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See detailCauses of mortality in roe deer (Capreolus capreolus) in Southern Belgium : results of the passive surveillance 2010.
Grégoire, Fabien; Wirtgen, Marc; Volpe, Rosario ULiege et al

Conference (2011, October)

Detailed reference viewed: 6 (2 ULiège)
See detailLes causes structurelles des inégalités scolaires
Baye, Ariane ULiege

Conference given outside the academic context (2014)

Detailed reference viewed: 19 (2 ULiège)
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See detailA cautionary note on the impact of protocol changes for Genome-Wide Association SNP x SNP Interaction studies: an example on ankylosing spondylitis
Bessonov, Kyrylo ULiege; Gusareva, Elena ULiege; Van Steen, Kristel ULiege

in Human Genetics (2015)

Genome-wide association interaction (GWAI) studies have increased in popularity. Yet to date, no standard protocol exists. In practice, any GWAI workflow involves making choices about quality control ... [more ▼]

Genome-wide association interaction (GWAI) studies have increased in popularity. Yet to date, no standard protocol exists. In practice, any GWAI workflow involves making choices about quality control strategy, SNP filtering, linkage disequilibrium (LD) pruning, analytic tool to model or to test for genetic interactions. Each of these can have an impact on the final epistasis findings and may affect their reproducibility in follow-up analyses. Choosing an analytic tool is not straightforward, as different such tools exist and current understanding about their performance is based on often very particular simulation settings. In the present study, we wish to create awareness for the impact of (minor) changes in a GWAI analysis protocol can have on final epistasis findings. In particular, we investigate the influence of marker selection and marker prioritization strategies, LD pruning and the choice of epistasis detection analytics on study results, giving rise to 8 GWAI protocols. Discussions are made in the context of the ankylosing spondylitis (AS) data obtained via the Wellcome Trust Case Control Consortium (WTCCC2). As expected, the largest impact on AS epistasis findings is caused by the choice of marker selection criterion, followed by marker coding and LD pruning. In MB-MDR, co-dominant coding of main effects is more robust to the effects of LD pruning than additive coding. We were able to reproduce previously reported epistasis involvement of HLA-B and ERAP1 in AS pathology. In addition, our results suggest involvement of MAGI3 and PARK2, responsible for cell adhesion and cellular trafficking. Gene Ontology (GO) biological function enrichment analysis across the 8 considered GWAI protocols also suggested that AS could be associated to the Central Nervous System (CNS) malfunctions, specifically, in nerve impulse propagation and in neurotransmitters metabolic processes. [less ▲]

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See detailA cautious approach to generalization in reinforcement learning
Fonteneau, Raphaël ULiege; Murphy, Susan; Wehenkel, Louis ULiege et al

in Proceedings of the 2nd International Conference on Agents and Artificial Intelligence (2010, January)

In the context of a deterministic Lipschitz continuous environment over continuous state spaces, finite action spaces, and a finite optimization horizon, we propose an algorithm of polynomial complexity ... [more ▼]

In the context of a deterministic Lipschitz continuous environment over continuous state spaces, finite action spaces, and a finite optimization horizon, we propose an algorithm of polynomial complexity which exploits weak prior knowledge about its environment for computing from a given sample of trajectories and for a given initial state a sequence of actions. The proposed Viterbi-like algorithm maximizes a recently proposed lower bound on the return depending on the initial state, and uses to this end prior knowledge about the environment provided in the form of upper bounds on its Lipschitz constants. It thereby avoids, in way depending on the initial state and on the prior knowledge, those regions of the state space where the sample is too sparse to make safe generalizations. Our experiments show that it can lead to more cautious policies than algorithms combining dynamic programming with function approximators. We give also a condition on the sample sparsity ensuring that, for a given initial state, the proposed algorithm produces an optimal sequence of actions in open-loop. [less ▲]

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See detailCautious operation planning under uncertainties
Capitanescu, Florin ULiege; Fliscounakis, Stéphane; Panciatici, Patrick et al

in IEEE Transactions on Power Systems (2012), 27(4), 1859-1869

This paper deals with day-ahead power systems security planning under uncertainties, by posing an optimization problem over a set of power injection scenarios that could show up the next day and modeling ... [more ▼]

