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See detailComparative study of four diagnostic methods of enzootic bovine leukemia.
Mammerickx, Marc; Burny, Arsène; Dekegel, D. et al

in Burny, Arsène (Ed.) Bovine leucosis: various methods of molecular virology. (1977)

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See detailComparative study of four safflower oils (Carthamus tinctorius) varieties grown in eastern of Morocco
Ben Moumen, A.; Mansouri, F.; Zraibi, L. et al

Poster (2013, April)

Safflower (Carthamus tinctorius) is an oilseed crop, which, for many years, has been grown on a relatively small scale in parts of North Africa and Middle East (Purdy and al., 1959).

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See detailComparative study of four safflower oils (Carthamus tinctorius) varieties grown in eastern of Morocco
Ben Moumen, A.; Mansouri, F.; Zraibi, L. et al

in Book of Proceedings InsideFood Symposium (2013, April)

In this study, four safflower varieties, originating from Spain (Rancho), India (Sharda) and Morocco (Cartamar and Cartafri) cultivated at the experimental station of OUJDA (semi-arid region of Eastern ... [more ▼]

In this study, four safflower varieties, originating from Spain (Rancho), India (Sharda) and Morocco (Cartamar and Cartafri) cultivated at the experimental station of OUJDA (semi-arid region of Eastern Morocco) were evaluated for their oil yield and seed oil quality. The analysis of results revealed significant differences among varieties for all traits. Indeed, our result show that seeds of the four varieties have important oil content ranged between 35.38% (Rancho) and 28.84% (Cartamar). Characterization of these oils showed a low value of acidity index less than 0.7% for all the varieties but significant differences in their peroxide values ranged between 4.5 meq O2/Kg (Cartamar) and 31.21 mEqO2/Kg (Rancho) and high value of phenolic content between 143 ppm (Rancho) and 97 ppm (Sharda). Analysis of the fatty acids shows that linoleic acid is the main fatty acid ranged between 77.94% (Cartamar) and 79.98% (Sharda). Oils of those four varieties can be classified in the linoleic acid group. The analysis of triglycerides by HPLC shows 10 molecular species of TAG (LLL, LPL, LLO, PLO, LLS, POP, OOO, POO, SOO, PPL). The trilinoleate (LLL) is the main molecular species with more than 50%. Safflower seed oil cultivated in eastern Morocco presents good physicochemical proprieties (polyphenols and Omega 6 richness); therefore, safflower culture could be suggested for all areas of Morocco, including the areas of low pluviometry, while the potential for culture of other oilseeds is more limited. [less ▲]

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See detailComparative study of gold and silver based nanobiosensors
Lismont, Marjorie ULg; Dreesen, Laurent ULg

Poster (2011, May 25)

Due to their particular optical properties, resulting from the surface plasmon resonance (SPR) phenomenon, silver and gold nanoparticles (NPs) can be used as robust tools for optical biosensing [1 ... [more ▼]

Due to their particular optical properties, resulting from the surface plasmon resonance (SPR) phenomenon, silver and gold nanoparticles (NPs) can be used as robust tools for optical biosensing [1]. Optical SPR biosensors are able to measure complex formation in real time. Indeed, the SPR absorption spectrum band of the NPs is sensitive to the shape, size, inter-particle distance and composition of the NP as well as the dielectric properties of the surrounding medium [2]. Due to the sensitivity of SPR to the local dielectric environment, plasmonic NPs can act as transducers that convert small changes in the local refractive index and the inter-particle distance into spectral shifts and broadening in the absorption spectra bands [3]. In our study, the prototypical biocytin-avidin interaction was used to study gradual changes with time in the absorption spectra bands of biotinylated 10 nm silver and gold NPs as a function of added avidin. After avidin addition, a SPR red-shift and a broadening of the SPR bands were observed with both NPs. These optical changes evolved with time and reached their final values after around 45 min for each system. The maximum SPR red-shifts were equal to 25 nm and 15 nm for silver NPs and gold NPs, respectively. The detection limit, described as the lowest concentration for clear identification of wavelength shift due to biomolecular recognition, is determined to be 4 nM for both silver and gold NPs. The specificity of the biocytin-avidin biosensors was checked by replacing avidin by BSA. When BSA was added, we observed a SPR band shift which was smaller than the detection limit of 3 nm, attesting the biosensor selectivity. Our work demonstrates the superiority of Ag over Au NPs for the elaboration of biosensors based on SPR. [less ▲]

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See detailComparative Study of High Bio-Availability Glaphenine and Paracetamol in Cervical and Lumbar Arthrosis
Urbin Choffray, D.; Crielaard, Jean-Michel ULg; Albert, Adelin ULg et al

in Clinical Rheumatology (1987), 6(4), 518-25

Seventy-eight patients, 40 suffering from cervical arthrosis and 38 from lumbar arthrosis, received for a period of two weeks paracetamol or a new preparation of glaphenine, in a double blind study. The ... [more ▼]

