Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailComparative prospective, double-blind, multicenter study of the efficacy of tiludronate and etidronate in the treatment of Paget's disease of bone.
Roux, C.; Gennari, C.; Farrerons, J. et al

in Arthritis and Rheumatism (1995), 38(6), 851-8

OBJECTIVE: To compare the efficacy and safety of tiludronate and etidronate at the same dosage (400 mg/day) for the treatment of active Paget's disease of bone. METHODS: We studied 234 patients with ... [more ▼]

OBJECTIVE: To compare the efficacy and safety of tiludronate and etidronate at the same dosage (400 mg/day) for the treatment of active Paget's disease of bone. METHODS: We studied 234 patients with radiologic lesions characteristic of Paget's disease of bone and serum alkaline phosphatase (AP) concentrations at least twice the upper limit of normal, in a prospective, randomized, double-blind, multicenter clinical trial lasting 6 months. Patients were randomly allocated into 1 of 3 treatment groups: tiludronate for 3 months followed by placebo for 3 months, tiludronate for 6 months, or etidronate for 6 months. Serum AP levels and urinary hydroxyproline excretion were measured at baseline and after 3 months and 6 months. Patients with a reduction of at least 50% in the serum AP concentration were considered to be responders. RESULTS: After 3 months, the proportion of responders was higher in the tiludronate group (57.4%) than in the etidronate group (13.9%) (P < 0.0001). In the etidronate group, this percentage was lower among patients who had received previous treatment with a bisphosphonate (2.3%) than among those who had not (28.6%) (P < 0.01). Previous bisphosphonate treatment was not associated with response in the tiludronate group. After 6 months, the proportion of responders did not differ between the 2 tiludronate groups (60.3% and 70.1%), but was lower in the etidronate group (25.3%) (P < 0.0001). There was a higher proportion of patients with treatment-resistant disease (< 25% reduction of serum AP) in the etidronate group (51.9%) than in the tiludronate 3-month group (17.9%) or the tiludronate 6-month group (19.5%) (P < 0.0001). Gastrointestinal disturbances were more common, and occurred earlier, with tiludronate, but they were mostly mild, requiring no treatment. CONCLUSION: Tiludronate at 400 mg/day for 3 months or 6 months is more effective than the same dosage of etidronate for 6 months in the treatment of Paget's disease. [less ▲]

Detailed reference viewed: 6 (2 ULg)
Full Text
Peer Reviewed
See detailComparative responses to sodium selenite and organic selenium supplements in Belgian Blue cows and calves
Guyot, Hugues ULg; Spring, P.; Andrieu, S. et al

in Livestock Science (2007), 111(3), 259-263

Belgian Blue (BB) beef cattle is particularly prone to selenium (Se) deficiency due to the poor Se content of soil and roughages on rearing farms and the higher requirements of this hypermuscled breed ... [more ▼]

