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See detailCirculating erythropoietin levels after bone marrow transplantation: inappropriate response to anemia in allogeneic transplants.
Beguin, Yves ULg; Clemons, G. K.; Oris, Renée ULg et al

in Blood (1991), 77(4), 868-73

We studied 24 recipients of autologous bone marrow transplantation (ABMT) or allogeneic BMT (BMT) to determine whether impaired erythropoietin (Epo) response to anemia could delay full erythropoietic ... [more ▼]

We studied 24 recipients of autologous bone marrow transplantation (ABMT) or allogeneic BMT (BMT) to determine whether impaired erythropoietin (Epo) response to anemia could delay full erythropoietic recovery. Observed Epo levels were compared with predicted levels based on the relationship between Epo and hematocrit in 125 control subjects. Circulating Epo levels were normal during conditioning and the early posttransplant period. Between days 21 and 180, Epo levels remained normal in ABMT patients but were inappropriately low for the degree of anemia in BMT patients. Median time to full erythropoietic engraftment was longer in BMT than in ABMT recipients. Circulating Epo returned to appropriate levels after day 180, except in patients with active cytomegalovirus infection. We conclude that impaired Epo response to anemia can contribute to delayed erythropoietic recovery after allogenic BMT. Renal toxicity of ciclosporin, interaction between host and donor marrow, and cytomegalovirus infection might play a role. This study could support the use of recombinant human Epo to accelerate erythropoietic engraftment after BMT. [less ▲]

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See detailCirculating insulin antibodies: influence of continuous subcutaneous or intraperitoneal insulin infusion, and impact on glucose control.
Radermecker, Régis ULg; Renard, E; Scheen, André ULg

in Diabetes/Metabolism Research & Reviews (2009)

The purification of animal insulin preparations and the use of human recombinant insulin have markedly reduced the incidence, but not completely suppressed, the development of anti-insulin antibodies (IAs ... [more ▼]

The purification of animal insulin preparations and the use of human recombinant insulin have markedly reduced the incidence, but not completely suppressed, the development of anti-insulin antibodies (IAs). Advances in technologies concerning the mode of delivery of insulin, i.e. continuous subcutaneous insulin infusion (CSII), continuous peritoneal insulin infusion (CPII) and more recently inhaled insulin administration, appear to significantly increase circulating levels of immunoglobulin G (IgG) anti-IAs in diabetic patients. However, the increase is usually moderate and mostly transient as compared to previous observations with poorly purified animal insulin preparations. The clinical impact of these circulating anti-IAs remains unclear. Nevertheless, several studies have suggested that antibodies could retard insulin action, leading to a worsening of postprandial hyperglycaemia and/or serve as a carrier, thus leading to unexpected hypoglycaemia. CPII may be associated with more marked and sustained increase in IAs levels, possibly related to the use of an unstable insulin and the formation of immunogenic aggregates of insulin. The possible clinical consequences of these high levels of IAs remain to be evaluated because a low-glucose morning syndrome or severe insulin resistance with ketone bodies production have been reported in some cases. In conclusion, even if CSII and CPII may promote the development of circulating IAs, this increase does not lead to immunological insulin resistance, compared to that previously described with animal non-purified insulin preparations, and seems to have only marginal influence on blood glucose control or complications in most diabetic patients. [less ▲]

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See detailCirculating microRNA-based screening tool for breast cancer
Freres, Pierre ULg; Wenric, Stéphane ULg; Boukerroucha, Meriem et al

in Oncotarget (2015)

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative ... [more ▼]

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative screening procedure to mammography for breast cancer diagnosis. A plasma miRNA profile was determined by RT-qPCR in a cohort of 378 women. A diagnostic model was designed based on the expression of 8 miRNAs measured first in a profiling cohort composed of 41 primary breast cancers and 45 controls, and further validated in diverse cohorts composed of 108 primary breast cancers, 88 controls, 35 breast cancers in remission, 31 metastatic breast cancers and 30 gynecologic tumors. A receiver operating characteristic curve derived from the 8-miRNA random forest based diagnostic tool exhibited an area under the curve of 0.81. The accuracy of the diagnostic tool remained unchanged considering age and tumor stage. The miRNA signature correctly identified patients with metastatic breast cancer. The use of the classification model on cohorts of patients with breast cancers in remission and with gynecologic cancers yielded prediction distributions similar to that of the control group. Using a multivariate supervised learning method and a set of 8 circulating miRNAs, we designed an accurate, minimally invasive screening tool for breast cancer. [less ▲]

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See detailCirculating microRNAs as diagnostic markers in breast cancer patients and their deregulation under neoadjuvant chemotherapy
FRERES, Pierre ULg

Poster (2014, April 24)

Breast cancer is the leading cause of death by cancer among women and there is an urgent need to improve its diagnosis and prognosis. MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression ... [more ▼]