Seventy-eight patients, 40 suffering from cervical arthrosis and 38 from lumbar arthrosis, received for a period of two weeks paracetamol or a new preparation of glaphenine, in a double blind study. The two drugs were found to have the same efficiency on the subjective parameters but high bioavailability glaphenine seems to have an effectiveness in the range of articulatory movements, which is not found with paracetamol. The side effects were quite equivalent. [less ▲]

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See detailA comparative study of isokinetic training using two brands of dynamometers
Croisier, Jean-Louis ULg; Herve, M. N.; Forthomme, Bénédicte ULg

in Abstract Book of the XIV International Congress on Sports Rehabilitation and Traumatology: «The Accelerated Rehabilitation of the Injured Athlete» (2005, April)

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See detailComparative study of mature and zymogen mite cysteine protease stability and pH unfolding.
Chevigne, A.; Dumez, Marie-Eve ULg; Dumoulin, Mireille ULg et al

in Biochimica et Biophysica Acta (2010), 1800(9), 937-945

BACKGROUND: Papain-like proteases (CA1) are synthesized as inactive precursors carrying an N-terminal propeptide, which is further removed under acidic conditions to generate active enzymes. METHODS: To ... [more ▼]

BACKGROUND: Papain-like proteases (CA1) are synthesized as inactive precursors carrying an N-terminal propeptide, which is further removed under acidic conditions to generate active enzymes. METHODS: To have a better insight into the mechanism of activation of this protease family, we compared the pH unfolding of the zymogen and the mature form of the mite cysteine protease Der p 1. RESULTS: We showed that the presence of the propeptide does not significantly influence the pH-induced unfolding of the catalytic domain but does affect its fluorescence properties by modifying the exposure of the tryptophan 192 to the solvent. In addition, we demonstrated that the propeptide displays weaker pH stability than the protease domain confirming that the unfolding of the propeptide is the key event in the activation process of the zymogen. GENERAL SIGNIFICANCE: Finally, we show, using thermal denaturation and enzymatic activity measurements, that whatever the pH value, the propeptide does not stabilize the structure of the catalytic domain but very interestingly, prevents its autolysis. [less ▲]

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See detailComparative study of Murid gamma-herpesvirus 4 infection in mice and in a natural host, the bank voles.
François, Sylvie ULg; Vidick, Sarah ULg; Sarlet, Michaël ULg et al

in Journal of General Virology (The) (2010)

Gamma-herpesviruses are archetypal pathogenic persistent viruses. The known human gamma-herpesviruses (Epstein-Barr virus and Kaposi's Sarcoma-associated Herpesvirus) are host-specific and therefore lack ... [more ▼]

Gamma-herpesviruses are archetypal pathogenic persistent viruses. The known human gamma-herpesviruses (Epstein-Barr virus and Kaposi's Sarcoma-associated Herpesvirus) are host-specific and therefore lack a convenient in vivo infection model. This makes related animal gamma-herpesviruses an important source of information. We are studying Murid herpesvirus 4 (MuHV-4), a virus originally isolated from bank voles (Myodes glareolus). MuHV-4 infection of inbred laboratory mouse strains (Mus musculus) is commonly used as a general model of gamma-herpesvirus pathogenesis. However, MuHV-4 has not been isolated from house mice, and no systematic comparison has been made between experimental MuHV-4 infections of mice and bank voles. We have therefore characterized MuHV-4 (strain MHV-68) infection of bank voles, both through global luciferase imaging and through classical virological methods. As in mice, intranasal virus inoculation led to productive replication in bank vole lungs, accompanied by massive cellular infiltrates. However, the extent of lytic virus replication was ~1000 fold lower in bank voles than in mice. Peak latency titers in lymphoid tissue were also lower, although latency was still established. Finally, we tested viral transmission between animals maintained in captivity. However, as observed in mice, MuHV-4 did not transmit between voles in these conditions. In conclusion, this study revealed that despite quantitative differences, replication and latency sites of MuHV-4 are comparable in bank voles and in mice. It appears therefore so far that Mus musculus represents a suitable host for studying gamma-herpesvirus pathogenesis with MuHV-4. Establishing transmission conditions in captivity will be a vital step for further research in that field. [less ▲]

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See detailComparative study of Murid gammaherpesvirus 4 infection in mice and in its natural host, the bank voles.
François, Sylvie ULg; Vidick, Sarah ULg; Koteja, Pawel et al

Poster (2009, December 11)

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. They are host-range specific and establish persistent, productive infections ... [more ▼]

