cardiopulmonary bypass in infants and children: Relation to postoperative multiple system organ failure
Seghaye, Marie-Christine ULg; Duchateau, J.; Grabitz, R. G. et al

in Journal of Thoracic and Cardiovascular Surgery (1993), 106(6), 978-987

Twenty-nine children 3 months to 17 years of age undergoing operations for congenital heart disease were included in this prospective study. Complement activation, activation of the plasma contact system ... [more ▼]

Twenty-nine children 3 months to 17 years of age undergoing operations for congenital heart disease were included in this prospective study. Complement activation, activation of the plasma contact system, leukocytes, leukocyte elastase release, and C-reactive protein were studied during and after cardiopulmonary bypass for the first postoperative week and related to multiple system organ failure occurring in eight (27.5 %) of the 29 children. During cardiopulmonary bypass complement activation via the alternative pathway as indicated by significant conversion of C3 (expressed by C3d/C3) and abnormally high C5a values at the end of cardiopulmonary bypass without consumption of C4 was shown in all children. At the end of cardiopulmonary bypass, C3 conversion was significantly higher in the eight patients with multiple system organ failure than in the others (p < 0.05), whereas no difference in C5a level was shown. All children had a significant increase in leukocyte count directly after protamine administration (p < 0.0001) and elastase release during cardiopulmonary bypass that was significantly higher in patients with multiple system organ failure than in those without (p < 0.05). Consumption of prekallikrein as an indicator of activation of the Hageman system was not detectable during cardiopulmonary bypass in any child. After cardiopulmonary bypass, in patients without multiple system organ failure, C3d/C3 decreased and reached preoperative values within the first postoperative week, whereas, in patients with multiple system organ failure, C3d/C3 increased further, reaching a maximal value on the third postoperative day. In comparison with patients without multiple system organ failure, patients with multiple system organ failure showed a severe decrease of C4 (with minimal values on the third postoperative day), suggesting consumption by activation of the classic pathway of the complement system or a hepatic synthesis deficiency. Prekallikrein values were also significantly lower in patients with multiple system organ failure than in the others, with a maximal difference on the third postoperative day (p < 0.005). C-reactive protein was significantly lower in patients with multiple system organ failure than in the others for the first 2 postoperative days (p < 0.05), probably because of severe hepatic failure in patients with multiple system organ failure. This study demonstrates that, in children, cardiopulmonary bypass induces complement activation principally via the alternative pathway. It suggests a relationship between complement activation and multiple system organ failure observed in the postoperative period. Furthermore, it points out the role of multiple system organ failure itself on the C3 conversion and on the synthesis of the markers of the inflammatory response in children after heart operations. [less ▲]

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See detailComplement activation during hemodialysis
Malaise, Michel ULg; Lust, Catherine ULg; Foidart, J. B. et al

in New England Journal of Medicine [=NEJM] (1985), 312(8), 514-515

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See detailComplement activation in patients at risk of developing the adult respiratory distress syndrome.
Duchateau, J.; Haas, M.; Schreyen, H. et al

in American Review of Respiratory Disease (1984), 130(6), 1058-64

In this prospective study of 50 patients, 36 of whom developed the adult respiratory distress syndrome (ARDS), early and intense complement activation was demonstrated. These patients were at risk of the ... [more ▼]

In this prospective study of 50 patients, 36 of whom developed the adult respiratory distress syndrome (ARDS), early and intense complement activation was demonstrated. These patients were at risk of the ARDS because of multiple injuries, major abdominal surgery, acute pancreatitis, severe burns, or disseminated intravascular coagulation. Abnormal C3 consumption (as measured by the C3d/C3 ratio) and elevated plasma C5a-like activity (as measured by a leukocyte aggregation assay) were associated with, respectively, 84 and 86% of cases of ARDS. Both tests were more sensitive indicators of complement consumption than were assays of total hemolytic complement activity (CH50) or total C3. The C3d/C3 ratio showed a close, inverse correlation with CH50 in 47 healthy subjects, and was increased in 12 control patients after minor surgery. The C5a-like activity was found only in patients at risk of ARDS; it was highly associated with clinical conditions that predispose to the ARDS, but it cannot be considered as a real predictor of ARDS occurrence in these patients. Sequential samples from both sides of the pulmonary circulation showed initial pulmonary clearance followed by the release of C5a-like activity. No simultaneous changes in C3 levels were found, suggesting the possible presence of modulating factors. These observations suggest that other factors (e.g., hypoxia and metabolic cascades) may influence the development of ARDS. [less ▲]

