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See detailCompetitive facility location problem with attractiveness adjustment of the follower: A bilevel programming model and its solution
Kucukaydin, Hande ULg; Aras, Necati; Altinel, I. Kuban

in European Journal of Operational Research (2011), 208(3), 206-220

We are concerned with a problem in which a firm or franchise enters a market by locating new facilities where there are existing facilities belonging to a competitor. The firm aims at finding the location ... [more ▼]

We are concerned with a problem in which a firm or franchise enters a market by locating new facilities where there are existing facilities belonging to a competitor. The firm aims at finding the location and attractiveness of each facility to be opened so as to maximize its profit. The competitor, on the other hand, can react by adjusting the attractiveness of its existing facilities with the objective of maximizing its own profit. The demand is assumed to be aggregated at certain points in the plane and the facilities of the firm can be located at predetermined candidate sites. We employ Huff's gravity-based rule in modeling the behavior of the customers where the fraction of customers at a demand point that visit a certain facility is proportional to the facility attractiveness and inversely proportional to the distance between the facility site and demand point. We formulate a bilevel mixed-integer nonlinear programming model where the firm entering the market is the leader and the competitor is the follower. In order to find the optimal solution of this model, we convert it into an equivalent one-level mixed-integer nonlinear program so that it can be solved by global optimization methods. Apart from reporting computational results obtained on a set of randomly generated instances, we also compute the benefit the leader firm derives from anticipating the competitor's reaction of adjusting the attractiveness levels of its facilities. The results on the test instances indicate that the benefit is 58.33% on the average. [less ▲]

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See detailCompetitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila
Horsfall, L. E.; Garau, G.; Lienard, B. M. et al

in Antimicrobial Agents and Chemotherapy (2007), 51(6), 2136-2142

Various inhibitors of metallo-beta-lactamases have been reported; however, none are effective for all subgroups. Those that have been found to inhibit the enzymes of subclass B2 (catalytically active with ... [more ▼]

Various inhibitors of metallo-beta-lactamases have been reported; however, none are effective for all subgroups. Those that have been found to inhibit the enzymes of subclass B2 (catalytically active with one zinc) either contain a thiol (and show less inhibition towards this subgroup than towards the dizinc members of B1 and B3) or are inactivators behaving as substrates for the dizinc family members. The present work reveals that certain pyridine carboxylates are competitive inhibitors of CphA, a subclass B2 enzyme. X-ray crystallographic analyses demonstrate that pyridine-2,4-dicarboxylic acid chelates the zinc ion in a bidentate manner within the active site. Salts of these compounds are already available and undergoing biomedical testing for various nonrelated purposes. Pyridine carboxylates appear to be useful templates for the development of more-complex, selective, nontoxic inhibitors of subclass B2 metallo-beta-lactamases. [less ▲]

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See detailCompetitive interaction of a synthetic polycation (PDMAEMA) to human platelets and erythrocytes
Flebus, Luca ULg; Lombart, François ULg; martinez, Lucia et al

Poster (2013, October)

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See detailCompetitively Neutral Universal Service Obligations
Gautier, Axel ULg; Wauthy, Xavier

in Information Economics and Policy (2012), 24

Universal service obligations impose specific costs on the universal service provider and the latter may call for an appropriate compensation. Most often, a two-step procedure is put forward to finance ... [more ▼]

Universal service obligations impose specific costs on the universal service provider and the latter may call for an appropriate compensation. Most often, a two-step procedure is put forward to finance the universal service in a competitive environment. Firstly, the cost of the universal service is assessed; secondly, the provider must be compensated for this cost. We argue that this procedure is problematic because the implementation of a compensation scheme affects the behavior of market participants and leads to an overcompensation of the universal service provider. We put forward an alternative approach to this problem that fully acknowledges the distortions that result from the compensation mechanism. [less ▲]

