Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailComment je traite... certaines pathologies cutanées par le biais de l'immunité innée.
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2008), 63

L’immunité innée repose sur une organisation biologique complexe qui a des implications certaines dans diverses pathologies, en particulier au niveau de la peau. Son fonctionnement dépend de deux piliers ... [more ▼]

L’immunité innée repose sur une organisation biologique complexe qui a des implications certaines dans diverses pathologies, en particulier au niveau de la peau. Son fonctionnement dépend de deux piliers principaux qui sont les récepteurs PRR (protein recognition receptor) et des peptides antimicrobiens. Chez l’homme, les principaux PRRs sont les Toll-like récepteurs (TLRs) et les peptides antimicrobiens majeurs comprennant les α- et β-défensines, et la cathélicidines. L’expression de ces composants de l’immunité innée est modulée par certains médicaments, ce qui représente un mode d’action qui était resté ignoré par le passé. [less ▲]

Detailed reference viewed: 35 (3 ULg)
Full Text
Peer Reviewed
See detailComment je traite... un herpès labial récidivant.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2008), 63

Detailed reference viewed: 44 (7 ULg)
Full Text
Peer Reviewed
See detailComment je traite... un intertrigo lie a l'embonpoint.
Henry, Frédérique ULg; Pierard, Claudine ULg; Flagothier, Caroline ULg et al

in Revue Médicale de Liège (2007), 62(2), 67-70

Intertrigo is a common inflammatory disorder of various origins. It can represent a single skin manifestation or be part of a disorder possibly exhibiting specific manifestations on other parts of the ... [more ▼]

Intertrigo is a common inflammatory disorder of various origins. It can represent a single skin manifestation or be part of a disorder possibly exhibiting specific manifestations on other parts of the body. Hence, intertrigo may represent a sign of a peculiar disease. It may also result from physicochemical aggressions of the skin following occlusion of the large skinfolds particularly in case of stoutness. In this intance, a treatment similar to that of diaper dermatitis can be offered. A paste enriched or not with miconazole nitrate is indicated to prevent or treat most presentations of intertrigo. [less ▲]

Detailed reference viewed: 88 (3 ULg)
Peer Reviewed
See detailComment je traite... un patient avec une insuffisance cardiaque sévère ou aggravée
Pierard, Luc ULg

in Revue Médicale de Liège (1995), 50(5), 197-8

Detailed reference viewed: 1 (0 ULg)
Peer Reviewed
See detailComment je traite... un patient diabetique de type 2: le projet "DREAM" pour une meilleure collaboration medecin generaliste-medecin specialiste. Diabetes Reinforcement of Adequate Management.
Scheen, André ULg

in Revue Médicale de Liège (1998), 53(2), 58-62

Type 2 diabetes is an important public health problem because of its high prevalence and morbidity rate which both are associated with a considerable social and human cost. The general practitioner should ... [more ▼]

Type 2 diabetes is an important public health problem because of its high prevalence and morbidity rate which both are associated with a considerable social and human cost. The general practitioner should play a central role in the management of patients with type 2 diabetes and try to meet the therapeutic objectives. Main goals include reinforcement of early diagnosis, by a better screening of individuals at risk for type 2 diabetes, achievement of a good glycaemic control, through an optimized antidiabetic treatment, correction of associated risk factors as well as detection and treatment of disease complications. DREAM ("Diabetes Reinforcement of Adequate Management") is a pilot project which started in Liege area end 1997 for at least 2 years. It aims at improving the management of type 2 diabetic patients through a better free collaboration between general practitioners and diabetologists and the adhesion to an optimized therapeutic strategy. This ambitious project benefits from the valuable support of three pharmaceutical companies. [less ▲]

Detailed reference viewed: 49 (0 ULg)
Full Text
Peer Reviewed
See detailComment je traite... Une acné par isotretinoine.
Pierard, Claudine ULg; Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2008), 63(3), 115-8

Acne benefits from a series of treatments. The introduction of isotretinoin was a therapeutic breakthrough which considerably improved both the evolution and the prognosis of the disease. Indications of ... [more ▼]

