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Peer Reviewed
See detailCentral neuroblastoma in a 14 year-old girl
Hoyoux, Cl; Dresse, Marie-Françoise ULg; Misson, Jean-Paul ULg et al

in 4th International Symposium on Neuroblastoma Screening (1995)

Detailed reference viewed: 12 (2 ULg)
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See detailCentral neuromodulation in cluster headache patients treated with occipital nerve stimulators: A PET study
Magis, Delphine ULg; Bruno, Marie-Aurélie ULg; Fumal, Arnaud ULg et al

in Acta Neurologica Belgica (2010), 110(Suppl 1), 17

OBJECTIVES: Use functional brain imaging to explore activity changes in centres involved in trigeminal pain processing and control before and after occipital neurostimulation in drug-resistant chronic ... [more ▼]

OBJECTIVES: Use functional brain imaging to explore activity changes in centres involved in trigeminal pain processing and control before and after occipital neurostimulation in drug-resistant chronic cluster headache patients. BACKGROUND: Occipital nerve stimulation (ONS) provides relief to about 60% of patients suffering from drug-resistant chronic cluster headache (drCCH). Its mode of action, however, remains elusive, but the long latency to meaningful effect suggests that ONS induces slow neuromodulation. METHODS: Ten drCCH patients underwent an 18FDG-PET scan after ONS durations varying between 0 and 30 months. All were scanned with ongoing ONS (ON) and with the stimulator switched OFF. RESULTS: After 6-30 months of ONS, 3 patients were pain free and 4 had a ≥ 90% reduction of attack frequency (responders). In patients overall compared to controls, several areas of the pain matrix were hypermetabolic: ipsilateral hypothalamus, midbrain and ipsilateral lower pons. All normalized after ONS, except the hypothalamus. Switching ON or OFF the stimulator had little influence on brain glucose metabolism. The perigenual anterior cingulate cortex (PACC) was hyperactive in ONS responders compared to non-responders. INTERPRETATION AND CONCLUSIONS: Metabolic normalization in the pain neuromatrix and lack of short-term changes induced by the stimulation support the hypothesis that ONS acts in drCCH through slow neuromodulatory processes. Selective activation in responders of PACC, a pivotal structure in the endogenous opioid system, suggests that ONS may restore balance within dysfunctioning pain control centres. That ONS is nothing but a symptomatic treatment might be illustrated by the persistent hypothalamic hypermetabolism which could explain why autonomic attacks may persist despite pain relief and why cluster attacks recur shortly after stimulator arrest. [less ▲]

Detailed reference viewed: 72 (4 ULg)
See detailCentral Pelvic spaces: Limits, content & landmarks
Bonnet, Pierre ULg

Scientific conference (2015, April 20)

Detailed reference viewed: 20 (0 ULg)
See detailCentral Pelvic spaces: Limits, content & landmarks
Bonnet, Pierre ULg

Scientific conference (2014, April 14)

Detailed reference viewed: 10 (1 ULg)
Peer Reviewed
See detailCentral pontine myelinolysis associated with acquired folate depletion
RAMAEKERS, Vincent ULg; Reul, J.; Kusenbach, G. et al

in Neuropediatrics (1997), 28(2), 126-30

After long-standing malnutrition a 15-month-old boy with signs of kwashiorkor was admitted in a moribund state with serious hyponatraemic dehydration, hypothermia, somnolence, and signs of a pontine ... [more ▼]

After long-standing malnutrition a 15-month-old boy with signs of kwashiorkor was admitted in a moribund state with serious hyponatraemic dehydration, hypothermia, somnolence, and signs of a pontine disconnection syndrome. Folic acid levels were below the detection level in the presence of normal cobalamin levels. MRI of the brain showed global volume loss and signal abnormalities on the T2-weighted images suggestive for central pontine myelinolysis (CPM). Brainstem acoustic evoked responses have remained normal. The serious metabolic and nutritional derangements required substitution of folic acid, vitamins and trace elements as well as slow correction of hyponatraemic dehydration with return of the sodium level over a period of four days. This therapeutic regimen resulted in complete neurological recovery. Follow-up MRI documented normalisation of the initial pathologic findings. The hypothesis was put forward linking the pathogenesis of CPM with the combination of folate depletion and superimposed hyponatraemic dehydration. The previously acquired folate depletion could affect normal appositional function of myelin basic protein molecules due to insufficient methylation of arginine in position 107. The subsequent development of intramyelinic edema and CPM will then be triggered by the superimposed hyponatraemic dehydration. The verification of this hypothesis requires further investigations. [less ▲]