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See detailCompétitivité des filières rizicoles burundaises: le riz de l'Imbo et le riz des marais
Gahiro, Léonidas ULg

Doctoral thesis (2011)

Le riz est une culture récente, pratiquée surtout dans la plaine de l'Imbo et dans les marais de moyenne altitude du Burundi. D'une part, les ressources disponibles et les technologies de production ... [more ▼]

Le riz est une culture récente, pratiquée surtout dans la plaine de l'Imbo et dans les marais de moyenne altitude du Burundi. D'une part, les ressources disponibles et les technologies de production rendent le riz de l'Imbo plus compétitif que le riz des marais. D'autre part, la majorité des qualités locales s'avèrent moins compétitives que celles importées de l'Asie et la Tanzanie. [less ▲]

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See detailCompilation commentée de la littérature portant sur le soutien public et privé à la culture par d'autres voies et moyens que la subvention publique directe
Husson, Jean-François ULg; Paindavoine, Isabelle; Sepulchre, Vincent ULg

Report (2009)

Revue de la littérature et de sources officielles concernant les instruments budgétaires et fiscaux, autre que le financement budgétaire direct, concourant au financement de la culture. Le rapport aborde ... [more ▼]

Revue de la littérature et de sources officielles concernant les instruments budgétaires et fiscaux, autre que le financement budgétaire direct, concourant au financement de la culture. Le rapport aborde la situation en Belgique et dans plusieurs autres pays : France, Grande-Bretagne, Allemagne, Italie, Hongrie, Pays-Bas, Suisse, Etats-Unis et Canada. [less ▲]

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See detailCompilation of data collected and fed into a hydrogeological database in the Walloon Meuse catchment region
Batlle-Aguilar, Jordi; Wojda, Piotr; Brouyère, Serge ULg

Report (2005)

The objectives of this deliverable are to provide a general description of a hydrogeological database developed by HGULg, including specific adaptations made to meet the AQUATERRA project’s needs and to ... [more ▼]

The objectives of this deliverable are to provide a general description of a hydrogeological database developed by HGULg, including specific adaptations made to meet the AQUATERRA project’s needs and to provide a synthesis of available datasets for the selected test sites in the Meuse basin. First, a general description of the Walloon Meuse basin and the selected AQUATERRA test sites is provided. Then, the general concepts, the conceptual model and the developed interfaces of the HGULg hydrogeological database are presented. Finally, a summary of datasets available for the selected test sites is provided. [less ▲]

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See detailCompilation of data collected and fed into a hydrogeological database in the Walloon Meuse catchment region
Batlle-Aguilar, Jordi; Wojda, Piotr; Brouyère, Serge ULg

Report (2005)

Based on a first inventory of available case studies, test sites have been selected in the Walloon part of the Meuse Basin in Belgium. These sites meet the requirements and objectives of the researches ... [more ▼]

Based on a first inventory of available case studies, test sites have been selected in the Walloon part of the Meuse Basin in Belgium. These sites meet the requirements and objectives of the researches performed by different partners in AquaTerra. Available information and datasets have been collected for these sites and complementary investigations and experiments have been organized. Existing data and recently collected data have been compiled into a hydrogeological database developed by HGULg for the Walloon region and adapted to the specificities and needs of the AquaTerra project. The deliverable provides a general description of the hydrogeological database developed by HGULg: the conceptual model, specific adaptations performed for the AquaTerra project and interfaces for encoding, querying and exporting hydrogeological information stored in the database. A synthesis of datasets available in the HGULg Hydrogeological Database for the selected test sites in the Meuse basin is also provided. [less ▲]

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See detailCompiling polymorphic miRNA-target interactions: the Patrocles database.
Hiard, Samuel ULg; Tordoir, Xavier ULg; Coppieters, Wouter ULg et al

Poster (2007, November 12)

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of ... [more ▼]

