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Peer Reviewed
See detailCellular and nervous environment of mouse mesenteric lymph node germinal centres
Wenders, Frédéric ULg; Dorban, G.; Piret, Joëlle ULg et al

Conference (2005, April)

Detailed reference viewed: 24 (0 ULg)
Peer Reviewed
See detailCellular Aspects of the Pathogenesis of Radiation--Induced Thymic Lymphomas in C57 Bl Mice (Review)
Boniver, Jacques ULg; Humblet, Chantal ULg; Rongy, A. M. et al

in In Vivo (Athens, Greece) (1990), 4(1, Jan-Feb), 41-3

Radiation-induced thymic lymphomas in C57Bl/Ka mice are interesting models for studying the successive steps of carcinogenesis. Irradiation initiates "preleukemic" cells, which are promoted to become ... [more ▼]

Radiation-induced thymic lymphomas in C57Bl/Ka mice are interesting models for studying the successive steps of carcinogenesis. Irradiation initiates "preleukemic" cells, which are promoted to become neoplastic. Studies in mice in which lymphoma development is inhibited by a bone marrow transplantation after irradiation suggest that radiation--induced alterations to the T cell lineage, and particularly to thymic microenvironment, are critical for the promotion of preleukemic cells. It is proposed that the lack of physiological differentiation signals within the thymus, as a result of irradiation, allows these cells to escape the normal controls of thymocyte production and pushes them towards neoplastic transformation. A disturbance in the production of cytokines may be involved, since exogenous cytokines, such as Interferon gamma or Tumor Necrosis Factor a, can inhibit radiation-induced lymphomagenesis, reproducing the effects of bone marrow transplantation. The model is thus suitable for studying the mechanisms of carcinogenesis and designing biological manipulation devoted to cancer prevention in individuals who have been exposed to oncogenic agents. [less ▲]

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See detailCellular automata urban expansion model based on support vector machines
El Saeid Mustafa, Ahmed Mohamed ULg; Rienow, Andreas; Saadi, Ismaïl ULg et al

in Mostafavi, Mir‐Abolfazl; Pinto, Nuno (Eds.) PROCEEDINGS of Second International Symposium on Cellular Automata Modeling for Urban and Spatial Systems (2016, October 30)

Land-use change models are used to explore the dynamics and drivers of land-use/landcover change and to inform policies affecting such change. A broad array of applications and modeling methods are ... [more ▼]

Land-use change models are used to explore the dynamics and drivers of land-use/landcover change and to inform policies affecting such change. A broad array of applications and modeling methods are available and each type has certain advantages and disadvantages depending on the objective of the research. This work presents an approach combining cellular automata (CA) model and supported vector machine (SVM) and binary logistic regression model (Logit) for simulating urban expansion in Wallonia (Belgium). This article emphasizes the interest in comparing combining CA with conventional Logit versus combining CA with SVM method as a base of CA model transition rule. Relative operating characteristic (ROC) and spatial matrices are used to validate the model. Model validation shows that the allocation performance of CA-SVM outperformed CALogit approach. [less ▲]

Detailed reference viewed: 35 (5 ULg)
Peer Reviewed
See detailCellular composition of bronchial brushings obtained from dogs with experimental chronic bronchitis
Bolognin, M.; Tual, Charlotte ULg; Day, M. J. et al

in 18th ECVIM Meeting - Gent - Belgique - 2-5 septembre 2008 (2008, September 02)

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See detailCellular context regulates magnitude and direction of Ets-mediated transcriptional regulation of collagen
Czuwara-Ladykowska, Joanna; Shirasaki, Fumiaki; Jackers, Pascale ULg et al

Poster (2000, December 09)

Detailed reference viewed: 10 (4 ULg)
See detailCellular distribution of NSP in normal pituitary and in pituitary adenomas. Comparison with pituitary hormone expression.
Dukers, N.; Senden, N.; Timmer, E. et al

in 4th Euregional oncology meeting - abstract book (1997)

