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See detailComparative CCN concentration measurements between two sites in the Meuse valley and occurrence of localized dense fogs in relation with industrial activities
Boreux, Jean-Jacques ULg; Serpolay, R.

in Takahashi; Masuda (Eds.) Proceedings of the 3rd international aerosol conference (1990)

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See detailComparative Chemical and Molecular Variability of Cananga odorata (Lam.) Hook.f. Thomson forma genuina (Ylang-Ylang) in the Western Indian Ocean Islands: Implication for Valorization
Benini, Céline ULg; Mahy, Grégory ULg; Bizoux, Jean-Philippe ULg et al

in Chemistry & Biodiversity (2012), 9(7), 13891402

Cananga odorata (Lam.) Hook.f. Thomson forma genuina (Annonaceae) is a tropical tree, grown for the production of ylang-ylang essential oil, which is extracted from its fresh and mature flowers. Despite ... [more ▼]

Cananga odorata (Lam.) Hook.f. Thomson forma genuina (Annonaceae) is a tropical tree, grown for the production of ylang-ylang essential oil, which is extracted from its fresh and mature flowers. Despite its economic and social importance, very little information is available on its variability and the possible factors causing it. Therefore, the relationship between the genetic structure, revealed by amplified fragment length polymorphism (AFLP), and the essential oil chemical composition, determined by GC/MS analysis, of ylang-ylang grown in semi-managed systems in three Indian Ocean islands (Grande Comore, Mayotte, and Madagascar) was investigated. Our results revealed a low genetic variation within plantations and contrasted situations between islands. Variations of the chemical composition could be observed within plantations and between islands. The genetic differentiation pattern did not match the observed pattern of chemical variability. Hence, the chemical variation could not be attributed to a genetic control. As Grande Comore, Madagascar, and Mayotte present different environmental and agronomic conditions, it can be concluded that the influence of these conditions on the ylang-ylang essential oil composition is consistent with the patterns observed. Finally, several strategies were proposed to valorize the chemical composition variations. [less ▲]

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See detailComparative Citizenship Project: International Working Groups Meeting
Martiniello, Marco ULg

Scientific conference (1999, November 08)

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See detailComparative clinical and electrometric assessments of the impact of surfactants on forearm skin.
Uhoda, Emmanuelle ULg; Paye, Marc; Pierard, Gérald ULg

in Exogenous Dermatology : Physical, Chemical, Biological (2003), 2

Surfactant-based skin care products can induce minimal to more severe alterations to human stratum corneum (SC). These changes can be conveniently assessed using electrometric devices. Four different ... [more ▼]

Surfactant-based skin care products can induce minimal to more severe alterations to human stratum corneum (SC). These changes can be conveniently assessed using electrometric devices. Four different surfactant-based solutions were applied on the forearms of 10 healthy volunteers following a soap chamber test method. The 2-day patch testing was followed by a 2-week follow-up. Clinical and instrumental assessments were performed at 7 time points. Data generated by the Corneometer® CM820, the DermaLab Moisture Module® and the Nova Dermal Phase Meter (DPM)® 9003 were compared. The significant differences between the product aggressiveness to the SC were similarly disclosed by the Corneometer® and the DermaLab Moisture Module®. The ranking of product aggressiveness given by the 3 devices 5 days after patch removal was similar to that given by the clinical assessment of erythema. A high level of correlation were found between the values yielded by the immediate and continuous mode assessments using the DermaLab Moisture Module with the Pin Probe, while the correlation was weaker with the Nova DPM®. This finding may be related to the fact that the Nova DPM is influenced by the accumulation of the transepidermal water loss in the continuous mode assessment while there is no significant occlusion effect of the DermaLab Moisture® Pin Probe that is more representative of the initial level of SC hydration. In conclusion, the Corneometer® and the DermaLab Moisture Module® respond similarly to changes in the SC content. This finding is different from some previous reports. [less ▲]

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See detailComparative clinicopathological manifestations of human aspergillosis. A review.
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg

in Exogenous Dermatology : Physical, Chemical, Biological (2004), 3

Aspergillus species are important fungi of the environment, some of them being responsible for severe infections. Many distinct diseases form the human aspergillosis spectrum. The pathomechanisms differ ... [more ▼]

