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See detailComparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes.
Beaune, P H; Kremers, P G; Kaminsky, L S et al

in Drug Metabolism and Disposition : The Biological Fate of Chemicals (1986), 14(4), 437-42

Concentrations of three human liver microsomal cytochrome P-450 isozymes and 20 different monooxygenase activities were determined in human liver microsomal preparations. The results of correlation ... [more ▼]

Concentrations of three human liver microsomal cytochrome P-450 isozymes and 20 different monooxygenase activities were determined in human liver microsomal preparations. The results of correlation analysis suggest that: there are important variations in the amounts of the three cytochrome P-450 isozymes measured, particularly P-450(8) and P-450(9); aldrin epoxidase, d-benzphetamine N-demethylase, and S-warfarin 4-hydroxylase activities are linked to cytochrome P-450(5); aryl hydrocarbon (benzo(a)pyrene) hydroxylase and 4-nitroanisole-O-demethylase activities are linked to P-450(8); hydroxylations at the 4'-, 6-, 7-, and 8-positions of R-warfarin are closely linked to each other but are not correlated with other measured monooxygenase activities or P-450 isozyme levels; and P-450(9) is not related to any of the catalytic activities tested. Thus, certain monooxygenase activities can be attributed to specific cytochrome P-450 isozymes. This approach should be useful in suggesting the roles of different cytochromes P-450 in drug metabolism in man which can be further examined using in vitro and in vivo methods. [less ▲]

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See detailComparison of MRI images obtained at 7T in a dog to macroscopic and histopathological examination
Van Thielen, B.; Visser, F.; Denolin, V. et al

Poster (2010, July 20)

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See detailComparison of muscle energetics during voluntary and electrically induced contractions in humans
Vanderthommen, Marc ULg; Duteil, S.; Wary, C. et al

in Rainoldi, A.; Minetto, M. A.; Merletti, R. (Eds.) Biomedical engineering in exercise and sports (2006)

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See detailA comparison of Nash equilibria analysis and agent-based modelling for power markets
Krause, Thilo; Andersson, Goran; Ernst, Damien ULg et al

in Proceedings of the 15th Power System Computation Conference (PSCC 2005) (2005)

In this paper we compare Nash equilibria analysis and agent-based modelling for assessing the market dynamics of network-constrained pool markets. Power suppliers submit their bids to the market place in ... [more ▼]

In this paper we compare Nash equilibria analysis and agent-based modelling for assessing the market dynamics of network-constrained pool markets. Power suppliers submit their bids to the market place in order to maximize their payoffs, where we apply reinforcement learning as a behavioral agent model. The market clearing mechanism is based on the locational marginal pricing scheme. Simulations are carried out on a benchmark power system.We show how the evolution of the agent-based approach relates to the existence of a unique Nash equilibrium or multiple equilibria in the system. Additionally, the parameter sensitivity of the results is discussed. [less ▲]

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See detailA comparison of Nash equilibria analysis and agent-based modelling for power markets
Krause, Thilo; Beck, Elena Vdovina; Cherkaoui, Rachid et al

in International Journal of Electrical Power & Energy Systems (2006), 28(9), 599-607

In this paper we compare Nash equilibria analysis and agent-based modelling for assessing the market dynamics of network-constrained pool markets. Power suppliers submit their bids to the market place in ... [more ▼]

In this paper we compare Nash equilibria analysis and agent-based modelling for assessing the market dynamics of network-constrained pool markets. Power suppliers submit their bids to the market place in order to maximize their payoffs, where we apply reinforcement learning as a behavioral agent model. The market clearing mechanism is based on the locational marginal pricing scheme. Simulations are carried out on a benchmark power system. We show how the evolution of the agent-based approach relates to the existence of a unique Nash equilibrium or multiple equilibria in the system. Additionally, the parameter sensitivity of the results is discussed. (C) 2006 Elsevier Ltd. All rights reserved. [less ▲]

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See detailComparison of native and inherited immunoglobulins in rabbits immunized against bovine pregnancy-associated glycoprotein-1 (boPAG-1).
Melo de Sousa, Noelita ULg; Banga-Mboko, H.; El Amiri, B. et al

in Pflügers Archiv : European Journal of Physiology (2000), 440

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See detailComparison of necrotoxigenic Escherichia coli isolates from farm animals and humans
Mainil, Jacques ULg; Jacquemin, E.; Pohl, P. et al

in Veterinary Microbiology (1999), 70

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See detailComparison of Neuromuscular Block of Atracurium and Rocuronium in Adults
Hans, Pol ULg; Brichant, Jean-François ULg; Franzen, A. et al

in Acta Anaesthesiologica Belgica (1996), 47(2), 53-8

We studied the time-course of action of atracurium 0.5 mg kg-1 and rocuronium 0.6 mg kg-1 in 24 healthy adult patients. Anesthesia was induced with thiopentone and sufentanil, and maintained with 50 ... [more ▼]

