Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Peer Reviewed
See detailCombined hemodynamic effects of low dose of Dopamine and Dobutamine in patients with acute infarction and cardiac failure
EL ALLAF, D; D'Orio, Vincenzo ULg; cremers, s et al

in Archives Internationales de Physiologie et de Biochimie (1984), 92

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailCombined holography and thermography in a single sensor through image-plane holography at thermal infrared wavelengths
Georges, Marc ULg; Vandenrijt, Jean-François ULg; Thizy, Cédric ULg et al

in Optics Express (2014), 22(21), 25517-25529

Holographic interferometry in the thermal wavelengths range, combining a CO2 laser and digital hologram recording with a microbolometer array based camera, allows simultaneously capturing temperature and ... [more ▼]

Holographic interferometry in the thermal wavelengths range, combining a CO2 laser and digital hologram recording with a microbolometer array based camera, allows simultaneously capturing temperature and surface shape information about objects. This is due to the fact that the holograms are affected by the thermal background emitted by objects at room temperature. We explain the setup and the processing of data which allows decoupling the two types of information. This natural data fusion can be advantageously used in a variety of nondestructive testing applications. [less ▲]

Detailed reference viewed: 31 (11 ULg)
Full Text
Peer Reviewed
See detailA combined hydrochemical, isotopic and multivariate statistics approach for pollutant source identification in a regional aquifer
Gesels, Julie ULg; Joniau, Claire; Knöller, Kay et al

Conference (2013, April 23)

In an urban and industrial context, a detailed hydrogeochemical characterization of groundwater has been performed in an alluvial aquifer, with the aim of determining the origin of the inorganic ... [more ▼]

In an urban and industrial context, a detailed hydrogeochemical characterization of groundwater has been performed in an alluvial aquifer, with the aim of determining the origin of the inorganic contaminations and the main processes involved that contribute to a poor groundwater quality. [less ▲]

Detailed reference viewed: 23 (4 ULg)
Full Text
Peer Reviewed
See detailThe combined immunodetection of AP-2alpha and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors.
Allouche, Abdelkader; Nolens, Gregory ULg; Tancredi, Annalisa ULg et al

in Breast Cancer Research [=BCR] (2008), 10(1), 9

INTRODUCTION: Overexpression of the ERBB2 oncogene is observed in about 20% of human breast tumors and is the consequence of increased transcription rates frequently associated with gene amplification ... [more ▼]

INTRODUCTION: Overexpression of the ERBB2 oncogene is observed in about 20% of human breast tumors and is the consequence of increased transcription rates frequently associated with gene amplification. Several studies have shown a link between activator protein 2 (AP-2) transcription factors and ERBB2 gene expression in breast cancer cell lines. Moreover, the Yin Yang 1 (YY1) transcription factor has been shown to stimulate AP-2 transcriptional activity on the ERBB2 promoter in vitro. In this report, we examined the relationships between ERBB2, AP-2alpha, and YY1 both in breast cancer tissue specimens and in a mammary cancer cell line. METHODS: ERBB2, AP-2alpha, and YY1 protein levels were analyzed by immunohistochemistry in a panel of 55 primary breast tumors. ERBB2 gene amplification status was determined by fluorescent in situ hybridization. Correlations were evaluated by a chi2 test at a p value of less than 0.05. The functional role of AP-2alpha and YY1 on ERBB2 gene expression was analyzed by small interfering RNA (siRNA) transfection in the BT-474 mammary cancer cell line followed by real-time reverse transcription-polymerase chain reaction and Western blotting. RESULTS: We observed a statistically significant correlation between ERBB2 and AP-2alpha levels in the tumors (p < 0.01). Moreover, associations were found between ERBB2 protein level and the combined high expression of AP-2alpha and YY1 (p < 0.02) as well as between the expression of AP-2alpha and YY1 (p < 0.001). Furthermore, the levels of both AP-2alpha and YY1 proteins were inversely correlated to ERBB2 gene amplification status in the tumors (p < 0.01). Transfection of siRNAs targeting AP-2alpha and AP-2gamma mRNAs in the BT-474 breast cancer cell line repressed the expression of the endogenous ERBB2 gene at both the mRNA and protein levels. Moreover, the additional transfection of an siRNA directed against the YY1 transcript further reduced the ERBB2 protein level, suggesting that AP-2 and YY1 transcription factors cooperate to stimulate the transcription of the ERBB2 gene. CONCLUSION: This study highlights the role of both AP-2alpha and YY1 transcription factors in ERBB2 oncogene overexpression in breast tumors. Our results also suggest that high ERBB2 expression may result either from gene amplification or from increased transcription factor levels. [less ▲]