This paper deals with day-ahead power systems security planning under uncertainties, by posing an optimization problem over a set of power injection scenarios that could show up the next day and modeling the next day's real-time control strategies aiming at ensuring security with respect to contingencies by a combination of preventive and corrective controls. We seek to determine whether and which day-ahead decisions must be taken so that for scenarios over the next day there still exists an acceptable combination of preventive and corrective controls ensuring system security for any postulated contingency. We formulate this task as a three-stage feasibility checking problem, where the first stage corresponds to day-ahead decisions, the second stage to preventive control actions, and the third stage to corrective post-contingency controls. We propose a solution approach based on the problem decomposition into successive optimal power flow (OPF) and security-constrained optimal power flow (SCOPF) problems of a special type. Our approach is illustrated on the Nordic32 system and on a 1203-bus model of a real-life system. [less ▲]

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See detailLes « cavaliers budgétaires » sont-ils éphémères ? Une controverse qui perdure (note sous C.C., arrêt n° 58/2016 du 28 avril 2016)
Miny, Xavier ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), (3), 110-117

L’affaire relative à la réglementation wallonne du financement du vote électronique a été l’occasion, pour la Cour constitutionnelle, de revenir dans son arrêt n° 58/2016 du 28 avril 2016 sur les notions ... [more ▼]

L’affaire relative à la réglementation wallonne du financement du vote électronique a été l’occasion, pour la Cour constitutionnelle, de revenir dans son arrêt n° 58/2016 du 28 avril 2016 sur les notions de budget et de cavalier budgétaire, ainsi que sur la durée de vie de ce genre controversé de dispositions et sur la compétence d’avis du Conseil d’État en la matière. Confrontée pour la première fois à certaines problématiques qu’engendrent les cavaliers budgétaires, la Cour constitutionnelle s’est néanmoins refusée à trancher l’ensemble des débats. [less ▲]

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See detailLa cave de la villa gallo-romaine de Neuville "Les Machenées" (Philippeville, province de Namur, Belgique) : étude du matériel archéologique
Cattelain, Laureline; Venant, Nelly; Cosyns, Peter et al

in Archeo-Situla (2013), 32-33

Detailed reference viewed: 82 (2 ULiège)
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See detailCAVEAT: technique and tool for computer aided verification and transformation
Gribomont, Pascal ULiege; Rossetto, Didier

in Computer Aided Verification (1995)

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See detailCaveolin plays a central role in endothelial progenitor cell mobilization and homing in SDF-1-driven postischemic vasculogenesis.
SBAA, E; DE WEVER, J; MARTINIVE, Philippe ULiege et al

in Circulation Research (2006), 98(9), 121927

When neovascularization is triggered in ischemic tissues, angiogenesis but also (postnatal) vasculogenesis is induced, the latter requiring the mobilization of endothelial progenitor cells (EPC) from the ... [more ▼]

When neovascularization is triggered in ischemic tissues, angiogenesis but also (postnatal) vasculogenesis is induced, the latter requiring the mobilization of endothelial progenitor cells (EPC) from the bone marrow. Caveolin, the structural protein of caveolae, was recently reported to directly influence the angiogenic process through the regulation of the vascular endothelial growth factor (VEGF)/nitric oxide pathway. In this study, using caveolin-1 null mice (Cav(-/-)), we examined whether caveolin was also involved in the EPC recruitment in a model of ischemic hindlimb. Intravenous infusion of Sca-1(+) Lin(-) progenitor cells, but not bone marrow transplantation, rescued the defective neovascularization in Cav(-/-) mice, suggesting a defect in progenitor mobilization. The adhesion of Cav(-/-) EPC to bone marrow stromal cells indeed appeared to be resistant to the otherwise mobilizing SDF-1 (Stromal cell-Derived Factor-1) exposure because of a defect in the internalization of the SDF-1 cognate receptor CXCR4. Symmetrically, the attachment of Cav(-/-) EPC to SDF-1-presenting endothelial cells was significantly increased. Finally, EPC transduction with caveolin small interfering RNA reproduced this advantage in vitro and, importantly, led to a more extensive rescue of the ischemic hindlimb after intravenous infusion (versus sham-transfected EPC). These results underline the critical role of caveolin in ensuring the caveolae-mediated endocytosis of CXCR4, regulating both the SDF-1-mediated mobilization and peripheral homing of progenitor cells in response to ischemia. In particular, a transient reduction in caveolin expression was shown to therapeutically increase the engraftment of progenitor cells. [less ▲]

