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See detailComparative study of pirlindole, a selective RIMA, and its two enantiomers using biochemical and behavioural techniques.
Bruhwyler, J.; Liégeois, Jean-François ULg; Gerardy, J. et al

in Behavioural Pharmacology (1998), 9(8), 731-7

The interaction with monoamine oxidase A (MAO-A) and B has been shown to be sensitive to the absolute configuration of molecules. Therefore, the aim of this study was to compare the effects of the racemic ... [more ▼]

The interaction with monoamine oxidase A (MAO-A) and B has been shown to be sensitive to the absolute configuration of molecules. Therefore, the aim of this study was to compare the effects of the racemic pirlindole (a selective and reversible MAO-A inhibitor) and its two enantiomers using biochemical techniques (in vitro and ex vivo determination of rat brain MAO-A and MAO-B activity) and behavioural models (forced swimming test and reserpine-induced hypothermia and palpebral ptosis test). In vitro, the MAO-A IC50 of (+/-)-pirlindole, R-(-)-pirlindole and S-(+)-pirlindole were 0.24, 0.43 and 0.18 microM, respectively. Ex vivo, their ID50 were 24.4, 37.8 and 18.7 mg/kg i.p. The differences between the three compounds were not significant, with a ratio between the two enantiomers [R-(-)/S-(+)] of 2.2 in vitro and 2.0 ex vivo. MAO-B was only slightly inhibited. In the forced swimming test and the reserpine-induced hypothermia and ptosis model, the three compounds had an antidepressant profile. In the forced swimming test, the minimal effective dose ratio between the R-(-) and the S-(+) was again around 2.0. The behavioural observations were thus clearly in accordance with the biochemical data. [less ▲]

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See detailComparative study of psychopathological features and temporalis second exteroceptive silent period in chronic tension-type headache: is 5-HT the common denominator?
Dawans, A.; Schoenen, Jean ULg; Timsit, M. et al

in Olesen, J.; Saxena, P. R. (Eds.) 5-Hydroxytrytamine Mechanisms in Primary Headaches (Frontiers in Headache Research) (1992)

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See detailA comparative study of quantitative shape analysis techniques in sedimentology
Pirard, Eric ULg; Hoyez, Bernard

in Zentralblatt für Geologie und Paläontologie. Teil I, Allgemeine, Angewandte, Regionale und Historische Geologie (1995), 1(H11/12), 1061-1066

Detailed reference viewed: 24 (3 ULg)
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See detailA comparative study of reporter gene activities in fish cells and embryos
Sekkali, B.; Hellemans, B.; Belayew, A. et al

in Molecular Marine Biology and Biotechnology (1994), 3

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See detailA comparative study of sexual product quality in F1 hybrids of the bream Abramis brama X the silver bream Blicca bjoerkna
Nzau Matondo, Billy ULg; Ovidio, Michaël ULg; Philippart, Jean-Claude ULg et al

in Fisheries Science (2012), 78

The gonadosomatic index at spawning, absolute fecundity, and egg size for the female sexual products as well as the density and consistency of semen for the male sexual products were examined in cultured ... [more ▼]

The gonadosomatic index at spawning, absolute fecundity, and egg size for the female sexual products as well as the density and consistency of semen for the male sexual products were examined in cultured Abramis brama 9 Blicca bjoerkna F1 hybrids and compared with the parental species at their first sexual maturity. Females ovulated under environmental conditions, and their eggs were weighed, counted and measured. Semen of males was macroscopically examined and spermatozoa counted using a hemocytometer. Results revealed that hybridization affected the quality of female and male gametes but with an overlap between hybrids and parents. The gonadosomatic index and fecundity were significantly lower than those of parental species. Egg sizes in hybrids showed a parental effect but to the benefit of hybrids. Semen of hybrids was more diluted which was classified into two groups: the white semen overlapping slightly with parents and the aqueous without any overlap with parents. Overlapped areas between hybrids and parents in term of quality of sexual products could translate that females and males of these hybrids have the biological capacity to produce high quality gametes and thus, a greater chance to produce F2 and backcross generations in rivers. [less ▲]

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See detailCOMPARATIVE STUDY OF SPR BIOSENSORS BASED GOLD AND SILVER COLLOIDAL NANOPARTICLES
Lismont, Marjorie ULg; Dreesen, Laurent ULg

Poster (2011, June)