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of muscle growth - and creates an illegitimate target site for miRNA expressed in the same tissue. This causes miRNA-mediated translation inhibition of mutant GDF8 transcripts which leads to muscle hypertrophy. We followed up on this finding by searching for common polymorphisms and mutations that affect either (i) RNAi silencing machinery components, (ii) miRNA precursors or (iii) target sites. These might likewise alter miRNA-target interaction and could be responsible for substantial differences in gene expression level. They have been compiled in a public database (“Patrocles”: www.patrocles.org), where they are classified in (i) DNA sequence polymorphisms (DSP) affecting the silencing machinery, (ii) DSP affecting miRNA structure or expression and (iii) DSP affecting miRNA target sites. DSP from the last category were organized in four classes: destroying a target site conserved between mammals (DC), destroying a non-conserved target site (DNC), creating a non-conserved target site (CNC), or shifting a target site (S). To aid in the identification of the most relevant DSP (such as those were a target site is created in an antitarget gene), we have quantified the level of coexpression for all miRNA-gene pairs. Analysis of the numbers of Patrocles-DSP as well as their allelic frequency distribution indicates that a substantial proportion of them undergo purifying selection. The signature of selection was most pronounced for the DC class but was significant for the DNC and CNC class as well, suggesting that a significant proportion of non-conserved targets is truly functional. The Patrocles database allowed for the selection of DSP that are likely to affect gene function and possibly disease susceptibility. The effect of these DSP is being studied both in vitro and in vivo. In conclusion, Patrocles-DSP could be widespread and underlie an appreciable amount of phenotypic variation, including common disease susceptibility. [less ▲]

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See detailCompiling polymorphic miRNA-target interactions: the Patrocles database.
Hiard, Samuel ULg; Tordoir, Xavier ULg; Coppieters, Wouter ULg et al

Poster (2007, February 15)

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of ... [more ▼]

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of muscle growth - and creates an illegitimate target site for miRNA expressed in the same tissue. This causes miRNA-mediated translation inhibition of mutant GDF8 transcripts which leads to muscle hypertrophy. We followed up on this finding by searching for common polymorphisms and mutations that affect either (i) RNAi silencing machinery components, (ii) miRNA precursors or (iii) target sites. These might likewise alter miRNA-target interaction and could be responsible for substantial differences in gene expression level. They have been compiled in a public database (“Patrocles”: www.patrocles.org), where they are classified in (i) DNA sequence polymorphisms (DSP) affecting the silencing machinery, (ii) DSP affecting miRNA structure or expression and (iii) DSP affecting miRNA target sites. DSP from the last category were organized in four classes: destroying a target site conserved between mammals (DC), destroying a non-conserved target site (DNC), creating a non-conserved target site (CNC), or shifting a target site (S). To aid in the identification of the most relevant DSP (such as those were a target site is created in an antitarget gene), we have quantified the level of coexpression for all miRNA-gene pairs. Analysis of the numbers of Patrocles-DSP as well as their allelic frequency distribution indicates that a substantial proportion of them undergo purifying selection. The signature of selection was most pronounced for the DC class but was significant for the DNC and CNC class as well, suggesting that a significant proportion of non-conserved targets is truly functional. The Patrocles database allowed for the selection of DSP that are likely to affect gene function and possibly disease susceptibility. The effect of these DSP is being studied both in vitro and in vivo. In conclusion, Patrocles-DSP could be widespread and underlie an appreciable amount of phenotypic variation, including common disease susceptibility. [less ▲]

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See detailComplement activation during cardiopulmonary bypass in infants and children: Relation to postoperative multiple system organ failure
Seghaye, Marie-Christine ULg; Duchateau, J.; Grabitz, R. G. et al

in Journal of Thoracic and Cardiovascular Surgery (1993), 106(6), 978-987

Twenty-nine children 3 months to 17 years of age undergoing operations for congenital heart disease were included in this prospective study. Complement activation, activation of the plasma contact system ... [more ▼]