Detailed reference viewed: 19 (0 ULg)
See detailThe central region of quasars seen with gravitational microlensing
Sluse, Dominique ULg

Scientific conference (2012, March 29)

Detailed reference viewed: 12 (0 ULg)
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See detailThe Central Role of FORS1/2 Spectropolarimetric Observations for the Progress of Stellar Magnetism Studies
Schöller, M.; Hubrig, S.; Ilyin, I. et al

in The Messenger (2016), 163

The spectropolarimetric mode of the FOcal Reducer and low dispersion Spectrographs (FORS), which was first implemented in FORS1, and then moved to FORS2 seven years ago, has made it possible to probe the ... [more ▼]

The spectropolarimetric mode of the FOcal Reducer and low dispersion Spectrographs (FORS), which was first implemented in FORS1, and then moved to FORS2 seven years ago, has made it possible to probe the presence of magnetic fields in stars of different spectral classes at almost all stages of stellar evolution. While in the early days of FORS1, many of the observations were related to magnetic Ap/Bp stars and their progenitor Herbig Ae/Be stars, recent spectropolarimetric studies with FORS2 have involved more challenging targets, such as massive O- and B-type stars in clusters and in the field, very fast rotating massive stars with magnetospheres, Wolf-Rayet stars and central stars of planetary nebulae. The role of FORS observations for stellar magnetic field measurements is summarised and improvements in the measurement technique are described. [less ▲]

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See detailThe central role of the thymus in the development of self-tolerance and autoimmunity in the neuroendocrine system
Geenen, Vincent ULg; Brilot, Fabienne; Hansenne, Isabelle et al

in Geenen, Vincent; Chrousos, Geroge P. (Eds.) Immunoendocrinology in Health and Disease (2004)

Detailed reference viewed: 13 (4 ULg)
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See detailThe central role of the thymus in the education of T cells to neuroendocrine self principles
Geenen, Vincent ULg; Martens, Henri ULg; Cormann-Goffin, Nadine et al

in Archives Internationales de Physiologie et de Biochimie (1993), 101

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See detailThe central role of the thymus in the programming of immunological tolerance to neuroendocrine self: Implications for the pathogenesis of autoimmune diseases.

Geenen, Vincent ULg

Conference (2015, June)

Our studies have demonstrated that the thymus programs central self-tolerance to neuroendocrine functions through transcription of neuroendocrine-related genes in thymic epithelial cells (TECs). However ... [more ▼]

Our studies have demonstrated that the thymus programs central self-tolerance to neuroendocrine functions through transcription of neuroendocrine-related genes in thymic epithelial cells (TECs). However, thymic neuroendocrine precursors are not secreted but processed as the source of neuroendocrine self-antigens that are presented by thymic proteins of the major histocompatibility complex (MHC). This process, highly specific of the thymus, has allowed an integrated and harmonious coevolution of the neuroendocrine and immune systems when recombination-activating genes and the subsequent adaptive immune response have emerged in cartilaginous fishes some 450-500 millions years ago. All the members of the insulin gene family are expressed in murine TECs under the control of AutoImmune Regulator (AIRE) according a precise hierarchy: Igf2 >Igf1>Ins2>Ins1. Igf2 transcription is defective in TECs of autoimmune diabetes-prone BB rats, and tolerance to insulin is severely impaired in Igf2-/- mice as well as in Igf2-loxP/Foxn1-cre mice with Igf2 deletion targeted in TECs. In addition, the diabetogenic coxsackievirus B4 (CV-B4) is able to persistently infect human and murine TECs and to inhibit Igf2 transcription and IGF-2 synthesis in a murine medullary TEC line (coolaboration with D. Hober, Laboratory of Virology, CHRU and University of Lille 2, France). These studies show that: 1° IGF-2 is the dominant tolerogenic precursor of the family and mediates cross-tolerance to insulin; 2° a thymus dysfunction plays a crucial role in the development of the diabetogenic autoimmune response; and 3° a thymic infection by CV-B4 is implicated in type 1 diabetes (T1D) pathogenesis. Most probably due to its very low level of expression in the thymus, the protein insulin is highly immunogenic and is the primary autoantigen tackled in T1D. On the basis of the tolerogenic properties of IGF-2, we are currently working on the development of a negative/tolerogenic self-vaccine against T1D. [less ▲]