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. They are host-range specific and establish persistent, productive infections of immunocompetent hosts. Thus, infected individuals simultaneously both elicit antiviral protective immune response and secrete infectious virions. The best studied gammaherpesviruses are Human herpesvirus 4 and Human herpesvirus 8. As these viruses have no well-established in vivo infection model, related animal gammaherpesviruses are an important source of information. We are studying Murid herpesvirus 4 (MuHV-4), a virus that has originally been isolated from bank voles (Myodes glareolus). Although MuHV-4 has not been isolated from house mice (Mus musculus), infection of inbred laboratory mouse strains is commonly accepted as a good model for studying gammaherpesviruses in vivo. It has however never been possible to monitor viral reexcretion and virus transmission in this species suggesting that this model could be imperfect. In this study, we therefore characterized MuHV-4 infection in its natural host, the bank voles, through classical virological methods but also through global luciferase imaging for an anatomical complete view of the infection. Results obtained show that, after intra-nasal infection, the natural route of infection is similar in mice and voles. Following nasal productive infection, the virus spreads to the lung where the infection is accompanied by massive cellular infiltrates. By opposition to extensive viral replication observed in mice, the different analyses indicated that the viral replication was ~1000 fold lower in bank voles. This lower replication did however not affect colonization of latency sites in superficial cervical lymph nodes and spleen as measured by real-time PCR quantification of viral genomes in these organs. In conclusion, this study revealed that MuHV-4 can experimentally infect bank voles, the supposed natural host, but with a lower replicative power. As, gammaherpesvirus epidemiology indicates that transmission correlates with the latent load, our results suggest that gammaherpesviruses may have evolved to infect their hosts without extensive lytic spread. In the future, establishment of experimental transmission in a population of Myodes glareolus should help us to better understand mechanisms used by gammaherpesviruses to evade immune response. [less ▲]

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See detailComparative study of numerical explicit schemes for impact problems
Nsiampa, Nestor; Ponthot, Jean-Philippe ULg; Noels, Ludovic ULg

in International Journal of Impact Engineering (2008), 35(12), 1688-1694

Explicit numerical schemes are used to integrate in time finite element discretization methods. Unfortunately, these numerical approaches can induce high-frequency numerical oscillations into the solution ... [more ▼]

Explicit numerical schemes are used to integrate in time finite element discretization methods. Unfortunately, these numerical approaches can induce high-frequency numerical oscillations into the solution. To eliminate or to reduce these oscillations, numerical dissipation can be introduced. The paper deals with the comparison of three different explicit schemes: the central difference scheme which is a nondissipative method, the Hulbert Chung dissipative explicit scheme and the Tchamwa-Wielgosz dissipative scheme. Particular attention is paid to the study of these algorithms’ behavior in problems involving high-velocity impacts like Taylor anvil impact and bullet-target interactions. It has been shown that Tchamwa-Wielgosz scheme is efficient in filtering the high-frequency oscillations and is more dissipative than Hulbert Chung explicit scheme. Although its convergence rate is only first order, the loss of accuracy remains limited to acceptable values. [less ▲]

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See detailA comparative study of O2 measurements in experimental (Interice II) and natural (ISPOL, Western Weddell Sea, Antarctica) first-year sea ice
Tison, Jean-Louis; Mock, T.; Thomas, David et al

Poster (2006, December)

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See detailA comparative study of oral acetylsalicyclic acid and metoprolol for the prophylactic treatment of migraine. A randomized, controlled, double-blind, parallel group phase III study.
Diener, H. C.; Hartung, E.; Chrubasik, J. et al

in Cephalalgia : An International Journal of Headache (2001), 21(2), 120-8

This study was a multinational, multicentre, double-blind, active controlled phase III trial designed to investigate efficacy and safety of 300 mg acetylsalicyclic acid (ASA) (n = 135) vs. 200 mg ... [more ▼]

This study was a multinational, multicentre, double-blind, active controlled phase III trial designed to investigate efficacy and safety of 300 mg acetylsalicyclic acid (ASA) (n = 135) vs. 200 mg metoprolol (n = 135) in the prophylaxis of migraine. In total 270 (51 male and 219 female) patients, aged 18-65 years, suffering between two and six migraine attacks per month were recruited. The main objective was to show equivalence with respect to efficacy, defined as a 50% reduction in the rate of migraine attacks. A run-in phase was carried out with placebo for 4 weeks, followed by a 16-week drug phase. In both treatment groups the median frequency of migraine attacks improved during the study period, from three to two in the ASA group and from three to one in the metoprolol group; 45.2% of all metoprolol patients were responders compared with 29.6% with ASA. Medication-related adverse events were less frequent in the ASA group (37) than in the metoprolol group (73). The findings from this trial show that metoprolol is superior to ASA for migraine prophylaxis but has more side-effects. Acetylsalicylic acid is better tolerated than metoprolol. Using a strict responder criterion ASA showed a responder rate comparable with the placebo rate in the literature. [less ▲]