Noble metal nanoparticles (NPs) can be used as a robust tool for optical bio-sensing. These NPs are known for their strong interactions with light through their surface plasmon resonance (SPR), which ... [more ▼]

Noble metal nanoparticles (NPs) can be used as a robust tool for optical bio-sensing. These NPs are known for their strong interactions with light through their surface plasmon resonance (SPR), which corresponds to the collective oscillations of the conduction electrons on the particles [1]. Among metals, silver and gold NPs are of particular interest not only because they are air-stable but also because their SPR absorption bands are in the visible and near ultra-violet spectral regions, that appear as the most appropriate for technological applications [2]. The first advantage of such optical SPR biosensors is their ability to measure complex formation in real time. Indeed, the SPR absorption spectrum band of the NPs is sensitive to the shape, size, inter-particle distance and composition of the NP as well as the dielectric properties of the surrounding medium [2]. Because of the sensitivity of SPR to the local dielectric environment, plasmonic NPs can act as transducers that convert small changes in the local refractive index and the inter-particle distance into spectral shifts and broadening in the absorption spectra bands [3]. Biotin is a water-soluble B complex vitamin necessary for the production of fatty acids and the metabolism of fats and amino acids. The avidin is a tetrameric protein which can react with biotin to form the strongly bonded biotin-avidin complex.The prototypical biotin-avidin interaction forms the basis of a simple sol-based diagnostic technique for biological analytes. We focused on this well-known couple of bio-molecules to compare optical properties of silver and gold colloidal NPs. Gradual changes with time in the absorption spectra bands of biotinylated 10 nm silver and gold NPs were studied as a function of added avidin. After avidin addition, an increased red-shift of the SPR wavelength and a broadening of the absorption band with time are observed. These changes in the optical properties of colloidal NPs are due to the biomolecular recognition process between biotin and avidin which leads to aggregation of these NPs arising from cross-linking by the tetrameric protein. Moreover, the recognition process induces a variation of the local refractive index around these NPs and thus induces a red-shift of SPR also. The maximum SPR red-shift was reached after 45 minutes and was equal to 25 nm and 15 nm for silver NPs and gold NPs respectively. We concluded that the dielectric sensitivity of gold NPs is smaller than the silver NPs one for a same geometry and for an equivalent concentration of avidin. Therefore, the silver sol is more adapted to detection of avidin than the gold sol. The detection limit, described as the lowest concentration for clear identification of wavelength shift [4] due to biomolecular recognition is determined to be 4 nM for both silver and gold NPs. In this case, the corresponding wavelength shift is about 3 nm. The specificity of the interaction between biocytin and avidin was checked by replacing avidin by BSA. When BSA was added, we observed a SPR shift which was smaller than the detection limit of 3 nm. Future works will be devoted to transpose this kind of biomolecular recognition experiments on gold nanorods in order to improve the dynamic phototherapy efficiency of cancers. [less ▲]

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See detailA Comparative Study of the Antimycotic Activity of a Miconazole Hp-Beta Cyclodextrin Solution and a Surfactant Solution
Piel, Géraldine ULg; Hayette, Marie-Pierre ULg; Evrard, Brigitte ULg et al

in Journal de Pharmacie de Belgique (1999), 54(3, May-Jun), 87-8

The antimycotic activity of a new parenteral solution containing miconazole was compared to that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the belgian market ... [more ▼]

The antimycotic activity of a new parenteral solution containing miconazole was compared to that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the belgian market probably because of the toxic effects related to the presence of polyoxyl 35 castor oil. We propose a new formulation containing 10 mg of miconazole per ml (as the marketed solution), in combination with HP-beta cyclodextrin and lactic acid. The MIC of these two solutions were determined by broth microdilution method (following the NCCLS guidelines) against 15 yeasts and 16 filamentous fungi isolates. This study showed that MIC obtained with these two solutions are not significantly different. In vitro, the cyclodextrin solution has the same antimycotic activity as the Daktarin IV solution and can be proposed as a safe and effective parenteral solution to replace the previous surfactant solution. [less ▲]

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See detailComparative study of the body surface electrocardiogram in double-muscled and conventional calves.
Amory, Hélène ULg; Rollin, Frédéric ULg; Genicot, Bruno et al

in Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire (1993), 57(3), 139-45

The purpose of this work was to study electrocardiographic features of double-muscled beef cattle. Electrocardiograms were recorded on one to six occasions from each of a group of 18 conventional calves ... [more ▼]

