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Peer Reviewed
See detailA Comparative Investigation of Contraceptive Reliability, Cycle Control and Tolerance of Two Monophasic Oral Contraceptives Containing Either Drospirenone or Desogestrel
Foidart, Jean-Michel ULg; Wuttke, W.; Bouw, G. M. et al

in European Journal of Contraception & Reproductive Health Care : The Official Journal of the European Society of Contraception (2000), 5(2), 124-34

OBJECTIVE: To assess the contraceptive reliability, cycle control and tolerance of a new monophasic oral contraceptive (Yasmin) containing 30 microg ethinylestradiol and 3 mg drospirenone and compare it ... [more ▼]

OBJECTIVE: To assess the contraceptive reliability, cycle control and tolerance of a new monophasic oral contraceptive (Yasmin) containing 30 microg ethinylestradiol and 3 mg drospirenone and compare it with a preparation containing an equal dose of ethinylestradiol combined with 150 microg desogestrel (Marvelon). METHODS: A multicenter, open-label, randomized study was carried out in 26 European centers. Contraceptive efficacy, cycle control and tolerance (including body weight, blood pressure and heart rate) were assessed over 26 cycles, plus a 3-month follow-up period. RESULTS: Of 900 women who were randomized, 887 started treatment and 627 completed the 26 cycles plus follow-up (310 in the ethinylestradiol/drospirenone group and 317 in the ethinylestradiol/desogestrel group). Both study preparations were found to be effective with regard to contraceptive reliability and cycle control was good. There were six pregnancies (three in each group), but none were considered to have been the result of method failures. The subjective and objective tolerances were good in both groups. A statistically significant difference was found in body weight changes between the two groups. While there was an increase in mean body weight in the ethinylestradiol/desogestrel group from cycle 5 onward, the mean body weight per cycle in the ethinylestradiol/drospirenone group was slightly below the baseline value throughout the study. The incidence ofpremenstrual symptoms was higher in the ethinylestradiol/drospirenone group than in the ethinylestradiol/desogestrel group during the 6 months prior to the study, but lower during treatment. The rates ofdysmenorrhea were identical under both treatments but the symptoms were more often mild and less often severe in the ethinylestradiol/drospirenone group. CONCLUSION: The combination of 30 microg ethinylestradiol combined with 3 mg drospirenone provides effective oral contraception and good cycle control, and is well tolerated. Ethinylestradiol/drospirenone had a more favorable effect on body weight than ethinylestradiol/desogestrel, with the mean body weight remaining lower than baseline for the majority of the women. [less ▲]

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See detailComparative joint imaging in smalls animals
van bree; Gielen; Van Rijssen et al

Conference (2001, October 25)

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See detailComparative long-term effects of coronary artery bypass graft surgery and percutaneous transluminal coronary angioplasty on regional coronary flow reserve.
Bates, E. R.; Aueron, F. M.; Legrand, Victor ULg et al

in Circulation (1985), 72(4), 833-9

To evaluate the relative long-term improvement in coronary artery hemodynamics after revascularization by coronary artery bypass graft surgery (CABG) or percutaneous transluminal coronary angioplasty ... [more ▼]

To evaluate the relative long-term improvement in coronary artery hemodynamics after revascularization by coronary artery bypass graft surgery (CABG) or percutaneous transluminal coronary angioplasty (PTCA), regional coronary flow reserve (CFR) was measured, by digital computer analysis of 35 mm cine film, in 50 men undergoing cardiac catheterization. CFR (mean +/- SEM) in 12 atherosclerotic arteries before revascularization was 1.02 +/- 0.05. Mean CFR in 29 normal arteries of men with normal coronary arteriograms was significantly higher (2.59 +/- 0.11) than that in 16 atherosclerotic arteries of patients revascularized by CABG (2.02 +/- 0.17, p less than .01) or in 14 atherosclerotic arteries of those revascularized by PTCA (1.97 +/- 0.12, p less than .01). No difference in CFR between the CABG and PTCA groups was found and variables known to influence CFR were similar between groups. Equivalent and significant long-term improvement in coronary artery hemodynamics is provided by CABG or PTCA. We postulate that the difference in CFR in the men with normal arteries and those who underwent revascularization was related to the effects of the general atherosclerotic process, which remain despite successful treatment by these techniques. [less ▲]