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See detailComplément au rapport final de synthèse du projet 4M-µpompe 2004
Raucent, Benoit; Dereine, E.; Smal, Olivier et al

Report (2004)

The 4M-µpump project attempts to breach the gap between traditional mechanics and micro mechanics and this in two ways. The first one consists in producing a general set of rules suitable for the ... [more ▼]

The 4M-µpump project attempts to breach the gap between traditional mechanics and micro mechanics and this in two ways. The first one consists in producing a general set of rules suitable for the miniaturisation of well-known macromachines. The second one consists in developing this fundamental aspect of the research through the design and realization of an implantable pump dedicated to the administration of medication agents inside the human body. The project thus touches upon the field of design, manufacturing, metrology and assembly of mini components as well as the study of minimotors. [less ▲]

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See detailComplément d'épidémiologie
Bruyère, Olivier ULg

Learning material (2011)

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See detailComplement extraposition: what is it a diagnostic of?
Gentens, Caroline; Brems, Lieselotte ULg

Conference (2013, May)

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See detailLe complément sujet : Etude de l'utilisation des pronoms moi et je dans le discours d'enfants âgés de 2 ans et demi à 10 ans.
Boulard, Aurore ULg; Gauthier, Jean-Marie ULg

in Bolasco, Sergio; Chiari, Isabella; Giuliano, Luca (Eds.) Statistical Analysis of Textual Data: Proceedings of 10th International Conference Journées d’Analyse statistique des Données Textuelles 9-11 June 2010 - Sapienza University of Rome (2010)

Grâce à l’analyse statistique discursive d’un corpus constitué du discours de 90 enfants, nous avons pu observer l’évolution de l’utilisation des pronoms personnels moi et je et mettre en évidence ... [more ▼]

Grâce à l’analyse statistique discursive d’un corpus constitué du discours de 90 enfants, nous avons pu observer l’évolution de l’utilisation des pronoms personnels moi et je et mettre en évidence certaines variations d’utilisation en fonction de l’âge et de trois conditions d’enregistrement. Le protocole de recherche utilisé nous permet de laisser le sujet libre de s’exprimer. Aucun thème n’a été proposé aux enfants. « En recueillant paroles et textes libres, le chercheur accède à tout l’univers du sujet, riche de sa singularité individuelle et de son appartenance culturelle et sociale. » (Moscarola, 2001). Ce n’est pas le développement du langage qui est étudié mais bien le discours qui, selon nous, permet un accès au sens, aux structures psychiques de l’individu. L’analyse du discours nous permet d’étudier le développement de la conscience de soi grâce à une méthodologie simple et non contraignante pour les enfants. Cette recherche trouve son originalité dans le croisement des résultats de l’analyse statistique textuelle (Lexico3, Tropes) avec les théories du développement de la conscience de soi. Les résultats de ces analyses nous montrent que dès l’instant où le je apparaît, le moi auparavant utilisé seul en tant que sujet se transforme en complément du sujet-je. En tant que complément du sujet, il objective le sujet parlant, lui permettant une mise à distance. Le sujet peut donc se regarder agir, faire où être en tant qu’objet. La forme moi-je, également fréquente dans le discours de l’enfant, est pour nous, sans doute, la forme réflexive la plus claire de l’avènement de la conscience de soi se manifestant par le biais du discours narratif autobiographique. Plus tard dans le discours de l’enfant, le je va pouvoir exister seul. Notre hypothèse est qu’étant davantage conscient de lui-même, l’enfant n’aurait plus systématiquement recours à la projection de son moi pour prendre conscience de son existence en tant qu’être parmi les autres. [less ▲]