Belgian Blue (BB) beef cattle is particularly prone to selenium (Se) deficiency due to the poor Se content of soil and roughages on rearing farms and the higher requirements of this hypermuscled breed. The goal of this trial was to compare the effects of different forms and concentrations of Se supplementation on Se status, health and performance in 60 pregnant Se-deficient BB cows. Cows were allocated to 3 experimental groups receiving selenized-yeast at 0.5 ppm Se on total ration (Y-Se 0.5), Na-selenite at 0.5 ppm Se on total ration (Na-Se 0.5) and Na-selenite at 0.1 ppm Se on total ration (Na-Se 0.1), respectively. Cows were supplemented from 2 months before calving until 2 months after calving. Data on performance, health and Se status of the dams and their calves were analyzed using a linear model, least squares means and logistic regression. At the end of the study, plasmatic Se (pSe) was significantly higher (P<0.01) in cows receiving Y-Se than in cows from other groups. Glutathion-peroxidase in erythrocytes (GSH-pxe) was higher in Y-Se and Na-Se 0.5 than Na-Se 0.1 group (P<0.01). Se content in colostrum and milk was significantly higher (P< 0.01) in Y-Se than other groups. At birth, Se status of calves from group Y-Se was significantly higher than those of other groups (P<0.01). Plasmatic Se in calves remained higher for 75 days after birth in Y-Se compared to other groups (P<0.01). Diarrhoea was the most commonly observed disease in the calves and, during the first 15 days of life, diarrhoea occurred in 6%, 21% and 35% of calves from groups Y-Se, Na-Se 0.5 and Na-Se 0.1, respectively. Over the whole 75 days trial period, incidence of diarrhoea was 19, 29 and 65%, respectively. Average daily gain (ADG) in calves born from Y-Se group of cows tended to be higher than in Na-Se 0.5 (P=0.06) and Na-Se 0.1 (P<0.05) but there was no difference between Na-Se 0.5 and Na-Se 0.1 (P>0.1). At the same dosage, Y-Se conferred better Se status in both dams and their calves than did Na-Se. Requirement of 0.1 ppm Se seems to be insufficient in BB to optimise health and performance. Regarding health status and ADG in calves, Y-Se seems also to result in better performance. (C) 2007 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 163 (5 ULg)
Full Text
Peer Reviewed
See detailComparative responses to sodium selenite and Sel-Plex® organic selenium supplements in Belgian Blue cows and calves
Guyot, Hugues ULg; Rollin, Frédéric ULg; Andrieu, Sylvie et al

in Nutritional Biotechnology in the Feed and Food Industries (Alltech’s 22nd Annual Symposium) (2006)

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailComparative semi-empirical and ab initio atomic structure calculations in Yb-like tungsten W4+
Enzonga Yoca, S; Quinet, Pascal ULg; Palmeri, P et al

in Journal of Physics : B Atomic Molecular & Optical Physics (2012), 45

Detailed reference viewed: 9 (1 ULg)
Peer Reviewed
See detailComparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region.
Paulsen, M.; Takada, S.; Youngson, N. A. et al

in Genome Research (2001), 11(12), 2085-94

The Dlk1-Gtl2 domain on mouse chromosome 12 contains reciprocally imprinted genes with the potential to contribute to our understanding of common features involved in imprinting control. We have sequenced ... [more ▼]

The Dlk1-Gtl2 domain on mouse chromosome 12 contains reciprocally imprinted genes with the potential to contribute to our understanding of common features involved in imprinting control. We have sequenced this conserved region in the mouse and sheep and included the human sequence in a three species comparison. This analysis resulted in a precise conservation map and identification of highly conserved sequence elements, some of which we have shown previously to be differentially methylated in the mouse. Additionally, this analysis facilitated identification of a CpG-rich tandem repeat array located approximately 13-15 kb upstream of Gtl2. Furthermore, we have identified a third imprinted transcript that overlaps with the last Dlk1 exon in the mouse. This transcript lacks a conserved open reading frame and is probably generated by cleavage of extended Dlk1 transcripts. Because Dlk1 and Gtl2 share many of the imprinting properties of the well-characterized Igf2-H19 domain, it has been proposed that the two regions may be regulated in the same way. Comparative genomic examination of the two domains indicates that although there are similarities, other features are very different, including the location of conserved CTCF-binding sites, and the level of conservation at regulatory regions. [less ▲]

Detailed reference viewed: 10 (3 ULg)
Full Text
Peer Reviewed
See detailComparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs
Amarger, V.; Nguyen, Minh Ngoc ULg; Van Laere, Anne-Sophie ULg et al

in Mammalian Genome (2002), 13(7), 388-398

IGF2 is the major candidate gene for a paternally expressed Quantitative Trait Locus (QTL) in the pig primarily affecting muscle development. Here we report two sequence contigs together comprising almost ... [more ▼]