Twenty-nine children 3 months to 17 years of age undergoing operations for congenital heart disease were included in this prospective study. Complement activation, activation of the plasma contact system, leukocytes, leukocyte elastase release, and C-reactive protein were studied during and after cardiopulmonary bypass for the first postoperative week and related to multiple system organ failure occurring in eight (27.5 %) of the 29 children. During cardiopulmonary bypass complement activation via the alternative pathway as indicated by significant conversion of C3 (expressed by C3d/C3) and abnormally high C5a values at the end of cardiopulmonary bypass without consumption of C4 was shown in all children. At the end of cardiopulmonary bypass, C3 conversion was significantly higher in the eight patients with multiple system organ failure than in the others (p < 0.05), whereas no difference in C5a level was shown. All children had a significant increase in leukocyte count directly after protamine administration (p < 0.0001) and elastase release during cardiopulmonary bypass that was significantly higher in patients with multiple system organ failure than in those without (p < 0.05). Consumption of prekallikrein as an indicator of activation of the Hageman system was not detectable during cardiopulmonary bypass in any child. After cardiopulmonary bypass, in patients without multiple system organ failure, C3d/C3 decreased and reached preoperative values within the first postoperative week, whereas, in patients with multiple system organ failure, C3d/C3 increased further, reaching a maximal value on the third postoperative day. In comparison with patients without multiple system organ failure, patients with multiple system organ failure showed a severe decrease of C4 (with minimal values on the third postoperative day), suggesting consumption by activation of the classic pathway of the complement system or a hepatic synthesis deficiency. Prekallikrein values were also significantly lower in patients with multiple system organ failure than in the others, with a maximal difference on the third postoperative day (p < 0.005). C-reactive protein was significantly lower in patients with multiple system organ failure than in the others for the first 2 postoperative days (p < 0.05), probably because of severe hepatic failure in patients with multiple system organ failure. This study demonstrates that, in children, cardiopulmonary bypass induces complement activation principally via the alternative pathway. It suggests a relationship between complement activation and multiple system organ failure observed in the postoperative period. Furthermore, it points out the role of multiple system organ failure itself on the C3 conversion and on the synthesis of the markers of the inflammatory response in children after heart operations. [less ▲]

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See detailComplement activation during hemodialysis
Malaise, Michel ULg; Lust, Catherine ULg; Foidart, J. B. et al

in New England Journal of Medicine [=NEJM] (1985), 312(8), 514-515

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See detailComplement activation in patients at risk of developing the adult respiratory distress syndrome.
Duchateau, J.; Haas, M.; Schreyen, H. et al

in American Review of Respiratory Disease (1984), 130(6), 1058-64

In this prospective study of 50 patients, 36 of whom developed the adult respiratory distress syndrome (ARDS), early and intense complement activation was demonstrated. These patients were at risk of the ... [more ▼]

In this prospective study of 50 patients, 36 of whom developed the adult respiratory distress syndrome (ARDS), early and intense complement activation was demonstrated. These patients were at risk of the ARDS because of multiple injuries, major abdominal surgery, acute pancreatitis, severe burns, or disseminated intravascular coagulation. Abnormal C3 consumption (as measured by the C3d/C3 ratio) and elevated plasma C5a-like activity (as measured by a leukocyte aggregation assay) were associated with, respectively, 84 and 86% of cases of ARDS. Both tests were more sensitive indicators of complement consumption than were assays of total hemolytic complement activity (CH50) or total C3. The C3d/C3 ratio showed a close, inverse correlation with CH50 in 47 healthy subjects, and was increased in 12 control patients after minor surgery. The C5a-like activity was found only in patients at risk of ARDS; it was highly associated with clinical conditions that predispose to the ARDS, but it cannot be considered as a real predictor of ARDS occurrence in these patients. Sequential samples from both sides of the pulmonary circulation showed initial pulmonary clearance followed by the release of C5a-like activity. No simultaneous changes in C3 levels were found, suggesting the possible presence of modulating factors. These observations suggest that other factors (e.g., hypoxia and metabolic cascades) may influence the development of ARDS. [less ▲]

