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Peer Reviewed
See detailLes cellules dendritiques folliculaires: phenotype, origine et fonctions.
Heinen, Ernst ULg

in Pathologie Biologie (1995), 43(10), 848-57

Follicular dendritic cells (FDC) are only located in lymph node follicles and particularly developed in the light zones of the germinal centers. FDC differ on important points from the classical dendritic ... [more ▼]

Follicular dendritic cells (FDC) are only located in lymph node follicles and particularly developed in the light zones of the germinal centers. FDC differ on important points from the classical dendritic cells presenting antigens to T cells. They are long-lived and derived from local mesenchymal cells. Their complex cytoplasmic extensions, covered with dendrites, are intermingled in a network which surrounds germinal B and T cells. On their surface, receptors fix immune complexes without endocytosis and adhesion molecules ensure close contacts to the lymphoid cells. FDC influence the migration, activation, proliferation, survival and differentiation of B cells into memory cells and probably act also on the germinal center T cells. [less ▲]

Detailed reference viewed: 99 (6 ULg)
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See detailLes cellules ECL et leurs récepteurs: rôle physiologique et intérêt physiopathologique
Belaiche, Jacques ULg; Delwaide, Jean ULg; Louis, Edouard ULg et al

in Acta Gastro-Enterologica Belgica (1993), 56(3-4, May-Aug), 235-44

The enterochromaffin-like (ECL) cells represent the predominating endocrine cell population in the oxyntic mucosa of the stomach. They are under the influence of gastrin. Recently, a histamine production ... [more ▼]

The enterochromaffin-like (ECL) cells represent the predominating endocrine cell population in the oxyntic mucosa of the stomach. They are under the influence of gastrin. Recently, a histamine production was shown within the secretory granules of ECL cells. ECL cells appear to play a crucial role in the physiology of gastric acid secretion. There are many unknowns concerning the intervention of other trophic factors in addition to gastrin and concerning the receptors located on the cells. ECL cell hyperplasia is a well documented consequence of hypergastrinemia. The latter can result from a gastrinoma or from a reduction of gastric acid secretion related to pernicious anemia or to long-term treatment with antisecretory drugs. [less ▲]

Detailed reference viewed: 53 (3 ULg)
See detailLes cellules enterochromaffin-like (ECL) : de la physiologie à la pathologie
Belaiche, Jacques ULg; Delwaide, Jean ULg; Louis, Edouard ULg et al

in Médecine et Hygiène (1992), 50

Detailed reference viewed: 24 (2 ULg)
See detailLes cellules Immobilisées. Techniques du Génie Biochimique
Thonart, Philippe ULg; Paquot, Michel ULg; Baijot, B. et al

in Annales de Gembloux (1983), 89

Detailed reference viewed: 19 (2 ULg)
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See detailLes cellules souches cancereuses.
Boniver, Jacques ULg; Herfs, Michael ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2011), 166(3-4), 141-5146

In tumours, a significant fraction of neoplastic cells are engaged in the cell cycle (growth fraction) and are therefore targets for radiation therapy and chemotherapy. Unfortunately, in most disseminated ... [more ▼]

In tumours, a significant fraction of neoplastic cells are engaged in the cell cycle (growth fraction) and are therefore targets for radiation therapy and chemotherapy. Unfortunately, in most disseminated cancers, such treatments cannot lead to complete cure. Many different mechanisms have been described to explain this resistance. The hypothesis of the existence of "cancer stem cells "has been recently proposed. Indeed, the tumour would contain a small subpopulation of cancer cells displaying the phenotypical characteristics of multipotential stem cells. Since such cells display different signalling pathways compared with more differentiated cells, this might explain at least partially the resistance to treatments. Chronic myeloid leukaemia is a good model in favour of cancer stem cells, but the presence of such cells in all types of cancers is still a matter of debate. Several questions emerge: is the multipotential stem cell, the cell of origin of cancer? What is the relevance of the cancer stem cell paradigm for understanding cancer cell biology and to envision new therapeutic, hopefully curative, therapies? The case of chronic myeloid leukaemia is used to discuss these questions. [less ▲]

