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See detailCombined Liver - Spleen -small intestine grafting in a rat model: Role of transplanting additional lymphoid tissue on survival.
D'Silva, Milbhor; Pirenne, Jacques; Nakhleh, R. E. et al

in International Surgery (1996), (81), 109-114

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See detailCombined locked nucleic acid and molecular beacon technologies for sensitive detection of the JAK2(V617F) somatic single-base sequence variant
Sidon, P.; Heimann, P.; Lambert, Frédéric ULg et al

in Clinical Chemistry (2006), 52(7), 1436-1438

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See detailCombined metabolomic and genetic approaches reveal a link between the polyamine pathway and albumin 2 in developing pea seeds.
Vigeolas, Hélène ULg; Chinoy, Catherine; Zuther, Ellen et al

in Plant Physiology (2008), 146(1), 74-82

Several legume seed proteins that are potentially allergenic, poorly digested by farm animals, and/or have undesirable functional properties, have been described. One of these is the albumin protein in ... [more ▼]

Several legume seed proteins that are potentially allergenic, poorly digested by farm animals, and/or have undesirable functional properties, have been described. One of these is the albumin protein in pea (Pisum sativum) called PA2. A naturally occurring mutant line that lacks PA2 has been exploited in studies to determine the biological function of this nonstorage protein in seed development. The mutant, which has a small seed, a tall plant phenotype, and lacks most of the PA2-encoding genes, has been crossed with a standard cultivar, 'Birte,' which contains PA2 to give rise to a recombinant inbred (RI) population. An F(3) line carrying the mutation and having a short plant phenotype has been used to generate backcross (BC) lines with 'Birte.' Despite having a lower albumin content, seeds from the mutant parent and RI lines lacking PA2 have an equivalent or higher seed nitrogen content. Metabolite profiling of seeds revealed major differences in amino acid composition and polyamine content in the two parent lines. This was investigated further in BC lines, where the effects of differences in seed size and plant height between the two parents were eliminated. Here, differences in polyamine synthesis were maintained as was a difference in total seed protein between the BC line lacking PA2 and 'Birte.' Analysis of enzyme activities in the pathways of polyamine synthesis revealed that the differences in spermidine content were attributable to changes in the overall activities of spermidine synthase and arginine decarboxylase. Although the genes encoding spermidine synthase and PA2 both localized to the pea linkage group I, the two loci were shown not to be closely linked and to have recombined in the BC lines. A distinct locus on linkage group III contains a gene that is related to PA2 but expressed predominantly in flowers. The results provide evidence for a role of PA2 in regulating polyamine metabolism, which has important functions in development, metabolism, and stress responses in plants. [less ▲]

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See detailCombined method for the sequential measurement of (1) the enzymatically active fraction and (2) the total amount of an enzyme
Serteyn, Didier ULg; Deby-Dupont, Ginette; Franck, Thierry ULg et al

Patent (2009)

The present invention is related to a combined method and kit (or device) for the sequential measurement of the enzymatically active fraction and the total amount of an enzyme [(such as myeloperoxidase ... [more ▼]

The present invention is related to a combined method and kit (or device) for the sequential measurement of the enzymatically active fraction and the total amount of an enzyme [(such as myeloperoxidase (MPO)] in a sample, and that find improved applications in veterinary and human health fields. [less ▲]

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See detailCombined mexiletine and amiodarone treatment of refractory recurrent ventricular tachycardia.
Waleffe, A.; Mary-Rabine, L.; Legrand, Victor ULg et al

in American heart journal (1980), 100(6 Pt 1), 788-93

A combined mexiletine and amiodarone treatment was applied in nine cases with recurrent refractory ventricular tachycardia. During the first two days of treatment, mexiletine and amiodarone were perfused ... [more ▼]

A combined mexiletine and amiodarone treatment was applied in nine cases with recurrent refractory ventricular tachycardia. During the first two days of treatment, mexiletine and amiodarone were perfused intravenously at a dose of 1,000 mg. and 1,500 mg. per 24 hours, respectively. Simultaneously amiodarone was also given orally at a dose of 600 mg. per 24 hours. From the third day onwards, the intravenous administration was interrupted and both drugs were continued orally at a dose of 600 mg. daily. The first three patients were very critically ill and had had at least five episodes of ventricular tachycardia per 24 hours during the last 10 days in the intensive care unit. The treatment resulted in total suppression of the tachycardic episodes within three days after initiation of therapy. In the remaining six cases, ventricular tachycardia was easily initiated by programmed electrical stimulation of the heart. No arrhythmia could be elicited by repeated testing on the seventh day of treatment. The mean follow-up period was 6 months. Two patients with poor left ventricular function died in intractable heart failure. Another one died suddenly 4-1/2 months after his release from the hospital. He had a large aneurysm and whether he continued his treatment is unknown. A fourth patient had an aneurysmectomy; he suffered a recurrence, and died at his second operation. All the others presently remain asymptomatic. The association of a class I (mexiletine) with a class III (amiodarone) agent is theoretically attractive for the treatment of refractory ventricular arrhythmias. The present findings corroborate this hypothesis, but show that this association is not able to protect individuals with severe underlying myocardial damage. [less ▲]