Detailed reference viewed: 137 (17 ULg)
See detailThe combined impact of changing terrestrial organic carbon reservoirs and fractionation effects induced by changing carbonate ion concentrations on the glacial-interglacial marine C-13 record
Munhoven, Guy ULg; François, Louis ULg; Ouberdous, Mohamed ULg

Conference (2005, April 27)

On the basis of the marine and atmospheric glacial-interglacial C-13 isotopic records, it has been calculated that the land biospheric carbon stock must have increased by 270–720 GtC from the Last Glacial ... [more ▼]

On the basis of the marine and atmospheric glacial-interglacial C-13 isotopic records, it has been calculated that the land biospheric carbon stock must have increased by 270–720 GtC from the Last Glacial Maximum (LGM) to the present. Estimates derived from vegetation mapping based on palynological or sedimentological data generally indicate a larger increase of the biospheric stock in the range of 700–1350 GtC and above. Although there is some overlap between the two ranges, they substantially disagree. Further complications arise when carbonate-ion dependent fractionation effects in the marine C-13 record are considered. A detailed budget of the C-13 isotope in the land biosphere at the LGM, as well as in the other reservoirs of the global carbon cycle is therefore required. Here, we analyse the response of the atmosphere–ocean–surface sediment system under the influence of variable release and uptake fluxes of C by the terrestrial biosphere. Glacial-interglacial variations of the carbon stocks and isotopic budgets of the land biosphere were derived from simulation experiments carried out with the global biosphere model CARAIB (CARbon Assimilation In the Biosphere) under boundary conditions typical for the Last Glacial Maximum and for mid-Holocene times. CARAIB uses a mechanistic description of both C3 and C4 photosynthetic pathways. It thus provides information on the C-13 signature of carbon fluxes involved. Using the eleven-box model MBM of the ocean-atmosphere system, we then investigate the effect of these biospheric changes on the oceanic carbon cycle and the CO2 concentration in the atmosphere. MBM has a complete representation of the transfer processes of carbon and alkalinity from the land to the ocean, and between the ocean and the surface sediment, including parameterisations for processes in the shelf area. MBM also considers C-13 signatures of the carbon fluxes and stocks represented. On the basis of empirical relationships for the incorporation of C-13 isotopes in foraminiferal shells as a function of carbonate ion concentration, synthetic carbon isotopic records are generated from the calculated seawater C-13 isotopic evolution, helping to better constrain estimates of the land biosphere carbon stock changes derived from the marine C-13 record. These simulations also test various scenarios for the alkalinity input to the system from weathering, which, through their effect on carbonate ion concentration, may also impinge to a non negligible extent on C-13 variations recorded in deep-sea sediments. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailCombined implicit-explicit algorithms for non-linear structural dynamics
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg et al

in Revue Européenne des Éléments Finis (2002), 11(5), 565-591

To solve fast dynamic problems, an explicit method is the most adapted. But for slower dynamics, an implicit method is more stable. The industrial problems are governed by high frequency (impact ... [more ▼]

To solve fast dynamic problems, an explicit method is the most adapted. But for slower dynamics, an implicit method is more stable. The industrial problems are governed by high frequency (impact, ...) during short time intervals and slower dynamics (spring-back, ...) during other time intervals. The optimal solution is then to have both implicit algorithm and explicit methods readily available in the same code and to be able to switch automatically from one to another. Criteria that decide when to shift from a method to another have been developed here. Implicit balanced restarting conditions that annihilate numerical oscillations resulting for an explicit calculation are also proposed. [less ▲]

Detailed reference viewed: 73 (8 ULg)
Full Text
Peer Reviewed
See detailCombined implicit/explicit algorithms for crashworthiness analysis
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

in International Journal of Impact Engineering (2004), 30(8-9, SEP-OCT), 1161-1177

In order to simulate an industrial process, an explicit method, which is conditionally stable, is the most adapted while the non-linearities evolve rapidly (impact phase, stamping process, etc.). But when ... [more ▼]

In order to simulate an industrial process, an explicit method, which is conditionally stable, is the most adapted while the non-linearities evolve rapidly (impact phase, stamping process, etc.). But when the dynamics becomes quasi-linear (post-impact analysis, springback simulation, etc.), an implicit method, which is iterative, presents the advantage of unconditional stability. The optimal solution is then to have both implicit and explicit methods readily available in the same code and to be able to switch automatically from one to the other. Criteria that decide to switch from one method to another, depending on the current dynamics, have been developed. Implicit restarting conditions are also proposed that annihilate numerical oscillations resulting from an explicit calculation. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 38 (3 ULg)
See detailCombined implicit/explicit time integration algorithms for crashworthiness analysis and metal forming simulation
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

in Proceedings of IMPLAST'2003, 8th International Symposium on Plasticity and Impact Mechanics (2003, March)