IGF2 is the major candidate gene for a paternally expressed Quantitative Trait Locus (QTL) in the pig primarily affecting muscle development. Here we report two sequence contigs together comprising almost 90 kb containing the INS-IGF2 and H19 genes. A comparative sequence analysis of the pig, human, and mouse genomic sequences was conducted to identify the exon/intros organization, all promoters, and other evolutionarily conserved elements. RT-PCR analysis showed that IGF2 transcripts originated from four different promoters and included various combinations of seven untranslated exons together with three coding exons, in agreement with previous findings in other mammals. The observed sequence similarity in intronic and intragenic regions among the three species is remarkable and is most likely explained by the complicated regulation of imprinting and expression of these genes. The general trend was, as expected, a higher sequence similarity between human and pig than between these species and the mouse, but a few exceptions to this rule were noted. This genomic region exhibits several striking features, including a very high GC content, many CpG islands, and a low amount of interspersed repeats. The high GC and CpG content were more pronounced in the pig than in the two other species. The results will facilitate the further characterization of this important QTL in the pig. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailComparative studies for the serodiagnosis of Chlamydophila and Mycoplasma pneumoniae infections
Huynen, Pascale ULg; Goebel, Marie-Rose ULg; Meex, Cécile ULg et al

in ESCMID (Ed.) Abstract book of the 20th ECCMID (2010, April)

Detailed reference viewed: 39 (7 ULg)
Full Text
Peer Reviewed
See detailComparative studies of dispersant optimisation techniques for evaluating the stability of concentrated alumina slurries
Gaydardzhiev, Stoyan ULg; Ay, Peter; Janeczko, Marta

in Particle & Particle Systems Characterization (2006), 23

Detailed reference viewed: 27 (7 ULg)
Full Text
Peer Reviewed
See detailA comparative study between proximal radial morphology and the floating radial head prosthesis.
Popovic, Nebojsa; Djekic, Julien; Lemaire, Roger ULg et al

in Journal of Shoulder and Elbow Surgery (2005), 14(4), 433-40

A morphometric study of the proximal radius was performed with computed tomography scanning in 51 healthy adults. These dimensions were then compared with those of a commercially available floating radial ... [more ▼]

A morphometric study of the proximal radius was performed with computed tomography scanning in 51 healthy adults. These dimensions were then compared with those of a commercially available floating radial head prosthesis. Results were expressed as mean values, SD, and minimum and maximum values. The minimum and maximum diameters of the radial head were 21.9 +/- 1.9 mm and 22.9 +/- 1.9 mm, respectively. The minimum and maximum intramedullary diameters of the radial neck were 8.3 +/- 1.3 mm and 9.3 +/- 1.5 mm, respectively. The combined length of the radial head and neck was 22.47 +/- 2.84 mm. The implications for prosthetic design are as follows: the small floating cup (19 mm in diameter) is too small for the large majority of adults, the large floating cup (22 mm in diameter) is closer to the radial anatomy, the mean values are significantly different between male and female patients, and a single component would suffice for right and left elbows. [less ▲]

Detailed reference viewed: 43 (5 ULg)
Full Text
Peer Reviewed
See detailComparative study of Ag and Au nanoparticles biosensors based on surface plasmon resonance phenomenon
Lismont, Marjorie ULg; Dreesen, Laurent ULg

in Materials Science & Engineering : C (2012)

The specific sensitivity of surface plasmon resonance to changes in the local environment of nanoparticles allows their use as platforms to probe chemical and biochemical binding events on their surfaces ... [more ▼]

The specific sensitivity of surface plasmon resonance to changes in the local environment of nanoparticles allows their use as platforms to probe chemical and biochemical binding events on their surfaces without any labeling [1- 4]. In this paper, we perform a comparative study of gold and silver nanoparticle based biosensors, prepared within the same conditions, in order to determine which metal seems the best for biological sensing. The prototypical biocytin-avidin interaction is used to study gradual changes over time and with avidin concentration in the absorption spectra bands of biocytinylated 10 nm silver and gold nanospheres. First, the Ag nanoparticles plasmon resonance absorbance signal is about 10 times larger than the Au one. Secondly, for an equivalent concentration of avidin, the optical properties modifications are more pronounced for silver nanoparticles than for gold ones of the same geometry. These observations attest the superiority of Ag on Au nanoparticles when optical considerations are only taken into account. Finally, with both biosensors, the specificity of the interaction, checked by replacing avidin with bovine serum albumin, is relatively poor and needs to be improved. [less ▲]