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See detailComparative magnetotail flapping: An overview of selectec events ad Earth, Jupiter and Saturn
Volwerk, M.; Andre, N.; Arridge, C. et al

in Annales Geophysicae [= ANGEO] (2013)

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See detailComparative magnetotail flapping: Overview of observations at Earth, Jupiter and Saturn
Volwerk, M.; Andre, N.; Arridge, C. et al

Conference (2011)

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See detailComparative Measures of Technical Efficiency for 500 French SCOP
Defourny, Jacques ULg

in Jones, Derek C.; Svejnar, Jan (Eds.) Advances in the Economic Analysis of Participatory and Labor-Managed Firms (1992)

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See detailComparative morphological studies on some species of the genus Fumaria
Paltinean, Ramona; Wauters, Jean-Noël ULg; Tits, Monique ULg et al

in Farmacia (2013), 61(2), 371-377

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See detailComparative Morphometric Study of Eruptive Puva-Induced and Chronic Sun-Induced Lentigines of the Skin
Nikkels, Arjen ULg; Ben Mosbah, T.; Pierard-Franchimont, Claudine ULg et al

in Analytical and Quantitative Cytology and Histology (1991), 13(1), 23-26

Computerized image analysis was used to compare lentigines (brown freckle-like cutaneous spots) induced by treatment with psoralens and ultraviolet light A (PUVA-induced lentigines) with those induced by ... [more ▼]

Computerized image analysis was used to compare lentigines (brown freckle-like cutaneous spots) induced by treatment with psoralens and ultraviolet light A (PUVA-induced lentigines) with those induced by solar exposure (actinic lentigines). For these conditions, which appear to be distinctive clinically and histologically, the number, size and shape of the macules were analyzed, revealing significant differences in the two latter parameters. This indicates that UV irradiations of different wave lengths act differently on melanocytes and/or on the interrelation between melanocytes and keratinocytes. The overall effect is much more self-limited in PUVA lentigines than in actinic lentigines, suggesting that the pathophysiology of these lesions is probably different. [less ▲]

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See detailComparative Nationality Law - Selected Questions (2012)
Wautelet, Patrick ULg

Learning material (2012)

These slides were used as support for a course taught in English (in 2012) which provides an overview of the major questions arising in the field of nationality law. The course focuses on acquisition and ... [more ▼]

These slides were used as support for a course taught in English (in 2012) which provides an overview of the major questions arising in the field of nationality law. The course focuses on acquisition and loss of nationality and touches upon other issues such as multiple nationalities and the influence of the European construction on nationality law. All these questions are studied using comparative materials (mainly from Western Europe) as basis. Reference is also made to the European Convention on Nationality (1997) as well as to other relevant international instruments dealing with nationality law. [less ▲]

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See detailComparative Nationality Law - Selected Questions (2014)
Wautelet, Patrick ULg

Learning material (2013)

This collection of ppt presentation was used as support for a course taught in English (in 2013) which provides an overview of the major questions arising in the field of nationality law. The course ... [more ▼]

This collection of ppt presentation was used as support for a course taught in English (in 2013) which provides an overview of the major questions arising in the field of nationality law. The course focuses on acquisition and loss of nationality and touches upon other issues such as multiple nationalities and the influence of the European construction on nationality law. All these questions are studied using comparative materials (mainly from Western Europe) as basis. Reference is also made to the European Convention on Nationality (1997) as well as to other relevant international instruments dealing with nationality law. [less ▲]

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See detailComparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5.
JOURET, François ULg; Igarashi, Takashi; Gofflot, Francoise et al

in Kidney International (2004), 65(1), 198-208

BACKGROUND: The renal chloride channel ClC-5, which is responsible for Dent's disease, is coexpressed with the vacuolar H+-ATPase in proximal tubules (PT) and alpha-type intercalated cells (IC) of the ... [more ▼]