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See detailCombined micro-Fourier transform infrared (FTIR) spectroscopy and micro-Raman spectroscopy of Proterozoic acritarchs: A new approach to Palaeobiology
Marshall, C. P.; Javaux, Emmanuelle ULg; Knoll, A. H. et al

in Precambrian Research (2005), 138(3-4), 208-224

Micro-scale analytical techniques permit correlation of chemistry with morphology of individual Proterozoic acritarchs (organic-walled microfossils), and thus provide new approaches for elucidating their ... [more ▼]

Micro-scale analytical techniques permit correlation of chemistry with morphology of individual Proterozoic acritarchs (organic-walled microfossils), and thus provide new approaches for elucidating their biological affinities. A combination of micro-Fourier transform infrared (FTIR) spectroscopy and laser micro-Raman spectroscopy was used to investigate the organic structure and composition of individual acritarchs. Well preserved Neoproterozoic acritarchs from the Tanana Formation, Australia (ca. 590-565 Ma), and Mesoproterozoic acritarchs from the Roper Group (1.5-1.4 Ga), Australia, and Ruyang Group, China (1.4-1.3 Ga, age poorly resolved but certainly > 1000 Ma and < 1625 Ma) have thermal maturities that range from immature to oil window. FTIR spectra of Tanarium conoideum from the Tanana Formation contain intense aliphatic C-H stretching bands in the 2900 cm(-1) region relative to the C=C aromatic ring stretching band at 1600 cm(-1). This FTIR spectrum is consistent with the FTIR spectra obtained from algaenans isolated from extant chlorophyte and eustigmatophyte microalgae. FTIR spectra of Leiosphaeridia sp. from the Tanana Formation contain a less intense aliphatic C-H stretching band relative to the C=C aromatic ring stretching band. By comparison, the spectra acquired from the Mesoproterozoic acritarchs were dominated by C=C aromatic ring stretching bands at 1600 cm(-1) relative to moderate-weak CH3 terminal groups (1345 cm(-1)), C-H aliphatic stretching (3000-2700 cm(-1)), and C=O (1710 cm-1), although some differences in biopolymer composition occurred between species. Curve-fitting of the aliphatic C-H, stretching region provides greater insight into the aliphatic structures of the acritarchs. The CH2/CH3 intensity ratio can be used to assess the relative chain length and degree of branching. Organic material in the Tanarium conoideum consists of straight long chain hydrocarbons, while the other acritarchs contain hydrocarbons consisting of short chains that are highly branched. In this study it was found that Raman spectroscopy does not provide additional information about biopolymer composition of Proterozoic acritarchs, but rather offers complementary data regarding the aromaticity and degree of saturation of the macromolecular structure of acritarch cysts. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailCombined Mitochondrial and Nuclear Markers Revealed a Deep Vicariant History for Leopoldamys neilli, a Cave-Dwelling Rodent of Thailand
Latinne, Alice ULg; Waengsothorn, Surachit; Rojanadilok, Prateep et al

in PLoS ONE (2012), 7(10), 47670

Background: Historical biogeography and evolutionary processes of cave taxa have been widely studied in temperate regions. However, Southeast Asian cave ecosystems remain largely unexplored despite their ... [more ▼]

