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See detailCombating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes
SCHEEN, André ULg; Van Gaal, Luc

in The Lancet Diabetes & Endocrinology (2014)

The increasing prevalence of obesity is contributing substantially to the ongoing epidemic of type 2 diabetes. Abdominal adiposity, a feature of ectopic fat syndrome, is associated with silent ... [more ▼]

The increasing prevalence of obesity is contributing substantially to the ongoing epidemic of type 2 diabetes. Abdominal adiposity, a feature of ectopic fat syndrome, is associated with silent inflammation, abnormal hormone secretion, and various metabolic disturbances that contribute to insulin resistance and insulin secretory defects, resulting in type 2 diabetes, and induce a toxic pattern that leads to cardiovascular disease, liver pathologies, and cancer. Despite the importance of weight control strategies in the prevention and management of type 2 diabetes, long-term results from lifestyle or drug interventions are generally disappointing. Furthermore, most of the classic glucose-lowering drugs have a side-effect of weight gain, which renders the management of most overweight or obese people with type 2 diabetes even more challenging. Many anti-obesity pharmacological drugs targeting central control of appetite were withdrawn from the market because of safety concerns. The gastrointestinal lipase inhibitor orlistat was the only anti-obesity drug available until the recent US, but not European, launch of phentermine–controlled-release topiramate and lorcaserin. Improved knowledge about bodyweight regulation opens new prospects for the potential use of peptides derived from the gut or the adipose tissue. Combination therapy will probably be necessary to avoid compensatory mechanisms and potentiate initial weight loss while avoiding weight regain. New glucose-lowering treatments, especially glucagon-like peptide-1 receptor agonists and sodium glucose cotransporter-2 inhibitors, offer advantages over traditional antidiabetic drugs by promoting weight loss while improving glucose control. In this Review, we explore the overlapping pathophysiology and also how various treatments can, alone or in combination, combat the dual burden of obesity and type 2 diabetes. [less ▲]

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See detailCombien de litres de kérosène dans notre assiette?
Ozer, Pierre ULg; Perrin, Dominique ULg

Article for general public (2008)

L’aviation commerciale émet près de 5% des émissions mondiales de CO2 dues aux activités humaines. Sa part ne fait qu’augmenter et le développement de la mobilité internationale des biens et des personnes ... [more ▼]

L’aviation commerciale émet près de 5% des émissions mondiales de CO2 dues aux activités humaines. Sa part ne fait qu’augmenter et le développement de la mobilité internationale des biens et des personnes laisse présager une prolongation des tendances historiques de croissance du transport aérien. Avec comme conséquence, une assiette de plus en plus lourde en CO2 lorsque nos aliments proviennent de contrées lointaines par voie aérienne (kérosène). [less ▲]

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See detailCombinaison d'informations génomiques, phénotypiques et généalogiques
Vandenplas, Jérémie ULg; Gengler, Nicolas ULg

Conference given outside the academic context (2013)

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See detailCombinaison de la radiographie et de l'échographie pour l'examen du grasset sur le terrain
Busoni, Valeria ULg

in Proceedings de la Journée de la Belgian Equine Practitioners Society (BEPS) (2003)

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See detailCombinaison fixe perindopril-amlodipine (Coveram®) dans le traitement de l'hypertension artérielle et de l'insuffisance coronaire.
Scheen, André ULg; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2009), 64(4), 223-227

Coveram® is a new fixed combination of an angiotensin converting enzyme inhibitor, perindopril, and a calcium antagonist, amlodipine. This new medication is indicated for the treatment of arterial ... [more ▼]

Coveram® is a new fixed combination of an angiotensin converting enzyme inhibitor, perindopril, and a calcium antagonist, amlodipine. This new medication is indicated for the treatment of arterial hypertension and/or stable coronary heart disease. Such fixed combination of two molecules that have been extensively evaluated according to evidence-based medicine offers the advantage of an excellent efficacy, associated with a good tolerance profile, and favours patient’s compliance. The marketing of different formulations of Coveram® combining various dosages allows easy adjustment and titration of each of the components according to the individual patient’s characteristics. [less ▲]

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See detailCombination of actor’s play training and assertiveness program to reduce difficulties in self-affirmation: A preliminary study.
Wagener, Aurélie ULg; Delvaux, Muriel ULg; Sarto, Danielle et al

in 2013 BAPS Annual Meeting : Conference booklet (2013, May 28)