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See detailA Comparative Study of Path Performance Metrics Predictors
Narino Mendoza, Juan Pablo; Donnet, Benoît ULg; Dupont, Pierre

in Advanced Learning for Networking Workshop (2009, June)

Using quality-of-service (QoS) metrics for Internet traffic is expected to improve greatly the performance of many network enabled applications, such as Voice-over-IP (VoIP) and video conferencing ... [more ▼]

Using quality-of-service (QoS) metrics for Internet traffic is expected to improve greatly the performance of many network enabled applications, such as Voice-over-IP (VoIP) and video conferencing. However, it is not possible to constantly measure path performance metrics (PPMs) such as delay and throughput without interfering with the network. In this work, we focus on PPMs measurement scalability by considering machine learning techniques to estimate predictive models from past PPMs observations. Using real data collected from PlanetLab, we provide a comparison between three different predictors: AR(MA) models, Kalman filters and support vector machines (SVMs). Some predic- tors use delay and throughput jointly to take advantage of the possible relationship between PPMs, while other predictors consider PPMs individually. Our current results illustrate that the best performing model is an individual SVM specific to each time series. Overall, delay can be predicted with very good accuracy while accurate forecasting of throughput remains an open problem. [less ▲]

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See detailComparative study of period determination methods
Manfroid, Jean ULg; Heck, A.; Mersch, G.

in Statistical Methods in Astronomy (1983, November 01)

Simulations have been run to compare the performance of several period determination algorithms: essentially Fourier's, Lafler-Kinman's and Stellingwerf's methods have been considered, as well as a couple ... [more ▼]

Simulations have been run to compare the performance of several period determination algorithms: essentially Fourier's, Lafler-Kinman's and Stellingwerf's methods have been considered, as well as a couple of variants. The application to single-periodic phenomena shows that none of the methods is clearly superior to the others. Fourier's and the non-parametric methods have relatively different scopes and they are, to some extent, complementary. [less ▲]

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See detailComparative study of pirlindole, a selective RIMA, and its two enantiomers using biochemical and behavioural techniques.
Bruhwyler, J.; Liégeois, Jean-François ULg; Gerardy, J. et al

in Behavioural Pharmacology (1998), 9(8), 731-7

The interaction with monoamine oxidase A (MAO-A) and B has been shown to be sensitive to the absolute configuration of molecules. Therefore, the aim of this study was to compare the effects of the racemic ... [more ▼]

The interaction with monoamine oxidase A (MAO-A) and B has been shown to be sensitive to the absolute configuration of molecules. Therefore, the aim of this study was to compare the effects of the racemic pirlindole (a selective and reversible MAO-A inhibitor) and its two enantiomers using biochemical techniques (in vitro and ex vivo determination of rat brain MAO-A and MAO-B activity) and behavioural models (forced swimming test and reserpine-induced hypothermia and palpebral ptosis test). In vitro, the MAO-A IC50 of (+/-)-pirlindole, R-(-)-pirlindole and S-(+)-pirlindole were 0.24, 0.43 and 0.18 microM, respectively. Ex vivo, their ID50 were 24.4, 37.8 and 18.7 mg/kg i.p. The differences between the three compounds were not significant, with a ratio between the two enantiomers [R-(-)/S-(+)] of 2.2 in vitro and 2.0 ex vivo. MAO-B was only slightly inhibited. In the forced swimming test and the reserpine-induced hypothermia and ptosis model, the three compounds had an antidepressant profile. In the forced swimming test, the minimal effective dose ratio between the R-(-) and the S-(+) was again around 2.0. The behavioural observations were thus clearly in accordance with the biochemical data. [less ▲]

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See detailComparative study of psychopathological features and temporalis second exteroceptive silent period in chronic tension-type headache: is 5-HT the common denominator?
Dawans, A.; Schoenen, Jean ULg; Timsit, M. et al

in Olesen, J.; Saxena, P. R. (Eds.) 5-Hydroxytrytamine Mechanisms in Primary Headaches (Frontiers in Headache Research) (1992)

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See detailA comparative study of quantitative shape analysis techniques in sedimentology
Pirard, Eric ULg; Hoyez, Bernard

in Zentralblatt für Geologie und Paläontologie. Teil I, Allgemeine, Angewandte, Regionale und Historische Geologie (1995), 1(H11/12), 1061-1066

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See detailA comparative study of reporter gene activities in fish cells and embryos
Sekkali, B.; Hellemans, B.; Belayew, A. et al

in Molecular Marine Biology and Biotechnology (1994), 3

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