Background: Historical biogeography and evolutionary processes of cave taxa have been widely studied in temperate regions. However, Southeast Asian cave ecosystems remain largely unexplored despite their high scientific interest. Here we studied the phylogeography of Leopoldamys neilli, a cave-dwelling murine rodent living in limestone karsts of Thailand, and compared the molecular signature of mitochondrial and nuclear markers. Methodology/Principal Findings: We used a large sampling (n = 225) from 28 localities in Thailand and a combination of mitochondrial and nuclear markers with various evolutionary rates (two intronic regions and 12 microsatellites). The evolutionary history of L. neilli and the relative role of vicariance and dispersal were investigated using ancestral range reconstruction analysis and Approximate Bayesian computation (ABC). Both mitochondrial and nuclear markers support a large-scale population structure of four main groups (west, centre, north and northeast) and a strong finer structure within each of these groups. A deep genealogical divergence among geographically close lineages is observed and denotes a high population fragmentation. Our findings suggest that the current phylogeographic pattern of this species results from the fragmentation of a widespread ancestral population and that vicariance has played a significant role in the evolutionary history of L. neilli. These deep vicariant events that occurred during Plio-Pleistocene are related to the formation of the Central Plain of Thailand. Consequently, the western, central, northern and northeastern groups of populations were historically isolated and should be considered as four distinct Evolutionarily Significant Units (ESUs). Conclusions/Significance: Our study confirms the benefit of using several independent genetic markers to obtain a comprehensive and reliable picture of L. neilli evolutionary history at different levels of resolution. The complex genetic structure of Leopoldamys neilli is supported by congruent mitochondrial and nuclear markers and has been influenced by the geological history of Thailand during Plio-Pleistocene. [less ▲]

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See detailCombined Mossbauer Spectral and Density Functional Theory Determination of the Magnetic Easy-Axis in Two High-Spin Iron(II) 2-Pyrazinecarboxylate Complexes
Long, G. J.; Tanase, S.; Remacle, Françoise ULg et al

in Inorganic Chemistry (2009), 48(17), 8173-8179

A combination of density functional theory (DFT) calculations and Mossbauer spectroscopy has been used to determine that the magnetic easy-axis is coincident with its crystallographic c-axis in [Fe(pca)(2 ... [more ▼]

A combination of density functional theory (DFT) calculations and Mossbauer spectroscopy has been used to determine that the magnetic easy-axis is coincident with its crystallographic c-axis in [Fe(pca)(2)(py)(2)]center dot py, where pac is the 2-pyrazinecarboxylate ligand. This easy-axis bisects the approximately axial O-Fe-O coordination axes of molecules adjacent to each other along the b-axis. In {[Fe(pca)(2)(H2O)]center dot H2O}(n) the easy magnetic axis is not coincident with any of its crystallographic axes nor with the Fe-O(water) coordination axis, but is coincident with one of the Fe center dot center dot center dot Fe axes in the crystal structure. The DFT calculations, which use the B3LYP functional and the 6-311 + +G(d,p) basis set, yield s-electron probability densities and electric field gradient tensors for the iron(II) ion that are in excellent agreement with the observed iron-57 Mossbauer spectral isomer shifts and quadrupole interactions. The gas phase results are very similar for calculations based either on the X-ray structures of the two complexes or on their optimized structures; the optimized structures indicate that the iron to ligand bond distances increase in the absence of any solid-state lattice interactions. The results of a normal coordinate vibrational mode analysis of the two optimized structures are compared with the observed infrared spectra. [less ▲]

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See detailCombined One Stage Cardiac and Pulmonary Surgery by Median Sternotomy
Adant, J. P.; Defraigne, Jean-Olivier ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1990), 90(4), 197-202

From 1985 to 1989, 6 patients underwent a pulmonary surgical procedure simultaneously with a cardiac operation. All patients were male with a mean age of 60 +/- 8 years. The cardiac procedures included: 1 ... [more ▼]

From 1985 to 1989, 6 patients underwent a pulmonary surgical procedure simultaneously with a cardiac operation. All patients were male with a mean age of 60 +/- 8 years. The cardiac procedures included: 1 aortic and 1 mitral valve replacement, 3 coronary artery bypass grafts and 1 closure of an atrial septal defect. Four patients had primary pulmonary nodules: 2 bronchogenic carcinomas and 2 benign hamartomas. They presented with cardiac symptoms, and lung nodules were incidentally found on preoperative Chest X-Rays. The 2 last patients had pulmonary metastases of colonic neoplasms previously resected, respectively 3 and 6 years before. After completion of the cardiac procedures, during the rewarming of the patient, the pulmonary resection was performed on a deflated lung, via the median sternotomy. Pulmonary procedures included: right upper segmentectomy (n = 1), left pneumonectomy (n = 1), left interior lobectomy (n = 1), right middle lobectomy (n = 1), left upper wedge resection (n = 1), and right upper lobe wedge resection (n = 1). All patients were extubated on day one. One patient died from rythm disturbances on day 13. All other patients are alive with a mean survival of 30 months. The authors conclude that combined surgery is feasible in selected cases. Sternal approach is not a limitation to pulmonary resection. [less ▲]