Detailed reference viewed: 30 (7 ULg)
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See detailLes cellules souches mesenchymateuses: une nouvelle therapeutique polyvalente.
Baron, Frédéric ULg; Gothot, André ULg

in Revue Médicale de Liège (2007), 62 Spec No

Mesenchymal stem cells (MSC) reside in the stromal compartment of the hematopoietic bone marrow. Although present in small numbers in vivo, MSC may be easily isolated and expanded in cell culture. MSC are ... [more ▼]

Mesenchymal stem cells (MSC) reside in the stromal compartment of the hematopoietic bone marrow. Although present in small numbers in vivo, MSC may be easily isolated and expanded in cell culture. MSC are able to generate bone, cartilage, fat, and under specific conditions, liver, muscle and nerve. Numerous studies have suggested a potential use of MSC to repair degenerative or traumatic lesions, in organs where tissue repair is limited. Furthermore, MSC are endowed with immunosuppressive properties, utilized to control graft versus host disease and rejection of allogenic hematopoietic stem cell transplants. [less ▲]

Detailed reference viewed: 122 (8 ULg)
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See detailCellules stromales mésenchymateuses et transplantation d'organes
DETRY, Olivier ULg; JOURET, François ULg; VANDERMEULEN, Morgan ULg et al

in Revue Médicale de Liège (2014), 69

Mesenchymal stromal cells (MSC) are multipotent and self-renewing cells. MSC are studied for their in vivo and in vitro immunomodulatory effects, in the prevention or the treatment of ischemic injury, and ... [more ▼]

Mesenchymal stromal cells (MSC) are multipotent and self-renewing cells. MSC are studied for their in vivo and in vitro immunomodulatory effects, in the prevention or the treatment of ischemic injury, and for their potential properties of tissue or organ reconstruction. Over the last few years, the potential role of MSC in organ transplantation has been studied both in vitro and in vivo, and their properties make them an ideal potential cell therapy after solid organ transplantation. A prospective, controlled, phase 1-2 study has been initiated at the CHU of Liege, Belgium. This study assesses the potential risks and benefits of MSC infusion after liver or kidney transplantation. Even if the preliminary results of this study look promising, solely a prospective, randomized, large scale, phase 3 study will allow the clinical confirmation of the theoretical benefits of MSC in solid organ transplantation. [less ▲]

Detailed reference viewed: 93 (34 ULg)
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See detailCellules Tumorales Circulantes : détection, caractérisation et intérêts cliniques
Gilles, Christine ULg; COLLIGNON, Joëlle ULg; Noël, Agnès ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 279-84

The metastatic process generates circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in bone marrow and other organs which can remain as occult metastases. Various methods and systems have ... [more ▼]

The metastatic process generates circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in bone marrow and other organs which can remain as occult metastases. Various methods and systems have been developed to allow the isolation and identification of those cells but major technical limitations still exist. Research on CTCs is a nevertheless tremendously growing field of cancer research because of their potential clinical applications. CTCs indeed convey predictive information for the development of metastasis and recurrence, and prognostic information regarding patient survival. CTCs enumeration could also be used to monitor the effectiveness of adjuvant treatments. Moreover, enhancing our basic understanding of the metastatic process, CTCs, and DTCs in particular, are thought to contain subpopulations of cells with stem cells properties that would be responsible for relapses. [less ▲]

Detailed reference viewed: 256 (14 ULg)
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See detailCellulite faciale sévère au départ d'une lésion de varicelle - à propos d'un cas
Bourcy, Emilie ULg; Saliba, Mariane ULg; NYAMUGABO MUNYERE NKANA, Kindja ULg et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015, January), 17(1), 113