BACKGROUND: The renal chloride channel ClC-5, which is responsible for Dent's disease, is coexpressed with the vacuolar H+-ATPase in proximal tubules (PT) and alpha-type intercalated cells (IC) of the mature kidney. Neonatal cases of Dent's disease suggest that ClC-5 distribution must be acquired before birth. However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related proteins during nephrogenesis remain unknown. METHODS: Immunoblotting, real-time polymerase chain reaction (RT-PCR), immunostaining, and deglycosylation studies were used to investigate the expression, distribution, and maturation of ClC-5 during mouse and human nephrogenesis, in comparison with H+-ATPase, type II carbonic anhydrase (CAII), and aquaporin-1 (AQP1). RESULTS: An early induction (E13.5-E14.5) of ClC-5 was observed in mouse kidney, with persistence at high levels through late nephrogenesis. This pattern contrasted with the progressive expression of H+-ATPase and AQP1, and the postnatal upregulation of CAII. Immunostaining showed expression of ClC-5 in ureteric buds and, from E14.5, its location in developing PT. From E15.5, ClC-5 codistributed with H+-ATPase in PT cells and alpha-type IC. In the human kidney, ClC-5 was detected from 12 gestation weeks; its distribution was similar to that observed in mouse, except for a later detection in IC. Although mouse and human ClC-5 proteins are glycosylated, biochemical differences between fetal and adult proteins were observed in both species. CONCLUSION: The segmental expression of ClC-5 and H+-ATPase is essentially achieved during early nephrogenesis, in parallel with the onset of glomerular filtration. These data give insight into PT and IC maturation, and explain early phenotypic variants of Dent's disease. [less ▲]

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See detailComparative Pathogenesis of Acute and Latent Infections of Calves with Bovine Herpesvirus Types 1 and 5
Meyer, Gilles; Lemaire, Mylène; Ros, C. et al

in Archives of Virology (2001), 146(4), 633-52

This study was conducted to compare the pathogenesis of acute and latent infections with closely related bovine herpesvirus types 1 (BHV-1) and 5 (BHV-5) in their natural host. Two groups of eight calves ... [more ▼]

This study was conducted to compare the pathogenesis of acute and latent infections with closely related bovine herpesvirus types 1 (BHV-1) and 5 (BHV-5) in their natural host. Two groups of eight calves were inoculated intranasally with BHV-1 or BHV-5. Although BHV-1 and BHV-5 similarly replicate in the nasal mucosa after inoculation, both viruses differ markedly in their ability to cause disease, BHV-5 being responsible of some fatal encephalitis while BHV-1 inducing rhinotracheitis. Virus isolation and immunohistochemistry demonstrated that BHV-5 replicates extensively in neurons of the central nervous system (CNS) and in respiratory cells of lungs, tracheal and nasal mucosae. Invasion of the CNS likely occurs through the trigeminal and olfactory pathways. Both groups developed cross-neutralising antibodies during this experiment suggesting partial clinical cross-protection afforded by the two infections. Three months after primary infection, experimental reactivation showed that BHV-5 was able to establish latency in the trigeminal ganglia but also the CNS of surviving calves. Moreover, laboratory findings suggested that BHV-5 could also persist in the tracheal and nasal mucosae. These results indicate that, after primary infection, BHV-1 and BHV-5 displayed similar biological features and consequently need to be considered together for the control of BHV-1 infection. [less ▲]

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See detailThe comparative performance of for-profit, public and third sector providers. The case of the "service-vouchers" field in Belgium".
Defourny, Jacques ULg; Henry, Arnaud

E-print/Working paper (2011)

Within the Belgian service-voucher system, various types of organizations can provide services (house cleaning, ironing and various types of help to vulnerable persons). Based on a detailed survey ... [more ▼]

Within the Belgian service-voucher system, various types of organizations can provide services (house cleaning, ironing and various types of help to vulnerable persons). Based on a detailed survey covering 50 providers of different types, this paper examines their comparative performance based on three different specifications of the latter and by using Data Envelopment Analysis. [less ▲]