We studied the time-course of action of atracurium 0.5 mg kg-1 and rocuronium 0.6 mg kg-1 in 24 healthy adult patients. Anesthesia was induced with thiopentone and sufentanil, and maintained with 50% nitrous oxide and 1% enflurane in oxygen. Neuromuscular transmission was monitored by stimulating the ulnar nerve at the wrist and measuring the acceleration of the thumb using the TOF-Guard accelerograph monitor. Supramaximal stimuli of 0.2 ms duration were applied in a single twitch stimulation mode at 1 Hz frequency until completion of block, and in train-of four (TOF) sequence at 2 Hz every 15 sec thereafter. Onset time was longer with atracurium (mean +/- SD:90 +/- 18 sec) than with rocuronium (49 +/- 6 sec). Clinical duration of action (Tl25) was longer with atracurium (52.3 +/- 7.2 min) than with rocuronium (40.0 +/- 6.4 min). Recovery index (Tl25-Tl75) and time for TOF ratio to recover to 0.75 were 17.8 +/- 4.2 and 73.9 +/- 8.8 min with atracurium, and 13.8 +/- 4.1 and 70.4 +/- 14.1 min with rocuronium. The differences between both groups were statistically significant except the difference in the time for TOF to return to 0.75. [less ▲]

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See detailComparison of noise, hot and cold contrast of eight tomographic camera models.
Seret, Alain ULg; Nguyen, Thibaut

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(S2), 282

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See detailComparison of non-linear growth models to describe the growth curve in West African Dwarf Sheep
Gbangboche, A. B.; Gleke-Kakai, R.; Albuquerque, L. G. et al

in Animal (2008), 2(7), 1003-1012

The objectives of this study were to compare the goodness of fit of four non-linear growth models, i.e. Brody, Gompertz, Logistic and Von Bertalanffy, in West African Dwarf (WAD) sheep. A total of 5274 ... [more ▼]

The objectives of this study were to compare the goodness of fit of four non-linear growth models, i.e. Brody, Gompertz, Logistic and Von Bertalanffy, in West African Dwarf (WAD) sheep. A total of 5274 monthly weight records from birth up to 180 days of age from 889 lambs, collected during 2001 to 2004 in Betecoucou breeding farm in Benin were used. In the preliminary analysis, the General Linear Model Procedure of the Statistical Analysis Systems Institute was applied to the dataset to identify the significant effects of the sex of lamb (male and female), type of birth (single and twin), season of birth (rainy season and dry season), parity of dam (1, 2 and 3) and year of birth (2001, 2002, 2003 and 2004) on the observed birth weight and monthly weight up to 6 months of age. The models parameters (A, B and k), coefficient of determination (R2), mean square error (MSE) were calculated using language of technical computing package Matlab􏰀 R , 2006. The mean values of A, B and k were substituted into each model to calculate the corresponding Akaike’s Information Criterion (AIC). Among the four growth functions, the Brody model has been selected for its accuracy of fit according to the higher R2, lower MSE and AIC. Finally, the parameters A, B and k were adjusted in Matlab􏰀 R , 2006 for the sex of lamb, year of birth, season of birth, birth type and the parity of ewe, providing a specific slope of the Brody growth curve. The results of this study suggest that Brody model can be useful for WAD sheep breeding in Betecoucou farm conditions through growth monitoring. [less ▲]

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See detailComparison of O2 IR and NO UV night airglow variations on Mars and Venus
Brecht; Bougher, S. W.; Gérard, Jean-Claude ULg et al

Conference (2009, May)

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See detailComparison of output-only methods for condition monitoring of industrials systems
Rutten, Christophe ULg; Nguyen, Viet Ha; Golinval, Jean-Claude ULg

in Journal of Physics: Conference Series (2011), 305

In the field of structural health monitoring or machine condition monitoring, the activation of nonlinear dynamic behavior complicates the procedure of damage or fault detection. Blind source separation ... [more ▼]

In the field of structural health monitoring or machine condition monitoring, the activation of nonlinear dynamic behavior complicates the procedure of damage or fault detection. Blind source separation (BSS) techniques are known as efficient methods for damage diagnosis. However, most of BSS techniques repose on the assumption of the linearity of the system and the need of many sensors. This article presents some possible extensions of those techniques that may improve the damage detection, e.g. Enhanced-Principal Component Analysis (EPCA), Kernel PCA (KPCA) and Blind Modal Identification (BMID). The advantages of EPCA rely on its rapidity of use and its reliability. The KPCA method, through the use of nonlinear kernel functions, allows to introduce nonlinear dependences between variables. BMID is adequate to identify and to detect damage for generally damped systems. In this paper, damage is firstly examined by Stochastic Subspace Identification (SSI); then the detection is achieved by comparing subspace features between the reference and a current state through statistics and the concept of subspace angle. Industrial data are used as illustration of the methods. [less ▲]