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See detailA Combined Optical/Digital SAR Processor for Quicklook Applications
Litovchenko, Konstantin Ts.; Lemaire, Philippe; Barbier, Christian ULg

in Proc. EUSAR'02 Conference (2002)

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See detailCombined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female Beagle dogs
Noël, Stéphanie; Cambier, Carole; Baert, Kris et al

in Veterinary Journal (2010)

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h ... [more ▼]

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h periods, after single or three times daily (T0-T6h-T12h) administration of phenylpropanolamine (PPA). Maximal concentration (Cmax) was reached 2 h after PPA administration (Tmax). The half-life lasted 4 h and, because of bioaccumulation, three times daily administration induced an increase in Cmax. Compared to the control group, a significant increase in urethral resistance was observed at Tmax after 1 week of once daily administrations. After one week of administering PPA every 6 h during the daytime, but not during the night, and despite higher plasma concentrations, the urethral resistance did not increase at any time, compared to the control group. The increase in mean arterial pressure values was compensated by a decreased heart rate. The clinical efficacy of the temporary increase in urethral resistance following single daily administration of PPA in dogs suffering from urethral sphincter mechanism incompetence (USMI) needs to be further investigated in a randomised clinical trial. [less ▲]

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See detailCombined PIXE/PIGE and IBIL with external beam applied to the analysis of Merovingian glass beads
Mathis, François ULg; Othmane, G.; Vrielynck, Olivier et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2010), 268(11-12), 2078-2082

New improvements on our archaeometry line at the cyclotron of the Institute of Nuclear and Atomic Physics and of Spectrometry of the University of Liege have allowed the use of PIXE/PIGE and IBIL in-air ... [more ▼]

New improvements on our archaeometry line at the cyclotron of the Institute of Nuclear and Atomic Physics and of Spectrometry of the University of Liege have allowed the use of PIXE/PIGE and IBIL in-air for the analysis of cultural heritage objects. The extraction is performed through a 100 nm thick Si3N4 window. The detection set-up consists now of two X-ray and one gamma-ray detectors, together with a fiber optic UV-visible spectrometer. This set-up has already been tested for the analysis of modern corundum [1] and is now adapted to the analysis of archaeological artefacts. In this work, we have used it to analyse 216 out of the 5000 Merovingian glass beads that come from the necropolis of Bossut-Gottechain (Belgium), one of the most important ever found in Belgium. The IBA analyses confirmed the typological division of different beads groups through chemical composition that gives us new insights on fabrication techniques of glass matrices and colorants. (C) 2010 Elsevier B.V. All rights reserved. [less ▲]

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See detailCombined radiotherapy and radioimmotherapy of human colon carcinoma grafted in nude mice.
Buchegger, F; Rojas, A; Delaloye, A et al

in Cancer Research (1995), 55

The effect of combined radioimmunotherapy (RIT) and fractionated external beam radiotherapy (RT) was assessed in two human colon cancer xenografts, Col 12 and LS174T in nude mice. These tumors were ... [more ▼]

The effect of combined radioimmunotherapy (RIT) and fractionated external beam radiotherapy (RT) was assessed in two human colon cancer xenografts, Col 12 and LS174T in nude mice. These tumors were selected for being resistant to RIT alone, as is usually the case in the clinical situation. Tumor-bearing mice were treated with a combination of five X-ray fractions over 5 days followed by RIT with two doses of 1.5 mCi 131I-labeled anticarcinoembryonic antigen monoclonal antibody F(ab')2. In Col 12 and LS174T, RIT alone achieved a regrowth delay similar to that of fractionated RT with total doses of 28 and 26 Gy, respectively. In both tumor types, an additive therapeutic effect, measured as increased regrowth delay or local control, was observed when combining RT of different dose levels with RIT. Normal tissue responses were assessed by monitoring acute peak skin reactions and blood cell count. Bone marrow depression for the combination treatment was similar to that of RIT alone; relative to skin, at equitoxic levels, no mice bearing Col 12 tumors were locally controlled with a 32 Gy RT dose alone, while this RT combined with RIT gave a local control of 100%. These studies show a therapeutic benefit when external beam RT is combined with RIT. [less ▲]