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See detailComplement, leukocytes, and leukocyte elastase in full-term neonates undergoing cardiac operation.
SEGHAYE, Marie-Christine ULg; Duchateau, J.; Grabitz, R. G. et al

in Journal of Thoracic and Cardiovascular Surgery (The) (1994), 108(1), 29-36

In 13 neonates undergoing cardiac operations for congenital cardiac defects, complement, leukocytes, and leukocyte elastase were studied during and after cardiopulmonary bypass. All but two neonates ... [more ▼]

In 13 neonates undergoing cardiac operations for congenital cardiac defects, complement, leukocytes, and leukocyte elastase were studied during and after cardiopulmonary bypass. All but two neonates received prostaglandin E1 before the operation. The C3d/C3 ratio rose significantly during cardiopulmonary bypass from 0.86 +/- 0.55 to 1.40 +/- 0.56 (mean +/- standard deviation; p < 0.0001). Abnormally elevated C5a levels (18.6 +/- 7.3 micrograms/L) were measured at the end of cardiopulmonary bypass. C4 was not overtly consumed during the procedure. Leukocytes fell from a preoperative value of 10.06 +/- 3.15 x 10(9)/L to 3.21 +/- 0.64 x 10(9)/L after beginning of cardiopulmonary bypass (p < 0.0001) and rose at the end of the procedure from 2.33 +/- 0.67 x 10(9)/L to 7.19 +/- 1.84 x 10(9)/L, after protamine administration (p < 0.0001). Neutrophils fell from a preoperative value of 5.14 +/- 1.18 x 10(9)/L to 1.46 +/- 0.35 x 10(9)/L after beginning of cardiopulmonary bypass and rose at the end of extracorporeal circulation from 1.00 +/- 0.31 x 10(9)/L to 4.10 +/- 1.18 x 10(9)/L, after protamine administration (p < 0.005). Elastase release occurred in all neonates during cardiopulmonary bypass and averaged 331.5 +/- 175.7 micrograms/L. Complement activation and leukocyte stimulation did not correlate with postoperative complications or outcome. This study demonstrates complement activation and leukocyte stimulation in neonates undergoing cardiac operation. [less ▲]

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See detailComplémentarité des systèmes d'étanchéité-drainage en matériaux naturels et synthétiques dans le confinement des déchets
Courard, Luc ULg

in De Paepe, Robert (Ed.) Les géotextiles et géomembranes dans les travaux fluviaux et maritimes (1997)

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See detailComplementary approaches to measure environmental odours emitted by landfill areas
Romain, Anne-Claude ULg; Delva, Julien ULg; Nicolas, Jacques ULg

in Sensors and actuators. B, Chemical (2008), 131(1), 18-23

This paper presents different methods to assess the odour emission and the odour annoyance in the surroundings. It is shown, on the example of landfill areas and composting facilities, that chemical ... [more ▼]

This paper presents different methods to assess the odour emission and the odour annoyance in the surroundings. It is shown, on the example of landfill areas and composting facilities, that chemical analyses are helpful to identify key compounds of the odour release, and to set up the specification of a monitoring instrument. Sensitive methods, like dynamic olfactometry or sniffing team investigation, are mainly applicable to provide a global odour plume or an average annoyance zone. And the electronic nose can supply a warning signal to the plant manager or a real time estimation of the annoyance zone. [less ▲]

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See detailComplementary Feeding: A Commentary by the ESPGHAN Committee on Nutrition
Agostoni, Carlo; Decsi, Tamas; Fewtrell, Mary et al

in Journal of Pediatric Gastroenterology and Nutrition (2008), 46(1), 99-110

This position paper on complementary feeding summarizes evidence for health effects of complementary foods. It focuses on healthy infants in Europe. After reviewing current knowledge and practices, we ... [more ▼]