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See detailCellular engineering of Bacillus subtilis to enhance the biosynthesis of highly active anti fungal lipopeptides
Guy, J.; Guez, Jean-Sébastien; Coucheny, F. et al

Poster (2010)

Detailed reference viewed: 14 (4 ULg)
Peer Reviewed
See detailCellular Events in Radiation-Induced Lymphomagenesis
Boniver, Jacques ULg; Humblet, Chantal ULg; Rongy, A. M. et al

in International Journal of Radiation Biology (1990), 57(4), 693-8

Fractionated whole-body irradiation induces thymic lymphomas in most of treated C57Bl/Ka mice. The cellular events occurring during the latency period consist of the emergence of preleukaemic cells and of ... [more ▼]

Fractionated whole-body irradiation induces thymic lymphomas in most of treated C57Bl/Ka mice. The cellular events occurring during the latency period consist of the emergence of preleukaemic cells and of marked alterations to the T-cell lineage and the microenvironment within the thymus. The proportions of the various thymocyte subsets are modified, suggesting a blockage in the normal differentiation process. Thymic epithelial cells are functionally modified, leading to decreased interactions with immature thymocytes. Interestingly, bone marrow grafting early after irradiation, which inhibits the development of lymphomas, induces the disappearance of preleukaemic cells from the thymus, whereas thymocyte subpopulations and thymic epithelium are restored. Interferon gamma and tumor necrosis factor alpha also prevent the onset of lymphomas. Studies on the effect of bone marrow transplantation and cytokine inoculation in split-dose irradiated mice should allow characterization of the factors that modulate the progression of preleukaemic cells towards the neoplastic state. [less ▲]

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See detailCellular immunotherapy in multiple myeloma : lessons from preclinical models
Binsfeld, Marilène ULg; Fostier, K.; Muller, Joséphine ULg et al

in Biochimica et Biophysica Acta - Reviews on Cancer (2014), 1846

The majority of multiple myeloma patients relapse with the current treatment strategies, raising the need for alternative therapeutic approaches. Cellular immunotherapy is a rapidly evolving field and ... [more ▼]

The majority of multiple myeloma patients relapse with the current treatment strategies, raising the need for alternative therapeutic approaches. Cellular immunotherapy is a rapidly evolving field and currently being translated into clinical trials with encouraging results in several cancer types, including multiple myeloma. Murine multiple myeloma models are of critical importance for the development and refinement of cellular immunotherapy. In this review,we summarize the immune cell changes that occur inmultiplemyelomapatients and we discuss the cell-based immunotherapies that have been tested in multiple myeloma, with a focus on murine models. [less ▲]

Detailed reference viewed: 69 (10 ULg)
Peer Reviewed
See detailCellular localization of IGF-I and IGF-II mRNAs in immature hypophysectomized rat testis and epididymis after in vivo hormonal treatment.
Dombrowicz, D.; Hooghe-Peters, E. L.; GOTHOT, André ULg et al

in Archives internationales de physiologie, de biochimie et de biophysique (1992), 100(5), 303-8

IGF-I and II genes expression has been localized by in situ hybridization in testis and epididymis of immature hypophysectomized rats treated in vivo with either pFSH, hLH, bGH, hPRL or with saline. IGF-I ... [more ▼]

IGF-I and II genes expression has been localized by in situ hybridization in testis and epididymis of immature hypophysectomized rats treated in vivo with either pFSH, hLH, bGH, hPRL or with saline. IGF-I mRNA expression was found in both Sertoli and Leydig cells after treatment with either FSH or LH. IGF-I mRNA was highly expressed in germ cells after FSH stimulation and to a lesser extent after GH or LH treatments. However, its expression was very low in hypophysectomized control or PRL treated rats. IGF-I mRNA was also expressed in stromal cells of epididymis after LH treatment and to a lesser extent after GH stimulation. In contrast, IGF-II mRNA expression was detected in all testicular cell types whatever the hormonal treatment (FSH, LH, GH, PRL). For each hormonal treatment testicular sections were examined after immunohistochemical staining with specific antisera against IGF-I and IGF-II. Both in situ hybridization and immunohistochemical data were examined in order to determine the testicular sites of synthesis of IGF-I and IGF-II. [less ▲]