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See detailcaveolin-1 expression is critical for VEGF-induced inschemic hindlimb collateralization and NO-mediated angiogenisis.
Martinive, Philippe ULiege; Sonveaux, P; DeWever, J et al

in Circulation Research (2004), (95 (2)), 154-61

Nitric oxide (NO) is a powerful angiogenic mediator acting downstream of vascular endothelial growth factor (VEGF). Both the endothelial NO synthase (eNOS) and the VEGFR-2 receptor colocalize in caveolae ... [more ▼]

Nitric oxide (NO) is a powerful angiogenic mediator acting downstream of vascular endothelial growth factor (VEGF). Both the endothelial NO synthase (eNOS) and the VEGFR-2 receptor colocalize in caveolae. Because the structural protein of these signaling platforms, caveolin, also represses eNOS activity, changes in its abundance are likely to influence the angiogenic process in various ways. In this study, we used mice deficient for the caveolin-1 gene (Cav-/-) to examine the impact of caveolae suppression in a model of adaptive angiogenesis obtained after femoral artery resection. Evaluation of the ischemic tissue perfusion and histochemical analyses revealed that contrary to Cav+/+ mice, Cav-/- mice failed to recover a functional vasculature and actually lost part of the ligated limbs, thereby recapitulating the effects of the NOS inhibitor L-NAME administered to operated Cav+/+ mice. We also isolated endothelial cells (ECs) from Cav-/- aorta and showed that on VEGF stimulation, NO production and endothelial tube formation were dramatically abrogated when compared with Cav+/+ ECs. The Ser1177 eNOS phosphorylation and Thr495 dephosphorylation but also the ERK phosphorylation were similarly altered in VEGF-treated Cav-/- ECs. Interestingly, caveolin transfection in Cav-/- ECs redirected the VEGFR-2 in caveolar membranes and restored the VEGF-induced ERK and eNOS activation. However, when high levels of recombinant caveolin were reached, VEGF exposure failed to activate ERK and eNOS. These results emphasize the critical role of caveolae in ensuring the coupling between VEGFR-2 stimulation and downstream mediators of angiogenesis. This study also provides new insights to understand the paradoxical roles of caveolin (eg, repressing basal enzyme activity but facilitating activation on agonist stimulation) in cardiovascular pathophysiology. [less ▲]

Detailed reference viewed: 30 (5 ULiège)
Peer Reviewed
See detailLa cavernostomie: une ancienne technique parfois efficace dans le traitement des abcès pulmonaires
Defraigne, Jean-Olivier ULiege; Siquet, J.; Limet, Raymond ULiege

in Revue Médicale de Liège (1997), 52(7), 498-501

Detailed reference viewed: 51 (2 ULiège)
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See detailCavernous hemangiosarcoma in a free-living red deer (Cervus elaphus)
Grégoire, Fabien ULiege; Mousset, Bénédicte ULiege; Hanrez, David ULiege et al

in Veterinary Record : Journal of the British Veterinary Association (2008), 162

Detailed reference viewed: 65 (13 ULiège)
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See detailUn cavigliere "al femminile" di parmigianinesca leziosità: la cetera D.MR.R.434 del Musée de la Musique di Parigi
Bugini, Mariaelena ULiege

in Santarelli, Cristina (Ed.) Ut musica pictura (2010)

Detailed reference viewed: 17 (0 ULiège)
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See detailCB1 receptor blockade and its impact on cardiometabolic risk factors: overview of the RIO programme with rimonabant.
Scheen, André ULiege

in Journal of Neuroendocrinology (2008), 20 Suppl 1

Rimonabant, the first selective CB(1) receptor antagonist in clinical use, has been extensively investigated in the Rimonabant in Obesity (RIO) programme, comprising four 1-2 year placebo-controlled ... [more ▼]