Aspergillus species are important fungi of the environment, some of them being responsible for severe infections. Many distinct diseases form the human aspergillosis spectrum. The pathomechanisms differ according to the affected organ and the immune status of the patient. The fungus can be responsible for allergic reactions. It may also act as a saprophytic colonizer of air spaces. Infection may remain limited to the skin and nails. It may also be invasive, particularly in immunocompromised patients, in the lungs, paranasal sinus and gastro-intestinal tract. Hematogeneous disseminated aspergillosis represents another dramatic form of the disease. [less ▲]

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See detailComparative cytokine production by in vitro stimulated mononucleated cells from cord blood and adult blood.
Sautois, Brieuc ULg; Fillet, Georges ULg; Beguin, Yves ULg

in Experimental hematology (1997), 25(2), 103-8

Cord blood transplantations successfully reconstituted hemopoiesis in patients treated with myeloablative therapies. These transplantations were associated with a low rate of acute graft-versus-host ... [more ▼]

Cord blood transplantations successfully reconstituted hemopoiesis in patients treated with myeloablative therapies. These transplantations were associated with a low rate of acute graft-versus-host disease (aGVHD), a major life-threatening complication of allo-transplantation. The physiopathology of aGVHD implies the recognition of host alloantigens by donor T cells but also involves a cytokine cascade. In this cascade, interleukin (IL)-1, IL-2, IL-6, tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) produced by donor T cells and monocytes/macrophages play a major effector role. Therefore, we investigated whether the lower percentage of aGVHD in cord blood transplants could be related to a lower ability to produce these cytokines in vitro compared with adult blood. Mononucleated cells (MNCs) isolated from term cord blood and adult peripheral blood were stimulated with a combination of lipopolysaccharide and phytohemaglutinin and incubated for 96 hours. Levels of IL-1beta, IL-2, IL-3, IL-4, IL-6, TNF-alpha, IFN-gamma, and granulocyte-macrophage colony-stimulating factor (GM-CSF) were measured in the supernatants after various times of incubation. The productions of IL-1beta, IL-6, and GM-CSF were similar in stimulated cord and adult blood and IL-3 levels, though lower and delayed in cord blood, were not statistically different. On the other hand, we found markedly lower levels of IFN-gamma, TNF-alpha, and IL-4 in cord blood throughout the incubation period. The stimulated levels of IL-2 were similar in cord and adult samples throughout the first 48 hours of incubation but became significantly lower in cord blood after 72 and 96 hours. We suggest that the cytokine production pattern that characterizes cord blood could provide an explanation for the lower occurence of aGVHD following cord blood transplants. [less ▲]

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See detailComparative degradation rates of chitinous exoskeletons from deep-sea environments
Ravaux, J.; Zbinden, M.; Voss-Foucart, M. F. et al

in Marine Biology (2003), 143(2), 405-412

Hydrothermal vent environments, particularly those associated with the vestimentiferan Riftia pachyptila, are believed to be among the highest chitin-producing systems. In order to elucidate the chitin ... [more ▼]

Hydrothermal vent environments, particularly those associated with the vestimentiferan Riftia pachyptila, are believed to be among the highest chitin-producing systems. In order to elucidate the chitin cycle in these environments, we estimate the in situ chitin degradation rates of tube-worm exoskeletons. Our in situ experiments show that the tubes of Riftia are highly stable structures. Comparative measurements of the degradation rates of Riftia tubes and crab shells immersed at deep-sea vents show that the tubes would be degraded within 2.5 years, whereas the time for the total degradation of the vent crab (Bythograea thermydron) carapaces would not exceed 36 days. The importance of the microbial participation in this degradation was estimated for Riftia tubes. Based on previous work, we calculated chitin production by a population of Riftia tubes of about 750 g m(-2) year(-1) (763). From our in situ experiments, we estimated a microbial chitinolysis rate of about 500 g m(-2) year(-1) (496) (65% of the chitin produced). Exoskeletons containing beta-chitin appear more stable in natural environments than those containing alpha-chitin and would thus be less available as carbon and nitrogen sources. In contrast, isolated beta-chitin was hydrolysed faster than alpha-chitin during in vitro degradation experiments; for instance, Riftia beta-chitin was degraded about 3- to 4-fold faster than Bythograea alpha-chitin. A stabilization process by disulfide bonds of the proteins-chitin link, rather than the crystalline form of the chitin (alpha/beta), accounts for the resistance of Riftia tubes to enzymatic attacks. [less ▲]