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See detailCombined reconstruction of the diabetic foot including revascularization and free-tissue transfer
Verhelle, N. A.; Despret, Vinciane ULg; Nelissen, Xavier ULg et al

in Journal of Reconstructive Microsurgery (2004), 20(7), 511-517

Diabetic patients, presenting with both peripheral vascular disease and large soft-tissue defects, are too often treated by primary amputation. A combined revascularization and free-tissue transfer ... [more ▼]

Diabetic patients, presenting with both peripheral vascular disease and large soft-tissue defects, are too often treated by primary amputation. A combined revascularization and free-tissue transfer procedure can extend limb salvage in these patients. The authors report their experience over 4 years with 19 diabetic patients with peripheral vascular disease and large soft-tissue defects of the foot requiring free-tissue transfer. Although there was a 100 percent flap survival, early local wound problems occurred in three patients (16.6 percent). The recurrence rate was about 18.7 percent, but no complementary flap procedures were mandatory. With a mean follow-up of 38 months (range: 23 to 55 months), the limb salvage rate was 94.4 percent. Although there was one limb loss and one patient with ambulation difficulties, 16 patients (84.2 percent) were fully rehabilitated and were able to function independently. Despite a rather small series, this study confirms that in selected diabetic patients, a combined approach of vascular and reconstructive surgeons can reduce the limb amputation rate with acceptable complication rates. This combined approach offers major benefits to these patients, especially stable coverage and preservation of ambulation, and should always be considered before amputation. [less ▲]

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See detailCombined Ring Inversion and Side Group Rotation in Geminal Diphosphoryl Substituted Pyrrolinoxyl Radicals: ESR Analysis of Chemical Exchange between Four Nonequivalent Sites
Rockenbauer, Antal; Mercier, Anne; Le Moigne, François et al

in Journal of Physical Chemistry A (1997), 101(43), 7965-7970

The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found ... [more ▼]

The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found, for the 2,2-disubstituted compounds 2 and 3, dramatic changes in the spectra were observed as a function of the temperature. These changes were explained by a four-site chemical exchange model including both ring inversion and hindered rotation around the carbon-phosphorus bonds. For radical 3, the presence of additional 5,5-dimethyl substitution can completely block rotations around carbon-phosphorus bonds for certain ring geometries, while for other ring conformations chemical exchange still occurs through combined inversionrotation processes. An effective two-site model composed of nonequivalent sites and a superposition model composed of a pair of exchanging conformers and a pair of nonexchanging conformers were used to simulate spectrum variations. A satisfactory fit was obtained over the entire temperature range investigated. From the temperature dependence of the exchange frequencies the potential barriers for ring inversion (27 kJ/mol), for combined inversion-rotation (11 kJ/mol), and for rotation around the carbon-phosphorus bonds (14 kJ/mol) were estimated. [less ▲]

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See detailCombined spastic paresis of both gastrocnemius and femoral quadriceps muscles in Belgian blue calves
Janda, Jozef; Uyttenhoef, Aude; Vandeputte, Sébastien ULg et al

Conference (2006)

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See detailCombined study of cerebral glucose metabolism and [11C] methionine accumulation in probable Alzheimer's disease using positron emission tomography
Salmon, Eric ULg; Grégoire, M. C.; Delfiore, Guy et al

in Journal of Cerebral Blood Flow & Metabolism (1996), 16(3), 399-408

There is a characteristic decrease in glucose metabolism in associative frontal and temporo-parietal cortices of patients suffering from Alzheimer's disease (AD). The decrease in metabolism might result ... [more ▼]

There is a characteristic decrease in glucose metabolism in associative frontal and temporo-parietal cortices of patients suffering from Alzheimer's disease (AD). The decrease in metabolism might result from local neuronal loss or from a decrease of synaptic activity. We measured in vivo [11C]methionine accumulation into proteins with positron emission tomography (PET) to assess cortical tissue loss in AD. Both global regional activity and compartmental analysis were used to express [11C]methionine accumulation into brain tissue. Glucose metabolism was measures with [18F]fluorodeoxyglucose and autoradiographic method. Combined studies were performed in 10 patients with probable AD, compared to age-matched healthy volunteers. There was a significant 45% decrease of temporo-parietal glucose metabolism in patients with AD, and frontal metabolism was lowered in most patients. Temporo-parietal metabolism correlated to dementia severity. [11C]methionine incorporation into temporo-parietal and frontal cortices was not significantly decreased in AD. There was no correlation with clinical symptoms. Data suggest that regional tissue loss, assessed by the decrease of [11C]methionine accumulation, is not sufficient to explain cortical glucose hypometabolism, which reflects, rather, reduced synaptic connectivity. [less ▲]

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