Rimonabant, the first selective CB(1) receptor antagonist in clinical use, has been extensively investigated in the Rimonabant in Obesity (RIO) programme, comprising four 1-2 year placebo-controlled randomised clinical trials recruiting more than 6600 overweight/obese patients with or without co-morbidities. Rimonabant 20 mg daily consistently reduced body weight, waist circumference, triglycerides, blood pressure, insulin resistance and C-reactive protein levels, and increased HDL cholesterol concentrations in both non-diabetic and type-2 diabetic overweight/obese patients. Adiponectin levels were increased, an effect that correlated with HDL cholesterol augmentation, while small dense LDL cholesterol levels were decreased in patients receiving rimonabant 20 mg compared with those receiving placebo in RIO Lipids. Furthermore, in RIO Diabetes, a 0.7% reduction in glycated haemoglobin (HbA1c) levels was observed in metformin- or sulphonylurea-treated patients with type-2 diabetes, an effect recently confirmed in the 6-month SERENADE (Study Evaluating Rimonabant Efficacy in drug-NAive DiabEtic patients) trial in drug-naive diabetic patients. Almost half of metabolic changes occurred beyond weight loss, in agreement with direct peripheral effects. The positive effects observed after 1 year were maintained after 2 years. Rimonabant was generally well-tolerated, but with a slightly higher incidence of depressed mood disorders, anxiety, nausea and dizziness compared with placebo. In clinical practice, rimonabant has to be prescribed to the right patient, i.e. overweight/obese subjects with cardiometabolic risk factors and with no major depressive illness and/or ongoing antidepressive treatment, in order to both maximise efficacy and minimise safety issues. New trials are supposed to confirm the potential role of rimonabant in patients with abdominal adiposity, atherogenic dyslipidaemia and/or type-2 diabetes, i.e. at high cardiometabolic risk. [less ▲]

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See detailCBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein
Chariot, Alain ULiege; Van Lint, Carine; Chapelier, Muriel et al

in Oncogene (1999), 18

Homeodomain-containing proteins are transcription factors regulating the coordinated expression of multiple target genes involved in development, differentiation and cellular transformation. In this study ... [more ▼]

Homeodomain-containing proteins are transcription factors regulating the coordinated expression of multiple target genes involved in development, differentiation and cellular transformation. In this study, we demonstrated that HOXB7, one member of this family, behaved as a transactivator in breast cancer cells. Deletion of either the HOXB7 N-terminal domain or the C-terminal acidic tail abolished this transcriptional effect, suggesting a combination of distinct functional transactivating domains. HOXB7 physically interacted both in vitro and in vivo with the coactivator CREB-binding protein (CBP). This interaction led to an enhanced transactivating potential and required the N-terminal of HOXB7 as well as two domains located at the C-terminal part of CBP. Moreover, trichostatin A, a deacetylase inhibitor, strongly enhanced the transcriptional properties of HOXB7. Our data therefore indicate that HOX proteins can directly interact with CBP and that acetylation/deacetylation may regulate their transcriptional properties. [less ▲]

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See detailA Cbx8-containing polycomb complex facilitates the transition to gene activation during ES cell differentiation.
Creppe, Catherine ULiege; Palau, Ana; Malinverni, Roberto et al

in PLoS genetics (2014), 10(12), 1004851

Polycomb proteins play an essential role in maintaining the repression of developmental genes in self-renewing embryonic stem cells. The exact mechanism allowing the derepression of polycomb target genes ... [more ▼]

Polycomb proteins play an essential role in maintaining the repression of developmental genes in self-renewing embryonic stem cells. The exact mechanism allowing the derepression of polycomb target genes during cell differentiation remains unclear. Our project aimed to identify Cbx8 binding sites in differentiating mouse embryonic stem cells. Therefore, we used a genome-wide chromatin immunoprecipitation of endogenous Cbx8 coupled to direct massive parallel sequencing (ChIP-Seq). Our analysis identified 171 high confidence peaks. By crossing our data with previously published microarray analysis, we show that several differentiation genes transiently recruit Cbx8 during their early activation. Depletion of Cbx8 partially impairs the transcriptional activation of these genes. Both interaction analysis, as well as chromatin immunoprecipitation experiments support the idea that activating Cbx8 acts in the context of an intact PRC1 complex. Prolonged gene activation results in eviction of PRC1 despite persisting H3K27me3 and H2A ubiquitination. The composition of PRC1 is highly modular and changes when embryonic stem cells commit to differentiation. We further demonstrate that the exchange of Cbx7 for Cbx8 is required for the effective activation of differentiation genes. Taken together, our results establish a function for a Cbx8-containing complex in facilitating the transition from a Polycomb-repressed chromatin state to an active state. As this affects several key regulatory differentiation genes this mechanism is likely to contribute to the robust execution of differentiation programs. [less ▲]