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See detailComparative double-blind multicenter study of the efficacy of tiludronate and etidronate in Paget's disease of bone
Roux, C; Gennari, C; Farrerons, J et al

in BONE (1995), 16(S1), 503

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See detailComparative echocardiography in calves of double-muscled and of standard conformation
Amory, Hélène ULg; Lekeux, Pierre ULg

in Pflügers Archives - European journal of Physiology (1991)

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See detailComparative effect of hormone replacement therapy on bone mass density and skin tensile properties
Pierard, Gérald ULg; Vanderplaetsen, S.; Pierard-Franchimont, Claudine ULg

in Maturitas (2001), 40(3), 221-227

Objectives: connective tissues constitutive of skin and bones are affected during the climacteric. Hormone replacement therapy (HRT) can help mitigate their atrophy. The aim of this study was to compare ... [more ▼]

Objectives: connective tissues constitutive of skin and bones are affected during the climacteric. Hormone replacement therapy (HRT) can help mitigate their atrophy. The aim of this study was to compare the HRT effect on the skin tensile properties and bone mass density. Methods: a total of 120 postmenopausal women (60 untreated, 60 receiving HRT) were enrolled in the study. Skin tensile properties were assessed on the volar forearm using a computerized suction device. A 500 mbar suction was applied through a 4-mm diameter hollow probe. Two operating modes were applied using a steep and a progressive Suction, respectively. BMD was measured on the hip, femoral neck and lumbar spine using dual X-ray absorptiometry. Results: in both groups of women skin elasticity was correlated with BMD. HRT significantly reduced the climacteric-associated decline in skin elasticity. A trend in better preserved BMD was also found in these women without, however, reaching significance. Conclusions: it is concluded that measures of the skin tensile properties can be sensitive enough to disclose HRT efficacy upon connective tissue atrophy. Any decrease in skin elasticity during the climacteric should prompt to perform a BMD assessment. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailComparative effect of tacrolimus and betamethasone valerate on the passive sustainable hydration of the stratum corneum in atopic dermatitis.
Xhauflaire, Emmanuelle ULg; Thirion, L.; Pierard, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2007), 214(4), 328-32

BACKGROUND: There is ample evidence that the skin barrier function is altered in atopic dermatitis. Little information is available about the effect of topical corticosteroids and calcineurin inhibitors ... [more ▼]

BACKGROUND: There is ample evidence that the skin barrier function is altered in atopic dermatitis. Little information is available about the effect of topical corticosteroids and calcineurin inhibitors on this function. PURPOSE: To assess the water content and its rate of accumulation in the stratum corneum of atopic patients using an indirect electrometric method while on tacrolimus or betamethasone valerate treatment. METHOD: Twenty-one patients with moderate atopic dermatitis affecting both forearms completed this double-blind randomized study. One forearm was treated twice daily for 3 weeks with 0.1% tacrolimus ointment. The other forearm was similarly treated with 0.12% betamethasone valerate ointment. Electrometric measurements were made under continuous occlusion secured by a Nova Dermal Phase Meter sensor probe. Assessments were performed at inclusion, after the 3-week treatment and after a further 3-week follow-up out of treatment. RESULTS: During treatment, both compounds yielded a similar improvement in skin barrier function. Indeed, under probe occlusion, the rate of water accumulation was significantly decreased. This improvement was sustained after stopping the tacrolimus treatment. By contrast, the benefit was in part lost at the site that had been treated by betamethasone valerate. CONCLUSION: The difference in the effect of the 2 compounds may be due to the negative influence of betamethasone valerate on the epidermal metabolism leading to progressive atrophy of the tissue. The better preservation of the skin barrier function after stopping tacrolimus treatment may help retarding relapses of atopic dermatitis. [less ▲]