Detailed reference viewed: 13 (1 ULg)
See detailCellular mechanisms controlling rapid changes in brain aromatase activity
Charlier, Thierry; Cornil, Charlotte ULg; Ball, Gregory et al

in Balthazart, Jacques; Ball, Gregory (Eds.) Brain aromatase, estrogens and behavior (2012)

Detailed reference viewed: 18 (1 ULg)
Peer Reviewed
See detailCellular origin of HPV-related (pre)cancer
Herfs, Michael ULg

Conference (2016, May)

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See detailCellular Pathways Involved In The Ex Vivo Expression Of Bovine Leukemia Virus
Kerkhofs, P.; Adam, E.; Droogmans, L. et al

in Journal of Virology (1996), 70(4),

Detailed reference viewed: 4 (1 ULg)
Peer Reviewed
See detailCellular proliferation in villi of normal and pathological pregnancies.
Hustin, J.; Foidart, Jean-Michel ULg; Lambotte, R.

in Gynecologic & Obstetric Investigation (1984), 17(1), 1-9

DNA and protein synthesis have been studied in placental villi from normal and pathological cases by in vitro incorporation of tritiated thymidine or tritiated proline and subsequent counting or ... [more ▼]

DNA and protein synthesis have been studied in placental villi from normal and pathological cases by in vitro incorporation of tritiated thymidine or tritiated proline and subsequent counting or autoradiography. It appeared that cytotrophoblastic DNA synthesis continued until term and that it was particularly important in preeclampsia cases and in cases of villous immaturity (rhesus sensitization). Protein synthesis was also increased in preeclampsia and seemed to be due to a very active cytotrophoblastic metabolism. The most interesting finding was that in preeclampsia cases, especially when intrauterine growth retardation was superimposed, villous capillary endothelial cell proliferation was as prominent as in cases where villous maturation was not achieved. Such results are highly suggestive of an important compensatory proliferative mechanism in the placentae of preeclamptic women. [less ▲]

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See detailCellular regulation mechanisms : case study of up and down states in the Purkinje cell
Wehenkel, Marie ULg

Master's dissertation (2014)

In 1963, Hodgkin and Huxley obtained the Nobel Prize to have shown that the electrical activity of a neuron could be modelled by an electrical RC circuit containing non-linear conductances. This discovery ... [more ▼]

In 1963, Hodgkin and Huxley obtained the Nobel Prize to have shown that the electrical activity of a neuron could be modelled by an electrical RC circuit containing non-linear conductances. This discovery made it possible to reproduce the electrical behaviour of neurons with a level of detail that has steadily increased over the last fifty years as new quantitative knowledge became available about the specific ionic currents that regulate the activity of a given neuron. But models with too many details are often non-robust and too complex for analysis. As control engineers need simplified models for control design, experimental neurophysiologists are in need of models that are amenable to sensitivity and robustness analysis, beyond the mere simulation of a given neuronal behaviour recorded experimentally. The Purkinje cell has been studied for over hundred years because its large dendritic tree enables to recognize it easily with a microscope. This neuron exhibits a bistability between a stable hyperpolarized down-state and a stable depolarized spiking state. It is one of the first discovered neurons, however its electrical behaviour is not well understood so far. The principal question of the thesis is to model the electrophysiology of the Purkinje cell to advance the understanding of its regulation mechanisms. More particularly, the objective of the thesis is to explore recent work about the role of the calcium current in neuronal excitability as a possible mechanism underlying the bistability observed in the Purkinje cell. The electrical activity of the Purkinje cell is reproduced in this thesis thanks to a reduced physiological model which can be seen as an intermediate between a detailed model with dendritic compartments and an abstract model of bistability. This novel model is the main contribution of the thesis. Its main ingredients are on the one hand a fast sodium current and a slow potassium restorative current whose particular kinetics account for the up-state excitability, and on the other hand a slow regenerative calcium current and an ultraslow calcium-dependent potassium current for bistability. The proposed model suggests several implications. First, a complex compartmental model seems unnecessary to reproduce the electrophysiology of the cell, although the profuse dendrites are an important characteristic of the Purkinje neuron. Secondly, the Purkinje neuron appears to be regulated by the same mechanisms as other bistable neurons such as the thalamocortical (TC) or subthalamic nucleus (STN) neurons. Its behaviour depends on the same feedback mechanisms (a fast regenerative sodium current, a slow restorative potassium current and a slow regenerative calcium current), event though the temporal signature is markedly different because of the specific channel kinetics primarily of the slow potassium current. Finally this novel model makes the Purkinje cell modelling amenable to robustness and modulation studies, as recently shown for similar neurons. [less ▲]