This position paper on complementary feeding summarizes evidence for health effects of complementary foods. It focuses on healthy infants in Europe. After reviewing current knowledge and practices, we have formulated these conclusions: Exclusive or full breast-feeding for about 6 months is a desirable goal. Complementary feeding (ie, solid foods and liquids other than breast milk or infant formula and follow-on formula) should not be introduced before 17 weeks and not later than 26 weeks. There is no convincing scientific evidence that avoidance or delayed introduction of potentially allergenic foods, such as fish and eggs, reduces allergies, either in infants considered at increased brisk for the development of allergy or in those not considered to be at increased risk. During the complementary feeding period, > 90% of the iron requirements of a breast-fed infant must be met by complementary foods, which should provide sufficient bioavailable iron. Cow's milk is a poor source of iron and should not be used as the main drink before 12 months, although small volumes may be added to complementary foods. It is prudent to avoid both early (< 4 months) and late ( >= 7 months) introduction of gluten, and to introduce gluten gradually while the infant is still breast-fed, inasmuch as this may reduce the risk of celiac disease, type 1 diabetes mellitus, and wheat allergy. Infants and young children receiving a vegetarian diet should receive a sufficient amount (similar to 500 mL) of breast milk or formula and dairy products. Infants and young children should not be fed a vegan diet. [less ▲]

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See detailComplementary role of thallium-201 scintigraphy to predischarge exercise electrocardiography for patients stratification after a first myocardial infarction.
Legrand, Victor ULg; Albert, Adelin ULg; Rigo, Pierre ULg et al

in European Heart Journal (1986), 7(8), 644-53726

The value of a predischarge exercise test combined with thallium-201 myocardial scintigraphy in detecting patients with severe multivessel disease (MVD) was studied in 58 consecutive patients discharged ... [more ▼]

The value of a predischarge exercise test combined with thallium-201 myocardial scintigraphy in detecting patients with severe multivessel disease (MVD) was studied in 58 consecutive patients discharged after a first acute myocardial infarction. Twelve electrocardiographic, clinical and scintigraphic variables were analysed. Angiography at one month revealed MVD (greater than 70% narrowing in vessels unrelated to infarction) in 26 patients (45%). ST segment depression of 1mm or greater, thallium defects in multiple vascular distributions (MVTL), and reversible thallium defects in a vascular distribution different from the infarct related vessel predicted patients at risk for MVD (predictive value respectively of 68%, 65% and 75%). The other variables were not significantly associated with the presence of MVD. Only ST segment depression and thallium defects in multiple vascular distributions emerged as independent predictors of MVD. Their combination yielded a 77% sensitivity and a 59% specificity for MVD. Combination of thallium imaging with the predischarge exercise ECG significantly improved the stratification provided by the exercise test alone (P less than 0.05). A positive thallium scan (MVTl defects) associated with a positive ECG (ST depression) carried a risk for MVD of 80% in the population studied. When both tests were negative, MVD was infrequent (risk 22%). Because improvement in the stratification of patients is not as clear as expected from studies performed at a later stage, it appears that exercise thallium scintigraphy at a submaximal level one or two weeks after infarction does not provide optimal information. Predischarge exercise thallium-201 scintigraphy, however, is superior to an exercise tolerance test alone in separating patients into those with high and low risk of MVD. [less ▲]

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See detailThe complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription.
Gaudray, Gilles ULg; Gachon, Frederic; Basbous, Jihane et al

in Journal of virology (2002), 76(24), 12813-22

The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins involved in infectivity, replication, and transformation. We report in this study the characterization of a novel viral ... [more ▼]

The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins involved in infectivity, replication, and transformation. We report in this study the characterization of a novel viral protein encoded by the complementary strand of the HTLV-1 RNA genome. This protein, designated HBZ (for HTLV-1 bZIP factor), contains a N-terminal transcriptional activation domain and a leucine zipper motif in its C terminus. We show here that HBZ is able to interact with the bZIP transcription factor CREB-2 (also called ATF-4), known to activate the HTLV-1 transcription by recruiting the viral trans-activator Tax on the Tax-responsive elements (TxREs). However, we demonstrate that the HBZ/CREB-2 heterodimers are no more able to bind to the TxRE and cyclic AMP response element sites. Taking these findings together, the functional inactivation of CREB-2 by HBZ is suggested to contribute to regulation of the HTLV-1 transcription. Moreover, the characterization of a minus-strand gene protein encoded by HTLV-1 has never been reported until now. [less ▲]

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