The purpose of this work was to study electrocardiographic features of double-muscled beef cattle. Electrocardiograms were recorded on one to six occasions from each of a group of 18 conventional calves of the Friesian breed and 29 double-muscled calves of the Belgian White and Blue breed. Ages of the calves at the times of examination ranged from eight to 348 days. The Holmes semi-orthogonal lead system was used. The waves and interval durations and the tridimensional P, QRS, and T modal vector orientation and amplitude were calculated. The magnitude of the cardiac vectors was significantly lower and the ventricular waves and QT interval duration significantly shorter in the double-muscled than in the conventional calves. The P modal vector pointed significantly less downwards and the QRS modal vector pointed significantly more forwards and less up- and rightwards in the Belgian White and Blue, than in the Friesian group. Most of the observed differences might be a consequence of the bodily, and more specifically the thoracic, conformation of the former calves. However, the lower cardiac vector magnitude and shorter wave and interval durations might also reflect lower cardiac mass in the double-muscled subjects. [less ▲]

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See detailComparative study of the competitive models for the forward scattering data at high energies
Ezhela, V. V.; Lugovsky, S. B.; Tkachenko, N. P. et al

in Prokudin, A. V.; Petrov, V. (Eds.) ELASTIC AND DIFFRACTIVE SCATTERING (2000)

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See detailComparative study of the condensation of chicken erythrocyte and calf thymus chromatins by di- and multivalent cations.
Marquet, R.; Colson, Pierre ULg; Matton, Anne-Marie ULg et al

in Journal of Biomolecular Structure & Dynamics (1988), 5(4), 839-57

The condensation of chicken erythrocyte (CE) and calf thymus (CT) chromatins upon addition of di- and multivalent cations has been studied using turbidity, precipitation and electric dichroism ... [more ▼]

The condensation of chicken erythrocyte (CE) and calf thymus (CT) chromatins upon addition of di- and multivalent cations has been studied using turbidity, precipitation and electric dichroism measurements. For all the cations investigated (Mg2+, Tb3+, Co(NH3)6(3+), spermidine Spd2+ and spermine Sp4+) condensation of CE chromatin occurred before the onset of aggregation, while aggregation of CT chromatin started before condensation with all cations except Mg2+ and Tb3+. Precipitation of CE chromatin required lower di- and multivalent cations concentrations than CT chromatin. The electric dichroism data for both chromatins, at low ionic strength in the absence of di- or multivalent cations, indicated that the nucleoprotein molecules were not totally decondensed but that a "precondensed" state was already present. A positive electric dichroism was observed for the most condensed chromatin fibers, in agreement with the "cross-linker" models. Tb3+ led to less compact condensed particles as judged from the electric dichroism observations, but electron microscopy revealed that "30 nm fibers" were formed. Very little aggregation was produced by Tb3+. On the contrary, spermine produced very large networks of condensed molecules, but large spheroidal particles were also observed. The condensation of CE chromatin happened without changes of solution conductivity upon cation salt addition, regardless of the condensing cation, indicating a cooperative uptake of the ions during this process. [less ▲]

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See detailComparative study of the effect of drying temperatures and heat-moisture treatment on the physicochemical and functional properties of corn starch
Malumba Kamba, Paul ULg; Janas, Sébastien ULg; Roiseux, Olivier et al

in Carbohydrate Polymers (2010), 79(3), 633-641

This manuscript compares the modifications induced by the heat-moisture treatment of native starch (HMT) and by the hot-air drying of corn on wet-milled starch granules. High temperatures applied during ... [more ▼]

This manuscript compares the modifications induced by the heat-moisture treatment of native starch (HMT) and by the hot-air drying of corn on wet-milled starch granules. High temperatures applied during both corn drying and HMT reduced the swelling capacity of granules, increased the starch gelatinization temperatures and decreased their residual enthalpy. Pasting behaviour of pre-treated starch showed a decrease of peak and breakdown viscosity when corn drying and HMT temperatures increased. Microscopic analysis showed that after hydrothermal treatment, starch granules extracted from corn dried at lower temperature swell more significantly than those extracted from corn dried at higher temperature. All these changes suggest the occurring of structural modifications within starch granules during high-temperature pre-treatments. At similar temperatures and initial moisture contents, HMT affected the physicochemical and functional properties of cornstarch more dramatically than hot-air drying. Differences induced by these two treatments were attributed to the availability of water around granules during these two pre-treatment procedures. [less ▲]