Detailed reference viewed: 22 (1 ULg)
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See detailCellulite histopathology and related mechanobiology.
Quatresooz, Pascale ULg; Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg et al

in International Journal of Cosmetic Science (2006), 28(3), 207-10

Cellulite, sometimes called gynoid lipodystrophy, is much more prevalent in women than in men. There are glaring discrepancies regarding the microanatomical descriptions of this condition in the ... [more ▼]

Cellulite, sometimes called gynoid lipodystrophy, is much more prevalent in women than in men. There are glaring discrepancies regarding the microanatomical descriptions of this condition in the literature. A lumpy aspect of the dermo-hypodermal interface is often cited, but it appears to represent a gender-linked characteristic of the thighs and buttocks without being a specific sign of cellulite. Incipient cellulite recognized by a discrete padded look or 'orange peel' aspect appears correlated with the presence of a network of focally enlarged fibrosclerotic strands partitioning the hypodermis and serving as a physiological buttress limiting the outpouching of fat lobules on pinching the skin. These connective tissue structures might represent a hormonal-dependent reactive process to sustained mechanical tensions caused by the adipocyte lobules. Full blown cellulite is recognized by a lumpy-bumpy and dimpled skin surface. It likely represents subjugation of the hypertrophic response of the hypodermal connective tissue strands when their resistance is overcome by progressive fat accumulation. In these cases, histological aspects reminiscent of striae distensae are identified within the hypodermal connective tissue strands. The mechanical properties of skin involved by cellulite process are altered, but may tend to resume to normal under treatment. These functional changes influence the mechanobiology of connective tissue cells, in particular the Factor XIIIa-positive dermal dendrocytes. [less ▲]

Detailed reference viewed: 62 (1 ULg)
Peer Reviewed
See detailCellulite: from standing fat herniation to hypodermal stretch marks.
Pierard, Gérald ULg; NIZET, Jean-Luc ULg; PIERARD-FRANCHIMONT, Claudine ULg

in American Journal of Dermatopathology (2000), 22(1), 34-7

There are glaring discrepancies in the microanatomical descriptions of cellulite in the literature. We revisited this common skin condition in women with a microscopic examination of 39 autopsy specimens ... [more ▼]

There are glaring discrepancies in the microanatomical descriptions of cellulite in the literature. We revisited this common skin condition in women with a microscopic examination of 39 autopsy specimens. A control group consisted of 4 women and 11 men showing no evidence of cellulite. The lumpy aspect of the dermohypodermal interface appeared to represent a gender-linked characteristic of the thighs and buttocks without being a specific sign of cellulite. Incipient cellulite identified by the mattress phenomenon was related to the presence of focally enlarged fibrosclerotic strands partitioning the subcutis. Such strands possibly serve as a physiologic buttress against fat herniation limiting the outpouching of fat lobules on pinching the skin. These structures might represent a reactive process to sustained hypodermal pressure caused by fat accumulation. Full-blown cellulite likely represents subjugation of the hypertrophic response when connective tissue is overcome by progressive fat accumulation. Histologic aspects reminiscent of stretch marks are identified within the hypodermal strands, resulting in clinical skin dimpling. [less ▲]

Detailed reference viewed: 51 (3 ULg)
See detailCellulose bioavailability in municipal solid waste
Rodriguez, Ch.; Hiligsmann, Serge ULg; Charlier, Robert ULg et al

Poster (2003, May 09)

Detailed reference viewed: 24 (4 ULg)
See detailCellulose bioavailability in waste
Rodriguez, Ch.; Hiligsmann, Serge ULg; Lardinois, M. et al

Poster (2002, October)

Detailed reference viewed: 15 (1 ULg)
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See detailCellulose enzymatic availability in Municipal solid waste
Rodriguez, C.; Hiligsmann, Serge ULg; Ongena, MARC ULg et al

in Christensen; Cossu; Stegmann (Eds.) Proceedings Sardinia 03, Ninth International Waste Management and Landfill Symposium (2003)