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See detailComparative Effects Of Deltamethrin And Neem Kernel Solution Treatments On Diamondback Moth And Cotesia Plutellae (Hym., Braconidae) Parasitoid Populations In The Cotonou Peri-Urban Area In Benin
Goudegnon, Ae.; Kirk, Aa.; Schiffers, Bruno ULg et al

in Journal of Applied Entomology-Zeitschrift Fur Angewandte Entomologie (2000), 124(3-4), 141-144

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See detailComparative effects of IL-1beta and hydrogen peroxide (H2O2) on catabolic and anabolic gene expression in juvenile bovine chondrocytes.
Martin, G.; Andriamanalijaona, R.; Mathy, Marianne ULg et al

in Osteoarthritis and Cartilage (2005), 13(10), 915-24

OBJECTIVE: To compare the effects of hydrogen peroxide (H(2)O(2)) to those of interleukin-1beta (IL-1beta) on gene expression in juvenile bovine articular chondrocytes (BAC). The study analyses the ... [more ▼]

OBJECTIVE: To compare the effects of hydrogen peroxide (H(2)O(2)) to those of interleukin-1beta (IL-1beta) on gene expression in juvenile bovine articular chondrocytes (BAC). The study analyses the activation of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) transcription factors, and the mRNA steady-state levels of the type II collagen, aggrecan core protein matrix, metalloproteinases (MMP-1, -3), and transforming growth factor-beta1 (TGF-beta1) genes. METHODS: Confluent BAC cultures were treated for 3 and 24h with IL-1beta and/or different concentrations of H(2)O(2) (Protocol 1). Following initial treatment, a part of the cells was further subjected to another 24h with medium, in the presence of IL-1beta, to determine the effect of the cytokine on H(2)O(2) pre-treated cells (Protocol 2). Total RNA and nuclear protein extractions were performed to study mRNA steady-state levels (real-time polymerase chain reaction) and AP-1/NF-kappaB DNA binding (Electrophoretic Mobility Shift Assays), respectively. RESULTS: IL-1beta enhanced both AP-1 and NF-kappaB binding, whereas H(2)O(2) only activated AP-1. H(2)O(2) pre-treatment decreased the IL-1beta activation of NF-kappaB. Both H(2)O(2) and IL-1beta down-regulated type II collagen and aggrecan expression and increased that of MMP-1 and -3. When cells were pre-treated with H(2)O(2), followed by IL-1beta, the effects were the same as those observed with H(2)O(2) alone. However, although H(2)O(2) and IL-1beta were capable of increasing TGF-beta1 expression separately, subsequent incubation with both factors led to a partial or total abolition of TGF-beta1 up-regulation. CONCLUSION: The different regulation of NF-kappaB and AP-1 by H(2)O(2) and IL-1beta underlines the distinct roles played by the two transcription factors in the regulation of gene expression. H(2)O(2) and IL-1beta exert similar effects on matrix, MMPs and TGF-beta1 gene expression. However, the association of H(2)O(2) and IL-1beta does not cause synergic effect, and rather leads, in some cases, to an opposite effect. These data provide further insights into the respective roles of reactive oxygen species and cytokine in the pathophysiology of joint diseases. [less ▲]

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See detailComparative effects of ketamine on Bispectral Index and spectral entropy of the electroencephalogram under sevoflurane anaesthesia
Hans, Pol ULg; Dewandre, Pierre-Yves; Brichant, Jean-François ULg et al

in British Journal of Anaesthesia (2005), 94(3), 336-340

BACKGROUND: The Bispectral Index (BIS) and spectral entropy of the electroencephalogram can be used to assess the depth of hypnosis. Ketamine is known to increase BIS in anaesthetized patients and may ... [more ▼]