Breast cancer is the leading cause of death by cancer among women and there is an urgent need to improve its diagnosis and prognosis. MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression and many have been implicated in breast cancer. In this article, we focus on circulating miRNAs as biomarkers for breast cancers and we describe the deregulation of their expression during neoadjuvant chemotherapy (NAC). [less ▲]

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See detailCirculation and coastal processes off NW Africa
Elmoussaoui, Abdellali; Djenidi, Salim ULg; Kostianoy, Andrey et al

in Oceanic Fronts and Related Phenomena : Konstantin Fedorov International Memorial Symposium Proceedings (2000)

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See detailCirculation atmosphérique simulée par les modèles de circulation générale en Europe de l'ouest : évaluation et projections futures
Belleflamme, Alexandre ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

in Fazzini, Massimiliano; Beltrando, Gérard (Eds.) XXIVème colloque de l'Association Internationale de Climatologie - Climat montagnard et risques (2011, September)

Atmospheric circulation simulations from general circulation models are used as forcing for downscaling methods and for future projections. Thus, it is essential to evaluate them. An automatic circulation ... [more ▼]

Atmospheric circulation simulations from general circulation models are used as forcing for downscaling methods and for future projections. Thus, it is essential to evaluate them. An automatic circulation type classification is applied to daily 500 hPa geopotential height data. Firstly, the classification is done for the NCEP-NCAR 1 reanalysis, and then the main circulation types are imposed to the simulations of six general circulation models. For recent climate (20C3M scenario), it appears that most models are not able to simulate well the circulation over western Europe, due to biases in the mean geopotential height and an underestimation of the circulation variability. For future climate (A1B scenario), a general increase of the geopotential height is projected, leading to the emergence of new circulation types. [less ▲]

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See detailCirculation de souches non cytopathogènes du virus BVD-MD dans des lots de taurillons
Waxweiler, Sophie; Karelle-Bui Thi, Lucie; Sneyers, M. et al

in Annales de Médecine Vétérinaire (1989), 133

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See detailLa circulation des discours axiologiques négatifs dans la cour de récréation
Meunier, Deborah ULg

in Lopéz Muñoz, Juan Manuel; Marnette, Sophie; Rosier, Laurence (Eds.) et al La circulation des discours (2009)

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See detailLa circulation des incunables à Louvain au XVe siècle : étude sur la production du relieur Ludovicus Ravescot
Adam, Renaud ULg

in Daelemans, Frank (Ed.) Miscellanea in memoriam Pierre Cockshaw (1938-2008). Aspects de la vie culturelle dans les Pays-Bas méridionaux (2009)

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See detailLa circulation des personnes dans et vers l'Union européenne
Carlier, Jean-Yves ULg

in Journal de Droit Européen [=JDE] (2010)

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See detailLa circulation du livre humaniste italien en Brabant au XVe siècle
Adam, Renaud ULg

in Publication du Centre Européen d'Etudes Bourguignonnes (2015), 55

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See detailCirculation du sang
Fredericq, Léon ULg

in Richet, Charles (Ed.) Dictionnaire de physiologie. 003. Tome III (1898)

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See detailCirculation of the western Mediterranean: From global to regional scales
Beckers, Jean-Marie ULg; Brasseur, P.; Nihoul, Jacques ULg

in Deep-Sea Research Part II, Topical Studies in Oceanography (1997), 44(3-4), 531-549

A free-surface, three-dimensional, primitive equation model has been implemented with a horizontal resolution of 4.6 km to study the ocean circulation in the Gulf of Lions at time scales ranging from ... [more ▼]

A free-surface, three-dimensional, primitive equation model has been implemented with a horizontal resolution of 4.6 km to study the ocean circulation in the Gulf of Lions at time scales ranging from weeks to seasons. Numerical experiments have been conducted, in which the regional model is nested into a basin-scale model of the whole western Mediterranean. The global model is operated with a relatively coarse resolution (16 km) and provides boundary conditions at the open-sea boundaries of the regional domain. There is, however, no Feedback loop from the regional to the global model. The simulations are consistently driven with atmospheric fluxes computed from the output of the French PERIDOT meteorological forecasting system, between August 1988 and 1989. In addition to the initial conditions, in situ measurements of temperature and salinity are assimilated in the simulation of the general circulation, adopting a simple nudging technique to prevent an excessive drift of the model against climatology. The response of the regional model below and above the thermocline is discussed in the context of the prevailing meteorological situations. Some experiments give indications that a double-gyre system may develop from wind regimes that exhibit a cyclonic/anticyclonic wind stress curl. Advection-diffusion of passive tracers are also examined on the basis of the local hydrodynamic features, because this work has been conceived with the aim of determining the physical conditions in which ecological and biochemical processes develop at the interface between river mouths and the open ocean. (C) 1997 Elsevier Science Ltd. [less ▲]

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See detailLa circulation utero-placentaire
Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Revue Française de Gynécologie et d'Obstétrique (1991), 86(10), 579-84

Detailed reference viewed: 15 (1 ULg)