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See detailComparative study of the effects of ethidium bromide and DNA-ethidium bromide complex on normal and cancer cells.
Heinen, Ernst ULg; Bassleer, R.; Calberg-Bacq, C. M. et al

in Biochemical Pharmacology (1974), 23(10), 1549-51

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See detailComparative study of the efficacy of fusidic acid and povidone iodine in childhood impetigo.
Szepetiuk, Gregory; Henry, Frédérique ULg; Pierard, Gérald ULg

in Journal of Pediatric Infectious Diseases (2006), 1

Impetigo is a superficial bacterial infection of the skin. It is a contagious condition particularly affecting children. In many instances, a topical antibacterial treatment is recommended to clear the ... [more ▼]

Impetigo is a superficial bacterial infection of the skin. It is a contagious condition particularly affecting children. In many instances, a topical antibacterial treatment is recommended to clear the disease. Topical antibiotics and antiseptics can be used, but the risk for antibiotic-induced bacterial resistance of the community-acquired type has been pointed out. The present study was undertaken as a randomized intraindividual comparative trial between fusidic acid (FA) cream and povidone iodine (PVP-I) gel in 40 children suffering from impetigo. Cultures revealed Staphylococcus aureus in the vast majority of the cases. The lesions present on each upper limb were treated twice daily with one or the other test formulation. Clinical assessments were performed twice weekly until cure. After one week, cure was obtained in 57.5% of the PVP-I-treated limbs compared to 32.5% of the FA-treated limbs. At the end of treatment cure was obtained first on the PVP-I treated sites in 67.5% of cases compared to 15% on the FA-treated sites. Clinical cure occurred simultaneously on both test sites in 17.5% of cases. In conclusion, PVP-I provided faster clinical cure than FA. Considering the treatment cost, the raising community-acquired staphylococci resistance to FA, and the results of the present study, PVP-I gel appears superior to FA cream in childhood impetigo. [less ▲]

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See detailA comparative study of the grammaticalized uses of English sort of and French genre de in teenage forum data
Davidse, Kristin; Brems, Lieselotte ULg; Willemse, Peter et al

in Miola, Emanuele (Ed.) Proceedings of the workshop languages go web (2013)

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See detailA comparative study of the hydrophyte flora from the Alpine Rhine to the Middle Rhine. Application to the conservation of the Upper Rhine aquatic ecosystems
Vanderpoorten, Alain ULg; Klein, J. P.

in Biological Conservation (1999), 87(2), 163-172

A typology of the main channel of the river Rhine according to its aquatic bryophyte and vascular hydrophyte assemblages is presented. The aquatic bryophytes are especially abundant in the main channel ... [more ▼]

A typology of the main channel of the river Rhine according to its aquatic bryophyte and vascular hydrophyte assemblages is presented. The aquatic bryophytes are especially abundant in the main channel, having found stable, rocky habitats with variable water levels in the regulated river, and segregate longitudinally along a gradient of water quality. Conversely, the vascular hydrophytes are restricted to side channels with constant discharges and silt deposits, and segregate laterally along a gradient of connectivity with the main river. The hydrophytes have been affected by water eutrophication which became obvious in the 1960s-1970s. The oligotrophic groundwater-fed side-channels disconnected since the river canalization consequently include a relic reference flora. Important hydraulic works are currently in progress in order to protect the areas located downstream from the canalized Rhine from flooding by retaining the river waters in lateral systems during the discharge peaks and to recreate a functional alluvial floodplain by reconnecting the disconnected side-channels to the main river. The floodpulse caused by the suddent input of surface water in the disconnected brooks will probably wash out most of the hydrophytes and it is very likely that the rare species with their low recolonization strategies will disappear in these conditions. It is highly desirable to preserve from flooding the last oligotrophic brooks with their original hydrophyte assemblages. Those brooks which show a tendency to silt up can be re-dynamized by ecological engineering without disturbing the flowing drains of the watertable. In areas (including flowing drains of the watertable) that have already been designated for flood retention, the hydraulic works should allow, as far as possible, the preservation of the flowing oligotrophy streams by only permitting the input of surface water in the silted-up brooks. The disconnected side-channels could then continue their role as refugia from where the main channel, whose water quality has been improving for a decade, could be recolonized by its primary flora. [less ▲]

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