We recently developed a new and rapid method to evaluate the biological reactivity of cellulose in Municipal Solid Waste (MSW). This test is based on the enzymatic hydrolysis of cellulose in MSW and can ... [more ▼]

We recently developed a new and rapid method to evaluate the biological reactivity of cellulose in Municipal Solid Waste (MSW). This test is based on the enzymatic hydrolysis of cellulose in MSW and can be related to the digestibility of this polymer in MSW. In this work, we showed that the enzymatic cellulose degradation test (ECD) correlated well with a Biochemical Methane Potential (BMP) assay so that the ECD test can be reliably applied to estimate cellulose bioavailability in various waste samples. These tests have also been used to evaluate the influence of some important parameters that could affect the extent and the rate of cellulose degradation in waste. It appeared that cellulose enzymatic hydrolysis is related to the moisture content but no clear relationship could be established with the cellulose content. Moreover, it is shown that acetic acid produced by the anaerobic degradation of organic matter, and responsible for high COD in young leachates, may slow down or inhibit the enzymatic hydrolysis step and the methanogenesis. [less ▲]

Detailed reference viewed: 125 (7 ULg)
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See detailCellulose enzymatic availability in waste refuse
Rodriguez, C.; Hiligsmann, Serge ULg; Lardinois, M. et al

in Christensen; Cossu; Stegmann (Eds.) Proceedings Sardinia 01, Eight International Waste Management and Landfill Symposium (2001)

This work presents an original method for testing the biological reactivity of cellulose. This test specifically targets one of the limiting steps of cellulose bioconversion into biogas, i.e. the ... [more ▼]

This work presents an original method for testing the biological reactivity of cellulose. This test specifically targets one of the limiting steps of cellulose bioconversion into biogas, i.e. the cellulose hydrolysis. From this point of view, enzymes-mediated hydrolysis has been performed to evaluate cellulose bioavailability in refuse samples from different layers of an old landfill. The relationship between the cellulose enzymatic accessibility and the lignin contents has also been studied. Similarly, the correlation between cellulose, lignin and humic acid contents has been investigated. On the other hand, moisture content in landfills is considered as one of the most important factors that favours methanogenesis. In this respect, the influence of moisture content on cellulose enzymatic hydrolysis has also been evaluated. [less ▲]

Detailed reference viewed: 73 (2 ULg)
See detailCellulose Hydrolysis of papermill sludge
Paquot, Michel ULg; Herman, L.

Book (1983)

Detailed reference viewed: 10 (2 ULg)
See detailCellwise robust regularized discriminant analysis
Aerts, Stéphanie ULg; Wilms, Ines

Conference (2017, June 02)

Quadratic and Linear Discriminant Analysis (QDA/LDA) are the most often applied classification rules under normality. In QDA, a separate covariance matrix is estimated for each group. If there are more ... [more ▼]

Quadratic and Linear Discriminant Analysis (QDA/LDA) are the most often applied classification rules under normality. In QDA, a separate covariance matrix is estimated for each group. If there are more variables than observations in the groups, the usual estimates are singular and cannot be used anymore. Assuming homoscedasticity, as in LDA, reduces the number of parameters to estimate. This rather strong assumption is however rarely verified in practice. Regularized discriminant techniques that are computable in high-dimension and cover the path between the two extremes QDA and LDA have been proposed in the literature. However, these procedures rely on sample covariance matrices. As such, they become inappropriate in presence of cellwise outliers, a type of outliers that is very likely to occur in high-dimensional datasets. We propose cellwise robust counterparts of these regularized discriminant techniques by inserting cellwise robust covariancematrices. Ourmethodologyresultsinafamilyofdiscriminantmethods that are robust against outlying cells, cover the gap between LDA and QDA and are computable in high-dimension. [less ▲]

Detailed reference viewed: 10 (1 ULg)