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See detailCellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors.
Sennino, Barbara; Kuhnert, Frank; Tabruyn, Sébastien ULg et al

in Cancer Research (2009), 69(10), 4527-36

Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and their receptors are important targets in cancer therapy based on angiogenesis inhibition. However, it is unclear ... [more ▼]

Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and their receptors are important targets in cancer therapy based on angiogenesis inhibition. However, it is unclear whether inhibition of VEGF and PDGF together is more effective than inhibition of either one alone. Here, we used two contrasting tumor models to compare the effects of inhibiting VEGF or PDGF alone, by adenovirally generated soluble receptors, to the effects of inhibiting both together. In RIP-Tag2 tumors, VEGF and PDGF inhibition together reduced tumor vascularity and abundance of pericytes. However, VEGF inhibition reduced tumor vascularity without decreasing pericyte density, and PDGF inhibition reduced pericytes without reducing tumor vascularity. By contrast, in Lewis lung carcinomas (LLC), inhibition of VEGF or PDGF reduced blood vessels and pericytes to the same extent as did inhibition of both together. Similar results were obtained using tyrosine kinase inhibitors AG-013736 and imatinib. In LLC, VEGF expression was largely restricted to pericytes and PDGF was largely restricted to endothelial cells, but, in RIP-Tag2 tumors, expression of both growth factors was more widespread and significantly greater than in LLC. These findings suggest that inhibition of PDGF in LLC reduced pericytes, and then tumor vessels regressed because pericytes were the main source of VEGF. The vasculature of RIP-Tag2 tumors, in which most VEGF is from tumor cells, was more resistant to PDGF inhibition. The findings emphasize the interdependence of pericytes and endothelial cells in tumors and the importance of tumor phenotype in determining the cellular effects of VEGF and PDGF inhibitors on tumor vessels. [less ▲]

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See detailCellular stress and β-lactamase BlaP induction in Bacillus licheniformis
Dauvin, Marjorie ULg; Joris, Bernard ULg

Poster (2017, February 01)

In presence of β-lactam antibiotic in its environment, B. licheniformis produces the β-lactamase BlaP, an enzyme hydrolyzing β-lactam antibiotic, conferring on the bacteria phenotypic resistance. To ... [more ▼]

In presence of β-lactam antibiotic in its environment, B. licheniformis produces the β-lactamase BlaP, an enzyme hydrolyzing β-lactam antibiotic, conferring on the bacteria phenotypic resistance. To induce BlaP, two conditions must be fulfilled. The first one is the acylation of the membrane receptor BlaR1 by the antibiotic. The second one is a cellular stress due to the presence of the antibiotic which acylate PBP1. The nature of this signal remains unknown. In this study we postulate that the extracytoplasmic function sigma factors (ECFs) σM and σX act together with the stringent response as a secondary and redundant layer of stress upon which the BlaP induction pathway relies. [less ▲]

Detailed reference viewed: 25 (4 ULg)