BACKGROUND. Difficulties in assertiveness are often reported by individuals suffering from various psychological problems involving anxiety, depression. Cognitive and behavioral therapeutic procedures ... [more ▼]

BACKGROUND. Difficulties in assertiveness are often reported by individuals suffering from various psychological problems involving anxiety, depression. Cognitive and behavioral therapeutic procedures have already proven their effectiveness in helping these patients. The aim of our study was to test the efficacy of new therapeutic procedure, inspired by the third wave of behavioral and cognitive psychotherapies. METHOD. Our study used an actor’s play training combined with an assertiveness program which comprised ten sessions: five of which were animated by an actress and five by a psychologist-psychotherapist. Each actor play’s session was given alternatively with a psychoeducation’s session. Twenty subjects participated in this program. They fulfilled these pre and post-test assessments: social self-efficacy questionnaire, self-affirmation scales, self-esteem scale, communication scale, anxiety and depression scales. Repeated measures’ ANOVAs have been used to compare pre and post-test results. RESULTS. Results showed statistically significant improvements on each dependent variable, except for the Communication Scale. The higher effects appeared for Beck Depression Inventory and Social Self-efficacy Questionnaire which presented an effect size of 0,74 and 0,56, respectively. Scores on STAI-A and B and on Self-affirmation Scale were over the effect size’s threshold. However, these improvements don’t attain control group’s scores reported in the scientific literature. DISCUSSION. The results highlighted that our program is effective in reducing difficulties in assertiveness. [less ▲]

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See detailCombination of actor's play training and assertiveness program to reduce difficulties in self-affirmation: A preliminary study.
Wagener, Aurélie ULg; Delvaux, Muriel ULg; Sarto, Danielle et al

Poster (2013, May 28)

BACKGROUND. Difficulties in assertiveness are often reported by individuals suffering from various psychological problems involving anxiety, depression. Cognitive and behavioral therapeutic procedures ... [more ▼]

BACKGROUND. Difficulties in assertiveness are often reported by individuals suffering from various psychological problems involving anxiety, depression. Cognitive and behavioral therapeutic procedures have already proven their effectiveness in helping these patients. The aim of our study was to test the efficacy of new therapeutic procedure, inspired by the third wave of behavioral and cognitive psychotherapies. METHOD. Our study used an actor’s play training combined with an assertiveness program which comprised ten sessions: five of which were animated by an actress and five by a psychologist-psychotherapist. Each actor play’s session was given alternatively with a psychoeducation’s session. Twenty subjects participated in this program. They fulfilled these pre and post-test assessments: social self-efficacy questionnaire, self-affirmation scales, self-esteem scale, communication scale, anxiety and depression scales. Repeated measures’ ANOVAs have been used to compare pre and post-test results. RESULTS. Results showed statistically significant improvements on each dependent variable, except for the Communication Scale. The higher effects appeared for Beck Depression Inventory and Social Self-efficacy Questionnaire which presented an effect size of 0,74 and 0,56, respectively. Scores on STAI-A and B and on Self-affirmation Scale were over the effect size’s threshold. However, these improvements don’t attain control group’s scores reported in the scientific literature. DISCUSSION. The results highlighted that our program is effective in reducing difficulties in assertiveness. [less ▲]

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See detailCombination of capillary electrophoresis, molecular modelling and nuclear magnetic resonance to study the interaction mechanisms between single-isomer anionic cyclodextrin derivatives and basic drug enantiomers in a methanolic background electrolyte.
Servais, Anne-Catherine ULg; Rousseau, Anne; Dive, Georges ULg et al

in Journal of Chromatography. A (2012), 1232

In order to improve our knowledge of the mechanisms of enantiomer recognition pattern in nonaqueous systems, an approach combining nonaqueous CE (NACE), molecular modelling and NMR was undertaken ... [more ▼]