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See detailComparison of ozone-induced effects on lung mechanics and hemodynamics in the rabbit.
Delaunois, Annie ULg; Segura, P.; Montano, L. M. et al

in Toxicology and Applied Pharmacology (1998), 150(1), 58-67

The effects of rabbit exposure to ozone (O3)(0.4 ppm for 4 h) on pulmonary mechanical properties and hemodynamics have been investigated on the isolated perfused lung model. Tracheal pressure, airflow ... [more ▼]

The effects of rabbit exposure to ozone (O3)(0.4 ppm for 4 h) on pulmonary mechanical properties and hemodynamics have been investigated on the isolated perfused lung model. Tracheal pressure, airflow, and tidal volume were measured in order to calculate lung resistance (RL) and dynamic compliance (Cdyn). Using the arterial/venous/double occlusion method, the total pressure gradient (deltaPT) was partitioned into four components (arterial, pre-, postcapillary and venous). Dose-response curves to acetylcholine (ACh), substance P (SP), and histamine were constructed in lungs isolated from rabbits immediately or 48 h after air or O3 exposure O3 induced a significant increase in the baseline value of deltaPt, more markedly 48 h after the exposure. Immediately after the exposure, O3 partly inhibited the ACh-, SP-, and histamine-induced decreases in Cdyn and increases in RL. This inhibitory effect was still in part present 48 h after O3 treatment. In the groups studied immediately after exposure, O3 did not significantly modify the ACh-, SP-, and histamine-induced vasoconstriction. Forty-eight hours after exposure, O3 induced a contractile response to ACh and SP in the arterial segment but decreased the response to histamine. We conclude that O3 can induce direct vascular constriction. Directly, but also 48 h after exposure, O3 can inhibit the ACh-, SP-, and histamine-induced changes in lung mechanical properties. Ozone can also induce some changes in the intensity and in the location of the vascular responses to ACh, SP, and histamine. [less ▲]

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See detailComparison of parameterization schemes for solving the discrete material optimization problem of composite structures
Duysinx, Pierre ULg; Guillermo Alonso, Maria ULg; Gao, Tong et al

Conference (2013, September)

In the context of weight reduction challenges in aerospace, automotive, and energy engineering problems, composite materials are gaining a revived interested. Because of the problem complexity and the ... [more ▼]

In the context of weight reduction challenges in aerospace, automotive, and energy engineering problems, composite materials are gaining a revived interested. Because of the problem complexity and the large number of design variables, their design of composite structures is greatly facilitated by using optimization techniques. While several formulations have been proposed for composite structure design, Stegmann and Lund [1] have showed that composite optimization can take advantage of the topology optimization approach. The fundamental idea of the Discrete Material Optimization (DMO) approach is 1/ to formulate the composite optimization problem as an optimal material selection problem in which the different laminates and ply orientations are considered as different materials and 2/ to solve the optimization problem using continuous existence variables. To transform the discrete problem into a continuous one, one introduces a suitable parametrization identifying each material by a unique set of design variables while the material properties are expressed as a weighted sum of all candidate materials. Using DMO approach, one can solve within a common approach, different design problems such as laminate distribution problem, stacking sequence optimization... The inherent difficulties of the discrete material selection using topology optimization are 1/ to find efficiency interpolation and penalization schemes of the material properties and 2/ to be able to tailor an efficient solution algorithm to handle very large scale optimization problems. Besides the reference DMO scheme by Lund and his co-authors, other interpolation schemes have been proposed: In this paper, work we are considering and comparing DMO with two other schemes namely the Shape Function with Penalization Parameterization (SFP) by Bruyneel [2] and it recent extension, the Bi-value Coding Parametrization (BCP) by Gao et al. [3]. In particular, the work considers the different schemes in the perspective of solving large-scale industrial applications. The work considers several aspects of the different schemes: • Nature of the different interpolation schemes, • Penalization strategies (power law (SIMP), RAMP, Tsai-Halpin or polynomial), • Number of design variables, the size and complexity of the optimization problem, • Sensitivity to local optima, to the initial design variable, and the development of continuous penalization techniques, • Ability to be extended to various formulations from compliance problems to local restrictions and buckling. As a major drawback, DMO, SFP and BCP approaches increase dramatically the number of design variables. Because of the computational burden to solve the optimization problems, in most of DMO implementations, the considered structural responses are generally limited to compliance-like objective functions. In order to extend the DMO formulation, the work investigates the selection of the most appropriate and efficient optimization algorithms to handle the problems. Different schemes of the sequential convex programming are compared. At first the classic schemes MMA and CONLIN are tested. Then more advanced schemes of the MMA family (Bruyneel et al. [4]) are experimented. The work and the comparisons are carried out on several numerical applications related to the selection of optimal local fibre orientations (with up to 36 candidate material orientations) in membrane and shell aerospace or automotive structures. The various numerical test problems include academic examples and benchmarks inspired by industrial applications. [less ▲]

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