Detailed reference viewed: 42 (1 ULiège)
See detailThe CCAMBIO project to characterize the biodiversity and distribution of microorganisms in microbial mats of Antarctic lakes
Durieu, Benoit ULiege; Lara, Yannick ULiege; Obbels, Dagmar et al

Poster (2016, April 29)

The BelSPO project CCAMBIO aims to study the biogeographical distribution of microorganisms in lacustrine microbial mats using a combination of techniques including microscopical observations (light and ... [more ▼]

The BelSPO project CCAMBIO aims to study the biogeographical distribution of microorganisms in lacustrine microbial mats using a combination of techniques including microscopical observations (light and electronic microscopy), strain isolation, and molecular diversity assessment using Next Generation Sequencing. The samples were collected in different Antarctic and sub-Antarctic biogeographical regions. A detailed microscopic study of the Antarctic diatom diversity allowed to revise a number of taxa and discover new ones. A multivariate analysis of diatoms showed that these regions hosted different diatom flora. Endemic diatom taxa were also observed, and a multigene molecular phylogeny of Pinnularia borealis showed a high genetic diversity. Pilot studies were conducted for the microeukaryotes and cyanobacteria to select NGS protocols and bioinformatic pipelines. Preliminary multivariate analysis of over 100 samples revealed that distinct biogeographic zones could be recognized in both the prokaryote and eukaryote data, which is in agreement with the classical subdivision of the Antarctic Realm into Maritime Antarctica, Continental Antarctica and the Sub-Antarctic Islands generally observed in plants and animals. Moreover, Sub-Antarctic assemblages harboured more complex foodwebs, with quite diverse metazoan groups. Lakes on the continent, however, were characterised by fewer metazoan groups and a greater importance of microbial herbivores and secondary consumers, including a relative high diversity of ciliates and tardigrades. Variation partitioning analysis revealed that spatial variables that approximated large-scale regional contrasts in historical (e.g. deglaciation history, geological origin) and climatic factors (e.g. mean annual air temperature) significantly explained the largest portion of the observed variation in community structure for eukaryotes, while in the prokaryote data environmental gradients related to conductivity were more important. In a first analysis of microbial mats from five Antarctic lakes and an aquatic biofilm from the Sub-Antarctic, the majority of the cyanobacterial OTUs retrieved were related to filamentous taxa such as Leptolyngbya and Phormidium, which are common genera in Antarctic lacustrine microbial mats. However, other phylotypes related to different taxa such as Geitlerinema, Pseudanabaena, Synechococcus, Chamaesiphon, Calothrix and Coleodesmium were also found. Results revealed a higher diversity than what had been reported using traditional methods based on microscopic observations and cultivation and also highlighted remarkable differences between the cyanobacterial communities of the studied lakes. In the next months, the molecular diversity data will be deposited into the “Microbial Antarctic Resource System (MARS)” presently developed into the webportal ‘biodiversity.aq’. The better knowledge of the diversity and distribution of microorganisms will contribute to a better assessment of their resilience and local/regional responses to global change. [less ▲]

Detailed reference viewed: 72 (4 ULiège)
See detailCCCP, une guerre stellaire plutot chaude - résumé
Nazé, Yaël ULiege

Article for general public (2011)

Detailed reference viewed: 12 (3 ULiège)
See detailCCD Detection of beam-foil light
Quevrin, A.; Bastin, Thierry ULiege; Dumont, Paul-Dominique ULiege et al

Poster (1999)

Detailed reference viewed: 16 (2 ULiège)