In order to improve our knowledge of the mechanisms of enantiomer recognition pattern in nonaqueous systems, an approach combining nonaqueous CE (NACE), molecular modelling and NMR was undertaken. Bupivacaine and propranolol were selected as model compounds and their interactions with two single-isomer highly charged beta-CD derivatives, namely heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-CD (HDMS-beta-CD) and heptakis(2,3-di-O-acetyl-6-O-sulfo)-beta-CD (HDAS-beta-CD), were studied. The CD-bupivacaine complexes were evaluated by 2-D Rotating-frame Overhauser Effect SpectroscopY (ROESY) experiments. From these experiments, it can be assumed that inclusion complexes are not formed, whatever the CD derivative used. Molecular modelling was performed at the RHF/MINI-1 or B3LYP/6-31G(d) level. External as well as inclusion type complexes with the alkyl chain of propranolol into both CD cavities were located. Interaction energies calculated for bupivacaine and propranolol correlated with the enantiomer migration order observed in the NACE experiments using both anionic CD derivatives. The interaction of propranolol with HDMS-beta-CD or HDAS-beta-CD gives rise to a family of external and inclusion complexes in which some are more probably obtained. [less ▲]

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See detailCombination of different techniques and multi-scale approach to understand CO2 budget in a temperate beech forest
Longdoz, Bernard; Epron, Daniel; Goffin, Stéphanie ULg et al

Conference (2010, November)

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See detailCombination of electrografting and atom-transfer radical polymerization for making the stainless steel surface antibacterial and protein antiadhesive
Ignatova, Miléna; Voccia, Samuel; Gilbert, Bernard ULg et al

in Langmuir (2006), 22(1), 255-262

A two-step "grafting from" method has been successfully carried out, which is based on the electrografting of polyacrylate chains containing an initiator for the atom transfer radical polymerization (ATRP ... [more ▼]

A two-step "grafting from" method has been successfully carried out, which is based on the electrografting of polyacrylate chains containing an initiator for the atom transfer radical polymerization (ATRP) of 2-(tert-butylamino)ethyl methacrylate (TBAEMA) or copolymerization of TBAEMA with either monomethyl ether of poly(ethylene oxide) methacrylate (PEOMA) or acrylic acid (AA) or styrene. The chemisorption of this type of polymer brushes onto stainless steel surfaces has potential in orthopaedic surgery. These films have been characterized by ATR-FTIR, Raman spectroscopy, atomic force microscopy (AFM), and measurement of contact angles of water. The polymer formed in solution by ATRP and that one detached on purpose from the surface have been analyzed by size exclusion chromathography (SEC) and H-1 NMR spectroscopy. The strong adherence of the films onto stainless steel has been assessed by peeling tests. AFM analysis has shown that addition of hydrophilic comonomers to the grafted chains decreases the surface roughness. According to dynamic quartz crystal microbalance experiments, proteins (e.g., fibrinogen) are more effectively repelled whenever copolymer brushes contain neutral hydrophilic (PEOMA) co-units rather than negatively charged groups (PAA salt). Moreover, a 2- to 3-fold decrease in the fibrinogen adsorption is observed when TBAEMA is copolymerized with either PEOMA or AA rather than homopolymerized or copolymerized with styrene. Compared to the bare stainless steel surface, brushes of polyTBAEMA, poly (TBAEMA-co-PEOMA) and poly(TBAEMA-co-AA) decrease the bacteria adhesion by 3 to 4 orders of magnitude as revealed by Gram-positive bacteria S. aureus adhesion tests. [less ▲]

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See detailCombination of electrografting and layer-by-layer deposition: an efficient way to tailor polymer coatings of (semi)-conductors
Charlot, Aurélia; Gabriel, Sabine ULg; Detrembleur, Christophe ULg et al

in Chemical Communications (2007), (44), 4656-4658

This communication reports on a novel, simple and highly versatile concept, which consists in combining the advantages of two complementary and relevant techniques (i) electrografting and (ii) layer-by ... [more ▼]

This communication reports on a novel, simple and highly versatile concept, which consists in combining the advantages of two complementary and relevant techniques (i) electrografting and (ii) layer-by-layer deposition process with the goal to tailor strongly adhering coatings to (semi)-conducting surfaces imparting them with tunable specific properties. [less ▲]

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See detailCombination of Electrografting and Ring-Opening Metathesis Polymerization: An Efficient Way to Prepare Polynorbornene Brushes on Conducting Substrates
Detrembleur, Christophe ULg; Jérôme, Christine ULg; Claes, Michaël et al

in Angewandte Chemie (International ed. in English) (2001), 40(7), 1268-1271

Detailed reference viewed: 23 (1 ULg)
See detailCombination of electrografting with controlled polymerization: building of anti-bacterial surfaces
Voccia, Samuel; Ignatova, Miléna; Gilbert, Bernard ULg et al

Conference (2005, June 01)

Detailed reference viewed: 14 (2 ULg)