Acne benefits from a series of treatments. The introduction of isotretinoin was a therapeutic breakthrough which considerably improved both the evolution and the prognosis of the disease. Indications of this retinoid kept changing over the past twenty years. New clinical conditions emerged including the management of disease recurrences. The daily dosages must be selected according to the type of acne, the gender of the patient and the pharmaco-economical implications. Teratogenicity must never be neglected as it represents the dreadful adverse event of the drug. A European Directive currently marks out the way to use this retinoid. [less ▲]

Detailed reference viewed: 130 (6 ULg)
Full Text
Peer Reviewed
See detailComment je traite... une hidradénite suppurée
Devillers, Céline ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2009), 64

Hidradenitis suppurativa is a chronic and debilitating inflammatory disease. It presents as recurrent abcesses, sinus tracts and scarring. The condition usually develops in the axillae and groins, and ... [more ▼]

Hidradenitis suppurativa is a chronic and debilitating inflammatory disease. It presents as recurrent abcesses, sinus tracts and scarring. The condition usually develops in the axillae and groins, and more rarely involves the breasts, perineum and buttocks. There are many myths around hidradenitis suppurativa including its origin and pathomechanisms. Some antibiotics as well as corticosteroids and other immune downregulators are porly effective in this stubborn condition. By contrast, TNF-α antagonists appear promising. Radical surgery is another effective option. [less ▲]

Detailed reference viewed: 145 (2 ULg)
Full Text
Peer Reviewed
See detailComment je traite... une intoxication au paracetamol.
Bertrand, Xavier ULg; Brasseur, Edmond ULg; Ghuysen, Alexandre ULg et al

in Revue Médicale de Liège (2008), 63(7-8), 465-8

Drug self-poisoning is a common cause of admission in ED. Among various incriminated substances, paracetamol is often implicated and presents a severe toxicity. We briefly describe the epidemiology and ... [more ▼]

Drug self-poisoning is a common cause of admission in ED. Among various incriminated substances, paracetamol is often implicated and presents a severe toxicity. We briefly describe the epidemiology and physiopathology of paracetamol self-poisoning. We then clarify the diagnostic elements, thresholds of toxicity, indications for treatment and different available therapeutic guidelines. [less ▲]

Detailed reference viewed: 109 (7 ULg)
Peer Reviewed
See detailComment je traite.... De la pharmacologie speciale a la therapeutique medicale: plaidoyer pour un enseignement privilegiant l'apprentissage au raisonnement therapeutique, de la decision a la prescription.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 811-6

Clinical pharmacology and therapeutics are two complementary disciplines which should lead the medical student, through an optimized training, to a rational prescription of drugs, ultimate and important ... [more ▼]

Clinical pharmacology and therapeutics are two complementary disciplines which should lead the medical student, through an optimized training, to a rational prescription of drugs, ultimate and important step of the medical approach. Such a learning should occur progressively throughout the medical education, focusing, first, on the therapeutic reasoning ("why?") and, second, on the practical application leading to the prescription ("how?"). The medical student should learn the difficult task of integrating disease, drug and patient, in order to optimize the benefit/risk ratio, while being informed about new concepts such as "Evidence-Based Medicine" and pharmacoeconomics. [less ▲]

Detailed reference viewed: 61 (0 ULg)
Full Text
Peer Reviewed
See detailComment je traite.... la colonisation bactérienne critique d'un ulcère de jambe. Le Yin et le Yang des pansements argentiques.
Pierard, Claudine ULg; Quatresooz, Pascale ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2004), 59(6), 403-6

The critical bacterial colonizaion of leg ulcers can impair their healing rate, aggravate the patient discomfort and increase the medical and nursing costs. In recent times, the dressings designed for leg ... [more ▼]

The critical bacterial colonizaion of leg ulcers can impair their healing rate, aggravate the patient discomfort and increase the medical and nursing costs. In recent times, the dressings designed for leg ulcers have followed a pace of conceptual revolution. Some of them are now offered containing an antiseptic of the silver salt family. The silver concentraton delivered into the wound bed is important to consider when assessing treatment efficacy. The diversity of the silver-based dressings currently on the European market is as large as their differences in activity. Only a minority of these dressings adequately control the wound biocenosis. Their cost which is high for the patient, must be compared to that of nursing care that may become less important. The expected beneficit is a reduction in healing time. [less ▲]