BACKGROUND: The Bispectral Index (BIS) and spectral entropy of the electroencephalogram can be used to assess the depth of hypnosis. Ketamine is known to increase BIS in anaesthetized patients and may confound that index as a guide to steer administration of hypnotics. We compared the effects of ketamine on BIS, response entropy (RE) and state entropy (SE) during surgery under sevoflurane anaesthesia. METHODS: Twenty-two women undergoing gynaecological surgery were enrolled in this double-blind, randomized study. Anaesthesia was induced i.v. and maintained with sevoflurane. Under stable surgical and anaesthetic conditions, patients were assigned to receive either a bolus of ketamine 0.5 mg kg(-1) or the same volume of saline. Blood pressure, heart rate, BIS, RE and SE were measured every 2.5 min from 10 min before (baseline) until 15 min after ketamine or saline administration. The maximum relative increase in BIS, RE and SE compared with baseline was calculated for each patient. Values are mean (sd). RESULTS: Baseline values were BIS 33 (4), RE 31 (5), SE 30 (5) for the ketamine patients and BIS 35 (3), RE 33 (5) and SE 32 (6) for the patients receiving saline. BIS, RE and SE increased significantly from 5 min (BIS) and 2.5 min (RE and SE) after ketamine administration, peaking at 46 (8) (BIS), 52 (12) (RE) and 50 (12) (SE) respectively. The maximum relative increase in RE [42.2 (10.4%)] and SE [41.6 (10.9)%] was higher than that of BIS [29.4 (10.4%)]. Blood pressure, heart rate and RE-SE gradient did not change in either group. CONCLUSIONS: Ketamine administered under sevoflurane anaesthesia causes a significant increase in BIS, RE and SE without modification of the RE-SE gradient. This increase is paradoxical in that it is associated with a deepening level of hypnosis. [less ▲]

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See detailComparative effects of nimesulide, nimesulide L-lysine and nimesulide L-lysine L-arginine on human articular chondrocytes in vitro
De Leval, X.; Dogné, Jean-Michel ULg; Delarge, J. et al

in Mediators of Inflammation (2000), 9

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See detailComparative effects of nimesulide, nimesulide L-lysine and nimesulide L-lysine L-arginine on human articular chondrocytes in vitro
De Leval, X.; Dogne, J. M.; Delarge, J. et al

Poster (1999, September 17)

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See detailComparative Effects of University of Wisconsin and Euro-Collins Solutions on Pulmonary Mitochondrial Function after Ischemia and Reperfusion
Detry, Olivier ULg; Willet, K.; Lambermont, Bernard ULg et al

in Transplantation (1998), 65(2), 161-6

BACKGROUND: The aim of this study was to compare the effects of Euro-Collins and University of Wisconsin solutions on pulmonary mitochondrial function after cold ischemia and subsequent warm reperfusion ... [more ▼]

BACKGROUND: The aim of this study was to compare the effects of Euro-Collins and University of Wisconsin solutions on pulmonary mitochondrial function after cold ischemia and subsequent warm reperfusion. METHODS: Seventeen pigs underwent lung harvesting after classical lung flush with either University of Wisconsin or Euro-Collins solutions. The mitochondria were isolated from fresh swine lungs, from swine lungs subjected to 24 hr of cold ischemia, and from swine lungs subjected to 24 hr of ischemia followed by 30 min of subsequent ex vivo reperfusion at 37 degrees C with Krebs-Henseleit buffer solution and air ventilation. Mitochondrial oxidative phosphorylation parameters were determined in isolated mitochondria by in vitro measurement of oxygen consumption rates. During reperfusion, the lung function was assessed by the pulmonary aerodynamic parameters and the pulmonary vascular resistance. RESULTS: Relative to controls, mitochondria submitted to cold ischemia showed an alteration in the oxidoreductase activities of the respiratory chain. However, the yield of oxidative phosphorylation was conserved. After reperfusion, pulmonary mitochondria underwent a significant worsening in the oxidoreductase activities of the respiratory chain, and a decrease in the respiratory control and the efficiency of oxidative phosphorylation. Meanwhile, the reperfused lungs showed evidence of early dysfunction, assessed by the aerodynamic parameters and pulmonary vascular resistance. In this model, there was no advantage of University of Wisconsin solution over Euro-Collins solution. CONCLUSIONS: The mild mitochondrial alterations after cold ischemia were not sufficient to explain the limited tolerance of lung to ischemia. After reperfusion, the mitochondrial damage was more severe and could be involved in the posttransplant lung dysfunction. [less ▲]

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