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See detailCentral self-tolerance by thymic presentation of self-antigens and autoimmunity
Geenen, Vincent ULg; Martens, Henri ULg; Hansenne, Isabelle et al

in Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents (2001), 1

Before reacting against non-self infectious agents, the immune system is educated to tolerate the host molecular structure (self). The induction of self-tolerance is a multistep process that begins in the ... [more ▼]

Before reacting against non-self infectious agents, the immune system is educated to tolerate the host molecular structure (self). The induction of self-tolerance is a multistep process that begins in the thymus during fetal ontogeny (central tolerance) and also involves inactivating mechanisms outside the thymus (peripheral tolerance). The thymus is the primary lymphoid organ implicated in the development of competent and self-tolerant T cells. During ontogeny, T cell progenitors originating from hemopoietic tissues (yolk sac, fetal liver, and then bone marrow) enter the thymus and undergo a program of proliferation, T cell receptor (TCR) gene rearrangement, maturation and selection. Close interactions between thymocytes (pre-T cells) and the thymic cellular environment are crucial both for T cell development and induction of central self-tolerance. Thymic epithelial and stromal cells synthesize polypeptides belonging to various neuroendocrine families. The thymic repertoire of neuroendocrine-related precursors transposes at the molecular level the dual role of the thymus in T cell negative and positive selection. Thymic precursors not only constitute a source of growth peptides for cryptocrine signaling between thymic stromal cells and pre-T cells, but are also processed in a way that leads to the presentation of self-antigens by thymic major histocompatibility complex (MHC) proteins. Thymic neuroendocrine self-antigens often correspond to peptide sequences highly conserved during the evolution of their corresponding family. The thymic presentation of some neuroendocrine self-antigens is not restricted by MHC alleles. Following the presentation of neuroendocrine self-antigens by thymic MHC proteins, the T cell system might be educated to tolerate main hormone families. Recent experiments argue that a defect in the thymic essential tolerogenic function is implicated as an important factor in the pathophysiology of many autoimmune diseases. [less ▲]

Detailed reference viewed: 33 (3 ULg)
See detailLa centrale positive des crédits aux particuliers
Biquet, Christine ULg; Dengis, Stéphanie ULg

in Actualité législative en droit immobilier (2000-2002) (2002)

Detailed reference viewed: 38 (1 ULg)
See detailCentralisation et décentralisation en droit wallon de l'urbanisme
Pâques, Michel ULg

in Liber amicorum Robert Andersen (2010)

Detailed reference viewed: 95 (10 ULg)
Peer Reviewed
See detailCentralized Model Predictive Control of Multi-Terminal Direct Current Grids
Papangelis, Lampros ULg

in Proc. of the 8th IEEE Benelux Young Researchers Symposium 2016 (2016, May 12)

This work describes a centralized control for Multi-Terminal Direct Current (MTDC) grids. It is based on Model Predictive Control (MPC) whose aim is to satisfy a desired schedule, while avoiding or ... [more ▼]

This work describes a centralized control for Multi-Terminal Direct Current (MTDC) grids. It is based on Model Predictive Control (MPC) whose aim is to satisfy a desired schedule, while avoiding or correcting any system limit violation. The central controller collects voltage and power measurements from the converters of the system in regular intervals and sends back converter power setpoints. The latter are calculated by solving a quadratic programming problem subject to linear constraints and using a simplified model for the DC system. In addition, the overall MTDC grid control structure including the local and the centralized controllers is described. [less ▲]

Detailed reference viewed: 50 (15 ULg)
See detailCentration soutenue sur une tâche intellectuelle simple: Ordination continue de chiffres
Rey, A.; Marchand, F.; Rappaz, R. et al

in Archives de Psychologie (1957), 36

Detailed reference viewed: 127 (2 ULg)