Detailed reference viewed: 60 (2 ULg)
Full Text
Peer Reviewed
See detailComment je traite.... Le cancer avance du pancreas par une approche innovante dirigee contre les nouvelles cibles
Polus, Marc ULg; Bours, Vincent ULg; Jerusalem, Guy ULg et al

in Revue Médicale de Liège (2002), 57(7), 428-32

A better knowledge of fundamental mechanisms of carcinogenesis allows the development of novel therapeutic tools specifically targeting the cancer cell. Our understanding of cellular and molecular ... [more ▼]

A better knowledge of fundamental mechanisms of carcinogenesis allows the development of novel therapeutic tools specifically targeting the cancer cell. Our understanding of cellular and molecular mechanisms controlling cellular cycle and cell survival is an important step for new anti-cancer treatments. This review will focus on new therapeutic's strategies in advanced pancreatic cancer. [less ▲]

Detailed reference viewed: 68 (3 ULg)
Full Text
Peer Reviewed
See detailComment je traite.... Un cancer du pancreas avance
Polus, Marc ULg; Jerusalem, Guy ULg; Sautois, Brieuc ULg et al

in Revue Médicale de Liège (2002), 57(3), 131-4

Median survival of advanced pancreatic cancer is about three months. Unfortunately, chemotherapy is not a curative approach. Chemotherapy improves the quality of life and overall survival compared to best ... [more ▼]

Median survival of advanced pancreatic cancer is about three months. Unfortunately, chemotherapy is not a curative approach. Chemotherapy improves the quality of life and overall survival compared to best supportive care. Nevertheless, as the overall survival remains disappointing, clinical research must ongoing to define better treatment regimen. [less ▲]

Detailed reference viewed: 79 (2 ULg)
Full Text
Peer Reviewed
See detailComment je traite.... Un carcinome basocellulaire par l'imiquimod topique (Aldara).
Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2005), 60(4), 207-209

Basal cell carcinoma is the most frequent cancer in humans. Several clinical types are distinguished. They are bound to distinct evolutive prognosis. The surgical excision is the treatment of choice which ... [more ▼]

Basal cell carcinoma is the most frequent cancer in humans. Several clinical types are distinguished. They are bound to distinct evolutive prognosis. The surgical excision is the treatment of choice which is rarely followed by recurrence. However, when the lesion is superficial and non aggressive and when the body site is adequate, topical applications of imiquimod can provoke the neoplastic regression. This type of immunotherapy brings 70 to 90% complete remission. A medical follow-up of the treated site is mandatory for a couple of years. [less ▲]

Detailed reference viewed: 136 (6 ULg)
Full Text
Peer Reviewed
See detailComment je traite.... Un pityriasis rubra pilaire.
Fraiture, A. L.; Braham, C.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(6), 363-5

Pityriasis rubra pilaris is a syndrome of unknown etiology. Six distinct clinical types have been described in infancy and adulthood. Oral retinoids have proven their efficacy. Emollients and topical ... [more ▼]

Pityriasis rubra pilaris is a syndrome of unknown etiology. Six distinct clinical types have been described in infancy and adulthood. Oral retinoids have proven their efficacy. Emollients and topical calcipotriol may improve the clinical presentation. [less ▲]

Detailed reference viewed: 110 (1 ULg)
Full Text
Peer Reviewed
See detailComment je traite...des cors et des callosités.
Hermanns-Lê, Trinh ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(7-8), 545-7

Corns and callosities are the expression of a peculiar aspect of mecanobiology of the foot. They are more frequent with ageing, particularly in women. These lesions represent a risk factor for the ... [more ▼]

Corns and callosities are the expression of a peculiar aspect of mecanobiology of the foot. They are more frequent with ageing, particularly in women. These lesions represent a risk factor for the diabetic foot. Prevention measures are important to follow in predisposed individuals. Several medicinal and non medicinal treatments have proven their efficacy. [less ▲]