Detailed reference viewed: 136 (20 ULg)
Full Text
Peer Reviewed
See detailComparative study of alkaline extraction process of hemicelluloses from pear pomace
Rabetafika, Holy-Nadia ULg; Bchir, Brahim ULg; Blecker, Christophe ULg et al

in Biomass & Bioenergy (2014), 61

Hemicelluloses were produced from pear pomace using direct alkaline extraction (sodium hydroxide and hydrogen peroxide) and two-step extraction with delignification pre-treatment (acidified sodium ... [more ▼]

Hemicelluloses were produced from pear pomace using direct alkaline extraction (sodium hydroxide and hydrogen peroxide) and two-step extraction with delignification pre-treatment (acidified sodium chlorite/sodium hydroxide). The aim of the study was to compare the extraction yield, composition and physicochemical characteristics of isolated hemicelluloses by size exclusion chromatography, FTIR and thermogravimetric analyses. Solid residues were analysed in order to evaluate the effect of processes on co-products (lignins and cellulose). Delignification of material (up to 995.4 g kg−1 of original lignins) during the direct alkaline hydrogen peroxide and two-step acidified sodium chlorite/sodium hydroxide processes improved the hemicellulose extraction yield attaining up to 945.3 g kg−1. Hemicelluloses were mainly composed of xylans (xylose/glucose ratio of 4.6–16.2) and had low lignin content (53.5–61.0 g kg−1 dry matter). Those from direct sodium hydroxide extraction were composed of xylans and glucans (xylose/glucose ratio of 1.5) with high content of lignins (149.3 g kg−1 dry matter). All isolated fractions were a mixture of polymers and oligomers with a molecular mass ranging from 1710 g mol−1 to 8 870 000 g mol−1. The two-step process gave the most pure cellulose residue (799.2 g kg−1 dry matter). According to results, the direct alkaline extraction with hydrogen peroxide was a promising process for the production of pure xylose-rich hemicelluloses from pear pomace solubilizing 802.2 g kg−1 of the original hemicelluloses but induced fragmentation of hemicelluloses. [less ▲]

Detailed reference viewed: 19 (8 ULg)
Full Text
Peer Reviewed
See detailComparative study of analytical formulae for the fire resistance of steel beam-columns
Talamona, D.; Castagne, S.; Lopes, N. et al

in Kodur; Tan (Eds.) Proceedings of the Fifth International Conference Structures in Fire (2008)

This paper investigates the difference between the buckling formulae published in the Eurocode 3 part 1.2 and the recommendations made in the final report of the Buckling Curves in Case of Fire (BCCF ... [more ▼]

This paper investigates the difference between the buckling formulae published in the Eurocode 3 part 1.2 and the recommendations made in the final report of the Buckling Curves in Case of Fire (BCCF) research project. This study compares the critical temperatures obtained with both formulations to assess the impact on the fire endurance of steel columns subjected to axial compression and bending. An extensive comparison of the ultimate temperatures obtained with both formulations has been performed (382 profiles, buckling about the strong and weak axis, 12 column lengths, 6 M/N ratios and uniform and triangular bending moment distributions). Failure temperatures between 400°C and 860°C have been considered. The formulations are also compared with Finite Elements (F.E.) calculations performed for a S235 HEA 200 at 600ºC. This analysis shows that for buckling about the strong axis the BCCF method is better than the EC3 but for buckling about the weak axis the EC3 predicts failure temperatures closer to the F.E. model than the BCCF formulation. Finally, the ultimate temperatures predicted by the two formulations have also been compared with experimental results from the database SCOFIDAT. This comparison shows that there is no major difference between the two formulations for small and large bending moments. This study concludes that the EC3 and BCCF formulations are generally equivalent and that either formulation can be used. [less ▲]

Detailed reference viewed: 36 (4 ULg)
Full Text
Peer Reviewed
See detailA comparative study of B-type pulsators and non-pulsating chemically peculiar Bp stars
Briquet, Maryline ULg; Hubrig, S.; De Cat, P. et al

in Communications in Asteroseismology (2007), 150

We carry out a comparative study between a sample of confirmed and well-studied B-type pulsators and a sample of well-studied Bp stars with known periods and magnetic field strengths. Our study indicates ... [more ▼]