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailCombined implicit/explicit time-integration algorithms for the numerical simulation of sheet metal forming
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

in Journal of Computational & Applied Mathematics (2004), 168(1-2, Sp. Iss. SI), 331-339

In order to simulate stamping processes, an explicit method, which is conditionally stable, is generally thought to be the most adapted. Such an algorithm presents the advantage of being noniterative ... [more ▼]

In order to simulate stamping processes, an explicit method, which is conditionally stable, is generally thought to be the most adapted. Such an algorithm presents the advantage of being noniterative while, the contact configuration evolves rapidly, and the conditional stability is not a disadvantage since time steps must be small enough anyway for an accurate computation. But during the springback simulation, an implicit method, which is iterative, presents the advantage of unconditional stability. The optimal solution is then to have both implicit and explicit methods readily available in the same code and to be able to switch automatically from one to the other. Criteria that decide to switch from a method to another, depending on the current dynamic, have been developed. Implicit restarting conditions are also proposed that annihilate numerical oscillations resulting from an explicit calculation. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 54 (4 ULg)
Full Text
Peer Reviewed
See detailA combined incremental-secant mean-field homogenization scheme with per-phase residual strains for elasto-plastic composites
Wu, Ling ULg; Noels, Ludovic ULg; Adam, Laurent et al

in International Journal of Plasticity (2013), 51

This paper presents an incremental secant mean-fi eld homogenization (MFH) procedure for composites made of elasto-plastic constituents. In this formulation, the residual stress and strain states reached ... [more ▼]

This paper presents an incremental secant mean-fi eld homogenization (MFH) procedure for composites made of elasto-plastic constituents. In this formulation, the residual stress and strain states reached in the elasto-plastic phases upon a fi ctitious elastic unloading are considered as starting point to apply the secant method. The mean stress fields in the phases are then computed using secant tensors, which are naturally isotropic and enable to de fine the Linear-Comparison-Composite. The method, which remains simple in its formulation, is valid for general non-monotonic and non-proportional loading. It is applied on various problems involving elastic, elasto-plastic and perfectly-plastic phases, to demonstrate its accuracy compared to other existing MFH methods. [less ▲]

Detailed reference viewed: 125 (64 ULg)
Full Text
Peer Reviewed
See detailCombined Interferon-Gamma and Tumor Necrosis Factor-Alpha Treatment Differentially Affects Adhesion and Migration of Keratinocyte-Derived Cells to Laminin-1
van den Brule, Frédéric A; Clausse, Nathalie; Delvenne, Philippe ULg et al

in Cell Adhesion and Communication (2000), 7(4), 321-9

Interactions with the extracellular matrix constitute basic steps in cervix carcinoma cell invasion. In this study, we examined the adhesion and migration profiles of two human papillomavirus (HPV) DNA ... [more ▼]

Interactions with the extracellular matrix constitute basic steps in cervix carcinoma cell invasion. In this study, we examined the adhesion and migration profiles of two human papillomavirus (HPV) DNA-transfected keratinocyte-derived cell lines, EIL8 and 18-11S3, and of the cervix adenocarcinoma SiHa cell line, towards laminin-1, and the selective effect of a 24-72 h treatment of 1000 U/ml interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), a treatment that significantly decreases cervix carcinoma cell proliferation and progression in nude mice, on these parameters. Compared to normal cervix keratinocytes (CK) and two HPV DNA-transfected keratinocyte cell lines, in basal conditions, the SiHa cell line was characterized by increased attachment (SiHa, 48.74 +/- 4.02 vs. normal keratinocytes, 4.32 +/- 0.40, EIL8, 17.80 +/- 3.03 and 18-11S3, 17.82 +/- 1.48% of attached cells after 30 min) and marked directed chemotactic migration towards laminin-1. Interestingly, treatment of the cells with the cytokines (1000 U/ml IFN-gamma and TNF-alpha) did not modulate the adhesion properties of the cells, but chemotactic migration of SiHa cells to laminin-1 was significantly decreased, while migration towards type I collagen was increased. Similar results were obtained with the Ca Ski cervix carcinoma cell line. Our results emphasize the altered pattern of interactions of cervix carcinoma cells with extracellular matrix components such as laminin-1, compared to normal and pre-neoplastic cells, and contributes to the understanding of the effects of cytokine treatment on cervix carcinoma cells. [less ▲]