Detailed reference viewed: 87 (4 ULg)
Full Text
Peer Reviewed
See detailComment je traite...l'acné de l'adolescent: un algorithme stratégique sans antibiotique.
Xhauflaire, Emmanuelle ULg; Goffin, Véronique ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2006), 61(10), 667-70

Acne is a multifaceted disorder. Its clinical presentation differs according to the age and gender of the subjects. Acne of the adolescent is a frequent disorder. Some topical and oral antibiotics have ... [more ▼]

Acne is a multifaceted disorder. Its clinical presentation differs according to the age and gender of the subjects. Acne of the adolescent is a frequent disorder. Some topical and oral antibiotics have proven their efficacy. However, the risk of bacterial resistance may be a concern for the clinicians and their patients. Hence, a therapeutic strategy without antibiotics merits to be considered. Retinoids have a place of choice in this therapeutic strategy. Benzoyl peroxide and miconazole are also active and valuable agents in this therapeutic algorithm. [less ▲]

Detailed reference viewed: 92 (0 ULg)
Full Text
Peer Reviewed
See detailComment je traite...La leucémie myéloblastique aiguë (LMA) du sujet age en bon état général.
Lejeune, Marie ULg; Beguin, Yves ULg; De Prijck, Bernard ULg et al

in Revue Médicale de Liège (2008), 63(2), 59-63

This article describes the treatment of acute myeloid leukemia in older patients with good performance status, and then discusses briefly some future therapeutic perspectives.

Detailed reference viewed: 184 (12 ULg)
Full Text
Peer Reviewed
See detailComment je traite...le "mehin" des mains sèches.
Xhauflaire, Emmanuelle ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2007), 62(3), 129-31

Suffering from dry skin on the hands is a common feature in the general population. This condition is influenced by daily habits and occupational duties. It commonly corresponds to the expression of ... [more ▼]

Suffering from dry skin on the hands is a common feature in the general population. This condition is influenced by daily habits and occupational duties. It commonly corresponds to the expression of irritation dermatitis modulated by climatic and other environmental conditions. Other diseases including allergic contact dermatitis, psoriasis and dermatomycosis can also be responsible for a similar clinical presentation. In the common discrete irritative type, a specifically designed cosmetic product may considerably improve the discomfort experienced by the patient. By contrast, the efficacy of most barrier creams remains unconfirmed. The chronic use of topical corticosteroids can lead to dependency and to progressive cutaneous atrophy. [less ▲]

Detailed reference viewed: 45 (1 ULg)
Full Text
Peer Reviewed
See detailComment je traite...un patient atteint de mycosis fongoide.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(11), 740-6

Primary lymphomas of the skin exhibit singular clinical, histological and prognostic features that are not shared by lymphomas originating from the lymphoid tissues. This review is an update of the ... [more ▼]

Primary lymphomas of the skin exhibit singular clinical, histological and prognostic features that are not shared by lymphomas originating from the lymphoid tissues. This review is an update of the current concepts about the diagnosis and treatment of mycosis fungoides, the most frequent entity among the primary cutaneous lymphomas. [less ▲]

Detailed reference viewed: 105 (0 ULg)
Full Text
Peer Reviewed
See detailComment je traite...un psoriasis du cuir chevelu.
Uhoda, I.; Flagothier, Caroline ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(9), 481-4

Scalp involvement by psoriasis requires a ted treatment suited to the particularities of the anatomical site In course of time, the improvement of therapeutic agents and the galenic refinement have ... [more ▼]

Scalp involvement by psoriasis requires a ted treatment suited to the particularities of the anatomical site In course of time, the improvement of therapeutic agents and the galenic refinement have enhanced both the efficacy and cosmetic acceptability of the scalp care. The main therapeutic classes encompass keratolytics, dermocorticosteroids and vitamine D3 analogues. The patient compliance is reported to be best for the liquid or foam formulations. [less ▲]

Detailed reference viewed: 158 (6 ULg)