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See detailComplément au rapport final de synthèse du projet 4M-µpompe 2004
Raucent, Benoit; Dereine, E.; Smal, Olivier et al

Report (2004)

The 4M-µpump project attempts to breach the gap between traditional mechanics and micro mechanics and this in two ways. The first one consists in producing a general set of rules suitable for the ... [more ▼]

The 4M-µpump project attempts to breach the gap between traditional mechanics and micro mechanics and this in two ways. The first one consists in producing a general set of rules suitable for the miniaturisation of well-known macromachines. The second one consists in developing this fundamental aspect of the research through the design and realization of an implantable pump dedicated to the administration of medication agents inside the human body. The project thus touches upon the field of design, manufacturing, metrology and assembly of mini components as well as the study of minimotors. [less ▲]

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See detailComplément d'épidémiologie
Bruyère, Olivier ULg

Learning material (2011)

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See detailComplement extraposition: what is it a diagnostic of?
Gentens, Caroline; Brems, Lieselotte ULg

Conference (2013, May)

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See detailLe complément sujet : Etude de l'utilisation des pronoms moi et je dans le discours d'enfants âgés de 2 ans et demi à 10 ans.
Boulard, Aurore ULg; Gauthier, Jean-Marie ULg

in Bolasco, Sergio; Chiari, Isabella; Giuliano, Luca (Eds.) Statistical Analysis of Textual Data: Proceedings of 10th International Conference Journées d’Analyse statistique des Données Textuelles 9-11 June 2010 - Sapienza University of Rome (2010)

Grâce à l’analyse statistique discursive d’un corpus constitué du discours de 90 enfants, nous avons pu observer l’évolution de l’utilisation des pronoms personnels moi et je et mettre en évidence ... [more ▼]

Grâce à l’analyse statistique discursive d’un corpus constitué du discours de 90 enfants, nous avons pu observer l’évolution de l’utilisation des pronoms personnels moi et je et mettre en évidence certaines variations d’utilisation en fonction de l’âge et de trois conditions d’enregistrement. Le protocole de recherche utilisé nous permet de laisser le sujet libre de s’exprimer. Aucun thème n’a été proposé aux enfants. « En recueillant paroles et textes libres, le chercheur accède à tout l’univers du sujet, riche de sa singularité individuelle et de son appartenance culturelle et sociale. » (Moscarola, 2001). Ce n’est pas le développement du langage qui est étudié mais bien le discours qui, selon nous, permet un accès au sens, aux structures psychiques de l’individu. L’analyse du discours nous permet d’étudier le développement de la conscience de soi grâce à une méthodologie simple et non contraignante pour les enfants. Cette recherche trouve son originalité dans le croisement des résultats de l’analyse statistique textuelle (Lexico3, Tropes) avec les théories du développement de la conscience de soi. Les résultats de ces analyses nous montrent que dès l’instant où le je apparaît, le moi auparavant utilisé seul en tant que sujet se transforme en complément du sujet-je. En tant que complément du sujet, il objective le sujet parlant, lui permettant une mise à distance. Le sujet peut donc se regarder agir, faire où être en tant qu’objet. La forme moi-je, également fréquente dans le discours de l’enfant, est pour nous, sans doute, la forme réflexive la plus claire de l’avènement de la conscience de soi se manifestant par le biais du discours narratif autobiographique. Plus tard dans le discours de l’enfant, le je va pouvoir exister seul. Notre hypothèse est qu’étant davantage conscient de lui-même, l’enfant n’aurait plus systématiquement recours à la projection de son moi pour prendre conscience de son existence en tant qu’être parmi les autres. [less ▲]

Detailed reference viewed: 173 (36 ULg)