Detailed reference viewed: 26 (5 ULg)
Full Text
Peer Reviewed
See detailCombined Intra- and Inter-domain Traffic Engineering using Hot-Potato Aware Link Weights Optimization
Balon, Simon ULg; Leduc, Guy ULg

in ACM SIGMETRICS Performance Evaluation Review (2008), 36(1), 441-442

A well-known approach to intradomain traffic engineering consists in finding the set of link weights that minimizes a network-wide objective function for a given intradomain traffic matrix. This approach ... [more ▼]

A well-known approach to intradomain traffic engineering consists in finding the set of link weights that minimizes a network-wide objective function for a given intradomain traffic matrix. This approach is inadequate because it ignores a potential impact on interdomain routing due to hot-potato routing policies. This may result in changes in the intradomain traffic matrix that have not been anticipated by the link weights optimizer, possibly leading to degraded network performance. <br /> <br />We propose a BGP-aware link weights optimization method that takes these hot-potato effects into account. This method uses the interdomain traffic matrix and other available BGP data, to extend the intradomain topology with external virtual nodes and links, on which all the well-tuned heuristics of a classical link weights optimizer can be applied. Our method can also optimize the traffic on the interdomain peering links. [less ▲]

Detailed reference viewed: 54 (10 ULg)
Peer Reviewed
See detailCombined Liver - Spleen -small intestine grafting in a rat model: Role of transplanting additional lymphoid tissue on survival.
D'Silva, Milbhor; Pirenne, Jacques; Nakhleh, R. E. et al

in International Surgery (1996), (81), 109-114

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailCombined locked nucleic acid and molecular beacon technologies for sensitive detection of the JAK2(V617F) somatic single-base sequence variant
Sidon, P.; Heimann, P.; Lambert, Frédéric ULg et al

in Clinical Chemistry (2006), 52(7), 1436-1438

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailCombined metabolomic and genetic approaches reveal a link between the polyamine pathway and albumin 2 in developing pea seeds.
Vigeolas, Hélène ULg; Chinoy, Catherine; Zuther, Ellen et al

in Plant Physiology (2008), 146(1), 74-82

Several legume seed proteins that are potentially allergenic, poorly digested by farm animals, and/or have undesirable functional properties, have been described. One of these is the albumin protein in ... [more ▼]

Several legume seed proteins that are potentially allergenic, poorly digested by farm animals, and/or have undesirable functional properties, have been described. One of these is the albumin protein in pea (Pisum sativum) called PA2. A naturally occurring mutant line that lacks PA2 has been exploited in studies to determine the biological function of this nonstorage protein in seed development. The mutant, which has a small seed, a tall plant phenotype, and lacks most of the PA2-encoding genes, has been crossed with a standard cultivar, 'Birte,' which contains PA2 to give rise to a recombinant inbred (RI) population. An F(3) line carrying the mutation and having a short plant phenotype has been used to generate backcross (BC) lines with 'Birte.' Despite having a lower albumin content, seeds from the mutant parent and RI lines lacking PA2 have an equivalent or higher seed nitrogen content. Metabolite profiling of seeds revealed major differences in amino acid composition and polyamine content in the two parent lines. This was investigated further in BC lines, where the effects of differences in seed size and plant height between the two parents were eliminated. Here, differences in polyamine synthesis were maintained as was a difference in total seed protein between the BC line lacking PA2 and 'Birte.' Analysis of enzyme activities in the pathways of polyamine synthesis revealed that the differences in spermidine content were attributable to changes in the overall activities of spermidine synthase and arginine decarboxylase. Although the genes encoding spermidine synthase and PA2 both localized to the pea linkage group I, the two loci were shown not to be closely linked and to have recombined in the BC lines. A distinct locus on linkage group III contains a gene that is related to PA2 but expressed predominantly in flowers. The results provide evidence for a role of PA2 in regulating polyamine metabolism, which has important functions in development, metabolism, and stress responses in plants. [less ▲]

Detailed reference viewed: 20 (4 ULg)
Full Text
See detailCombined method for the sequential measurement of (1) the enzymatically active fraction and (2) the total amount of an enzyme
Serteyn, Didier ULg; Deby-Dupont, Ginette; Franck, Thierry ULg et al

Patent (2009)

The present invention is related to a combined method and kit (or device) for the sequential measurement of the enzymatically active fraction and the total amount of an enzyme [(such as myeloperoxidase ... [more ▼]

The present invention is related to a combined method and kit (or device) for the sequential measurement of the enzymatically active fraction and the total amount of an enzyme [(such as myeloperoxidase (MPO)] in a sample, and that find improved applications in veterinary and human health fields. [less ▲]

Detailed reference viewed: 12 (1 ULg)