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See detailComparative performance study of postal services: a productive efficiency approach
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Annales d'Economie et de Statistique (1994), (33), 187-202

This paper first discusses the notion of economic performance as applied to public enterprises and argues that productive efficiency is an attractive approach to performance measurement for such firms. It ... [more ▼]

This paper first discusses the notion of economic performance as applied to public enterprises and argues that productive efficiency is an attractive approach to performance measurement for such firms. It then presents an empirical efficiency study of postal services which is aimed at comparing productive performance indicators across countries and at testing the effect of competition and regulation on these indicators. [less ▲]

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See detailComparative Pharmacokinetics of Two Intravenous Administration Regimens of Tiludronate in Healthy Adult Horses and Effects on the Bone Resorption Marker Ctx-1
Delguste, Catherine ULg; Amory, Hélène ULg; Guyonnet, J. et al

in Journal of Veterinary Pharmacology & Therapeutics (2008), 31(2), 108-16

Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days ... [more ▼]

Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days (group 1, n = 6) and as a single constant rate infusion (CRI) at a total dose of 1 mg/kg b.w. (group 2, n = 6) in healthy adult horses. Tiludronate and carboxy-terminal cross-linking telopeptide of type I collagen (CTX-1) were measured in plasma and urine. There was no statistically significant difference in area under the curve (AUC) and clearance (Cl) between the two groups. Bioavailability of the CRI was 103% (not significantly different) that of the 10 daily i.v. bolus doses. Cumulative urine tiludronate excretion could not be compared between groups because of poor sensitivity of the assay in urine. Plasma and urine CTX-1 levels were not different between groups throughout the study. However, interindividual variations were greater in group 1 than in group 2. A significant decrease in CTX-1 levels was observed in plasma after the first administration in group 1, but not in urine; while in group 2, a significant decrease in CTX-1 concentrations was observed after treatment in both plasma and urine. In conclusion, both dosage regimens of tiludronate produced similar plasma exposure and pharmacological effects in adult healthy horses. [less ▲]

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See detailComparative pharmacokinetics of two intravenous dosage rates of tiludronate in healthy adult horses
Delguste, Catherine ULg; Amory, Hélène ULg; Guyonnet, Jérôme et al

Conference (2007)

Plasma and urine pharmacokinetics of tiludronate administered once daily as an intravenous bolus of 0.1 mg/kg for ten consecutive days (group 1, n=6) was compared to a single slow infusion of 1 mg/kg ... [more ▼]

Plasma and urine pharmacokinetics of tiludronate administered once daily as an intravenous bolus of 0.1 mg/kg for ten consecutive days (group 1, n=6) was compared to a single slow infusion of 1 mg/kg (group 2, n=6) in healthy adult horses. Plasma samples were collected at regular intervals for a period of 16 and 7 days in groups 1 and 2 respectively. Continuous urine collection for determination of cumulative urinary excretion of tiludronate was performed during 16 and 7 days in groups 1 and 2 respectively, and over 24-hour periods every 10 days until 60 days after the last tiludronate administration in both groups. Tiludronate concentrations were obtained in all plasma and urine samples using HPLC with UV detection. Plasma pharmacokinetic parameters were determined using a noncompartmental approach. Group 1 mean (± SD) AUCss was 3.76 (±0.698) mg.h.L-1 and group 2 mean (± SD) AUCtot was 39.07 (±3.699) mg.h.L-1. Mean (± SD) clearance (Cl) was 0.027 (±0.0042) and 0.026 (±0.0022) L.h-1.kg-1 in groups 1 and 2, respectively. Neither the dose corrected AUC (p=0.724) nor the Cl (p=0.528) were statistically different between groups. Relative plasma bioavailability (infusion versus bolus) was 103%. Cumulative urine tiludronic acid excretion could not be compared between groups due to analytical limitations (LOQ of 0.025 mg.L-1), which led to numerous missing data particularly in group 1, and an inability to conduct appropriate statistical and pharmacokinetic analyses. In conclusion, both dosage rates of tiludronate were considered bioequivalent with regards to plasma pharmacokinetics. [less ▲]

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