We carry out a comparative study between a sample of confirmed and well-studied B-type pulsators and a sample of well-studied Bp stars with known periods and magnetic field strengths. Our study indicates that the group of Bp stars is younger than the group of SPB stars and that stars with stronger magnetic fields have much lower pulsation amplitudes. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailComparative study of beam-column interaction formulae
Jaspart, Jean-Pierre ULg; Briquet, C.; Maquoi, René ULg

in Proceedings of the Annual Technical Session and Meeting of the SSRC (1993)

Detailed reference viewed: 6 (0 ULg)
See detailA Comparative Study of Belgian Accounting Principles and International Accounting Standards
Schumesch, Patrice ULg; Dams, Eddy; Vermoesen, Raynald

Book published by Pricewaterhousecoopers (2004)

Detailed reference viewed: 7 (1 ULg)
See detailComparative study of bile salts hydrolase activity from Lactobacilli ssp.
El Mejdoub, Thami ULg; Roblain, D.; Destain, Jacqueline ULg et al

Poster (1999, July)

Detailed reference viewed: 9 (2 ULg)
Full Text
Peer Reviewed
See detailComparative study of biological hydrogen production by pure strains and consortia of facultative and strict anaerobic bacteria
Hiligsmann, Serge ULg; Masset, Julien ULg; Hamilton, Christopher ULg et al

in Bioresource Technology (2011), 102

In this paper, a simple and rapid method was developed in order to assess in comparative tests the production of binary biogas mixtures containing CO2 and another gaseous compound such as hydrogen or ... [more ▼]

In this paper, a simple and rapid method was developed in order to assess in comparative tests the production of binary biogas mixtures containing CO2 and another gaseous compound such as hydrogen or methane. This method was validated and experimented for the characterisation of the biochemical hydrogen potential of different pure strains and mixed cultures of hydrogen-producing bacteria (HPB) growing on glucose. The experimental results compared the hydrogen production yield of 19 different pure strains and sludges : facultative and strict anaerobic HPB strains along with anaerobic digester sludges thermally pre-treated or not. Significant yields variations were recorded even between different strains of the same species by i.e. about 20% for three Clostridium butyricum strains. The pure Clostridium butyricum and pasteurianum strains achieved the highest yields i.e. up to 1,36 mol H2/mol glucose compared to the yields achieved by the sludges and the tested Escherichia and Citrobacter strains. [less ▲]

Detailed reference viewed: 92 (42 ULg)
Full Text
Peer Reviewed
See detailA comparative study of class-D beta-lactamases.
Ledent, Philippe; Raquet, X; Joris, Bernard ULg et al

in Biochemical Journal (1993), 292 ( Pt 2)

Three class-D beta-lactamases (OXA2, OXA1 and PSE2) were produced and purified to protein homogeneity. 6 beta-Iodopenicillanate inactivated the OXA2 enzyme without detectable turnover. Labelling of the ... [more ▼]

Three class-D beta-lactamases (OXA2, OXA1 and PSE2) were produced and purified to protein homogeneity. 6 beta-Iodopenicillanate inactivated the OXA2 enzyme without detectable turnover. Labelling of the same beta-lactamase with 6 beta-iodo[3H]penicillanate allowed the identification of Ser-70 as the active-site serine residue. In agreement with previous reports, the apparent M(r) of the OXA2 enzyme as determined by molecular-sieve filtration, was significantly higher than that deduced from the gene sequence, but this was not due to an equilibrium between a monomer and a dimer. The heterogeneity of the OXA2 beta-lactamase on ion-exchange chromatography contrasted with the similarity of the catalytic properties of the various forms. A first overview of the enzymic properties of the three 'oxacillinases' is presented. With the OXA2 enzyme, 'burst' kinetics, implying branched pathways, seemed to prevail with many substrates. [less ▲]

Detailed reference viewed: 15 (0 ULg)